rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	SP1(1), SP3(2), TP53(20)	2651631	23	22	20	1	8	3	5	1	6	0	0.0124	6.54e-12	4.03e-09
2	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(4), AKT1(1), ATM(12), CDKN1A(2), CPB2(1), HIC1(1), HSPA1A(1), MDM2(1), NQO1(1), TP53(20)	7808812	44	38	41	2	15	9	8	4	8	0	0.000945	1.43e-11	4.04e-09
3	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CFL1(1), MDM2(1), PRB1(1), TP53(20)	3197612	31	29	28	3	11	3	5	0	12	0	0.0633	1.97e-11	4.04e-09
4	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(12), CHEK2(1), TP53(20)	5977834	33	30	30	2	8	8	7	4	6	0	0.0215	4.12e-11	6.35e-09
5	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(12), CDK4(1), CDKN1A(2), MDM2(1), RB1(3), TP53(20)	6785968	40	34	37	3	11	9	8	4	7	1	0.00750	3.53e-10	4.35e-08
6	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(1), ATM(12), BAD(1), CASP7(1), PRKCA(1), PTK2(2), PXN(1), STAT1(1), TLN1(2), TP53(20)	10294761	43	40	40	1	10	13	8	5	7	0	0.000165	8.44e-10	8.66e-08
7	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(12), CDC25A(1), CDC25B(1), CDK4(1), MYT1(1), RB1(3), TP53(20)	6574080	39	35	36	4	11	8	8	5	6	1	0.0259	9.94e-10	8.75e-08
8	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(1), MDM2(1), PIK3CA(9), PIK3R1(2), POLR1A(4), POLR1B(1), POLR1C(2), RAC1(1), RB1(3), TP53(20)	7626178	47	37	44	3	14	9	11	4	8	1	0.000858	2.20e-09	1.69e-07
9	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	NFKB1(2), RELA(1), TP53(20)	3678521	23	22	20	1	8	5	5	0	5	0	0.0165	3.95e-09	2.71e-07
10	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(1), CDKN1B(4), MAPK1(1), PDPK1(1), PIK3CA(9), PIK3R1(2), PTEN(13), PTK2(2), SHC1(2), SOS1(1)	7236178	37	33	37	3	8	8	4	2	15	0	0.0505	4.94e-08	3.04e-06
11	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(12), BRCA1(1), CDC25A(1), CDC25B(1), CDKN1A(2), CHEK2(1), EP300(4), MDM2(1), MYT1(1), PRKDC(8), RPS6KA1(1), TP53(20), YWHAQ(1)	15681850	54	47	51	4	19	14	8	5	8	0	0.00141	9.40e-07	5.26e-05
12	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(2), MAPK1(1), PDPK1(1), PIK3CA(9), PIK3R1(2), PRKCA(1), PTEN(13)	10547383	38	34	38	2	6	9	4	6	13	0	0.0120	1.41e-06	7.22e-05
13	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), PDPK1(1), PIK3CA(9), PIK3R1(2), PTEN(13), TSC2(2)	10373660	34	31	34	1	7	7	4	4	12	0	0.00424	1.59e-06	7.54e-05
14	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(12), BRCA1(1), CDKN1A(2), CHEK2(1), MDM2(1), NFKB1(2), RAD51(1), RELA(1), TP53(20)	11180170	44	35	41	2	11	13	8	4	8	0	0.00142	2.00e-06	8.78e-05
15	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(3), IGF1R(2), POLR2A(2), PRKCA(1), RB1(3), TEP1(4), TNKS(3), TP53(20)	10592845	39	36	36	3	11	11	8	2	6	1	0.00377	1.86e-05	0.000763
16	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), GSK3B(1), IGF1R(2), INPPL1(1), PDPK1(1), PIK3CA(9), PIK3R1(2), PTEN(13)	7368802	30	27	30	3	5	7	5	2	11	0	0.0852	3.02e-05	0.00116
17	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(12), CCNA1(1), CDC25A(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), DHFR(1), GSK3B(1), RB1(3), TGFB1(1), TGFB2(1), TP53(20)	11350317	52	42	49	7	13	10	10	4	14	1	0.0412	3.88e-05	0.00137
18	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(2), GHR(2), HRAS(2), IGF1R(2), PIK3CA(9), PIK3R1(2), SHC1(2), SOD2(1), SOD3(1)	5004973	24	22	24	2	7	7	6	2	2	0	0.0347	3.99e-05	0.00137
