rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	129925	2	2	2	0	0	0	1	0	1	0	0.885	0.0118	1.000
2	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(3), IL6(2), TGFB1(1), TGFB2(2)	724148	9	5	8	1	1	2	4	0	2	0	0.279	0.0174	1.000
3	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC2(1), CDC42(1), PAK1(2), PDGFRA(4), PIK3CA(1), PIK3R1(1), WASL(2)	1142933	12	6	11	2	2	2	2	3	3	0	0.398	0.0188	1.000
4	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), REN(4)	2187412	26	11	24	1	4	4	9	1	7	1	0.0299	0.0304	1.000
5	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TOB1(2)	915152	12	7	10	2	5	1	0	2	4	0	0.402	0.0401	1.000
6	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA3(1), LTB4R(3), P2RY1(2), P2RY2(1), P2RY6(1)	514396	9	5	8	1	4	1	2	0	2	0	0.186	0.0523	1.000
7	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IL12B(1)	256199	3	3	3	2	0	1	0	0	2	0	0.990	0.0758	1.000
8	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FSHB(1), FSHR(1), GNAS(6), XPO1(1)	837792	12	4	11	1	6	2	3	1	0	0	0.144	0.0787	1.000
9	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD4(2), CD58(2), IL6(2)	536223	8	3	8	1	1	0	2	3	2	0	0.367	0.0823	1.000
10	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), DPYD(3), DPYS(4), GAD1(5), GAD2(4), HADHA(1), HIBCH(2), UPB1(2)	2328770	29	10	28	5	9	5	6	3	5	1	0.0733	0.106	1.000
11	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(2), CR2(4), FCGR2B(1), ICAM1(1), ITGB2(1), PTPRC(2)	1305486	12	6	12	1	2	3	1	3	3	0	0.103	0.113	1.000
12	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC3B(1), APOBEC3F(1), APOBEC4(2)	626256	6	4	5	1	2	2	0	0	2	0	0.460	0.120	1.000
13	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(6), CDC25A(2), CDC25C(2), MYT1(6), YWHAH(1)	1182342	17	7	15	3	2	3	2	3	7	0	0.395	0.139	1.000
14	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(2)	485087	8	3	7	2	3	2	1	0	2	0	0.400	0.141	1.000
15	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(5), CRY1(1), CSNK1E(1), PER1(2)	747048	10	4	9	0	2	0	0	3	5	0	0.0888	0.142	1.000
16	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(1), ADSS(1), AGXT2(1), ASNS(3), CAD(4), CRAT(1), DARS(1), DDO(1), GAD1(5), GAD2(4), GOT1(2), GPT(1), GPT2(2), PC(2)	2251813	31	9	31	6	6	6	11	4	3	1	0.108	0.147	1.000
17	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(3), CASP1(2), CASP10(1), CASP8(2), PRF1(3)	1105130	14	6	13	4	2	3	0	2	7	0	0.691	0.154	1.000
18	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(1), FUT2(1)	620616	4	3	4	1	3	0	0	1	0	0	0.561	0.164	1.000
19	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CD4(2), IL1B(1), IL6(2)	394512	5	2	5	1	0	0	2	1	2	0	0.642	0.166	1.000
20	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	61729	3	1	3	1	2	0	0	0	1	0	0.718	0.172	1.000
21	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(2), CDC25C(2), CSK(1), SRC(1)	792964	6	5	4	1	1	1	0	0	4	0	0.686	0.174	1.000
22	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(1), PIK3R1(1), PLCG1(1), SOS1(2)	1340175	11	5	11	1	3	3	1	2	2	0	0.147	0.181	1.000
23	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	10	CAPN1(1), CAPNS1(3), CDK5(1), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(1)	683234	9	4	9	1	3	3	0	0	3	0	0.171	0.186	1.000
24	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(4), CPS1(4), GAD1(5), GAD2(4), GFPT1(1), GLS(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(3), PPAT(2), QARS(1)	2860782	35	10	35	8	7	5	13	4	4	2	0.229	0.191	1.000
25	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(7), RANGAP1(2)	720855	10	3	10	2	1	2	2	2	2	1	0.530	0.209	1.000
26	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ARPC2(1), CDC42(1), WASF1(1), WASL(2)	694502	7	4	7	3	1	3	1	2	0	0	0.671	0.212	1.000
27	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), FARS2(2), GOT1(2)	706983	5	3	4	1	0	0	3	2	0	0	0.685	0.215	1.000
28	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(1), IL6(2), LPL(2)	455143	7	2	7	0	1	2	2	0	2	0	0.105	0.227	1.000
29	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(6), ATR(5), CDC25C(2), YWHAH(1)	1293581	14	6	13	5	1	2	4	2	5	0	0.895	0.228	1.000
30	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(6), ABAT(1), ADSL(1), ADSS(1), AGXT2(1), ASNS(3), CAD(4), CRAT(1), DARS(1), DDO(1), DLAT(3), GAD1(5), GAD2(4), GOT1(2), GPT(1), GPT2(2), NARS2(1), PC(2), PDHA1(1)	3274451	42	12	41	9	8	8	13	4	8	1	0.141	0.228	1.000
31	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(6), CDC25A(2), CDC25C(2), CDK4(2), MYT1(6), RB1(1), YWHAH(1)	1439332	20	7	18	3	3	3	4	3	7	0	0.300	0.230	1.000
32	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(1), GOT1(2)	747034	5	3	4	1	1	0	3	1	0	0	0.649	0.238	1.000
33	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2)	642793	11	3	11	1	3	4	3	0	1	0	0.167	0.252	1.000
34	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCL3(1), CCR1(1), CCR4(2), CCR7(1), CD4(2), CXCR4(3), IFNGR1(1), IL12B(1), IL4R(1), TGFB1(1), TGFB2(2)	1616086	16	5	15	4	4	3	2	4	3	0	0.364	0.265	1.000
35	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(3), GAD1(5), GAD2(4), SLC18A3(1), TPH1(2)	1267040	17	7	17	6	6	1	6	1	2	1	0.516	0.271	1.000
36	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(4), PIK3CA(1), PIK3R1(1), SOD1(1)	1144953	12	4	12	3	3	2	1	2	4	0	0.468	0.272	1.000
37	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(1), IL6(2), IL7(1)	532430	6	2	6	1	0	1	2	2	1	0	0.508	0.274	1.000
38	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(2), SP1(1)	536378	3	3	3	0	0	0	1	0	2	0	0.841	0.275	1.000
39	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(1), FGA(3), FGB(4), FGG(1), PLAT(1), PLAU(3), SERPINB2(1), SERPINE1(1)	1148137	15	4	14	3	2	4	5	2	2	0	0.330	0.277	1.000
40	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(2), RETN(2)	495952	7	3	6	1	1	0	2	1	3	0	0.530	0.279	1.000
41	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(5), GAD2(4)	499548	11	5	11	5	3	2	3	1	1	1	0.731	0.282	1.000
42	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1), MST1(4), MST1R(3)	565292	9	5	9	3	0	4	0	1	4	0	0.527	0.292	1.000
43	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2)	592478	9	5	9	2	1	2	3	2	1	0	0.415	0.294	1.000
44	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(4), MMP2(2), MMP9(2), RECK(3)	651583	12	4	11	4	5	1	2	0	4	0	0.571	0.297	1.000
45	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	HLA-A(2), KLRC1(1), KLRC2(2), PAK1(2), PIK3CA(1), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4)	1599610	19	6	18	3	5	2	3	4	4	1	0.168	0.305	1.000
46	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(4), GLS(1), GOT1(2)	670218	7	2	7	0	1	1	2	2	0	1	0.168	0.315	1.000
47	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(5), TPH1(2)	530093	7	3	7	3	1	0	2	1	2	1	0.768	0.316	1.000
48	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), BIRC2(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), LMNB1(1), LMNB2(1), PRF1(3)	1667335	19	7	18	3	4	5	2	1	7	0	0.252	0.322	1.000
49	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(1), CAMP(2), CREB1(1), SNX13(4), SRC(1), TERF2IP(1)	967945	13	4	13	2	2	1	2	4	4	0	0.350	0.325	1.000
50	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(8), ATM(6), BRCA1(3), MAPK8(1), MDM2(1), MRE11A(2), NFKBIA(2), RBBP8(2), RELA(1)	2494766	26	8	25	2	4	5	7	2	8	0	0.0648	0.338	1.000
51	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR2(1), NOS3(6), REN(4)	869950	13	6	11	2	3	0	5	0	5	0	0.462	0.344	1.000
52	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(3), SULT1A2(1), SULT2A1(1)	520093	9	2	9	1	0	2	1	3	3	0	0.297	0.350	1.000
53	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(2), WASF1(1), WASF2(2), WASL(2)	1224212	17	5	17	3	6	5	2	3	1	0	0.163	0.352	1.000
54	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), KEAP1(1), MAFF(1), MAPK8(1), NFE2L2(1)	779413	5	3	5	1	1	0	0	2	2	0	0.548	0.358	1.000
55	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3)	277523	3	2	3	0	3	0	0	0	0	0	0.337	0.360	1.000
56	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(2), ACADL(1), ACADSB(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), DPYD(3), DPYS(4), GAD1(5), GAD2(4), HADHA(1), UPB1(2)	2500933	30	8	30	5	9	7	6	4	3	1	0.0383	0.367	1.000
57	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(2), CDC25C(2), CDK7(1), XPO1(1)	749706	6	4	4	1	1	0	0	0	5	0	0.737	0.371	1.000
58	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(2), ARFGAP3(2), ARFGEF2(2), CLTB(1), COPA(2), GBF1(3), GPLD1(2), KDELR2(1), KDELR3(1)	1390394	17	4	16	0	3	2	3	4	4	1	0.0104	0.377	1.000
59	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), BAD(1), HRAS(1), IGF1R(4), PIK3CA(1), PIK3R1(1), SOS1(2), YWHAH(1)	1411983	13	4	13	4	3	3	0	3	4	0	0.609	0.381	1.000
60	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFLAR(2)	331209	4	2	4	3	0	0	1	1	2	0	0.908	0.382	1.000
61	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(3)	171962	3	1	3	0	0	0	2	0	1	0	0.420	0.382	1.000
62	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDK7(1)	603514	3	3	2	1	0	0	0	0	3	0	0.899	0.385	1.000
63	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCNE1(1), CDK4(2), HRAS(1), NFKBIA(2), PAK1(2), PIK3CA(1), PIK3R1(1), RB1(1), RELA(1)	1750102	14	6	13	6	2	2	4	2	4	0	0.919	0.388	1.000
64	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(1), RAB27A(1), RAB3A(1), RAB9A(2)	365555	7	2	7	1	3	3	0	1	0	0	0.188	0.392	1.000
65	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1)	355588	1	1	1	0	0	0	0	0	1	0	0.830	0.405	1.000
66	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), GLS(1), OAT(2), PRODH(1)	488144	7	2	7	1	2	1	2	0	2	0	0.353	0.406	1.000
67	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(1), GLB1(1), HEXB(1), LCT(3), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1)	1361930	17	5	16	6	7	3	1	0	6	0	0.388	0.410	1.000
68	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(4), INPPL1(3), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1)	1696671	15	6	15	4	3	3	0	3	6	0	0.570	0.411	1.000
69	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(6), LY96(1), NCK1(3), NCK2(2), NCL(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(2)	4427332	51	12	50	8	14	10	9	9	9	0	0.0155	0.416	1.000
70	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(6), LY96(1), NCK1(3), NCK2(2), NCL(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(2)	4427332	51	12	50	8	14	10	9	9	9	0	0.0155	0.416	1.000
71	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA4(5), GABRA5(3), GABRA6(1), PRKCE(1), SOD1(1)	680877	11	2	11	1	3	3	1	1	2	1	0.0677	0.417	1.000
72	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), DHFR(1), FPGS(3), GCH1(1), GGH(1)	582636	16	4	15	3	6	5	0	1	4	0	0.0715	0.419	1.000
73	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT2(1), CHST2(1), CHST4(1), CHST6(3), ST3GAL1(2)	1091684	10	4	10	0	3	1	3	1	2	0	0.0394	0.426	1.000
74	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	191010	2	1	2	1	0	0	0	1	1	0	0.765	0.434	1.000
75	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(8), MDM2(1), PIK3CA(1), PIK3R1(1), POLR1A(3), POLR1B(2), RB1(1)	1635759	17	4	16	3	3	3	5	1	5	0	0.259	0.437	1.000
76	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), SDHA(3)	567857	4	2	4	0	2	0	0	0	2	0	0.356	0.437	1.000
77	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(2), CYP11B1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2)	821285	9	5	9	3	3	1	2	2	1	0	0.649	0.444	1.000
78	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(2), CYP11B1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2)	821285	9	5	9	3	3	1	2	2	1	0	0.649	0.444	1.000
79	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(1), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4)	1101673	10	3	10	1	2	3	0	2	2	1	0.152	0.447	1.000
80	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), JUND(1)	331008	2	2	2	0	0	0	0	1	1	0	0.809	0.448	1.000
81	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1L(1), MTHFD2(1)	1094018	8	4	7	0	1	2	0	0	5	0	0.187	0.455	1.000
82	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2)	203972	2	1	2	1	0	0	0	1	1	0	0.905	0.458	1.000
83	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(1), HRAS(1), MAPK7(4), MEF2A(1), MEF2D(1), NTRK1(2), PIK3CA(1), PIK3R1(1), PLCG1(1), RPS6KA1(1)	1647659	16	5	16	2	3	5	2	1	5	0	0.155	0.459	1.000
84	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	140735	3	1	3	0	1	1	0	1	0	0	0.348	0.460	1.000
85	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(2), CHRNA1(3), FLT1(2), FLT4(8), KDR(1), NOS3(6), PDE2A(1), PDE3A(7), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(8), SLC7A1(1), TNNI1(1)	3545570	51	13	50	9	18	9	11	3	10	0	0.0141	0.483	1.000
86	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1L(1), MTHFD2(1)	1146428	8	4	7	1	1	2	0	0	5	0	0.429	0.485	1.000
87	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), EGFR(2), IGF1R(4), POLR2A(2), RB1(1), TEP1(7), TERF1(2), TERT(3), TNKS(3), XRCC5(2)	2367465	28	9	25	8	8	5	2	5	8	0	0.506	0.487	1.000
88	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(3)	550460	6	2	6	1	1	0	3	1	1	0	0.435	0.487	1.000
89	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), TOP2A(1), TOP2B(1)	794597	3	2	3	1	0	2	0	1	0	0	0.660	0.497	1.000
90	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), FH(1), IDH1(1), IDH2(3), IDH3A(2), MDH2(1), PC(2), PCK1(2), SDHA(3), SUCLA2(1), SUCLG1(1)	1772020	19	5	18	1	4	3	4	4	4	0	0.0411	0.502	1.000
91	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(5), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(2), PER2(3)	1483276	17	4	16	1	3	2	2	5	5	0	0.0416	0.503	1.000
92	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	159529	1	1	1	0	0	0	0	1	0	0	0.795	0.504	1.000
93	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CDH1(1), CREBBP(1), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4)	2206311	21	7	19	5	7	2	3	4	5	0	0.438	0.515	1.000
94	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR171(1), GPR18(1), GPR39(3), GPR75(1)	845494	7	3	7	3	1	1	0	3	2	0	0.781	0.519	1.000
95	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), LCT(3), PGM1(1), PYGM(2), TPI1(2)	1167521	10	3	10	9	1	2	2	1	4	0	0.948	0.531	1.000
96	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(1), PRF1(3), SET(1)	917489	6	4	5	2	0	1	1	1	3	0	0.838	0.534	1.000
97	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(2), CASP8(2), CRADD(2), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(2), PAK2(2), PRKDC(4), RB1(1), SPTAN1(2), TNFRSF1A(2), TRADD(1), TRAF2(1)	3378256	34	11	32	5	10	1	9	4	10	0	0.135	0.534	1.000
98	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD4(2)	275009	2	1	2	1	0	0	0	1	1	0	0.909	0.551	1.000
99	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F5(3), FGA(3), FGB(4), FGG(1), PROC(1), PROS1(1), SERPINC1(2), TFPI(2)	1405235	21	4	21	3	3	6	9	3	0	0	0.0979	0.555	1.000
100	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(1), ITGAM(1), ITGB2(1), SELP(3)	1377510	9	3	9	1	2	2	1	2	2	0	0.128	0.555	1.000
101	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB4(1), PSMB5(1)	748779	7	4	7	5	1	0	2	1	3	0	0.970	0.557	1.000
102	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(1)	289160	3	1	3	0	0	2	0	0	1	0	0.447	0.558	1.000
103	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(1)	1006344	7	3	7	0	2	1	2	0	2	0	0.148	0.569	1.000
104	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(1), GPI(1), HK1(2), PFKL(1), PGAM1(1), PGK1(2), PKLR(1), TPI1(2)	805357	12	2	12	4	2	5	1	2	2	0	0.317	0.572	1.000
105	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(1), IL1B(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFSF8(3)	1171760	16	6	15	5	4	1	4	3	4	0	0.536	0.579	1.000
106	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), GAD1(5), GAD2(4), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1)	2223655	21	6	21	4	5	5	4	4	2	1	0.154	0.579	1.000
107	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(3), AKT1(2), BAD(1), CSF2RB(1), IGF1R(4), KIT(3), PIK3CA(1), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1)	1853392	23	4	23	4	7	5	3	4	4	0	0.0820	0.591	1.000
108	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(2), AKT1(2), ATM(6), CSNK1D(1), FHL2(1), HIC1(1), HIF1A(1), MAPK8(1), MDM2(1)	1737889	16	4	16	4	1	2	4	4	5	0	0.543	0.591	1.000
109	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(2), FH(1), IDH1(1), IDH2(3), IDH3A(2), MDH2(1), OGDH(2), OGDHL(1), PC(2), PCK1(2), PCK2(3), SDHA(3), SUCLA2(1), SUCLG1(1)	2563823	27	6	26	4	9	3	4	4	6	1	0.0768	0.593	1.000
110	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), CHST12(1), PAPSS1(2), PAPSS2(3), SULT1A2(1), SULT2A1(1)	804074	11	4	11	2	2	2	1	3	3	0	0.344	0.595	1.000
111	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	HLA-A(2), ICAM1(1), ITGB2(1), PRF1(3)	751354	7	3	6	0	1	1	1	1	3	0	0.158	0.595	1.000
112	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNG(1), MUSK(3), PIK3CA(1), PIK3R1(1), PTK2(3), SRC(1), TERT(3), YWHAH(1)	1436502	17	5	17	3	3	4	0	4	6	0	0.186	0.596	1.000
