Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.025 0.132 -9999.0 0.0 -0.514 1.0 1.0 IHH -0.072 0.206 -9999.0 0.0 -0.47 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.032 0.128 -9999.0 0.0 -0.295 10.0 10.0 LRPAP1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.032 0.127 0.293 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.024 0.16 -9999.0 0.0 -0.406 7.0 7.0 SMO -0.04 0.16 -9999.0 0.0 -0.425 7.0 7.0 AKT1 0.004 0.088 -9999.0 0.0 -0.352 1.0 1.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.073 -9999.0 0.0 -0.52 1.0 1.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.039 0.158 -9999.0 0.0 -0.419 7.0 7.0 STIL -0.043 0.166 0.263 2.0 -0.425 5.0 7.0 DHH N/PTCH2 -0.008 0.123 -9999.0 0.0 -0.345 6.0 6.0 DHH N/PTCH1 -0.038 0.15 -9999.0 0.0 -0.496 2.0 2.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.012 0.135 -9999.0 0.0 -0.49 4.0 4.0 PTHLH -0.037 0.157 -9999.0 0.0 -0.6 1.0 1.0 determination of left/right symmetry -0.039 0.158 -9999.0 0.0 -0.419 7.0 7.0 PIK3R1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.037 0.156 -9999.0 0.0 -0.595 1.0 1.0 IHH N/Hhip -0.081 0.201 -9999.0 0.0 -0.424 12.0 12.0 DHH N/Hhip -0.05 0.171 -9999.0 0.0 -0.38 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.039 0.158 -9999.0 0.0 -0.419 7.0 7.0 pancreas development -0.047 0.183 -9999.0 0.0 -0.489 8.0 8.0 HHAT 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.022 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.107 -9999.0 0.0 -0.439 3.0 3.0 somite specification -0.039 0.158 -9999.0 0.0 -0.419 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.054 0.162 -9999.0 0.0 -0.419 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.027 0.129 -9999.0 0.0 -0.303 9.0 9.0 SHH Np/Cholesterol/Megalin -0.074 0.159 -9999.0 0.0 -0.295 17.0 17.0 SHH -0.04 0.135 -9999.0 0.0 -0.366 8.0 8.0 catabolic process -0.031 0.139 -9999.0 0.0 -0.345 7.0 7.0 SMO/Vitamin D3 -0.055 0.178 -9999.0 0.0 -0.481 5.0 5.0 SHH Np/Cholesterol/Hhip -0.061 0.148 -9999.0 0.0 -0.293 15.0 15.0 LRP2 -0.073 0.198 -9999.0 0.0 -0.465 11.0 11.0 receptor-mediated endocytosis -0.089 0.204 -9999.0 0.0 -0.473 10.0 10.0 SHH Np/Cholesterol/BOC -0.017 0.104 -9999.0 0.0 -0.28 7.0 7.0 SHH Np/Cholesterol/CDO -0.024 0.123 -9999.0 0.0 -0.316 8.0 8.0 mesenchymal cell differentiation 0.061 0.147 0.292 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 -0.05 0.165 -9999.0 0.0 -0.446 5.0 5.0 IHH N/PTCH2 -0.036 0.153 -9999.0 0.0 -0.362 8.0 8.0 CDON 0.016 0.073 -9999.0 0.0 -0.52 1.0 1.0 IHH N/PTCH1 -0.026 0.143 -9999.0 0.0 -0.348 7.0 7.0 Megalin/LRPAP1 -0.036 0.15 -9999.0 0.0 -0.333 11.0 11.0 PTCH2 0.01 0.092 -9999.0 0.0 -0.459 2.0 2.0 SHH Np/Cholesterol -0.026 0.106 -9999.0 0.0 -0.281 8.0 8.0 PTCH1 -0.031 0.139 -9999.0 0.0 -0.346 7.0 7.0 HHIP -0.047 0.184 -9999.0 0.0 -0.49 8.0 8.0