19	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(12), BRCA1(1), BRCA2(5), CHEK2(1), FANCA(1), FANCF(1), FANCG(1), HUS1(1), RAD17(1), RAD51(1), TP53(20), TREX1(1)	16484979	46	41	43	4	9	13	9	5	10	0	0.0187	7.05e-05	0.00228
20	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	HSPA1A(1), JAK2(2), NFKB1(2), RB1(3), RELA(1), TNF(1), TP53(20)	6849483	30	26	27	4	11	7	6	0	5	1	0.0395	0.000261	0.00803
21	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(9), PIK3R1(2), PLCB1(2), PLCG1(1), PRKCA(1), VAV1(2)	4804903	18	16	18	1	6	5	3	4	0	0	0.0390	0.000793	0.0233
22	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), HRAS(2), KLK2(1), NTRK1(3), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), SHC1(2), SOS1(1)	5833918	23	20	23	2	8	7	4	3	1	0	0.0372	0.000928	0.0260
23	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(12), CDC25A(1), CDC25B(1), MYT1(1)	5150175	15	15	15	1	2	5	2	5	1	0	0.128	0.00113	0.0301
24	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(1), BPNT1(3), MAPK1(1), PDK1(1), PIK3CA(9), PIK3CD(1), PTEN(13), RBL2(1), SHC1(2), SOS1(1)	7643139	34	32	34	6	8	8	5	2	11	0	0.238	0.00117	0.0301
25	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), BAD(1), GHR(2), NFKB1(2), PDPK1(1), PIK3CA(9), PIK3R1(2), RELA(1)	5297076	19	16	19	1	4	10	3	2	0	0	0.0252	0.00298	0.0733
26	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), HRAS(2), MAPK1(1), MEF2C(2), MEF2D(2), NTRK1(3), PIK3CA(9), PIK3R1(2), PLCG1(1), RPS6KA1(1), SHC1(2)	7123024	26	22	26	2	12	7	5	2	0	0	0.0104	0.00418	0.0990
27	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(5), DAXX(1), HRAS(2), PML(1), RB1(3), SP100(1), TNF(1), TP53(20)	7148321	34	33	31	7	13	4	9	1	6	1	0.168	0.00484	0.110
28	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(1), CDKN1A(2), HRAS(2), NTRK1(3), PIK3CA(9), PIK3CD(1), SHC1(2), SOS1(1)	6074461	22	20	22	3	8	7	4	2	1	0	0.0671	0.00599	0.132
29	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(3), SP1(1), SP3(2)	2482692	9	8	9	1	1	3	1	1	2	1	0.219	0.00634	0.134
30	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), BAD(1), HRAS(2), NFKB1(2), PIK3CA(9), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(1), RELA(1)	7152243	22	20	22	2	5	8	6	2	1	0	0.0330	0.00653	0.134
31	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT2(1), BAD(1), BTK(1), CDKN2A(1), GSK3A(1), GSK3B(1), IARS(1), INPP5D(2), PDK1(1), PIK3CA(9), PPP1R13B(1), PTEN(13), RPS6KA1(1), SHC1(2), SOS1(1), YWHAQ(1)	13547494	40	36	40	5	9	9	5	2	15	0	0.0613	0.00698	0.139
32	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(12), CDK4(1), CDKN1B(4), CEBPB(1), EGR1(1), FSHR(1), GJA4(1), LHCGR(1), MLH1(1), MSH5(1), NCOR1(5), NRIP1(1), PGR(2), PTGER2(1), VDR(1), ZP2(1)	13143520	35	30	35	4	5	6	6	4	14	0	0.0873	0.00797	0.154
33	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(1), IL10RA(3), IL6(1), JAK1(2), STAT1(1), STAT3(6), STAT5A(1), TNF(1)	4574340	17	15	17	2	4	5	5	1	2	0	0.0933	0.0104	0.193
34	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), PDGFRA(3), PIK3CA(9), PIK3R1(2), RAC1(1)	5010143	16	15	16	2	6	2	4	3	1	0	0.169	0.0116	0.210
35	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN3(1), BCAR1(1), CSK(1), CTNNA2(4), CTNNB1(9), PTK2(2), PXN(1)	7226346	19	18	17	0	5	3	5	4	2	0	0.00811	0.0119	0.210