113	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1)	760971	9	3	8	0	1	1	2	2	3	0	0.184	0.597	1.000
114	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(3), ATM(6), CCNE1(1), CDK4(2), MDM2(1), RB1(1)	1492424	14	3	14	3	3	3	4	2	2	0	0.427	0.599	1.000
115	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1)	800665	8	2	8	3	3	4	0	1	0	0	0.444	0.601	1.000
116	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), IDH2(3), OGDH(2), SDHA(3), SUCLA2(1)	805527	10	2	10	1	3	1	2	2	2	0	0.170	0.602	1.000
117	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(2), HK2(2), HK3(2), PGM1(1), PGM3(1)	884423	9	2	9	4	3	1	2	0	3	0	0.590	0.602	1.000
118	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(1), ITGAM(1), ITGB2(1)	903677	6	2	6	1	1	1	1	2	1	0	0.336	0.606	1.000
119	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(2), EPHA4(2), ITGA1(4), L1CAM(1), RAP1B(1), SELP(3)	1245848	13	4	13	2	4	3	1	2	3	0	0.141	0.607	1.000
120	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADHA(1), HSD17B4(2), NTAN1(2), SIRT1(1)	1020230	6	3	6	0	1	0	1	2	2	0	0.339	0.607	1.000
121	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(1), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(6), NCF2(1), PAK1(2), PDGFRA(4), PIK3CA(1), PIK3R1(1), RALBP1(2), TRIO(6), VAV1(4), WASF1(1)	3012660	35	6	34	9	9	6	6	6	6	2	0.305	0.609	1.000
122	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(1), GRM1(7), PLCB1(1), PPP1CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1382628	22	6	20	4	8	4	2	4	4	0	0.140	0.609	1.000
123	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA3(2), LPO(4), MPO(2), TPO(3)	726403	15	3	15	5	8	0	4	1	2	0	0.471	0.611	1.000
124	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(2), PIK3CA(1), PIK3R1(1), PLCB1(1), ROCK1(2)	2243034	17	6	16	3	2	3	3	3	6	0	0.331	0.614	1.000
125	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD86(1), IFNGR1(1), IL12B(1), IL2RA(1), IL4R(1)	1031467	5	2	5	0	1	1	0	2	1	0	0.206	0.617	1.000
126	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(1), PIK3R1(1), RELA(1), YWHAH(1)	1223327	11	4	11	3	0	3	3	1	4	0	0.585	0.621	1.000
127	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA4(5), GABRA5(3), GABRA6(1), SRC(1), UBQLN1(3)	1038405	15	2	15	1	4	3	4	2	1	1	0.0350	0.623	1.000
128	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(3), BMPR2(1)	537379	9	3	9	2	2	3	1	1	2	0	0.451	0.624	1.000
129	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(3), NFKBIA(2), RELA(1)	788619	7	3	7	3	0	1	2	2	2	0	0.803	0.624	1.000
130	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR6(1), NFS1(1), PHPT1(1), TPK1(1)	550789	4	2	4	2	0	2	1	0	1	0	0.902	0.632	1.000
131	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(1)	340531	3	1	3	1	0	0	1	1	1	0	0.845	0.633	1.000
132	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(1), MAP2K6(3), MAP3K1(3), PIK3CA(1), PIK3R1(1), RB1(1), RELA(1), SP1(1)	1680605	14	5	13	5	1	1	6	2	4	0	0.858	0.647	1.000
133	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(2), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1)	1136616	14	5	13	2	5	1	2	2	4	0	0.265	0.649	1.000
134	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), DPYD(3), DPYS(4), ENPP3(2), PANK4(1), UPB1(2)	1213960	14	5	14	3	3	5	2	2	2	0	0.223	0.651	1.000
135	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHSY1(1), DSE(2), XYLT1(2), XYLT2(4)	1292106	16	8	14	9	7	2	2	1	4	0	0.809	0.655	1.000
136	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(4), AXIN1(3), CD14(2), CTNNB1(6), DVL1(4), FZD1(4), GNAI1(1), GSK3B(1), LEF1(2), LY96(1), PIK3CA(1), PIK3R1(1), RELA(1), WNT1(1)	2679433	34	8	34	5	11	7	5	7	4	0	0.0420	0.661	1.000
137	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(1), ITGB2(1)	1041413	5	2	5	1	1	0	1	2	1	0	0.473	0.661	1.000
138	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(2), LPO(4), MPO(2), PRDX1(1), TPO(3), TYR(2)	836919	18	3	18	6	9	0	6	1	2	0	0.443	0.665	1.000
139	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B5(1), ELAVL1(1), FLT1(2), FLT4(8), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(1), PIK3R1(1), PLCG1(1), PTK2(3)	2945460	27	7	27	4	7	5	8	1	6	0	0.0590	0.670	1.000
140	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(1), IL12B(1), IL6(2), IL7(1), TGFB1(1), TGFB2(2)	1160604	10	4	9	2	1	2	2	2	3	0	0.462	0.673	1.000
141	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(2), ABCB11(2), ABCB4(5), ABCC3(2), GSTP1(1)	1231186	12	5	10	3	0	3	1	3	5	0	0.634	0.684	1.000
142	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(2), HK2(2), HK3(2), ISYNA1(1), PGM1(1), PGM3(1)	1016390	10	2	10	5	4	1	2	0	3	0	0.613	0.686	1.000
143	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(3), GNAQ(1), MAPK8(1), PLCG1(1)	1189126	6	2	6	2	0	2	1	1	2	0	0.516	0.690	1.000
144	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), SHMT1(1), SHMT2(3)	367490	6	1	6	3	2	1	2	0	1	0	0.735	0.694	1.000
145	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(2), CREB1(1), EDN1(1), EP300(4), HIF1A(1), NOS3(6)	1470519	15	3	15	2	3	2	4	2	4	0	0.211	0.698	1.000
146	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD80(1), CD86(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1)	1093621	6	2	6	3	1	1	1	1	2	0	0.851	0.699	1.000
147	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(1), HRAS(1), IGF1R(4), MAPK8(1), PIK3CA(1), PIK3R1(1), RASA1(1), SOS1(2)	1928801	12	3	12	6	3	2	0	3	4	0	0.885	0.701	1.000
148	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(2), ERBB3(3), NRG1(3), UBE2D1(1)	882106	11	3	11	1	1	2	3	2	3	0	0.222	0.702	1.000
149	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(1), CASP10(1), CASP7(1), CASP8(2), PRF1(3), SCAP(1), SREBF2(4)	1616744	16	6	14	3	3	5	0	1	7	0	0.227	0.705	1.000
150	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(1), CREBBP(1), EP300(4), NCOA3(3), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1782717	16	3	16	5	5	2	4	2	2	1	0.474	0.710	1.000
151	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(4), AXIN1(3), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMPR1A(3), BMPR2(1), CHRD(2), CTNNB1(6), DVL1(4), FZD1(4), GATA4(1), GSK3B(1), MAP3K7(2), RFC1(3), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), WNT1(1)	3173810	50	10	48	6	19	10	5	11	5	0	0.00384	0.711	1.000
152	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(2), GOT1(2), LDHB(1), SULT1B1(2), SULT1C4(1), SULT4A1(1)	1085208	9	3	8	1	1	1	2	2	3	0	0.384	0.715	1.000
153	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3)	533277	9	2	9	1	3	0	1	2	3	0	0.215	0.718	1.000
154	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(2), EGFR(2), HRAS(1), PTPRB(8), RASA1(1), SOS1(2), SPRY4(2), SRC(1)	2146213	21	6	20	2	1	7	2	5	5	1	0.0824	0.718	1.000
155	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(1), DAXX(2), HRAS(1), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAP3K9(2), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2D(1), RPS6KA5(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRADD(1), TRAF2(1)	3194471	31	12	28	9	7	2	8	4	10	0	0.633	0.719	1.000
156	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1B(1), PRMT3(1), PRMT6(1), PRMT8(1)	1219211	10	3	10	3	0	3	5	0	2	0	0.662	0.725	1.000
157	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), B4GALT5(2), ST3GAL1(2)	689852	5	2	5	1	1	0	2	1	1	0	0.665	0.727	1.000
158	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), PAPSS1(2), PAPSS2(3), SCLY(2)	1070799	9	2	9	7	2	2	2	1	2	0	0.930	0.727	1.000
159	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F12(1), F13B(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), LPA(3), PLAT(1), PLAU(3), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(4)	3030724	33	7	32	5	9	8	11	2	3	0	0.0420	0.727	1.000
160	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), MUT(2)	426371	3	1	3	2	0	0	0	1	2	0	0.905	0.735	1.000
161	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(3), EGF(2), EGFR(2), MET(4), PDGFRA(4), SH3GLB1(1), SRC(1)	1666327	19	4	18	2	4	4	3	3	5	0	0.0932	0.736	1.000
162	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(5), C6(3), C7(3), C8A(3), C9(1)	1075527	15	4	15	5	2	5	4	3	1	0	0.618	0.736	1.000
163	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	742852	7	3	7	4	3	0	2	0	2	0	0.793	0.737	1.000
164	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), HBXIP(1), HRAS(1), SOS1(2), SRC(1)	760205	6	2	6	1	1	2	1	1	1	0	0.445	0.740	1.000
165	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK2(2), PTPRU(6), STAT1(1)	982768	10	3	10	4	4	1	3	1	1	0	0.660	0.743	1.000
166	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(1), ACAT1(2), HADHA(1)	466393	5	1	5	0	0	3	1	0	1	0	0.238	0.746	1.000
167	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(3), TPO(3)	1001311	20	3	20	6	8	3	4	2	3	0	0.302	0.749	1.000
168	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT2(1), B4GALT5(2), DDOST(1), DPAGT1(2), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), ST6GAL1(1)	1741660	13	6	12	4	4	1	1	2	5	0	0.742	0.749	1.000
169	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(2), APAF1(3), ATM(6), BAD(1), CASP7(1), PTK2(3), STAT1(1), TLN1(7)	2253406	24	4	24	4	6	8	3	3	4	0	0.0836	0.752	1.000
170	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), GLB1(1), HEXB(1), LCT(3), MANBA(2), NEU4(1)	1452219	11	4	11	4	4	1	2	0	4	0	0.563	0.753	1.000
171	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(2), GNAS(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1)	1149627	18	4	17	4	8	6	3	1	0	0	0.162	0.760	1.000
172	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), SHMT1(1), SHMT2(3), TPO(3)	1023769	20	3	20	5	8	3	5	1	3	0	0.193	0.760	1.000
173	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPNS1(3), EP300(4), MEF2D(1), NFATC1(4), NFATC2(4), PPP3CA(1), PPP3CC(1)	2097941	20	7	20	7	5	6	0	2	7	0	0.450	0.761	1.000
174	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX3(1), PLA2G3(2), PLA2G6(3)	805917	6	2	6	4	0	2	2	1	1	0	0.932	0.764	1.000
175	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(2), CPOX(1), PPOX(2)	661850	5	4	5	2	1	2	1	0	1	0	0.779	0.769	1.000
176	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), DPYD(3), DPYS(4), ENPP3(2), ILVBL(2), PANK4(1), UPB1(2), VNN1(1)	1506150	18	5	18	3	5	6	3	2	2	0	0.0882	0.769	1.000
177	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	EPOR(2), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1)	959328	8	2	8	1	2	1	4	0	1	0	0.377	0.771	1.000
178	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(2), EIF4A2(1), EIF4G1(6), EIF4G3(5), GHR(1), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1)	2092030	19	5	19	4	4	6	3	3	3	0	0.257	0.772	1.000
179	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(5), CCKBR(2), CCR1(1), CCR10(2), CCR4(2), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(1), GALR1(2), GALR2(1), GNRHR(1), GPR77(1), GRPR(1), MC2R(2), MC3R(2), MC5R(1), NPY1R(1), NPY2R(3), NPY5R(1), OPRD1(1), OPRL1(2), OPRM1(1), OXTR(1), SSTR1(2), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3)	4466353	62	15	62	16	20	8	17	10	6	1	0.0220	0.774	1.000
180	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(1), SCAP(1), SREBF2(4)	1074016	6	4	5	6	1	1	0	1	3	0	0.988	0.775	1.000
181	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(1), PIK3CD(1), SOS1(2)	1427480	10	4	10	6	5	1	0	2	2	0	0.883	0.775	1.000
182	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), CYP3A7(3), DHRS1(1), DHRS3(2), PON1(1), PON2(1)	1562047	19	5	18	5	7	3	1	4	4	0	0.312	0.778	1.000
183	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(2), NR1H4(2)	465961	4	1	4	1	0	2	1	0	1	0	0.452	0.779	1.000
184	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS1(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1)	1294451	11	3	11	4	0	3	5	1	2	0	0.731	0.782	1.000
185	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	145540	1	1	1	1	0	0	1	0	0	0	0.968	0.783	1.000
186	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(2), SHMT1(1), SHMT2(3)	485875	6	1	6	3	2	1	2	0	1	0	0.763	0.785	1.000
187	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(1), EP300(4), ESR1(1), SRC(1)	1293597	7	2	7	1	1	2	2	1	1	0	0.274	0.785	1.000
188	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), CDK5R1(1), HRAS(1), KLK2(1), NGFR(1)	627865	5	3	5	3	3	0	1	0	1	0	0.897	0.786	1.000
189	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA5(1), PSMB1(1), PSMB4(1), PSMB5(1), UBE3A(3)	1109524	9	4	9	4	3	0	2	1	3	0	0.849	0.788	1.000
190	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(2), ANXA1(1), GNAS(6), GNB1(1), NOS3(6), NR3C1(2), PIK3CA(1), PIK3R1(1), RELA(1)	1574187	21	5	20	5	5	3	8	2	3	0	0.515	0.789	1.000
191	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), BAD(1), CDC42(1), CHUK(1), HRAS(1), PIK3CA(1), PIK3R1(1), RALBP1(2), RALGDS(1), RELA(1)	1634120	12	4	12	5	2	4	1	2	3	0	0.771	0.792	1.000
192	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKACG(2), PRKAR2B(1)	869441	6	2	6	0	1	2	1	1	1	0	0.185	0.796	1.000
193	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), PTPRU(6), STAT1(1), STAT2(1), TYK2(1)	1078205	11	3	11	4	6	1	3	1	0	0	0.545	0.796	1.000
194	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(1), AGTR2(1), ANPEP(2), CMA1(1), CTSG(1), ENPEP(3), LNPEP(2), MME(2), REN(4), THOP1(1)	1824729	20	7	18	4	3	5	4	4	4	0	0.247	0.798	1.000
195	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(2), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1), PTK2(3), SOS1(2)	1676503	13	4	13	3	3	5	0	2	3	0	0.278	0.799	1.000
196	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(3), DDX20(1), E2F4(3), ETS1(1), ETS2(2), HDAC5(1), HRAS(1), NCOR2(4), RBL1(1), RBL2(2), SIN3A(3)	2295405	23	5	22	8	4	6	5	3	5	0	0.572	0.800	1.000
197	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(1)	779972	9	2	9	3	2	1	4	1	1	0	0.667	0.803	1.000
198	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(6), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1)	1457169	23	7	23	7	9	5	7	1	1	0	0.264	0.804	1.000
199	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS3(2), HSD3B7(2), PON1(1), PON2(1), RDH11(2)	774976	9	2	9	2	2	1	2	3	1	0	0.450	0.809	1.000
200	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), FURIN(2), NOTCH1(5), PSEN1(1)	848285	11	2	11	4	5	5	1	0	0	0	0.243	0.813	1.000
201	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(1), SOS1(2), STAT5A(1)	2639601	19	5	19	4	6	3	4	3	3	0	0.251	0.817	1.000
202	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), F10(4), F12(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1)	3841222	43	9	43	4	6	10	18	3	5	1	0.0141	0.818	1.000
203	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), ATIC(1), DHFR(1), FTCD(2), MTFMT(2), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(3), TYMS(1)	1631687	19	5	18	7	3	3	4	3	6	0	0.659	0.822	1.000
204	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), HEXB(1), HK1(2), HK2(2), HK3(2), PGM3(1), RENBP(1)	1467187	17	4	17	6	6	3	4	1	3	0	0.422	0.824	1.000
205	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), SLC2A1(2)	2184023	21	6	21	5	3	5	7	1	4	1	0.517	0.827	1.000
206	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ2(2)	1916732	15	5	15	5	2	4	2	2	5	0	0.603	0.830	1.000
207	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(5), C6(3), C7(3), ICAM1(1), IL6(2), ITGB2(1), SELP(3)	2122250	18	5	18	7	3	6	5	1	3	0	0.587	0.831	1.000
208	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), SH3GLB1(1)	1420605	9	4	9	5	1	2	0	3	3	0	0.901	0.833	1.000
209	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CCND2(1), CCND3(1), CCNE1(1), CDC25A(2), CDK4(2), CDK7(1), RB1(1), RBL1(1)	1344187	12	3	11	4	1	2	3	3	3	0	0.698	0.834	1.000
210	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), BPNT1(2), PDK1(1), PIK3CA(1), PIK3CD(1), PTEN(1), RBL2(2), SOS1(2)	1759494	12	4	12	5	2	3	1	4	2	0	0.733	0.840	1.000
211	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(1)	601181	7	2	7	2	2	2	0	2	1	0	0.555	0.841	1.000
212	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1)	623763	5	1	5	1	0	3	0	0	2	0	0.420	0.842	1.000
213	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	6	CDK5(1), CDK5R1(1), RELN(6)	1096439	8	3	8	6	3	1	1	1	2	0	0.951	0.844	1.000
214	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(1), BIRC2(1), CASP7(1), CASP8(2)	1132071	8	2	8	2	2	3	0	1	2	0	0.367	0.848	1.000
215	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNB1(1), PLCB1(1), TUB(1)	613657	4	1	4	1	0	1	0	2	1	0	0.577	0.849	1.000
216	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(4), CPS1(4), GAD1(5), GAD2(4), GFPT1(1), GFPT2(1), GLS(1), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(3), NAGK(1), PPAT(2), QARS(1)	3408057	38	10	38	10	7	6	14	5	4	2	0.305	0.850	1.000
217	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(1), EIF4B(2), EIF4G1(6), EIF4G3(5), FKBP1A(1), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1), TSC1(1), TSC2(4)	2383621	26	5	26	8	7	8	5	3	3	0	0.453	0.852	1.000
218	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	183461	3	1	3	0	0	1	2	0	0	0	0.409	0.856	1.000