36	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CDK4(1), CDKN1A(2), CDKN1B(4), HRAS(2), MAPK1(1), NFKB1(2), PIK3CA(9), PIK3R1(2), RAC1(1), RAF1(1), RB1(3), RELA(1)	7594186	30	23	30	4	9	7	7	2	4	1	0.0733	0.0126	0.215
37	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4)	1113489	4	4	4	1	1	1	1	1	0	0	0.667	0.0165	0.274
38	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(12), BAI1(2), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(1), GTSE1(1), MDM2(1), MDM4(1), PPM1D(2), PTEN(13), RCHY1(1), RRM2B(1), SERPINB5(1), SESN1(1), SESN2(1), SESN3(3), THBS1(4), TNFRSF10B(1), TP53(20), TSC2(2)	24578385	77	63	73	11	21	12	16	4	24	0	0.0125	0.0178	0.289
39	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), BAD(1), HRAS(2), IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(9), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1)	7109345	24	22	24	4	8	6	6	3	1	0	0.153	0.0187	0.295
40	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(12), BUB1(1), BUB1B(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(1), CDC25A(1), CDC25B(1), CDC6(2), CDC7(1), CDH1(3), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(1), DTX4(1), E2F3(1), EP300(4), ESPL1(1), GSK3B(1), HDAC5(2), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), MDM2(1), MPEG1(4), PLK1(2), PRKDC(8), PTPRA(3), RB1(3), RBL1(2), SMAD4(4), TGFB1(1), TP53(20)	41159041	106	76	103	10	30	31	17	12	15	1	1.08e-05	0.0207	0.319
41	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(3), DHFR(1), FTCD(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), SHMT1(3), SHMT2(1)	7105204	18	17	18	2	4	6	0	2	6	0	0.0976	0.0216	0.325
42	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	CRK(1), HGF(2), HRAS(2), MAP4K1(1), MAPK1(1), MET(1), PIK3CA(9), PIK3R1(2), PTEN(13), PTK2(2), PXN(1), RAF1(1), SOS1(1), STAT3(6)	16585533	43	38	43	6	9	10	10	3	11	0	0.0595	0.0258	0.378
43	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(2), CTNNB1(9), DVL1(1), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LEF1(1), NFKB1(2), PDPK1(1), PIK3CA(9), PIK3R1(2), RELA(1)	11566448	35	30	33	5	9	10	10	4	2	0	0.0308	0.0276	0.395
44	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(3), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), SHMT1(3), SHMT2(1)	6699692	17	16	17	2	4	6	0	2	5	0	0.120	0.0295	0.414
45	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(3), F2(1), F2RL3(1), GNA12(1), GNAI1(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(9), PIK3R1(2), PLCB1(2), PRKCA(1), ROCK1(4)	9696150	30	23	30	4	8	9	6	4	3	0	0.0605	0.0417	0.571
46	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	271587	2	2	2	1	1	1	0	0	0	0	0.795	0.0476	0.637
47	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(3)	1997020	6	6	6	1	2	3	0	1	0	0	0.366	0.0554	0.726
48	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(1), LPO(1), MTHFR(2), SHMT1(3), SHMT2(1), TPO(1)	4366846	11	11	11	1	4	3	1	0	3	0	0.114	0.0906	1.000
49	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), AKT1(1), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(2), MAPK1(1), PDGFRA(3), PIK3CA(9), PIK3R1(2), PLCB1(2), PRKCA(1), PTK2(2), RAC1(1)	10289196	30	24	30	4	11	8	5	3	3	0	0.0509	0.110	1.000