219	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(1), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2)	2578259	24	8	21	6	3	2	7	4	8	0	0.488	0.862	1.000
220	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1S(4), C3(5), C6(3), C7(3), C8A(3), C9(1)	1509534	20	5	20	6	2	5	5	5	3	0	0.525	0.867	1.000
221	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(3), FH(1), IDH2(3), IDH3A(2), MDH2(1), OGDH(2), PC(2), PDHA1(1), PDK1(1), PDK2(1), SDHA(3), SUCLA2(1), SUCLG1(1)	2452323	22	3	22	4	8	3	3	4	4	0	0.129	0.867	1.000
222	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(1), EP300(4), IKBKB(2), IL1B(1), MAP2K6(3), MAP3K7(2), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(2), TGFBR2(4), TLR2(1)	2574604	27	6	25	5	5	5	7	4	6	0	0.140	0.868	1.000
223	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(3), PRL(1), TRH(2)	969078	10	3	10	4	4	1	2	1	2	0	0.637	0.869	1.000
224	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(2), AKT1(2), CDC42(1), FLNA(5), FLNC(7), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(2), MYLK(6), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), ROCK1(2), ROCK2(1), WASF1(1), WASL(2)	4174931	46	12	45	14	8	8	13	10	7	0	0.403	0.870	1.000
225	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2S(1), UBE3A(3)	909483	10	2	10	0	5	2	2	0	1	0	0.0329	0.873	1.000
226	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PAPSS1(2), PAPSS2(3), PRMT3(1), PRMT6(1), PRMT8(1), SCLY(2)	2156223	17	3	17	9	2	4	7	1	3	0	0.866	0.874	1.000
227	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCG2(1), BCHE(4), UGT1A1(2)	1674633	7	4	7	4	0	2	0	2	3	0	0.885	0.875	1.000
228	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(3), DAXX(2), FAS(1), FASLG(1), MAPKAPK3(1)	978899	10	3	10	3	2	4	1	2	1	0	0.429	0.880	1.000
229	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1116229	9	3	9	2	4	2	2	0	1	0	0.365	0.882	1.000
230	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT2(1), G6PC2(1), GAA(1), GANC(1), GCK(1), GLB1(1), HK1(2), HK2(2), HK3(2), HSD3B7(2), LCT(3), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH11(2), UGP2(2)	3360220	27	8	27	9	9	5	5	2	6	0	0.320	0.882	1.000
231	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CARM1(1), CREBBP(1), EP300(4), ERCC3(4), ESR1(1), GRIP1(1), GTF2F1(2), HDAC4(2), HDAC5(1), HDAC6(1), NCOR2(4), NR0B1(1), NRIP1(1), POLR2A(2), TBP(1)	4074998	30	9	28	9	7	8	4	3	8	0	0.427	0.883	1.000
232	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), BDH1(1), DDHD1(2), GAD1(5), GAD2(4), HADHA(1), HMGCS2(1), HSD17B4(2), HSD3B7(2), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2)	3511983	34	8	34	7	8	8	7	7	3	1	0.0822	0.883	1.000
233	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), HRAS(1), KLK2(1), MAPK8(1), NGFR(1), PIK3CA(1), PIK3R1(1), PLCG1(1), SOS1(2)	1656727	10	3	10	4	2	3	1	1	3	0	0.747	0.887	1.000
234	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(1), HEXB(1), LCT(3), NAGLU(2)	1269885	10	4	10	5	2	3	1	0	4	0	0.658	0.890	1.000
235	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), GREB1(3), MTA1(1), PDZK1(2), TUBA8(2)	965242	10	3	10	2	0	5	1	2	2	0	0.198	0.890	1.000
236	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(2), HK2(2), HK3(2), PFKFB1(2), PFKFB4(2), PFKM(1), PFKP(1), PMM2(1), TPI1(2)	2079132	23	6	23	6	9	4	6	1	3	0	0.165	0.893	1.000
237	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2)	224768	2	1	2	0	0	0	1	1	0	0	0.652	0.893	1.000
238	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(4), AXIN1(3), BTRC(1), CREBBP(1), CSNK1D(1), CSNK2A1(1), CTNNB1(6), DVL1(4), FZD1(4), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(2), WIF1(1), WNT1(1)	2578684	34	7	33	7	10	7	6	6	5	0	0.146	0.895	1.000
239	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT2(1), FBP2(1), GAA(1), GANAB(2), GCK(1), GLB1(1), HK1(2), HK2(2), HK3(2), LCT(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1)	2828284	21	7	21	9	7	2	5	1	6	0	0.637	0.897	1.000
240	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(3), CDC25C(2), GNAI1(1), GNAS(6), GNB1(1), HRAS(1), MYT1(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(1), SRC(1)	1801182	30	8	28	6	11	8	4	4	3	0	0.0812	0.899	1.000
241	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(2), MAP3K1(3), NCOR2(4)	1514202	11	3	11	7	1	3	2	2	3	0	0.938	0.899	1.000
242	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PAK1(2), PLCG1(1), SOS1(2), SRC(1)	2474345	16	3	15	7	2	4	3	3	4	0	0.813	0.901	1.000
243	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), AKT1(2), CAMK2D(1), CREB1(1), GNAS(6), HRAS(1), PIK3CA(1), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(1), RPS6KA5(1), SOS1(2)	2535181	26	6	25	4	9	5	4	3	5	0	0.102	0.901	1.000
244	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(3), GNAQ(1), GNB1(1), MYLK(6), PLCB1(1), ROCK1(2)	1779621	17	3	17	7	2	3	4	4	4	0	0.772	0.903	1.000
245	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(1), CD38(1), ENPP3(2), NADSYN1(3), NNT(4), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), NUDT12(1)	1858251	17	3	16	4	6	3	2	2	4	0	0.287	0.908	1.000
246	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP2(1), GPI(1), H6PD(5), PFKM(1), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1)	1765782	20	4	20	5	5	4	7	2	2	0	0.181	0.910	1.000
247	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1S(4), C3(5), C6(3), C7(3), C8A(3), C9(1), MASP1(1)	1790185	21	5	21	6	2	5	5	6	3	0	0.482	0.913	1.000
248	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E2(1), GTF2F1(2), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(1), TAF1(4), TAF1L(2), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6L(2)	3099549	22	7	22	8	7	2	5	4	4	0	0.763	0.913	1.000
249	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), RPE(2), UGDH(1), UGT1A1(2), UGT2B15(1), UGT2B4(1)	1500472	8	2	8	2	1	2	2	1	2	0	0.518	0.915	1.000
250	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), AXIN1(3), CREBBP(1), CTNNB1(6), DVL1(4), EP300(4), FZD1(4), GSK3B(1), LDB1(1), LEF1(2), TRRAP(7), WNT1(1)	2871748	38	6	38	7	13	8	6	9	2	0	0.0326	0.916	1.000
251	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), SNAP23(1), SNAP29(3), STX3(1), STX4(2), TSNARE1(1), VTI1A(1)	1456376	10	3	10	7	5	0	0	2	3	0	0.925	0.916	1.000
252	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1S(4), C3(5), C6(3), C7(3), C8A(3), C9(1), MASP1(1)	1837827	21	5	21	7	2	5	5	6	3	0	0.594	0.920	1.000
253	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA5(1), PSMB1(1), PSMB4(1), PSMB5(1), PSMD1(2), PSMD11(1), PSMD12(1)	1369197	10	3	10	7	1	1	3	3	2	0	0.963	0.920	1.000
254	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), MAF(3), NFATC1(4), NFATC2(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1072401	18	3	18	4	9	5	1	0	3	0	0.0600	0.921	1.000
255	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4), ASAH1(1), CAMP(2), CERK(1), CREB1(1), DAG1(2), EPHB2(1), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1)	2506213	28	5	28	5	9	3	4	6	6	0	0.0938	0.921	1.000
256	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(3), AGPAT4(3), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH2(2), PLA2G3(2), PLA2G6(3), PLD2(2), PPAP2B(2)	2008347	22	4	22	8	6	4	4	4	4	0	0.611	0.922	1.000
257	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(1), ANXA2(1), ANXA6(2), CYP11A1(2), EDN1(1), EDNRB(2), HSD11B1(1), PRL(1), PTGDR(2), PTGDS(2), PTGFR(1), PTGIS(2), TBXAS1(1)	1799327	19	5	19	7	8	2	4	3	2	0	0.488	0.922	1.000
258	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(2), IL4R(1), JAK3(3), STAT6(1)	1076349	7	2	7	7	2	1	1	2	1	0	0.986	0.923	1.000
259	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(5), CPOX(1), PPOX(2), UGT1A1(2), UGT2B15(1), UGT2B4(1)	2339583	14	5	14	2	1	4	1	2	6	0	0.273	0.928	1.000
260	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(1), NFKBIA(2), PPARA(1), RELA(1), TLR2(1), TLR3(2), TLR6(2), TLR9(6)	3167310	32	7	30	8	7	4	8	5	8	0	0.359	0.928	1.000
261	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(6), CCND2(1), CDK4(2), ESR2(1), FSHR(1), GJA4(1), MLH1(1), NCOR1(6), NRIP1(1), PGR(3), PRLR(2)	2933154	25	5	25	9	6	4	6	5	4	0	0.589	0.928	1.000
262	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), AKT1(2), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(2), ITGB3(1), PDGFRA(4), PIK3CA(1), PIK3R1(1), PLCB1(1), PTK2(3), SPHK1(1), SRC(1)	2358428	23	3	23	1	5	7	2	5	4	0	0.00336	0.929	1.000
263	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	265293	5	1	5	1	0	1	1	3	0	0	0.595	0.930	1.000
264	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	IL12B(1), JAK2(2), MAP2K6(3), MAPK8(1), TYK2(1)	1617609	8	2	7	1	2	1	2	0	3	0	0.198	0.930	1.000
265	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), MAP3K7(2), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	2389802	21	6	20	8	4	2	6	4	5	0	0.752	0.931	1.000
266	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	11	ACAA1(1), ACOX3(1), FADS1(1), FASN(9), HADHA(1)	1145968	13	3	13	3	4	4	3	0	1	1	0.136	0.931	1.000
267	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(1), HRAS(1), INSR(4), MAPK8(1), PIK3CA(1), PIK3R1(1), RASA1(1), SOS1(2)	1994744	12	3	12	5	4	2	0	3	3	0	0.747	0.935	1.000
268	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	12	CASR(3), GPRC5A(2), GPRC5B(4), GPRC5C(5), GRM1(7), GRM2(2), GRM3(2), GRM4(1), GRM5(4), GRM7(4), GRM8(2)	1640869	36	8	33	10	6	12	5	4	9	0	0.234	0.935	1.000
269	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCR(1), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(1), PIK3CA(1), PIK3R1(1), SOS1(2), STAT1(1), STAT5A(1)	2421536	18	4	18	5	3	2	5	4	4	0	0.525	0.936	1.000
270	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), MEF2A(1), MEF2D(1), PAK1(2), PTK2(3), SOS1(2), SRC(1)	2905959	20	3	19	6	2	4	3	4	7	0	0.552	0.940	1.000
271	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), FUT2(1), FUT4(1), FUT6(1), GCNT2(1), ST8SIA1(2)	1418020	11	2	11	1	6	2	2	0	1	0	0.0875	0.941	1.000
272	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), MAP3K1(3), MAP3K7(2), NFKBIA(2), RELA(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	2132857	16	5	15	9	2	2	7	2	3	0	0.964	0.945	1.000
273	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(1), ACTN2(4), ACTN3(1), CAPN1(1), CAPNS1(3), ITGA1(4), ITGB3(1), PTK2(3), SPTAN1(2), SRC(1), TLN1(7)	2478188	30	4	30	7	10	9	3	2	6	0	0.0783	0.946	1.000
274	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), EPX(4), GOT1(2), HPD(2), LPO(4), MPO(2), PRDX1(1), TPO(3)	1903218	28	3	28	7	14	3	6	3	2	0	0.110	0.946	1.000
275	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), SOS1(2), SYK(2), VAV1(4), VAV3(1)	2798487	21	4	21	4	6	3	3	4	4	1	0.144	0.947	1.000
276	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DLAT(3), GLO1(1), GRHPR(1), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), PC(2), PCK1(2), PDHA1(1), PKLR(1)	3182862	28	3	28	7	5	12	2	3	6	0	0.204	0.947	1.000
277	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), TRAF2(1), TRAF5(1)	2986646	23	5	23	6	5	7	4	3	4	0	0.189	0.947	1.000
278	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	KERA(2), LUM(1)	311184	3	1	3	1	0	1	0	2	0	0	0.631	0.947	1.000
279	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(1), CDC42(1), CREB1(1), DUSP10(1), MAP2K4(2), MAP2K6(3), MAP3K10(3), MAP3K4(2), MAP3K7(2), MAPK11(1), MAPK12(1), MAPKAPK5(1), MYEF2(1), NR2C2(1)	2938039	23	8	21	8	5	3	5	3	7	0	0.672	0.948	1.000
280	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP2(1), GPI(1), H6PD(5), PFKL(1), PFKM(1), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1)	2104472	21	4	21	4	5	5	7	2	2	0	0.0814	0.949	1.000
281	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(1), AKT1(2), BAD(1), BTK(1), DAPP1(1), GSK3A(1), GSK3B(1), IARS(2), INPP5D(1), PDK1(1), PIK3CA(1), PTEN(1), RPS6KA1(1), RPS6KA2(1), SOS1(2), SOS2(1), TEC(2), YWHAE(2), YWHAH(1)	3070432	24	5	24	8	5	8	0	4	7	0	0.484	0.950	1.000
282	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), RPE(2), UGDH(1), UGP2(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1), XYLB(2)	2321377	15	3	15	3	1	6	2	3	3	0	0.282	0.952	1.000
283	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), SH3GLB1(1)	2143527	19	4	19	9	5	6	1	4	3	0	0.798	0.953	1.000
284	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(1), EP300(4), LPL(2), NCOA2(2)	1584940	9	3	9	8	2	1	2	1	3	0	0.984	0.953	1.000
285	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), SP1(1)	1811531	19	4	19	4	4	6	2	2	5	0	0.168	0.953	1.000
286	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4B(1), INPP5A(1), INPPL1(3), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(1), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCG1(1), PLCG2(4)	3881706	40	6	40	6	14	5	4	10	7	0	0.0250	0.955	1.000
287	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(6), CARS2(2), DARS(1), FARS2(2), FARSB(1), GARS(4), IARS(2), KARS(1), LARS2(2), MTFMT(2), NARS2(1), PARS2(1), QARS(1), RARS(1), RARS2(2), SARS2(1), TARS(2), VARS(1), VARS2(1), WARS(2)	4660935	37	12	34	9	8	6	10	5	8	0	0.402	0.955	1.000
288	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGTR2(1), EDN1(1), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1)	1766111	13	2	13	1	2	3	3	1	4	0	0.0547	0.956	1.000
289	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DGAT1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), GK(2), GLB1(1), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(1), PPAP2B(2)	4104835	47	6	47	16	22	5	7	6	7	0	0.236	0.958	1.000
290	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	BCMO1(1)	331945	1	1	1	0	0	0	0	1	0	0	0.797	0.959	1.000
291	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(1), HEXB(1), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2)	1799275	14	4	14	9	3	5	2	0	4	0	0.824	0.959	1.000
292	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(1), EP300(4), IL7(1), IL7R(1), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5A(1)	2325064	14	3	14	7	4	3	3	2	2	0	0.771	0.961	1.000
293	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(2), ARSE(1), CYP11B1(2), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(2), STS(2), SULT2A1(1), UGT1A1(2), UGT2B15(1), UGT2B4(1)	2348939	17	4	17	6	4	5	3	1	4	0	0.518	0.961	1.000
294	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(2), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1R(4), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(1), MEF2D(1), NFATC1(4), NFATC2(4), PIK3CA(1), PIK3R1(1), PPP3CA(1), PPP3CC(1), YWHAH(1)	3022915	37	8	36	10	10	8	5	4	10	0	0.193	0.961	1.000
295	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(2), COX7A2(1), COX7C(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), SDHA(3), SHMT1(1), UQCRFS1(1)	3292756	28	6	28	7	6	6	6	5	4	1	0.298	0.961	1.000
296	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(1), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	1789011	15	3	15	6	3	1	5	2	4	0	0.797	0.962	1.000
297	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), GLB1(1), HEXB(1), LCT(3), MAN2B2(1), MANBA(2), NEU4(1)	1787869	12	4	12	6	5	1	2	0	4	0	0.719	0.962	1.000
298	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(6), FASN(9), MCAT(1)	1413005	20	3	20	4	8	7	2	1	1	1	0.0454	0.963	1.000
299	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), SH3GLB1(1)	2232521	14	4	14	7	2	3	2	3	4	0	0.865	0.963	1.000
300	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(3), DIAPH1(3), GSN(4), HRAS(1), ITGA1(4), MYLK(6), PIK3CA(1), PIK3R1(1), PTK2(3), ROCK1(2), SRC(1), TLN1(7)	3111267	36	6	34	10	8	9	6	5	8	0	0.318	0.963	1.000
301	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BAD(1), BRAF(1), CREB1(1), RPS6KA1(1), RPS6KA2(1), SOS1(2), SOS2(1)	2570866	9	4	9	9	2	2	1	1	3	0	0.998	0.964	1.000
302	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), APOA4(1), CYP7A1(2), DGAT1(2), HMGCR(1), LPL(2), LRP1(8), SCARB1(1), SOAT1(1)	2356959	20	4	20	5	9	4	3	1	3	0	0.137	0.964	1.000
303	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(2), GNAS(6), GNB1(1), HRAS(1), IGF1R(4), KLK2(1), NGFR(1), PDGFRA(4), RPS6KA1(1), RPS6KA5(1), SOS1(2), SRC(1), STAT3(1)	2896020	26	6	25	7	9	5	5	4	3	0	0.317	0.965	1.000
304	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1), TPI1(2)	333418	4	1	4	0	1	2	0	1	0	0	0.218	0.966	1.000
305	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(4), ACACB(6), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), HADHA(1), HIBCH(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(1)	3412159	28	5	27	5	10	5	3	4	6	0	0.121	0.967	1.000
306	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), OAT(2), PYCR1(1)	1540359	16	3	16	2	4	2	6	2	1	1	0.123	0.967	1.000
307	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(1), CAPNS1(3), EGF(2), EGFR(2), HRAS(1), ITGA1(4), MYLK(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(3), TLN1(7)	2850602	37	4	37	9	12	11	5	4	5	0	0.0644	0.968	1.000