50	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(2), ITPKB(2)	2286645	6	6	6	0	4	2	0	0	0	0	0.0913	0.110	1.000
51	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2A(1), ADORA3(1), P2RY1(1), P2RY6(1)	2238333	6	6	6	0	4	1	0	1	0	0	0.107	0.113	1.000
52	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), EHHADH(3), HADHB(1)	3133727	8	7	8	1	1	4	3	0	0	0	0.276	0.122	1.000
53	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BRAF(6), CREB3(1), MAPK1(1), RAF1(1), SNX13(2), TERF2IP(1)	4175936	14	14	13	4	3	2	3	2	4	0	0.733	0.130	1.000
54	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), GNGT1(1), HTR2C(2), PLCB1(2), TUB(1)	2682191	7	6	7	1	3	3	1	0	0	0	0.282	0.132	1.000
55	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3), JUND(1)	1415779	4	4	4	1	1	1	1	1	0	0	0.570	0.133	1.000
56	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(2), NEK1(2)	2599714	6	6	6	0	5	0	0	0	1	0	0.144	0.138	1.000
57	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO2(1), FH(1), IDH1(4)	3330090	6	6	4	0	3	0	1	2	0	0	0.167	0.142	1.000
58	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), LEPR(1), PRKAA2(3), PRKAG1(2), PRKAG2(1)	5418220	11	10	11	1	4	3	3	1	0	0	0.136	0.148	1.000
59	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(3), ERBB3(4), NRG1(1)	3855437	8	8	8	1	1	4	0	0	3	0	0.245	0.159	1.000
60	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS2(1), SULT1E1(2)	2279097	6	6	6	0	3	2	0	0	1	0	0.184	0.164	1.000
61	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), BAD(1), MUSK(2), PIK3CA(9), PIK3R1(2), PTK2(2)	6169017	17	14	17	2	6	6	3	2	0	0	0.0803	0.164	1.000
62	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(1), CSK(1), PRKCA(1), PTPRA(3)	3454703	7	7	7	1	3	2	0	2	0	0	0.351	0.172	1.000
63	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGDH(1), UGP2(1), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1)	10192259	18	17	18	2	2	6	2	4	4	0	0.134	0.175	1.000
64	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP3K1(1), MAPK1(1), NFKB1(2), PIK3CA(9), PIK3R1(2), RB1(3), RELA(1), SP1(1)	7289363	21	16	21	3	5	9	4	2	0	1	0.103	0.191	1.000
65	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	833516	2	2	2	0	0	0	0	0	2	0	0.517	0.192	1.000
66	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1)	3847569	7	7	7	1	2	2	1	1	1	0	0.332	0.193	1.000
67	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	HLA-DRA(1), IL4(1), IL5RA(1), IL6(1)	1998188	4	4	4	0	2	2	0	0	0	0	0.211	0.195	1.000
68	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST2(1), XYLT1(4)	2499819	8	8	8	0	4	2	0	0	2	0	0.0545	0.197	1.000
69	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST2(1), XYLT1(4)	2499819	8	8	8	0	4	2	0	0	2	0	0.0545	0.197	1.000
70	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CRK(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(2), MAPK1(1), NFKB1(2), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(2), PXN(1), RAF1(1), RELA(1)	10371735	28	21	28	4	9	8	7	3	1	0	0.0642	0.204	1.000
71	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(3)	1817230	4	4	4	0	0	2	1	1	0	0	0.339	0.207	1.000
72	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	190250	1	1	1	0	0	0	0	0	1	0	0.661	0.217	1.000
73	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(3), ITGAM(2), ITGB2(2), SELE(1)	3906322	8	7	8	1	4	2	1	1	0	0	0.208	0.229	1.000
74	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(1), BCR(1), BTK(1), CDKN2A(1), ITPR1(2), ITPR2(3), ITPR3(1), PDK1(1), PIK3CA(9), PITX2(1), PLCG2(1), PPP1R13B(1), PTEN(13), PTPRC(3), RPS6KA1(1), SYK(2), VAV1(2)	20789451	45	40	45	7	8	9	7	4	17	0	0.145	0.236	1.000
75	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	PIK3CA(9), PIK3R1(2), RAC1(1), SYK(2), VAV1(2)	6967896	16	15	16	3	6	3	4	3	0	0	0.243	0.237	1.000
76	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSB(1), ARSE(2), CYP11B2(1), HSD11B1(1), HSD17B3(1), STS(2), SULT1E1(2), UGT1A1(3), UGT2B15(2)	10232509	17	15	17	1	4	5	2	2	4	0	0.0289	0.244	1.000
77	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(1), BRD4(2), CAP1(1), CBL(1), CDKN2A(1), GSK3A(1), GSK3B(1), INPPL1(1), IRS1(2), IRS2(2), IRS4(3), MAPK1(1), PDK1(1), PIK3CA(9), PIK3CD(1), PIK3R1(2), PTEN(13), PTPN1(1), RAF1(1), RPS6KA1(1), SHC1(2), SORBS1(2), SOS1(1), YWHAQ(1)	22423013	53	45	53	9	14	10	6	5	18	0	0.108	0.256	1.000
78	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), FADS2(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1)	3814707	8	8	8	2	2	1	3	1	1	0	0.536	0.265	1.000
79	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(2), EXTL1(3), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST2(1), HS6ST1(1), NDST1(3), NDST2(1), NDST4(4)	7781966	20	18	20	3	5	7	5	3	0	0	0.103	0.272	1.000
80	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(2)	1459355	3	3	3	0	1	1	0	1	0	0	0.405	0.279	1.000
81	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(3), MEF2C(2), MEF2D(2)	2898700	9	8	8	2	6	1	1	1	0	0	0.316	0.284	1.000
82	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(1), LPO(1), SHMT1(3), SHMT2(1), TPO(1)	4442575	9	9	9	1	3	2	1	0	3	0	0.196	0.285	1.000
83	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE2(1), CDK4(1), CDKN1B(4), CDKN2A(1), PRB1(1)	3401725	9	9	9	2	1	2	1	0	5	0	0.699	0.290	1.000
84	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), HDAC5(2), MEF2C(2), MEF2D(2), PPARA(2), PPP3CA(1), PPP3CC(1), SYT1(1)	7606815	17	15	17	2	9	3	1	2	2	0	0.0811	0.290	1.000
85	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(1), SRPR(1)	2820817	5	5	5	0	1	1	0	1	2	0	0.244	0.300	1.000
86	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPT(2), ENPP1(2), ENPP3(2), RFK(1)	3637517	8	8	8	2	2	2	1	1	2	0	0.506	0.307	1.000
87	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SP1(1), SP3(2), SYT1(1)	7857473	14	12	14	1	5	2	1	4	2	0	0.0757	0.316	1.000
88	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(3), SHMT2(1)	1565789	4	4	4	0	2	0	0	0	2	0	0.205	0.317	1.000
89	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1)	4399671	7	7	7	1	2	2	1	1	1	0	0.318	0.321	1.000
90	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ACAT1(1)	2026645	3	3	2	1	2	1	0	0	0	0	0.676	0.326	1.000
91	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(3), CTNNB1(9), KRT18(1), PRKCA(1), ROCK1(4), ROCK2(1), TUBA1A(1), TUBA3C(3), TUBA3E(2), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(1), YWHAQ(1)	19612632	41	33	39	4	7	8	8	8	10	0	0.0287	0.328	1.000
92	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(3), CTNNB1(9), KRT18(1), PRKCA(1), ROCK1(4), ROCK2(1), TUBA1A(1), TUBA3C(3), TUBA3E(2), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(1), YWHAQ(1)	19612632	41	33	39	4	7	8	8	8	10	0	0.0287	0.328	1.000