308	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(1), HRAS(1), PIK3CA(1), PIK3R1(1), PLCG1(1), PTK2(3), RELA(1)	2416272	17	3	17	9	4	6	2	2	3	0	0.807	0.968	1.000
309	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	ABO(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), FUT2(1), FUT4(1), FUT6(1), GCNT2(1), PIGB(1), PIGG(2), PIGL(2), PIGO(2), PIGP(1), PIGQ(3), PIGS(2), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1)	4178764	37	8	36	7	15	7	5	4	6	0	0.0299	0.969	1.000
310	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), HAL(1)	1634208	12	3	12	2	3	4	2	1	1	1	0.222	0.969	1.000
311	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(1), DAXX(2), HRAS(1), PML(1), RB1(1), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(1)	1585162	14	2	14	5	4	2	4	3	1	0	0.586	0.970	1.000
312	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	CYP1A2(2), CYP2C19(3), CYP2E1(1), CYP2J2(2), CYP3A7(3), HSD3B7(2), PLA2G3(2), PLA2G6(3), RDH11(2)	2060711	20	4	20	7	4	2	8	4	2	0	0.651	0.970	1.000
313	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(1), CRHR2(1), ELTD1(4), EMR2(3), GHRHR(1), GLP2R(3), GPR64(1), LPHN1(1), LPHN2(3), VIPR1(1), VIPR2(1)	2334482	20	5	20	9	5	2	4	6	3	0	0.692	0.970	1.000
314	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLAT(3), ENO1(1), FBP2(1), GAPDHS(1), GCK(1), GOT1(2), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(2), PDHA1(1), PFKL(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PKLR(1), TPI1(2)	3654857	33	4	33	8	9	9	6	4	5	0	0.0980	0.971	1.000
315	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), HPD(2), LPO(4), MPO(2), SH3GLB1(1), TPO(3)	2950561	33	5	33	10	15	4	5	5	4	0	0.240	0.971	1.000
316	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GSK3A(1), GSK3B(1), PFKL(1), PFKM(1), PFKP(1), PLCG1(1), PRKCE(1), PRKCZ(1)	2202973	17	4	17	2	3	7	2	2	3	0	0.0429	0.972	1.000
317	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1), THPO(1)	2575485	14	2	14	5	2	5	2	2	3	0	0.650	0.973	1.000
318	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(6), ATR(5), BRCA1(3), CDC25A(2), CDC25C(2), CDC34(1), EP300(4), MDM2(1), MYT1(6), PRKDC(4), RPS6KA1(1), YWHAH(1)	3545467	36	13	34	10	5	6	6	8	11	0	0.599	0.973	1.000
319	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), GLUD2(1), HAL(1)	1827658	13	3	13	3	3	5	2	1	1	1	0.301	0.974	1.000
320	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(2), CD33(1), CD5(1), IL12B(1), ITGAX(1), TLR2(1), TLR9(6)	1599821	15	2	15	6	5	4	1	4	1	0	0.623	0.974	1.000
321	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(4), AXIN1(3), BTRC(1), CTNNB1(6), DVL1(4), FZD1(4), GSK3B(1), NOTCH1(5), PSEN1(1), WNT1(1)	1909871	33	4	33	5	12	11	4	5	1	0	0.00870	0.974	1.000
322	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), SOS1(2), SYK(2), VAV1(4)	3715508	40	5	40	9	10	11	6	6	6	1	0.104	0.974	1.000
323	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1D(3), EEF1G(3), EEF2(3), EIF2AK2(1), EIF2AK3(2), EIF2B5(1), EIF4A2(1), EIF4G1(6), EIF4G3(5), EIF5(1), EIF5B(3), KIAA0664(1), PABPC3(4), SLC35A4(2)	3706671	36	6	36	3	6	7	10	7	6	0	0.0115	0.975	1.000
324	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), FARS2(2), GARS(4), IARS(2), KARS(1), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2)	2731777	19	7	18	3	6	4	6	3	0	0	0.127	0.975	1.000
325	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG7(2), GABARAPL1(1), IFNA10(1), IFNA16(1), PIK3C3(2), PIK3R4(3), PRKAA2(1), ULK1(2), ULK3(1)	1834852	15	3	15	4	3	3	1	5	3	0	0.445	0.977	1.000
326	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PIGB(1), PIGG(2), PIGL(2), PIGO(2), PIGP(1), PIGQ(3), PIGS(2), PIGW(1)	2070293	16	4	16	3	5	3	2	4	2	0	0.146	0.977	1.000
327	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), PDE6B(3), PDE6C(1), TF(1)	2846295	25	4	25	8	9	4	5	2	5	0	0.474	0.978	1.000
328	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(2), AOC2(1), AOC3(2), DDHD1(2), ESCO1(4), ESCO2(1), PLA1A(1), SH3GLB1(1)	2177920	14	5	14	6	5	4	0	3	2	0	0.637	0.979	1.000
329	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(2), BCKDHB(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(2), HMGCS2(1), HSD17B4(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1)	3716060	34	5	33	4	7	6	7	4	10	0	0.0299	0.979	1.000
330	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), IARS(2), IL4R(1), INPP5D(1), JAK2(2), JAK3(3), PIK3CA(1), SOS1(2), SOS2(1), SRC(1), STAT6(1), TYK2(1)	3198496	18	3	18	7	5	3	2	4	4	0	0.673	0.980	1.000
331	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GLB1(1), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(1), UGCG(1)	2117481	14	3	14	6	5	3	1	1	4	0	0.528	0.980	1.000
332	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(1), HDAC5(1), MEF2A(1), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(1), YWHAH(1)	1762435	13	3	13	2	2	3	2	2	4	0	0.205	0.980	1.000
333	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(2), TYR(2)	401517	4	1	4	1	1	0	2	1	0	0	0.641	0.981	1.000
334	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(1)	417598	1	1	1	0	0	0	1	0	0	0	0.825	0.982	1.000
335	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(2), HK2(2), HK3(2), HSD3B7(2), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB4(2), PFKL(1), PFKM(1), PFKP(1), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1)	3245551	33	8	33	9	10	6	11	3	3	0	0.180	0.982	1.000
336	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGDH(1), UGP2(2)	422587	3	2	3	2	0	1	0	2	0	0	0.920	0.982	1.000
337	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(2), APC(4), AXIN1(3), AXIN2(1), CTNNB1(6), DACT1(2), DKK2(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(8), MVP(2), NKD1(3), PSEN1(1), SENP2(1), SFRP1(2), WIF1(1)	3547564	44	10	44	13	18	10	6	6	4	0	0.184	0.982	1.000
338	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(8), ATM(6), ATR(5), CCNA1(2), CCNE1(1), CDC25A(2), CDK4(2), DHFR(1), GSK3B(1), RB1(1), TGFB1(1), TGFB2(2)	2480456	32	9	29	10	4	5	10	3	10	0	0.749	0.983	1.000
339	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(1), ALDH3A1(1), CYP2C19(3), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), HADHA(1), SH3GLB1(1)	2661758	15	4	15	8	3	2	3	3	4	0	0.894	0.983	1.000
340	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2)	480194	8	1	8	3	4	2	1	1	0	0	0.595	0.985	1.000
341	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), RASA1(1), RELA(1), SOS1(2), VAV1(4), ZAP70(4)	4037743	41	5	41	8	9	11	7	6	7	1	0.0588	0.986	1.000
342	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DGAT1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), GK(2), GK2(3), GLB1(1), GPAM(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(1), PPAP2B(2)	5006115	56	6	56	18	25	7	9	8	7	0	0.170	0.986	1.000
343	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PDGFRA(4), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1)	3013300	21	2	21	7	4	4	5	5	3	0	0.629	0.987	1.000
344	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	HSD3B7(2), RDH11(2)	417291	4	1	4	0	1	0	2	1	0	0	0.349	0.988	1.000
345	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(1), ALG12(2), ALG5(1), ALG9(2), B4GALT2(1), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), ST6GAL1(1)	3699321	27	7	26	6	8	7	3	4	5	0	0.187	0.988	1.000
346	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	71	ACTN1(1), ACTN2(4), ACTN3(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(1), CSNK2A1(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), CTNND1(1), EGFR(2), EP300(4), ERBB2(5), FARP2(1), FER(6), IGF1R(4), INSR(4), IQGAP1(1), LEF1(2), LMO7(5), MAP3K7(2), MET(4), MLLT4(3), NLK(1), PARD3(3), PTPN6(4), PTPRB(8), PTPRF(6), PTPRJ(1), PTPRM(5), PVRL2(1), PVRL4(2), RAC2(1), SORBS1(1), SRC(1), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(1), TGFBR1(2), TGFBR2(4), TJP1(4), VCL(1), WASF1(1), WASF2(2), WASL(2), YES1(1)	9939555	127	18	122	24	33	28	21	22	21	2	0.00346	0.988	1.000
347	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CREB1(1), GNAI1(1), GNAQ(1), GNAS(6), GNB1(1), HRAS(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	3052937	37	7	36	8	13	10	4	4	6	0	0.0790	0.989	1.000
348	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(2), EGFR(2), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1)	3231479	21	2	21	7	2	6	4	5	4	0	0.588	0.990	1.000
349	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(1), CCKBR(2), CELSR1(3), CELSR2(4), CELSR3(10), CHRM2(3), CHRM3(1), EMR2(3), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(1), GPR132(1), GPR133(6), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GPR77(1), GRM1(7), GRPR(1), LGR6(1), LPHN2(3), LTB4R2(1), P2RY13(2), PTGFR(1), SMO(2), TAAR5(1), TSHR(3)	5757526	66	15	64	21	23	12	13	9	8	1	0.118	0.991	1.000
350	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(2), BLVRA(2), CP(5), CPOX(1), FTMT(2), PPOX(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1)	3618032	21	6	21	5	2	8	1	3	7	0	0.292	0.991	1.000
351	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), CYP19A1(1), CYP1A1(1), CYP1A2(2), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C19(3), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A7(3), PON1(1)	2532477	32	5	31	10	12	4	7	3	6	0	0.304	0.992	1.000
352	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(1), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), NOS1(5), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2084964	30	5	30	10	10	5	6	6	3	0	0.417	0.992	1.000
353	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	TGM2(1)	431242	1	1	1	1	1	0	0	0	0	0	0.845	0.992	1.000
354	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	GNAQ(1), GNAS(6), GNB1(1), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PTK2(3), ROCK2(1)	2127312	17	4	16	8	5	4	3	2	3	0	0.852	0.993	1.000
355	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(8), ATM(6), BUB1(1), BUB3(1), CCNA1(2), CCNA2(3), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(2), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK4(2), E2F3(3), E2F4(3), E2F5(2), EP300(4), ESPL1(3), GSK3B(1), HDAC4(2), HDAC5(1), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MPEG1(2), PRKDC(4), RB1(1), RBL1(1), TBC1D8(2), TGFB1(1)	9322259	91	16	88	16	20	13	21	18	18	1	0.0192	0.993	1.000
356	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(1), SP1(1)	570349	3	1	3	0	1	0	2	0	0	0	0.547	0.993	1.000
357	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(1), F2RL1(1), F2RL2(1), F2RL3(1), MAPK7(4), MAPK8(1), MYEF2(1), PLD2(2), PLD3(1), PTK2(3), RASAL1(2), SRC(1), TEC(2), VAV1(4)	2392343	27	2	27	7	8	8	4	2	4	1	0.137	0.994	1.000
358	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), SOS1(2), SYK(2), VAV1(4)	3304651	32	4	32	8	8	9	3	5	6	1	0.154	0.994	1.000
359	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(2), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(1), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2)	4307592	39	9	38	12	11	9	6	6	7	0	0.380	0.994	1.000
360	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(3), BIRC2(1), CASP2(2), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), CRADD(2), DAXX(2), GSN(4), LMNB1(1), LMNB2(1), MAP2K7(2), MAP3K1(3), MAPK8(1), MDM2(1), NFKBIA(2), NUMA1(3), PAK2(2), PRKCD(2), PRKDC(4), PSEN1(1), PSEN2(1), PTK2(3), RASA1(1), RB1(1), RELA(1), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	6016557	57	12	55	16	13	9	15	7	13	0	0.293	0.994	1.000
361	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(3), BAD(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), CRADD(2), DAXX(2), FAS(1), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(3), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	3753289	38	8	38	12	11	9	8	3	7	0	0.475	0.995	1.000
362	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), AOC2(1), AOC3(2), ESD(1)	517108	6	1	6	2	3	2	1	0	0	0	0.471	0.995	1.000
363	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ALDH18A1(1), ALDH1A3(1), ALDH3A1(1), AMD1(1), AOC2(1), AOC3(2), ARG2(1), CPS1(4), SAT2(1)	2561750	15	2	15	4	6	3	3	1	1	1	0.307	0.995	1.000
364	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT2(1), FUT6(1)	441507	3	1	3	1	3	0	0	0	0	0	0.595	0.995	1.000
365	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(6), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DLAT(3), GLO1(1), GRHPR(1), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), PC(2), PCK1(2), PCK2(3), PDHA1(1), PKLR(1)	4025805	40	6	40	11	12	13	2	3	9	1	0.176	0.996	1.000
366	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(1), CASP10(1), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(2), TNFRSF10B(2), TRADD(1), TRAF2(1)	2918040	23	4	23	7	7	5	4	2	5	0	0.346	0.996	1.000
367	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), ASAH1(1), BRAF(1), DAG1(2), DRD2(1), EGFR(2), EPHB2(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), SOS1(2), SOS2(1), SRC(1), STAT3(1), TERF2IP(1)	5080553	43	8	43	9	10	6	6	10	11	0	0.149	0.996	1.000
368	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT2(1), GCNT2(1), ST8SIA1(2)	538356	5	1	5	1	3	1	1	0	0	0	0.347	0.997	1.000
369	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNGR1(1), JAK2(2), STAT1(1)	644179	4	1	4	2	0	0	2	1	1	0	0.838	0.997	1.000
370	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), NR1I3(1), PAK1(2), PDE3A(7), PDE3B(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), RIPK3(2)	4239635	38	11	36	12	10	6	6	3	13	0	0.564	0.997	1.000
371	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(2), LDHB(1)	588488	3	1	3	0	1	0	1	1	0	0	0.455	0.997	1.000
372	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(3), BAD(1), BAK1(1), BIRC2(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), CHUK(1), FAS(1), FASLG(1), HELLS(1), IKBKB(2), IRF1(1), IRF3(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKBIA(2), NFKBIE(1), PRF1(3), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	4919600	50	12	49	12	9	10	11	7	12	1	0.211	0.997	1.000
373	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), CAMK1G(1), FPR1(1), GNA15(1), GNB1(1), HRAS(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), PAK1(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RELA(1)	3332326	35	7	33	11	6	7	11	4	7	0	0.560	0.998	1.000
374	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(4), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), RYR1(13)	3996897	43	8	43	13	16	2	9	7	9	0	0.384	0.998	1.000
375	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(1), GAL3ST1(1), GLB1(1), LCT(3), NEU4(1), PPAP2B(2), SGMS1(1), SGPP1(1), SMPD3(1), SMPD4(1), SPHK1(1), SPTLC1(1), UGCG(1)	3137733	20	3	20	9	7	4	1	5	3	0	0.538	0.998	1.000
376	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC1(3), RPA1(1), RPA2(1), RPA3(2), RPS27A(1)	4381152	38	8	38	7	11	6	7	6	7	1	0.0701	0.998	1.000
377	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT3(3), AGPAT4(3), CDIPT(1), CHAT(3), CPT1B(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), GPD1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(2), PLA2G6(3), PLCB2(3), PLCG1(1), PLCG2(4), PPAP2B(2)	4382186	48	7	48	10	18	5	10	7	8	0	0.0589	0.998	1.000
378	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(4), AXIN1(3), CCND2(1), CCND3(1), CSNK1E(1), CTNNB1(6), DVL1(4), DVL2(2), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(3), PPP2R5C(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), SFRP4(1), TCF7(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT5B(1), WNT7A(1), WNT7B(2)	5276583	66	18	64	19	23	18	5	10	10	0	0.0792	0.998	1.000
379	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), CARM1(1), FTCD(2), HAL(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), PRPS1(1), UROC1(2)	3430693	24	4	24	9	7	8	6	1	2	0	0.426	0.998	1.000
380	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), GCDH(2), HADHA(1)	671418	5	1	5	0	1	1	2	0	1	0	0.248	0.998	1.000
381	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), DAO(3), GLUD2(1), GOT1(2), LAP3(2), NOS1(5), NOS3(6), OAT(2), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), PYCR2(1), RARS(1), RARS2(2)	3126095	48	8	48	10	12	9	13	6	7	1	0.0936	0.998	1.000
382	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(4), POLH(1), POLI(1), POLL(2), POLM(1), POLQ(2), REV1(1), REV3L(3)	3517802	27	4	27	5	6	6	5	6	4	0	0.145	0.999	1.000
383	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CDK4(2), MDM2(1), NXT1(1)	610899	5	1	5	0	3	0	2	0	0	0	0.210	0.999	1.000
384	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(2), BCKDHB(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1)	3100288	29	4	29	3	5	8	6	3	7	0	0.0212	0.999	1.000
385	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(1), HSD17B2(1), HSD17B4(2), HSD3B1(2)	696129	7	1	7	3	1	3	2	1	0	0	0.636	0.999	1.000
386	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(2), HADHA(1), HADHB(2)	718327	6	1	6	0	0	2	1	0	3	0	0.187	0.999	1.000
387	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), AR(1), ESR1(1), ESR2(1), ESRRA(1), NR0B1(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(1), NR4A2(3), PGR(3), PPARA(1), PPARD(1), RARB(1), RARG(2), ROR1(2), RORA(1), RORC(1)	3702002	34	4	34	11	9	8	6	5	6	0	0.255	0.999	1.000
388	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD4(2), LCK(1), PTPRC(2), ZAP70(4)	678897	9	1	9	2	2	2	1	2	2	0	0.368	0.999	1.000
389	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	9	ACP5(1), ENPP3(2), RFK(1), TYR(2)	723843	6	1	6	1	2	3	1	0	0	0	0.303	0.999	1.000
390	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(6), CCNA1(2), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(2), GBA2(3), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MYT1(6), POLA2(1), POLE(6), POLE2(1), RB1(1), RBL1(1), RPA1(1), RPA2(1), RPA3(2), TFDP2(1), TNXB(6)	6602784	73	14	72	17	19	11	14	16	12	1	0.0593	0.999	1.000
391	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGTR2(1), CAMK2D(1), CDK5(1), GNA11(2), GNAI1(1), GNB1(1), HRAS(1), JAK2(2), MAPK8(1), MAPT(1), MYLK(6), PLCG1(1), SOS1(2), STAT1(1), STAT3(1), STAT5A(1)	3499349	24	3	24	9	5	6	5	4	4	0	0.574	0.999	1.000
392	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(6), CACNA1B(6), GNAS(6), GNB1(1), GNB3(1), GRM4(1), ITPR3(6), KCNB1(3), PLCB2(3), PRKACG(2), SCNN1A(2), SCNN1B(1), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(1), TAS2R16(2), TAS2R3(1), TAS2R38(1), TAS2R41(1), TAS2R42(1), TAS2R60(1), TAS2R9(1), TRPM5(1)	4899932	60	10	59	15	21	10	13	6	10	0	0.0309	0.999	1.000
393	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	C1QA(1), C1QC(1), C1S(4), C3(5), C3AR1(2), C6(3), C7(3), C8A(3), C9(1), CD55(1), CD59(1), CFB(4), CFH(3), CFI(1), CR1(2), CR2(4), F10(4), F12(1), F13A1(1), F13B(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), KLKB1(1), MASP1(1), PLAT(1), PLAU(3), PLAUR(2), PROC(1), PROS1(1), SERPINA1(1), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), TFPI(2), THBD(2), VWF(4)	7802629	85	15	83	19	17	18	22	15	13	0	0.0597	0.999	1.000
394	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(1), HADHB(2), HSD17B4(2), PPT2(2)	731370	7	1	7	0	1	1	1	2	2	0	0.122	0.999	1.000
395	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(2), CYP2A7(1), NAT2(1), XDH(4)	680285	10	2	10	5	5	1	0	2	2	0	0.761	0.999	1.000
396	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1)	712970	5	2	5	2	0	1	2	1	1	0	0.774	0.999	1.000
397	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(1), FBXW7(3), RB1(1)	717348	7	2	7	3	1	3	1	2	0	0	0.716	0.999	1.000
398	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(6), GNB1(1), PRKAR1A(1)	585170	11	3	10	2	5	3	2	1	0	0	0.259	0.999	1.000
399	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT3(3), AGPAT4(3), CDIPT(1), CHAT(3), CHPT1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), ESCO1(4), ESCO2(1), ETNK2(1), GPAM(3), GPD1(1), LYPLA2(1), PCYT1B(1), PISD(1), PLA2G3(2), PLA2G6(3), PLD2(2), PPAP2B(2), PTDSS1(2), SH3GLB1(1)	5736042	51	11	51	16	18	6	9	8	10	0	0.320	0.999	1.000
400	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(2), CPO(2), HBB(1)	702436	5	3	5	2	2	1	1	0	1	0	0.624	0.999	1.000
401	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(6), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G3(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), COX4I2(2), COX7A2(1), COX7C(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(2), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRC2(1), UQCRFS1(1)	4850391	51	10	50	16	10	10	9	9	12	1	0.435	0.999	1.000
402	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(2), BCR(1), BTK(1), CD19(1), DAPP1(1), FLOT1(1), FLOT2(1), ITPR1(5), ITPR2(3), ITPR3(6), PDK1(1), PHF11(1), PIK3CA(1), PLCG2(4), PREX1(4), PTEN(1), PTPRC(2), RPS6KA1(1), RPS6KA2(1), SYK(2), TEC(2), VAV1(4)	4753696	46	7	46	13	16	8	5	9	7	1	0.214	0.999	1.000
403	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(8), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), ATM(6), ATR(5), BUB1(1), BUB3(1), CCNA1(2), CCNA2(3), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25A(2), CDC25C(2), CDC6(1), CDC7(1), CDK4(2), CDK7(1), CREBBP(1), CUL1(1), E2F3(3), EP300(4), ESPL1(3), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), PKMYT1(2), PRKDC(4), RB1(1), RBL1(1), RBL2(2), SKP1(1), SMC1A(1), SMC1B(1), TGFB1(1), TGFB2(2), YWHAE(2), YWHAH(1)	11554067	103	18	99	25	20	19	25	14	24	1	0.153	0.999	1.000
404	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(3), MEF2A(1), MEF2D(1), YWHAH(1)	684413	8	1	8	1	0	2	3	1	2	0	0.352	0.999	1.000
405	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(3), PDHA1(1), SLC18A3(1)	613068	7	3	7	3	4	0	3	0	0	0	0.668	0.999	1.000
406	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), ASH2L(2), C17orf79(1), CARM1(1), DOT1L(1), EED(2), EHMT1(3), EHMT2(2), EZH2(3), FBXO11(1), HCFC1(2), KDM6A(1), MEN1(2), MLL(2), MLL2(13), MLL3(15), MLL5(1), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM9(3), PRMT6(1), PRMT8(1), SATB1(5), SETD1A(3), SETD2(3), SETD8(1), SETDB1(1), SUV39H2(2), SUV420H1(3), SUV420H2(2), WHSC1(1), WHSC1L1(1)	10401201	94	21	91	24	11	19	22	18	24	0	0.327	0.999	1.000
407	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(2), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), E2F4(3)	735587	12	1	12	2	2	2	5	3	0	0	0.288	0.999	1.000
408	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH3A1(1), UGDH(1)	739390	3	1	3	2	2	0	0	1	0	0	0.852	0.999	1.000
409	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(2), CD14(2), CD19(1), CD1A(1), CD1B(3), CD1C(1), CD1E(1), CD2(2), CD22(1), CD33(1), CD38(1), CD4(2), CD44(3), CD5(1), CD55(1), CD59(1), CR1(2), CR2(4), CSF1(1), CSF1R(3), CSF3R(1), DNTT(1), EPOR(2), FCGR1A(1), FLT3(3), GP9(2), IL1B(1), IL1R2(2), IL2RA(1), IL4R(1), IL6(2), IL7(1), IL7R(1), ITGA1(4), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(3), MME(2), MS4A1(2), THPO(1), TPO(3)	7057307	72	15	71	21	13	14	14	18	13	0	0.278	0.999	1.000
410	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(2), LARS2(2), PDHA1(1)	856918	7	3	7	2	3	2	0	2	0	0	0.521	1.000	1.000
411	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL6(2)	850791	3	2	3	2	0	1	2	0	0	0	0.831	1.000	1.000
412	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(4), AR(1), ASAH1(1), BRAF(1), CAMP(2), DAG1(2), EGFR(2), GNA11(2), GNA15(1), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(1), PIK3CD(1), PIK3R1(1), SRC(1)	4656160	45	9	45	13	13	4	7	8	13	0	0.385	1.000	1.000
413	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(6), PSEN1(1)	782094	10	2	10	2	1	5	1	2	1	0	0.317	1.000	1.000
414	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCBP2(1), CCKAR(5), CCKBR(2), CCR1(1), CCR10(2), CCR4(2), CCR7(1), CCR9(1), CCRL1(1), CCRL2(2), CHML(3), CHRM2(3), CHRM3(1), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD2(1), EDNRB(2), F2RL1(1), F2RL2(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(1), GPR77(1), GPR83(2), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), LTB4R(3), MC3R(2), MC5R(1), MLNR(1), MTNR1A(1), NMUR2(2), NPY1R(1), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRL1(2), OPRM1(1), OR1C1(2), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(2), P2RY14(1), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), SSTR1(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(1)	10547887	130	21	128	34	40	16	42	23	9	0	0.00815	1.000	1.000
415	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH4A1(3), AMD1(1), AOC2(1), AOC3(2), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), DAO(3), GOT1(2), NOS1(5), NOS3(6), OAT(2), P4HA1(3), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1)	3843113	48	7	48	10	16	10	11	5	5	1	0.0387	1.000	1.000
416	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(2), BLNK(1), BTK(1), CARD11(2), CD19(1), CD22(1), CHUK(1), CR2(4), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), LILRB3(1), MALT1(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC2(1), SYK(2), VAV1(4), VAV3(1)	6155182	69	15	69	20	16	20	7	10	15	1	0.144	1.000	1.000
417	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(2), AKT1(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(1), EDN1(1), ELSPBP1(1), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(1), MYH2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PIK3CA(1), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	4392482	46	7	46	12	16	10	7	4	9	0	0.0961	1.000	1.000
418	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(3), BAD(1), BAK1(1), CASP8AP2(2)	918854	7	1	7	2	2	4	0	0	1	0	0.487	1.000	1.000
419	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NOX1(2), RELA(1), SOD1(1), XDH(4)	859903	8	1	8	6	2	2	2	1	1	0	0.946	1.000	1.000
420	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), WDR1(2)	846622	11	2	11	3	3	2	0	5	1	0	0.355	1.000	1.000
421	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(1), AKT1(2), APAF1(3), ATM(6), BAD(1), BIRC2(1), CAPN1(1), CASP10(1), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK4(1), NFKBIA(2), NTRK1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	7180899	63	12	63	18	19	15	8	9	12	0	0.172	1.000	1.000
422	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK2(2), TYK2(1)	899255	4	1	4	1	1	0	1	1	1	0	0.579	1.000	1.000
423	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK2(2), TYK2(1)	899255	4	1	4	1	1	0	1	1	1	0	0.579	1.000	1.000
424	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), CASP8(2), CCL3(1), CD14(2), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(2), IRAK4(1), IRF3(1), IRF7(1), LY96(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(2), TLR2(1), TLR3(2), TLR5(2), TLR6(2), TLR8(1), TLR9(6)	7775663	75	15	73	20	15	16	18	8	18	0	0.161	1.000	1.000
425	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(2), STAT1(1), STAT2(1), TYK2(1)	934636	7	1	7	2	3	0	2	2	0	0	0.527	1.000	1.000
426	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	87	ACVR1B(2), ACVR1C(1), ACVR2A(2), ACVRL1(1), AMH(1), AMHR2(5), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BMPR1A(3), BMPR2(1), CHRD(2), COMP(2), CREBBP(1), CUL1(1), E2F4(3), E2F5(2), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBC(1), LEFTY2(1), PPP2R1A(1), PPP2R1B(2), RBL1(1), RBL2(2), ROCK1(2), ROCK2(1), SKP1(1), SMAD7(1), SMAD9(1), SP1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), THBS1(1), THBS2(4), ZFYVE16(4), ZFYVE9(3)	8371851	78	12	77	19	21	16	14	15	12	0	0.0757	1.000	1.000
427	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), AKR1C3(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C19(3), CYP2E1(1), CYP2F1(1), CYP2S1(2), CYP3A7(3), EPHX1(2), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM4(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1)	4949750	51	7	50	15	13	13	11	6	8	0	0.213	1.000	1.000
428	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), ICAM1(1), ITGB2(1), PTPRC(2)	920880	6	1	6	0	2	1	0	2	1	0	0.108	1.000	1.000
429	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1)	992396	6	1	6	1	1	2	1	0	2	0	0.410	1.000	1.000
430	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(2)	875586	6	1	6	1	3	1	1	0	1	0	0.288	1.000	1.000
431	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR1(2), IFNAR2(2), MAPK8(1), RELA(1), TNFRSF11A(2)	959360	9	1	9	2	1	2	2	3	1	0	0.419	1.000	1.000
432	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	851958	14	3	13	2	8	3	3	0	0	0	0.138	1.000	1.000
433	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD4(2), ICAM1(1), ITGB2(1), PTPRC(2)	965985	8	1	8	1	2	1	0	3	2	0	0.261	1.000	1.000
434	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(1), CR2(4), CSK(1), DAG1(2), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP4K1(2), NFATC1(4), NFATC2(4), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPRC(2), SOS1(2), SOS2(1), SYK(2), VAV1(4)	6415944	65	11	65	18	20	17	5	8	14	1	0.0937	1.000	1.000
435	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), CARD11(2), CBL(2), CBLB(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), GRAP2(1), HRAS(1), IKBKB(2), ITK(1), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), SOS1(2), SOS2(1), TEC(2), VAV1(4), VAV3(1), ZAP70(4)	8391871	89	15	88	27	24	23	10	11	20	1	0.192	1.000	1.000
436	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(2)	928258	6	1	6	1	3	1	1	0	1	0	0.281	1.000	1.000
437	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(2), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(2), NOD1(3), PAK1(2), PLCG1(1), PLCG2(4), PTPRZ1(2), RELA(1), SRC(1), TCIRG1(1), TJP1(4)	6080698	57	8	56	16	8	14	15	11	9	0	0.263	1.000	1.000
438	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(2), CSK(1), DAG1(2), EPHB2(1), FBXW7(3), GRAP2(1), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), SOS1(2), SOS2(1), VAV1(4), ZAP70(4)	4616773	45	7	44	10	13	10	6	7	8	1	0.122	1.000	1.000
439	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(1), IL6(2), STAT1(1), STAT3(1), STAT5A(1)	1046991	8	2	8	2	3	2	3	0	0	0	0.321	1.000	1.000
440	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BAD(1), CABIN1(2), CAMK4(2), CREBBP(1), CSNK2A1(1), EGR3(1), EP300(4), FCER1A(1), GATA3(1), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(2), ITK(1), KPNA5(1), MAP2K7(2), MAPK8(1), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(2), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4), VAV3(1)	7647962	74	15	73	24	24	18	10	6	15	1	0.298	1.000	1.000
441	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(2), EGFR(2), HGS(2), TF(1)	1102888	10	1	10	0	1	4	2	2	1	0	0.0349	1.000	1.000
442	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A3(1), ALDH3A1(1), HADHA(1)	1050345	3	1	3	2	2	0	1	0	0	0	0.854	1.000	1.000
443	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(2), JAK3(3), STAT3(1), TYK2(1)	1028013	7	1	7	5	2	2	2	0	1	0	0.869	1.000	1.000
444	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(2), ABCA10(1), ABCA12(9), ABCA13(7), ABCA2(5), ABCA3(4), ABCA4(5), ABCA5(3), ABCA6(3), ABCA7(3), ABCA8(6), ABCA9(7), ABCB1(2), ABCB10(2), ABCB11(2), ABCB4(5), ABCB5(4), ABCB6(1), ABCC10(1), ABCC11(2), ABCC3(2), ABCC4(3), ABCC5(2), ABCC6(1), ABCC9(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(2), TAP1(1)	9980845	95	14	93	29	20	22	16	23	14	0	0.149	1.000	1.000
445	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1B(2), ACVR2A(2), AMH(1), AMHR2(5), BMP2(1), BMP7(1), BMPR1A(3), BMPR2(1), CCL1(2), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR4(2), CCR7(1), CCR9(1), CSF1(1), CSF1R(3), CSF2RB(1), CSF3R(1), CX3CL1(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPOR(2), FAS(1), FASLG(1), FLT1(2), FLT3(3), FLT4(8), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(1), IFNK(1), IL10RA(1), IL12B(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1R2(2), IL1RAP(2), IL20RA(2), IL21R(1), IL23R(1), IL26(1), IL28B(1), IL2RA(1), IL2RB(2), IL4R(1), IL6(2), IL6ST(2), IL7(1), IL7R(1), INHBA(1), INHBC(1), KDR(1), KIT(3), LIF(2), LIFR(4), MET(4), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(2), PF4V1(1), PLEKHO2(1), PRL(1), PRLR(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(1), TNFSF14(1), TNFSF8(3), TPO(3), TSLP(1), XCR1(1)	15216541	161	26	159	33	45	38	29	29	20	0	0.000120	1.000	1.000
446	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1)	1143416	11	1	11	5	6	3	1	1	0	0	0.648	1.000	1.000
447	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	15	ACP5(1), ENPP3(2), MTMR6(1), PHPT1(1), RFK(1), TYR(2)	1184012	8	1	8	3	2	4	2	0	0	0	0.615	1.000	1.000
448	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), PRKAA2(1), PRKAB1(1), PRKAB2(1)	1236763	7	1	7	0	0	3	0	1	3	0	0.0939	1.000	1.000
449	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLD1(1), POLG(4), RRM1(1)	1111876	12	3	12	2	3	5	0	1	3	0	0.0994	1.000	1.000
450	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), CD38(1), ENPP3(2), NADSYN1(3), NNT(4), NT5E(1), NT5M(1)	1254091	13	1	13	3	4	3	2	2	2	0	0.270	1.000	1.000
451	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(8), ABL2(1), AKT1(2), ARAF(1), BAD(1), BRAF(1), CAMK2D(1), CBL(2), CBLB(1), CRK(1), EGF(2), EGFR(2), ERBB2(5), ERBB3(3), ERBB4(6), GSK3B(1), HRAS(1), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK9(1), NCK1(3), NCK2(2), NRG1(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PTK2(3), SHC2(2), SHC4(2), SOS1(2), SOS2(1), SRC(1), STAT5A(1)	8932933	90	15	88	22	24	21	13	10	22	0	0.0616	1.000	1.000
452	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AK3(1), CAD(4), CTPS2(1), DPYD(3), DPYS(4), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(1), NME4(1), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(1)	7016629	61	9	60	19	17	11	12	13	8	0	0.301	1.000	1.000
453	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(1), APOA5(1), CPT1B(3), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A22(1), CYP7A1(2), CYP8B1(1), FABP4(1), GK(2), GK2(3), HMGCS2(1), LPL(2), ME1(2), MMP1(1), NR1H3(2), PCK1(2), PCK2(3), PLTP(1), PPARA(1), PPARD(1), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SORBS1(1)	5504739	50	6	50	12	13	15	10	4	7	1	0.0338	1.000	1.000