93	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(2), PRKCA(1), RELA(1)	3094487	6	6	6	0	1	4	0	1	0	0	0.169	0.336	1.000
94	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRA(1), IL4(1)	1487139	2	2	2	0	2	0	0	0	0	0	0.463	0.349	1.000
95	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1), LARS(1), LARS2(1), PDHA2(1)	3747460	5	5	5	0	1	1	2	0	1	0	0.204	0.350	1.000
96	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1)	3482893	5	5	5	1	1	1	0	1	2	0	0.497	0.353	1.000
97	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1)	3482893	5	5	5	1	1	1	0	1	2	0	0.497	0.353	1.000
98	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX5AP(1), DPEP1(2), PLA2G2A(1), PTGS1(1), PTGS2(3)	5679677	10	10	10	1	3	5	0	1	1	0	0.107	0.359	1.000
99	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(2), CTNNB1(9), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(2), PSEN1(1)	8159075	18	17	16	4	4	3	7	2	2	0	0.279	0.359	1.000
100	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ7(1)	1507764	2	2	2	1	0	1	1	0	0	0	0.854	0.362	1.000
101	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), BAD(1), BTK(1), EEA1(2), GSK3A(1), GSK3B(1), PDPK1(1), PFKM(1), PFKP(1), PLCG1(1), PRKCZ(2), RAC1(1), VAV2(1)	9453402	15	15	15	1	4	7	2	1	1	0	0.0363	0.369	1.000
102	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	570494	1	1	1	0	0	1	0	0	0	0	0.803	0.372	1.000
103	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(2), AR(1), ASAH1(2), BRAF(6), DAG1(2), EGFR(3), GNAI1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(1), PIK3CA(9), PIK3CD(1), PIK3R1(2), PITX2(1), RAF1(1)	20034135	45	40	44	7	17	11	7	4	6	0	0.0360	0.376	1.000
104	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(4), ESR1(1), MAPK1(1), PELP1(1)	5556797	12	11	12	2	6	2	1	1	2	0	0.214	0.388	1.000
105	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1), KERA(1)	1347283	2	2	2	1	1	1	0	0	0	0	0.790	0.388	1.000
106	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGFR(3), TF(2)	4802991	7	7	7	0	1	6	0	0	0	0	0.125	0.394	1.000
107	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL16(2), IL4(1), IL6(1), IL9(1), LTA(1), TNF(1)	3713338	7	6	7	1	2	3	2	0	0	0	0.298	0.403	1.000
108	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), FCGR2B(1), HLA-DRA(1), ITGAL(3), ITGB2(2), PTPRC(3)	5683619	11	10	11	2	6	2	1	2	0	0	0.263	0.405	1.000
109	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	NFS1(2), THTPA(2)	2402927	4	4	4	1	2	0	1	0	1	0	0.532	0.419	1.000
110	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), NRG2(1), NRG3(2), PRKCA(1), PSEN1(1)	3382302	6	5	6	1	2	1	0	1	2	0	0.471	0.428	1.000
111	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(2), RELA(1), TNFRSF13B(3), TRAF2(2), TRAF5(1)	5461896	9	8	9	1	1	7	0	0	1	0	0.197	0.435	1.000
112	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCS1(2), HMGCS2(1)	2691387	4	4	4	1	1	2	0	0	1	0	0.619	0.435	1.000
113	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(3), CREBBP(5), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(1), TGFBR1(2)	9628905	20	16	20	3	7	3	3	2	5	0	0.186	0.435	1.000
114	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(1)	888619	1	1	1	0	1	0	0	0	0	0	0.679	0.436	1.000