454	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD4(2), IL12B(1), JAK2(2), TYK2(1)	1279067	8	1	8	2	2	1	1	2	2	0	0.512	1.000	1.000
455	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(1), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TRAF2(1), TRAF5(1)	1263435	7	1	7	3	1	1	3	0	2	0	0.763	1.000	1.000
456	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK2(2), JAK3(3), PIAS1(1), PIAS3(1), PTPRU(6), SOAT1(1)	1197602	14	4	14	8	6	3	4	0	1	0	0.842	1.000	1.000
457	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), ST3GAL1(2)	1233267	9	1	9	4	2	3	3	0	1	0	0.657	1.000	1.000
458	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), DRD2(1), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(6), GRM1(7), GRM5(4), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), HRAS(1), HTR2A(1), HTR2B(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP3K2(2), MAPK7(4), NPR1(1), NPR2(1), PDGFC(1), PDGFRA(4), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PRKACG(2), PRKG1(1), PRKG2(1), SOS1(2), SOS2(1), SRC(1), TJP1(4), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1)	11466660	128	16	125	30	42	24	23	22	17	0	0.00512	1.000	1.000
459	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	1297934	10	2	10	2	2	2	4	1	1	0	0.336	1.000	1.000
460	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	1297934	10	2	10	2	2	2	4	1	1	0	0.336	1.000	1.000
461	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1)	1297934	10	2	10	2	2	2	4	1	1	0	0.336	1.000	1.000
462	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BTRC(1), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G3(3), DHH(2), FBXW11(2), GLI1(4), GLI2(2), GLI3(6), GSK3B(1), HHIP(3), LRP2(2), PRKACG(2), PTCH1(2), PTCH2(4), SMO(2), STK36(1), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1), ZIC2(1)	5341938	62	16	60	22	23	11	13	7	8	0	0.452	1.000	1.000
463	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1)	1338118	6	2	6	3	1	1	3	1	0	0	0.882	1.000	1.000
464	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), HADHA(1), SCP2(1)	1447120	9	1	9	0	3	3	2	0	1	0	0.0474	1.000	1.000
465	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(1)	1381211	11	2	11	3	2	2	5	1	1	0	0.447	1.000	1.000
466	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), JAK2(2), JAK3(3), PIAS3(1), PTPRU(6), SRC(1), STAT3(1)	1329354	16	4	16	8	5	5	5	0	1	0	0.717	1.000	1.000
467	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), HLA-A(2), HRAS(1), ICAM1(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(1), ITGB2(1), KIR2DL1(1), KIR3DL2(1), KLRC1(1), KLRC2(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PAK1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRF1(3), PTPN6(4), RAC2(1), SHC2(2), SHC4(2), SOS1(2), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), VAV3(1), ZAP70(4)	9332162	88	13	86	24	25	20	10	14	18	1	0.0619	1.000	1.000
468	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(3), GNAS(6), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(1)	1309940	20	4	19	4	8	3	4	5	0	0	0.205	1.000	1.000
469	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADSL(1), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(1), ATIC(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G3(2), ENPP3(2), ENTPD2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(1), NT5E(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(1), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(1), PFAS(5), PKLR(1), POLD1(1), POLD2(1), POLE(6), POLG(4), POLL(2), POLQ(2), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(1), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1)	11157206	106	12	106	26	35	26	18	13	12	2	0.00823	1.000	1.000
470	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	DPEP1(1), LTA4H(1), PLA2G6(3), PTGDS(2), PTGIS(2), TBXAS1(1)	1318200	10	2	10	8	5	0	2	1	2	0	0.959	1.000	1.000
471	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(6), GNB1(1), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	1343789	19	3	18	2	8	5	3	1	2	0	0.0356	1.000	1.000
472	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(1), RELA(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(1)	1467866	14	2	14	6	3	2	5	2	2	0	0.712	1.000	1.000
473	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLD2(1), POLE(6), POLG(4), POLL(2), POLQ(2)	1452002	16	2	16	2	5	4	3	1	3	0	0.0815	1.000	1.000
474	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), ATIC(1), DHFR(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(3), TYMS(1)	1533771	15	2	15	5	2	2	4	3	4	0	0.534	1.000	1.000
475	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1)	1571953	12	2	12	5	0	4	5	2	1	0	0.766	1.000	1.000
476	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(8), ACTN1(1), AKT1(2), ARHGEF6(1), ARHGEF7(2), BCAR1(2), BRAF(1), CDC42(1), CRK(1), CSE1L(1), DOCK1(2), EPHB2(1), GRB7(1), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(6), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PIK3CA(1), PIK3CB(1), PKLR(1), PLCG1(1), PLCG2(4), PTEN(1), PTK2(3), ROCK1(2), ROCK2(1), SOS1(2), SOS2(1), SRC(1), TERF2IP(1), TLN1(7), TLN2(1), ZYX(1)	10515770	95	13	92	28	21	19	17	19	19	0	0.249	1.000	1.000
477	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	16	CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(1), NFKBIA(2), RELA(1), TRAF2(1)	1605781	11	2	11	3	1	2	4	2	2	0	0.583	1.000	1.000
478	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), HRAS(1), JAK2(2), PTPN6(4), SOS1(2), STAT5A(1)	1523724	11	2	11	3	3	1	3	3	1	0	0.515	1.000	1.000
479	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(2), ILVBL(2), LARS2(2), PDHA1(1), VARS(1), VARS2(1)	1604132	12	3	12	4	5	3	1	2	1	0	0.587	1.000	1.000
480	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), PGK1(2), PKLR(1), RPE(2), TKT(1), TPI1(2)	1559796	20	2	20	3	1	6	8	3	2	0	0.105	1.000	1.000
481	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), JAK2(2), JAK3(3), STAT1(1), STAT3(1), STAT5A(1), TYK2(1)	1607144	10	1	10	6	4	2	3	0	1	0	0.792	1.000	1.000
482	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), ACTN3(1), BCAR1(2), CSK(1), CTNNA1(3), CTNNA2(3), CTNNB1(6), PTK2(3), SRC(1), VCL(1)	1683706	26	3	26	6	11	8	1	4	2	0	0.0693	1.000	1.000
483	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), PGK1(2), PKLR(1), RPE(2), TKT(1), TPI1(2)	1740531	18	2	18	3	1	5	8	2	2	0	0.161	1.000	1.000
484	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), BAAT(1), CYP27A1(1), CYP7A1(2), HADHB(2)	1905735	17	3	17	8	6	4	3	2	2	0	0.740	1.000	1.000
485	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1), TNFRSF1B(1), TRAF2(1)	1943717	14	2	14	7	1	4	6	2	1	0	0.839	1.000	1.000
486	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), EPOR(2), HRAS(1), JAK2(2), MAPK8(1), PLCG1(1), PTPN6(4), SOS1(2), STAT5A(1)	1868758	15	2	15	5	5	2	3	2	3	0	0.583	1.000	1.000
487	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(5), HS2ST1(1), HS3ST2(3), HS6ST1(2), NDST1(2), NDST3(3), NDST4(2)	1822610	26	3	26	7	11	3	8	2	2	0	0.232	1.000	1.000
488	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(1), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	1949524	15	4	15	6	3	3	5	2	2	0	0.690	1.000	1.000
489	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1)	2008371	11	2	11	7	5	2	2	1	1	0	0.881	1.000	1.000
490	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT1(2), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(2), CAPN5(2), CAPN7(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), GIT2(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAD(1), ITGAE(5), ITGAM(1), ITGAV(2), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(4), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PIK3R2(2), PTK2(3), RAC2(1), RAP1B(1), ROCK1(2), ROCK2(1), SDCCAG8(1), SEPP1(1), SORBS1(1), SOS1(2), SRC(1), TLN1(7), TNS1(3), VAV3(1), VCL(1), ZYX(1)	11616358	98	14	96	27	22	24	23	14	15	0	0.0497	1.000	1.000
491	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(1), GNAI1(1), GNB1(1), HRAS(1), ITGA1(4), PLCB1(1), PTK2(3), SRC(1), SYK(2), TBXAS1(1)	2102026	16	1	16	5	4	4	2	4	2	0	0.556	1.000	1.000
492	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), RPL10A(1), RPL10L(1), RPL18A(1), RPL22L1(1), RPL24(1), RPL35(1), RPL3L(2), RPS11(2), RPS28(1), RPSA(2)	1961250	14	2	14	4	6	1	3	0	4	0	0.602	1.000	1.000
493	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(2), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP4K2(2), MAPK8(1), NFKBIA(2), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	2120966	26	3	25	6	7	4	9	3	3	0	0.215	1.000	1.000
494	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), HRAS(1), IL2RA(1), IL2RB(2), JAK3(3), LCK(1), MAPK8(1), SOS1(2), STAT5A(1), SYK(2)	2048680	15	2	15	9	6	4	1	2	2	0	0.875	1.000	1.000
495	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK3(1), COL2A1(3), CPSF1(3), CPSF2(4), CPSF3(2), CPSF4(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(2), DHX16(3), DHX38(1), DHX8(1), DHX9(2), DICER1(5), FUS(1), LOC440563(2), METTL3(1), NCBP2(1), NONO(1), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(2), PRPF8(2), PTBP1(1), RBM5(1), RNGTT(2), SF3A2(1), SF3B5(1), SNRPB(1), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(2), U2AF1(1), U2AF2(2), XRN2(3)	9144379	70	19	68	19	17	11	9	13	19	1	0.364	1.000	1.000
496	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD4(2), CREBBP(1), CSK(1), GNAS(6), GNB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(4)	2012567	27	4	26	5	11	6	5	3	2	0	0.0667	1.000	1.000
497	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD4(2), CREBBP(1), CSK(1), GNAS(6), GNB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(4)	2012567	27	4	26	5	11	6	5	3	2	0	0.0667	1.000	1.000
498	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(1), ACAD9(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), BAAT(1), CYP27A1(1), CYP7A1(2), HADHB(2), HSD3B7(2), RDH11(2), SLC27A5(2), SOAT1(1)	2648531	26	4	26	9	9	6	6	3	2	0	0.434	1.000	1.000
499	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(1)	2847780	20	1	20	2	4	5	3	5	3	0	0.0577	1.000	1.000
500	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), GALNT1(1), GALNT10(1), GALNT13(1), GALNT14(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(1), OGT(1), ST3GAL1(2)	2777876	20	2	20	9	5	5	4	3	3	0	0.711	1.000	1.000
501	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(1), ADRA2B(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CALCR(1), CCKAR(5), CCKBR(2), CGA(1), CHRM2(3), CHRM3(1), CHRM5(3), CRHR2(1), CTSG(1), CYSLTR2(1), DRD1(2), DRD2(1), EDNRB(2), F2RL1(1), F2RL2(1), F2RL3(1), FPR1(1), FSHB(1), FSHR(1), GABBR2(1), GABRA4(5), GABRA5(3), GABRA6(1), GABRB1(2), GABRB3(3), GABRD(1), GABRE(1), GABRG1(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GLP2R(3), GLRA2(2), GNRHR(1), GPR83(2), GRIA1(1), GRID1(5), GRID2(2), GRIK2(2), GRIK3(1), GRIK5(1), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), GRIN3A(3), GRIN3B(1), GRM1(7), GRM2(2), GRM3(2), GRM4(1), GRM5(4), GRM6(4), GRM7(4), GRM8(2), GRPR(1), HCRTR1(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), LTB4R(3), LTB4R2(1), MC2R(2), MC3R(2), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMUR2(2), NPBWR1(1), NPFFR2(1), NPY1R(1), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRL1(2), OPRM1(1), OXTR(1), P2RX2(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY13(2), P2RY14(1), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(1), PARD3(3), PRL(1), PRLR(2), PRSS1(2), PTGDR(2), PTGFR(1), RXFP1(1), SSTR1(2), SSTR4(3), SSTR5(3), TAAR1(1), TAAR2(1), TAAR5(1), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(1), TRHR(1), TRPV1(2), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1)	19029786	235	21	231	70	71	40	57	41	25	1	0.00717	1.000	1.000
502	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADSL(1), ADSS(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(1), ATIC(1), ENPP3(2), ENTPD2(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(1), GMPR(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), IMPDH1(2), IMPDH2(1), NME4(1), NPR1(1), NPR2(1), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), NUDT9(2), PAICS(2), PAPSS1(2), PAPSS2(3), PDE10A(5), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(1), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(1), PFAS(5), PKLR(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(4)	14179438	130	17	128	35	45	24	19	24	16	2	0.0320	1.000	1.000
503	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(5), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1C2(1), ATP6V1F(1), GNAS(6), PDIA4(1), PLCG1(1), PLCG2(4), SEC61A1(1), SEC61A2(2), SEC61G(1)	3201148	36	5	35	10	12	8	9	5	2	0	0.211	1.000	1.000
504	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTN1(1), ACTN2(4), ACTN3(1), AKT1(2), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(1), CCND2(1), CCND3(1), CDC42(1), CHAD(1), COL11A1(4), COL11A2(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), COMP(2), CRK(1), CTNNB1(6), DIAPH1(3), DOCK1(2), EGF(2), EGFR(2), ERBB2(5), FARP2(1), FLNA(5), FLNB(3), FLNC(7), FLT1(2), FN1(5), GSK3B(1), HRAS(1), IBSP(2), IGF1R(4), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAV(2), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), KDR(1), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(2), LAMC1(1), LAMC3(2), MAPK10(1), MAPK8(1), MAPK9(1), MET(4), MYLK(6), MYLK2(3), MYLPF(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PARVB(2), PARVG(1), PDGFC(1), PDGFRA(4), PDGFRB(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP5K1C(1), PPP1CA(1), PTEN(1), PTK2(3), RAC2(1), RAP1B(1), RELN(6), ROCK1(2), ROCK2(1), SHC2(2), SHC4(2), SOS1(2), SOS2(1), SRC(1), THBS1(1), THBS2(4), TLN1(7), TLN2(1), TNC(8), TNN(1), TNR(5), TNXB(6), VAV1(4), VAV3(1), VCL(1), VWF(4), ZYX(1)	32038471	320	34	317	92	87	70	56	55	48	4	0.00783	1.000	1.000
505	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(2), ACVR1C(1), AKT1(2), ARRB1(1), ARRB2(2), BDNF(1), BRAF(1), CACNA1A(6), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1F(1), CACNA1G(5), CACNA1H(1), CACNA1I(5), CACNA1S(4), CACNA2D1(1), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(1), CACNG3(1), CACNG5(1), CD14(2), CDC42(1), CHUK(1), CRK(1), DAXX(2), DUSP10(1), DUSP14(1), DUSP16(1), DUSP7(2), EGF(2), EGFR(2), FAS(1), FASLG(1), FGF12(1), FGF2(1), FGF23(1), FGF5(1), FGFR2(1), FGFR3(3), FGFR4(1), FLNA(5), FLNB(3), FLNC(7), HRAS(1), IKBKB(2), IL1B(1), IL1R2(2), JUND(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(2), MAP4K1(2), MAP4K2(2), MAP4K3(1), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(1), MAX(2), MRAS(2), NF1(2), NFATC2(4), NFATC4(4), NLK(1), NR4A1(1), NTF3(2), NTRK1(2), NTRK2(2), PAK1(2), PAK2(2), PDGFRA(4), PDGFRB(2), PLA2G3(2), PLA2G6(3), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACG(2), RAC2(1), RAP1B(1), RAPGEF2(3), RASA1(1), RASA2(1), RASGRF2(1), RASGRP1(2), RASGRP2(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS1(2), SOS2(1), STK4(2), STMN1(1), TAOK1(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TNFRSF1A(2), TRAF2(1)	24814869	242	32	235	75	72	43	39	39	45	4	0.0931	1.000	1.000
506	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(8), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CDK5(1), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(2), EFNA1(1), EPHA1(2), EPHA2(4), EPHA4(2), EPHA5(4), EPHA6(2), EPHA7(1), EPHA8(5), EPHB2(1), EPHB3(2), EPHB4(3), EPHB6(3), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(1), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NGEF(1), NRP1(1), NTNG1(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PLXNA1(4), PLXNA2(6), PLXNA3(6), PLXNB1(4), PLXNB2(3), PLXNB3(5), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(3), RAC2(1), RASA1(1), RGS3(1), RHOD(1), RND1(1), ROBO1(5), ROBO2(2), ROBO3(4), ROCK1(2), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3D(4), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(3), SEMA4G(2), SEMA5A(2), SEMA5B(3), SEMA6A(2), SEMA6C(2), SEMA7A(1), SLIT1(5), SLIT2(2), SLIT3(4), SRGAP1(2), SRGAP3(6), UNC5A(3), UNC5B(1), UNC5C(3), UNC5D(4)	16873467	210	31	204	70	63	40	33	31	43	0	0.239	1.000	1.000
507	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	CHAD(1), COL11A1(4), COL11A2(2), COL17A1(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), COMP(2), DES(1), DSC1(2), DSC2(3), DSC3(4), DSG1(2), DSG2(1), DSG4(2), FN1(5), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(1), GJC1(1), GJC2(2), GJC3(1), GJD4(2), IBSP(2), INA(1), ITGB4(5), KRT1(2), KRT10(1), KRT12(3), KRT15(3), KRT16(1), KRT17(2), KRT2(3), KRT20(1), KRT27(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(1), KRT40(1), KRT6A(2), KRT7(2), KRT73(2), KRT74(1), KRT75(1), KRT76(1), KRT77(2), KRT79(2), KRT82(1), KRT83(2), KRT85(1), KRT86(1), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(2), LAMC1(1), LAMC3(2), LMNB1(1), LMNB2(1), NES(4), PRPH(1), RELN(6), THBS1(1), THBS2(4), TNC(8), TNN(1), TNR(5), TNXB(6), VWF(4)	21554220	240	29	239	74	69	45	44	40	39	3	0.0763	1.000	1.000
508	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY7(2), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(1), ATP2A1(3), ATP2A2(3), ATP2B1(4), ATP2B2(1), ATP2B3(2), AVPR1B(1), CACNA1A(6), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1F(1), CACNA1G(5), CACNA1H(1), CACNA1I(5), CACNA1S(4), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(5), CCKBR(2), CD38(1), CHRM2(3), CHRM3(1), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(5), ERBB3(3), ERBB4(6), GNA11(2), GNA15(1), GNAQ(1), GNAS(6), GRIN2A(4), GRIN2C(5), GRIN2D(4), GRM1(7), GRM5(4), GRPR(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), LTB4R2(1), MYLK(6), MYLK2(3), NOS1(5), NOS3(6), OXTR(1), P2RX2(1), P2RX5(1), P2RX7(1), PDE1B(1), PDGFRA(4), PDGFRB(2), PHKA2(2), PHKB(2), PHKG1(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRKACG(2), PTGFR(1), RYR1(13), RYR2(8), RYR3(11), SLC25A4(1), SLC8A2(2), SLC8A3(2), SPHK1(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(1)	23512106	293	28	287	94	88	39	71	53	39	3	0.0778	1.000	1.000
509	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(2), CD44(3), CHAD(1), COL11A1(4), COL11A2(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), DAG1(2), FN1(5), FNDC1(5), GP6(1), GP9(2), HMMR(2), HSPG2(1), IBSP(2), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAV(2), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(2), LAMC1(1), LAMC3(2), RELN(6), SDC3(1), SDC4(2), SV2A(2), SV2C(1), THBS1(1), THBS2(4), TNC(8), TNN(1), TNR(5), TNXB(6), VWF(4)	19456320	197	27	196	57	53	40	39	33	29	3	0.0596	1.000	1.000
510	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ABI2(1), ACTN1(1), ACTN2(4), ACTN3(1), APC(4), APC2(1), ARAF(1), ARHGEF1(3), ARHGEF12(4), ARHGEF6(1), ARHGEF7(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(1), BCAR1(2), BRAF(1), CD14(2), CDC42(1), CHRM2(3), CHRM3(1), CHRM5(3), CRK(1), CSK(1), CYFIP2(1), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF12(1), FGF2(1), FGF23(1), FGF5(1), FGFR2(1), FGFR3(3), FGFR4(1), FN1(5), GIT1(2), GSN(4), HRAS(1), IQGAP1(1), IQGAP2(1), IQGAP3(2), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAD(1), ITGAE(5), ITGAM(1), ITGAV(2), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(5), ITGB5(3), ITGB8(3), LIMK1(1), LIMK2(1), MRAS(2), MYH10(8), MYH14(3), MYH9(1), MYLK(6), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDGFRA(4), PDGFRB(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(3), RAC2(1), RDX(2), ROCK1(2), ROCK2(1), SOS1(2), SOS2(1), SSH1(2), SSH3(1), TIAM1(2), VAV1(4), VAV3(1), VCL(1), WASF1(1), WASF2(2), WASL(2)	24123799	207	27	200	73	51	42	40	31	41	2	0.434	1.000	1.000
511	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADRA1A(1), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(2), ATP1B3(1), ATP2A2(3), ATP2B1(4), ATP2B2(1), ATP2B3(2), CACNA1A(6), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1S(4), CACNB1(1), CAMK1(1), CAMK2D(1), CAMK4(2), CASQ1(1), CHRM2(3), CHRM3(1), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(1), GNA11(2), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GRK6(1), ITPR1(5), ITPR2(3), ITPR3(6), KCNB1(3), KCNJ5(1), MIB1(1), PLCB3(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS1(1), RGS10(1), RGS17(1), RGS3(1), RGS7(2), RGS9(1), RYR1(13), RYR2(8), RYR3(11), SLC8A3(2), YWHAH(1)	16440144	182	26	179	67	58	32	37	24	28	3	0.302	1.000	1.000
512	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(4), APC2(1), AXIN1(3), AXIN2(1), BTRC(1), CAMK2D(1), CCND2(1), CCND3(1), CHD8(5), CREBBP(1), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CTBP2(2), CTNNB1(6), CUL1(1), DAAM1(5), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(2), EP300(4), FBXW11(2), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GSK3B(1), LEF1(2), LRP5(5), LRP6(3), MAP3K7(2), MAPK10(1), MAPK8(1), MAPK9(1), MMP7(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NKD1(3), NLK(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPARD(1), PPP2R1A(1), PPP2R1B(2), PPP3CA(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(3), PRKACG(2), PSEN1(1), RAC2(1), ROCK1(2), ROCK2(1), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), TCF7(1), TCF7L1(1), TCF7L2(1), VANGL1(1), WIF1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1)	13731428	151	25	149	47	46	32	19	29	25	0	0.0783	1.000	1.000
513	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTN1(1), ACTN2(4), ACTN3(1), AKT1(2), AMOTL1(2), ASH1L(4), CDC42(1), CDK4(2), CGN(1), CLDN17(2), CLDN3(1), CLDN9(1), CSNK2A1(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), EPB41L1(2), EPB41L2(1), EPB41L3(2), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HRAS(1), IGSF5(1), JAM2(1), LLGL1(4), LLGL2(2), MAGI1(1), MAGI2(6), MAGI3(1), MLLT4(3), MPDZ(2), MRAS(2), MYH1(4), MYH10(8), MYH11(5), MYH13(1), MYH14(3), MYH15(4), MYH2(2), MYH3(1), MYH4(4), MYH6(5), MYH7(4), MYH7B(7), MYH8(3), MYH9(1), MYLPF(1), PARD3(3), PPP2R1A(1), PPP2R1B(2), PPP2R3A(3), PPP2R3B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), PTEN(1), RAB13(1), SPTAN1(2), SRC(1), SYMPK(5), TJP1(4), TJP2(4), TJP3(1), YES1(1)	16825671	167	22	163	55	48	32	29	26	32	0	0.313	1.000	1.000
514	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(2), ACTA2(1), ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATP2A2(3), CALCA(1), CAMK2D(1), CNN2(1), CORIN(2), DGKZ(3), ETS2(2), GABPA(2), GBA2(3), GNAQ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(5), ITPR2(3), ITPR3(6), MAFF(1), MIB1(1), MYLK2(3), NOS1(5), NOS3(6), OXTR(1), PDE4D(1), PLCB3(2), PLCG1(1), PLCG2(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS1(1), RGS10(1), RGS17(1), RGS3(1), RGS7(2), RGS9(1), RYR1(13), RYR2(8), RYR3(11), SP1(1), TNXB(6), YWHAH(1)	15160464	160	22	159	58	50	24	36	24	25	1	0.312	1.000	1.000
515	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), BRAF(1), CACNA1A(6), GNA11(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(6), GNAZ(1), GRIA1(1), GRID2(2), GRM1(7), GRM5(4), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(3), HRAS(1), IGF1R(4), ITPR1(5), ITPR2(3), ITPR3(6), NOS1(5), NOS3(6), NPR1(1), NPR2(1), PLA2G3(2), PLA2G6(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPP2R1A(1), PPP2R1B(2), PRKG1(1), PRKG2(1), RYR1(13)	9600748	106	20	103	30	34	11	27	18	16	0	0.204	1.000	1.000
516	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CACNA1C(6), CACNA1D(8), CACNA1F(1), CACNA1S(4), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(6), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(1), MAPK9(1), MMP14(4), MMP2(2), PLA2G3(2), PLA2G6(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLD2(2), PRKACG(2), PRKCD(2), SOS1(2), SOS2(1), SRC(1)	11140406	127	20	122	36	36	23	24	18	23	3	0.0908	1.000	1.000
517	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	CADM1(1), CADM3(2), CD2(2), CD22(1), CD274(1), CD276(2), CD4(2), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(2), CDH2(3), CDH4(1), CDH5(2), CLDN17(2), CLDN3(1), CLDN9(1), CNTN1(3), CNTN2(1), CNTNAP1(1), CNTNAP2(4), ESAM(1), F11R(1), GLG1(1), HLA-A(2), HLA-DPA1(1), HLA-DQA2(1), HLA-F(1), ICAM1(1), ICAM3(1), ICOSLG(1), ITGA8(1), ITGAM(1), ITGAV(2), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(1), NEO1(1), NFASC(1), NLGN1(4), NLGN2(2), NLGN3(4), NRCAM(1), NRXN1(2), NRXN2(2), NRXN3(2), PTPRC(2), PTPRF(6), PTPRM(5), PVRL2(1), SDC3(1), SDC4(2), SELP(3), SIGLEC1(6), VCAN(7)	12543918	119	19	116	44	36	17	27	17	22	0	0.272	1.000	1.000
518	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), CBL(2), CBLB(1), CCND2(1), CCND3(1), CREBBP(1), CSF2RB(1), CSF3R(1), EP300(4), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(1), IFNK(1), IL10RA(1), IL12B(1), IL20RA(2), IL21R(1), IL23R(1), IL26(1), IL28B(1), IL2RA(1), IL2RB(2), IL4R(1), IL6(2), IL6ST(2), IL7(1), IL7R(1), IRF9(1), JAK2(2), JAK3(3), LIF(2), LIFR(4), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(1), PIAS4(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRL(1), PRLR(2), PTPN6(4), SOCS4(1), SOS1(2), SOS2(1), SPRED2(1), SPRY4(2), STAM(3), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT5A(1), STAT6(1), TPO(3), TSLP(1), TYK2(1)	12461022	102	18	101	41	27	22	16	20	17	0	0.634	1.000	1.000
519	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(4), ACACB(6), AKT1(2), ARAF(1), BAD(1), BRAF(1), CALML6(1), CBL(2), CBLB(1), CRK(1), EXOC7(1), FASN(9), FBP2(1), FLOT1(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS2(1), IRS4(2), LIPE(1), MAPK10(1), MAPK8(1), MAPK9(1), PCK1(2), PCK2(3), PDE3A(7), PDE3B(1), PFKL(1), PFKM(1), PFKP(1), PHKA2(2), PHKB(2), PHKG1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PKLR(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(1), PPP1R3D(1), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKACG(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PRKCZ(1), PTPRF(6), PYGB(2), PYGM(2), SHC2(2), SHC4(2), SOCS4(1), SORBS1(1), SOS1(2), SOS2(1), TRIP10(1), TSC1(1), TSC2(4)	13815618	131	18	127	53	37	35	12	15	30	2	0.565	1.000	1.000
520	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(1), BUB1(1), CDIPT(1), CDKL1(1), CLK1(3), CSNK2A1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), INPP4B(1), INPP5A(1), INPPL1(3), ITPKB(3), MAP3K10(3), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(1), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCG1(1), PLCG2(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKG1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), STK11(1), TGFBR1(2)	9882049	94	18	94	30	36	13	12	16	17	0	0.298	1.000	1.000
521	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(1), ACTN2(4), ACTN3(1), DES(1), DMD(5), FAM48A(1), MYBPC1(3), MYBPC3(3), MYH3(1), MYH6(5), MYH7(4), MYH8(3), MYOM1(2), NEB(11), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(2), TNNT3(1), TPM2(1), TTN(57)	11816555	114	17	113	43	30	28	29	16	9	2	0.738	1.000	1.000
522	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(3), ADCY8(3), ARAF(1), BRAF(1), CACNA1C(6), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(1), EP300(4), GNAQ(1), GRIA1(1), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), GRM1(7), GRM5(4), HRAS(1), ITPR1(5), ITPR2(3), ITPR3(6), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(1), PRKACG(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(1)	8537840	85	16	83	32	24	14	14	13	18	2	0.603	1.000	1.000
523	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CALML6(1), CAMK2D(1), CREB1(1), CREB3L1(1), CREB3L2(3), CREB3L3(1), CREBBP(1), CTNNB1(6), DCT(4), DVL1(4), DVL2(2), EDN1(1), EDNRB(2), EP300(4), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(6), GSK3B(1), HRAS(1), KIT(3), LEF1(2), MITF(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PRKACG(2), TCF7(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1)	9548115	114	16	112	37	42	22	16	18	16	0	0.0699	1.000	1.000
524	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(1), CHUK(1), CREB1(1), DAXX(2), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(2), MAP3K9(2), MAP4K1(2), MAP4K2(2), MAP4K3(1), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK7(4), MAPK8(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2D(1), NFKBIA(2), PAK1(2), PAK2(2), RELA(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRADD(1), TRAF2(1)	8410886	75	16	71	31	18	16	18	5	18	0	0.859	1.000	1.000
525	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), AMY2A(1), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(2), DDX50(2), DDX51(1), DDX54(2), DDX56(2), DHX58(1), ENPP3(2), ENTPD7(1), EP400(4), ERCC2(1), ERCC3(4), G6PC2(1), GAA(1), GANC(1), GBA3(2), GBE1(4), GCK(1), GPI(1), GYS1(1), HK1(2), HK2(2), HK3(2), IFIH1(3), MOV10L1(4), NUDT8(1), PGM1(1), PGM3(1), PYGB(2), PYGM(2), RAD54L(2), RUVBL2(2), SETX(3), SI(2), SKIV2L2(2), SMARCA2(2), UGDH(1), UGP2(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1)	10685266	91	15	89	38	18	22	14	18	18	1	0.851	1.000	1.000
526	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALML6(1), CDIPT(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), INPP4B(1), INPP5A(1), INPP5D(1), INPPL1(3), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(9), PIK3C3(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PTEN(1), SYNJ2(2)	10775430	97	14	97	31	32	15	12	19	19	0	0.192	1.000	1.000
527	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(1), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP12(1), AKAP3(2), AKAP4(1), AKAP6(2), AKAP7(2), AKAP9(3), ARHGEF1(3), GNA11(2), GNA15(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(1), GNB3(1), GNB5(1), HRAS(1), ITPR1(5), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(1), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), PRKD3(3)	10110338	88	13	88	39	32	15	17	13	9	2	0.735	1.000	1.000
528	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(2), BAD(1), CDC42(1), CREB1(1), ERBB4(6), F2RL2(1), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(3), IRS2(1), IRS4(2), MET(4), NOLC1(2), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PREX1(4), PTEN(1), PTK2(3), RPS6KA1(1), RPS6KA2(1), SOS1(2), SOS2(1), TSC1(1), TSC2(4), YWHAE(2), YWHAH(1)	6413150	61	13	59	23	11	12	9	12	17	0	0.749	1.000	1.000
529	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	ALG10(1), ALG10B(1), ALG12(2), ALG9(2), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(1), B4GALT5(2), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHST2(1), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), DPAGT1(2), EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(5), GALNT1(1), GALNT10(1), GALNT13(1), GALNT14(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS6ST1(2), MAN1A2(1), MAN1B1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST6GAL1(1), XYLT1(2), XYLT2(4)	9675898	88	12	85	30	28	16	18	11	15	0	0.326	1.000	1.000
530	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(2), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G3(2), PLA2G6(3), PLCG1(1), PLCG2(4), PRKCD(2), PRKCE(1), RAC2(1), SOS1(2), SOS2(1), SYK(2), VAV1(4), VAV3(1)	6114769	60	12	59	22	15	17	8	7	12	1	0.460	1.000	1.000
531	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(2), ARHGEF11(3), BTK(1), CDC42(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(6), LIMK1(1), MYLK(6), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PTEN(1), RACGAP1(2), ROCK1(2), ROCK2(1), WASF1(1), WASL(2)	6086562	59	12	58	20	15	11	12	9	12	0	0.476	1.000	1.000
532	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	INPP4B(1), INPP5A(1), INPPL1(3), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PTEN(1), SYNJ2(2)	6360722	49	11	49	20	10	9	7	13	10	0	0.668	1.000	1.000
533	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(1), ALPP(3), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(2), DDX50(2), DDX51(1), DDX54(2), DDX56(2), DHFR(1), DHX58(1), ENTPD7(1), EP400(4), ERCC2(1), ERCC3(4), FPGS(3), GCH1(1), GGH(1), IFIH1(3), MOV10L1(4), NUDT8(1), QDPR(1), RAD54L(2), RUVBL2(2), SETX(3), SKIV2L2(2), SMARCA2(2)	5455059	67	11	64	27	14	14	7	15	16	1	0.817	1.000	1.000
534	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(4), ACTN3(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN17(2), CLDN3(1), CLDN9(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), CTNND1(1), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(1), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(3), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PTK2(3), RAC2(1), RAP1B(1), RAPGEF3(2), RAPGEF4(3), RHOH(1), ROCK1(2), ROCK2(1), SIPA1(3), VAV1(4), VAV3(1), VCL(1)	10847449	99	11	99	37	30	20	13	16	18	2	0.413	1.000	1.000
535	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(2), BRD4(4), CBL(2), CDC42(1), F2RL2(1), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(1), INPPL1(3), IRS2(1), IRS4(2), LNPEP(2), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PTEN(1), RPS6KA1(1), RPS6KA2(1), SORBS1(1), SOS1(2), SOS2(1), YWHAE(2), YWHAH(1)	4915492	39	11	39	17	7	11	2	8	11	0	0.818	1.000	1.000
536	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(6), ATR(5), BRCA1(3), BRCA2(6), FANCA(3), FANCC(2), FANCF(1), FANCG(1), HUS1(1), MRE11A(2), RAD17(2), TREX1(1)	3690499	33	10	32	10	4	8	5	8	8	0	0.631	1.000	1.000
537	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), CASP7(1), CASP8(2), CFLAR(2), DAXX(2), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(2), PAK2(2), PRKDC(4), PTPN13(3), RB1(1), SPTAN1(2)	3549059	32	10	30	10	4	2	8	7	11	0	0.779	1.000	1.000
538	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(1), CPEB1(1), EGFR(2), ERBB2(5), ERBB4(6), ETS1(1), ETS2(2), ETV7(1), FMN2(4), NOTCH1(5), NOTCH2(2), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(1), PIWIL4(1), SOS1(2), SOS2(1)	4553635	50	10	49	22	15	8	13	7	7	0	0.857	1.000	1.000
539	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CHUK(1), DAXX(2), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(1), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAPK8(1), NFKBIA(2), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	4268928	41	10	40	16	9	8	10	6	8	0	0.648	1.000	1.000
540	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(2), ASAH1(1), ATF1(1), BRAF(1), CAMP(2), CREB1(1), CREBBP(1), DAG1(2), EGR3(1), GNAQ(1), MAP1B(5), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), SRC(1), TERF2IP(1)	4442584	38	10	38	19	11	7	6	5	9	0	0.870	1.000	1.000
541	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT1(2), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD2(2), PLD3(1)	3917384	35	10	35	12	9	5	6	5	10	0	0.617	1.000	1.000
542	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(2), BAD(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPKAPK3(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G3(2), PLA2G6(3), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTK2(3), RAC2(1), SH2D2A(1), SHC2(2), SPHK1(1), SRC(1)	6004500	62	9	62	25	16	18	10	7	11	0	0.567	1.000	1.000
543	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(1), CASP1(2), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(1), MAGI2(6), RERE(4), WWP1(1), WWP2(1)	2076557	28	9	28	10	7	7	2	4	8	0	0.611	1.000	1.000
544	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2F1(2), NCOA2(2), NCOA3(3), NCOR2(4), POLR2A(2), TBP(1)	2179117	18	9	16	15	3	3	3	1	7	1	0.999	1.000	1.000
545	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(1), BFAR(2), BTK(1), CAD(4), CASP10(1), CASP8(2), CASP8AP2(2), DAXX(2), DEDD(1), EGFR(2), EPHB2(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), ROCK1(2), TPX2(2), TRAF2(1)	6047203	51	9	51	19	10	10	13	9	9	0	0.652	1.000	1.000
546	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(3), BAK1(1), BIRC2(1), CASP2(2), CASP7(1), CASP8(2), FAS(1), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	3142555	32	8	31	12	7	5	9	4	7	0	0.675	1.000	1.000
547	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), DOT1L(1), EHMT1(3), EHMT2(2), GCDH(2), HADHA(1), HSD17B4(2), HSD3B7(2), NSD1(3), OGDH(2), OGDHL(1), PLOD1(1), PLOD2(1), RDH11(2), SETD1A(3), SETDB1(1), SHMT1(1), SHMT2(3), SUV39H2(2)	5035064	38	8	36	14	10	6	8	4	10	0	0.652	1.000	1.000
548	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(2), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), AOX1(1), CARM1(1), DCT(4), ESCO1(4), ESCO2(1), GOT1(2), HEMK1(1), HGD(2), HPD(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TPO(3), TYR(2)	5134431	49	8	49	18	16	9	11	6	7	0	0.444	1.000	1.000
549	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(3), ATM(6), ATR(5), BAI1(1), CASP8(2), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), EI24(1), FAS(1), GTSE1(2), MDM2(1), PERP(1), PTEN(1), RRM2B(1), SERPINB5(1), SERPINE1(1), SESN2(2), SESN3(2), STEAP3(1), THBS1(1), TNFRSF10B(2), TSC2(4), ZMAT3(2)	5571942	50	8	50	20	11	13	11	7	8	0	0.663	1.000	1.000
550	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(6), ACSL1(1), ACSL3(3), ACSL5(1), ADIPOR1(2), AKT1(2), CAMKK1(1), CHUK(1), CPT1B(3), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS2(1), IRS4(2), JAK2(2), JAK3(3), MAPK10(1), MAPK8(1), MAPK9(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(2), PCK2(3), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKAG3(1), PRKCQ(2), RELA(1), SLC2A1(2), STAT3(1), STK11(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(1)	7043244	67	8	67	26	17	16	10	10	13	1	0.455	1.000	1.000
551	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), CBR3(2), CYP4F2(3), CYP4F3(1), EPX(4), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(3), PRDX1(1), PTGDS(2), PTGIS(2), TBXAS1(1), TPO(3)	2425130	33	8	32	14	12	3	8	2	8	0	0.774	1.000	1.000
552	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(3), ARHGAP6(3), ARHGEF1(3), ARHGEF11(3), ARHGEF5(1), ARPC2(1), BAIAP2(1), DIAPH1(3), GSN(4), LIMK1(1), MYLK(6), PIP5K1B(2), ROCK1(2), SRC(1), TLN1(7), VCL(1)	3981190	42	8	40	14	10	9	9	6	8	0	0.474	1.000	1.000
553	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), CLOCK(5), CRY1(1), GFRA1(2), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), PER1(2), PER2(3), TOB1(2), TUBB3(1), UCP3(1), UGP2(2)	3174872	30	7	28	14	6	5	3	9	7	0	0.874	1.000	1.000
554	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	CD4(2), CREB1(1), CTSB(2), CTSS(1), HLA-A(2), HLA-DPA1(1), HLA-DQA2(1), HLA-F(1), HSP90AA1(4), HSP90AB1(1), HSPA5(3), IFI30(1), IFNA10(1), IFNA16(1), KIR2DL1(1), KIR3DL2(1), KLRC1(1), KLRC2(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1)	3967657	32	7	32	13	3	7	7	8	7	0	0.748	1.000	1.000
555	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BAD(1), CBL(2), CFLAR(2), HRAS(1), IL2RA(1), IL2RB(2), JAK3(3), PIK3CA(1), PIK3R1(1), PTPN6(4), SOS1(2), STAT5A(1), SYK(2)	2890167	25	7	25	10	6	6	4	5	4	0	0.692	1.000	1.000
556	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(2), ACTN1(1), ACTN2(4), ACTN3(1), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CSK(1), HRAS(1), ITGA1(4), MAPK8(1), PTK2(3), ROCK1(2), SOS1(2), SRC(1), TLN1(7), VCL(1), ZYX(1)	4018370	39	7	39	11	13	11	4	3	8	0	0.160	1.000	1.000
557	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CITED2(1), CPT1B(3), CREBBP(1), DUT(1), EP300(4), HSD17B4(2), LPL(2), ME1(2), NCOR1(6), NCOR2(4), NFKBIA(2), NR1H3(2), NRIP1(1), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RB1(1), RELA(1), SP1(1), STAT5A(1)	5487162	44	7	44	17	10	12	9	6	7	0	0.520	1.000	1.000
558	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(4), GTF2E2(1), GTF2H1(1), GTF2H4(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3B(1), POLR3E(3), TAF5(1), TBP(1)	3005279	24	7	22	10	9	4	4	1	6	0	0.777	1.000	1.000
559	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(1), ITPKB(3), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PLCG2(4), SOS1(2), SOS2(1), SYK(2), VAV1(4)	4319888	33	7	33	12	11	7	3	7	4	1	0.478	1.000	1.000
560	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), ARHGEF11(3), CDC42(1), DLG4(1), LPA(3), MAP2K4(2), MAP3K1(3), MAPK8(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD2(2), PLD3(1), PTK2(3), RDX(2), ROCK1(2), ROCK2(1), TBXA2R(1)	4249967	35	7	35	11	5	5	9	9	7	0	0.636	1.000	1.000
561	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), AMY2A(1), ENPP3(2), GAA(1), GANAB(2), GBA3(2), GBE1(4), GCK(1), GPI(1), GYS1(1), HK1(2), HK2(2), HK3(2), PGM1(1), PGM3(1), PYGB(2), PYGM(2), SI(2), UGDH(1), UGT1A1(2), UGT2B15(1), UGT2B4(1)	4906708	36	7	36	13	9	10	8	3	6	0	0.469	1.000	1.000
562	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(2), AGXT2(1), ALAS2(2), AOC2(1), AOC3(2), CHDH(1), CPT1B(3), DAO(3), DMGDH(3), GARS(4), GLDC(2), PISD(1), PLCB2(3), PLCG1(1), PLCG2(4), SARDH(1), SHMT1(1), SHMT2(3), TARS(2)	3672844	40	6	40	18	13	12	6	5	4	0	0.623	1.000	1.000
563	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(2), AGXT2(1), ALAS2(2), AOC2(1), AOC3(2), CHDH(1), DAO(3), DMGDH(3), GARS(4), GLDC(2), HSD3B7(2), PHGDH(1), PISD(1), RDH11(2), SARDH(1), SARS2(1), SHMT1(1), SHMT2(3), TARS(2)	3734738	35	6	35	16	13	10	5	5	2	0	0.637	1.000	1.000
564	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), CBR3(2), CYP2B6(1), CYP2C19(3), CYP2E1(1), CYP2J2(2), CYP4A22(1), CYP4F2(3), CYP4F3(1), DHRS4(1), GPX5(3), LTA4H(1), PLA2G3(2), PLA2G6(3), PTGDS(2), PTGIS(2), TBXAS1(1)	3388601	31	6	30	19	7	5	10	1	8	0	0.978	1.000	1.000
565	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), BRAF(1), CAB39(1), DDIT4(1), EIF4B(2), HIF1A(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRKAA2(1), RICTOR(5), RPS6KA1(1), RPS6KA2(1), STK11(1), TSC1(1), TSC2(4), ULK1(2), ULK3(1)	4648381	37	6	37	19	11	12	4	3	7	0	0.897	1.000	1.000
566	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(3), APH1A(2), CREBBP(1), CTBP2(2), DLL4(1), DTX1(3), DTX2(3), DVL1(4), DVL2(2), EP300(4), JAG2(3), LFNG(1), MAML1(2), MAML2(1), NCOR2(4), NOTCH1(5), NOTCH2(2), NOTCH3(7), NOTCH4(4), NUMBL(1), PSEN1(1), PSEN2(1), RBPJ(2), SNW1(1)	6022689	60	6	60	28	19	18	12	6	5	0	0.631	1.000	1.000
567	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ARRB2(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(1), CLCA4(1), CNGA3(1), CNGA4(1), CNGB1(6), GUCA1A(1), GUCA1C(1), PRKACG(2), PRKG1(1), PRKG2(1)	2640029	26	6	25	10	8	3	9	3	3	0	0.691	1.000	1.000
568	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(4), CTPS2(1), DPYD(3), DPYS(4), DUT(1), NT5E(1), NT5M(1), POLD1(1), POLD2(1), POLE(6), POLG(4), POLL(2), POLQ(2), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(1), RRM1(1), TYMS(1), UMPS(2), UPB1(2)	4995602	46	6	46	15	13	12	9	6	6	0	0.237	1.000	1.000
569	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(7), B3GALT4(1), DGKI(2), FAU(1), IL6ST(2), RPL10(2), RPL18A(1), RPL24(1), RPL35(1), RPL3L(2), RPL4(2), RPL7A(1), RPS11(2), RPS27A(1), RPS28(1), RPS6KA1(1), RPS6KA2(1), RPSA(2), SLC36A2(1), TSPAN9(1)	4548187	33	6	32	21	10	5	8	4	6	0	0.992	1.000	1.000
570	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(2), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), G6PC2(1), GAPDHS(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKL(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2)	5014183	47	5	47	14	19	11	7	4	6	0	0.131	1.000	1.000
571	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSE(1), CARM1(1), CYP11B1(2), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B2(1), HSD3B1(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), STS(2), SULT2A1(1), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1)	4314388	27	5	27	10	3	10	8	2	4	0	0.597	1.000	1.000
572	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), GALNS(1), GLB1(1), HEXB(1), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1)	3041857	21	5	21	12	7	5	4	0	5	0	0.811	1.000	1.000
573	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL3(1), FBXW11(2), FBXW7(3), ITCH(2), SKP1(1), TCEB1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(1), WWP2(1)	3475611	28	5	28	11	7	8	6	3	4	0	0.730	1.000	1.000
574	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), CRK(1), DOCK1(2), HRAS(1), ITGA1(4), MAP4K1(2), MAPK8(1), MET(4), PAK1(2), PIK3CA(1), PIK3R1(1), PTEN(1), PTK2(3), RAP1B(1), RASA1(1), SOS1(2), SRC(1), STAT3(1)	3865320	31	5	30	13	5	12	3	5	6	0	0.694	1.000	1.000
575	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(1), CHRM5(3), DRD1(2), DRD2(1), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1)	2256157	28	5	28	12	9	5	8	5	1	0	0.605	1.000	1.000
576	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(2), ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), AOX1(1), DCT(4), GOT1(2), HGD(2), HPD(2), TPO(3), TYR(2)	2743392	34	5	34	13	15	5	6	4	4	0	0.372	1.000	1.000
577	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(4), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1)	2419676	27	5	27	11	7	6	5	3	6	0	0.667	1.000	1.000
578	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(4)	595386	10	4	8	11	3	3	1	0	3	0	0.985	1.000	1.000
579	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(2), GPX5(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1)	1589099	19	4	18	10	3	5	2	4	5	0	0.829	1.000	1.000
580	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(4)	595386	10	4	8	11	3	3	1	0	3	0	0.985	1.000	1.000
581	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), DNMT3A(4), DNMT3B(2), MTFMT(2), MTR(1)	1792797	12	4	11	10	3	1	3	2	3	0	0.988	1.000	1.000
582	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(2), GPX5(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM4(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3)	1958548	23	4	22	12	5	6	4	3	5	0	0.793	1.000	1.000
583	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(3), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), HEXB(1), HK1(2), HK2(2), HK3(2), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1)	2483054	23	4	23	12	7	3	6	3	4	0	0.850	1.000	1.000
584	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), DOT1L(1), EHMT1(3), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), SHMT1(1), SHMT2(3)	3209730	22	4	22	12	6	5	7	0	4	0	0.876	1.000	1.000
585	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(2), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS2(1), JAK3(3), MAP4K1(2), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), SOS1(2), SOS2(1), STAT6(1)	3005079	20	4	20	12	5	7	1	4	3	0	0.901	1.000	1.000
586	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2)	4203400	40	3	40	13	16	9	6	4	5	0	0.221	1.000	1.000
587	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2)	4203400	40	3	40	13	16	9	6	4	5	0	0.221	1.000	1.000
588	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(2), CYP1B1(1), GCDH(2), HADHA(1), HEMK1(1), HSD17B4(2), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL6(1), OGDH(2), OGDHL(1), PRMT3(1), PRMT6(1), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2)	5225886	45	3	45	10	14	6	13	5	7	0	0.107	1.000	1.000
589	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(1), CYP1A1(1), CYP1A2(2), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C19(3), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A7(3), GCDH(2), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2)	4738587	44	3	44	12	14	6	12	6	6	0	0.192	1.000	1.000
590	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(1)	453739	4	2	4	4	3	1	0	0	0	0	0.949	1.000	1.000
591	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(3), MAP2(2), PPP1CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1)	1557445	10	2	10	6	4	3	1	2	0	0	0.889	1.000	1.000
592	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), HAL(1), PRPS1(1)	2105690	12	2	12	6	6	4	1	1	0	0	0.594	1.000	1.000
593	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), HRAS(1), IL6(2), IL6ST(2), JAK2(2), JAK3(3), SOS1(2), STAT3(1)	2086017	14	2	14	13	2	3	4	2	3	0	0.996	1.000	1.000
594	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), DNMT3A(4), DNMT3B(2), MTR(1)	1501426	9	2	9	9	3	1	3	2	0	0	0.984	1.000	1.000
595	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(1)	1179836	8	2	8	5	4	2	1	1	0	0	0.787	1.000	1.000
596	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(1), ALDH3A1(1)	690280	2	1	2	2	2	0	0	0	0	0	0.904	1.000	1.000
597	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(1), ALDH3A1(1)	690280	2	1	2	2	2	0	0	0	0	0	0.904	1.000	1.000
598	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), HMGCR(1), LSS(1), MVK(1), NQO2(2), SQLE(1), VKORC1(2)	968127	11	1	11	6	2	3	5	1	0	0	0.802	1.000	1.000
599	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(2), HMGCR(1), LSS(1), MVK(1), NSDHL(1), SQLE(1)	1147439	8	1	8	6	2	2	4	0	0	0	0.928	1.000	1.000
600	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), CPT1B(3), CPT1C(2), CPT2(1), CYP4A22(1), GCDH(2), HADHA(1), HADHB(2), HSD17B4(2)	4209314	38	1	38	8	12	11	5	4	6	0	0.0446	1.000	1.000
601	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), FDFT1(2), GGCX(1), HMGCR(1), LSS(1), MVK(1), NSDHL(1), SQLE(1), VKORC1(2)	1678567	11	1	11	7	3	2	5	1	0	0	0.891	1.000	1.000
602	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(1), KARS(1)	403590	2	1	2	3	0	0	1	1	0	0	0.989	1.000	1.000
603	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(1)	393021	2	1	2	2	1	1	0	0	0	0	0.914	1.000	1.000
604	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(1), PNPO(1)	417727	2	1	2	2	0	0	2	0	0	0	0.946	1.000	1.000
605	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), SQLE(1)	367777	3	1	3	3	1	1	1	0	0	0	0.922	1.000	1.000
606	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	579743	2	1	2	2	1	1	0	0	0	0	0.886	1.000	1.000
607	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(1), KARS(1)	593879	4	1	4	3	0	0	3	1	0	0	0.964	1.000	1.000
608	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1)	333282	1	1	1	2	0	0	0	1	0	0	0.993	1.000	1.000
609	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(1), RB1(1)	739343	3	1	3	4	0	1	1	1	0	0	0.989	1.000	1.000
610	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(1), CDC34(1), CUL1(1), RB1(1)	740661	6	1	6	4	1	2	2	1	0	0	0.911	1.000	1.000
611	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(1), PTGDR(2), PTGFR(1), TBXA2R(1)	999644	5	1	5	5	1	1	3	0	0	0	0.938	1.000	1.000
612	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), SQLE(1)	275947	3	1	3	3	1	1	1	0	0	0	0.921	1.000	1.000
613	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	6	THBS1(1)	528867	1	1	1	2	1	0	0	0	0	0	0.950	1.000	1.000
614	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7		198111	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		43203	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		97779	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