115	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(4), RB1(3)	3208457	7	6	7	2	0	1	1	0	4	1	0.870	0.445	1.000
116	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(3), CHST11(1), PAPSS2(1), SULT1E1(2)	3463090	7	7	7	0	4	2	0	0	1	0	0.101	0.456	1.000
117	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), GOT1(1), PAH(1)	3104839	4	4	4	1	3	0	0	0	1	0	0.548	0.461	1.000
118	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(1), CPOX(1), EPRS(2), HMBS(3), HMOX1(1), HMOX2(1), UGT1A1(3), UGT2B15(2)	10272527	15	14	15	1	8	2	2	2	1	0	0.0413	0.463	1.000
119	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(1), KARS(1)	2595538	3	3	3	0	1	0	2	0	0	0	0.371	0.468	1.000
120	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), UQCRC1(1)	2477500	3	3	3	0	0	1	1	0	1	0	0.561	0.470	1.000
121	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), LRP8(2), RELN(3), VLDLR(2)	5248625	9	9	9	2	2	3	2	1	1	0	0.475	0.474	1.000
122	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFB7(1), NDUFV1(1)	2614400	4	4	4	1	1	0	3	0	0	0	0.590	0.475	1.000
123	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	DIAPH1(1), GSN(2), HRAS(2), MAPK1(1), MYL2(1), MYLK(4), PIK3CA(9), PIK3R1(2), PTK2(2), PXN(1), RAF1(1), ROCK1(4), SHC1(2), TLN1(2)	13995464	34	30	34	7	13	5	8	4	4	0	0.126	0.476	1.000
124	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	THBS1(4)	2771408	4	4	4	1	2	0	1	0	1	0	0.540	0.478	1.000
125	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(3), SHMT2(1)	2075840	4	4	4	0	2	0	0	0	2	0	0.217	0.482	1.000
126	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(1), CES1(3)	2257403	5	4	5	1	1	4	0	0	0	0	0.397	0.493	1.000
127	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	792665	1	1	1	0	0	1	0	0	0	0	0.725	0.505	1.000
128	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(1), SNCAIP(2)	2409348	3	3	3	0	1	2	0	0	0	0	0.365	0.507	1.000
129	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), EHHADH(3)	2929337	4	4	4	1	0	3	1	0	0	0	0.627	0.518	1.000
130	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	617514	1	1	1	0	0	1	0	0	0	0	0.740	0.521	1.000
131	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), KARS(1)	1759169	2	2	2	0	1	0	1	0	0	0	0.518	0.541	1.000
132	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), IL4(1), IL6(1), IL9(1)	2286347	4	4	4	2	1	1	1	0	1	0	0.792	0.545	1.000
133	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOC(1), TPI1(1)	1465900	2	2	2	1	0	2	0	0	0	0	0.801	0.546	1.000
134	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(1), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS1(2), IRS2(2), JAK1(2), JAK3(2), MAP4K1(1), MAPK1(1), PDK1(1), PIK3CA(9), PIK3CD(1), PIK3R1(2), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), STAT6(1)	13806407	35	32	35	8	11	11	5	3	5	0	0.225	0.551	1.000
135	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), CYR61(1), JUND(1), WDR1(1)	4045828	4	4	4	0	0	0	3	0	1	0	0.463	0.564	1.000
136	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1)	1140023	1	1	1	0	1	0	0	0	0	0	0.670	0.564	1.000
137	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(2), ARFGEF2(1), COPA(2), GBF1(1), GPLD1(1), KDELR3(1)	6081977	9	9	9	2	3	4	0	0	2	0	0.347	0.574	1.000
138	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP2(1), MMP9(1)	2819815	4	4	4	1	1	2	1	0	0	0	0.568	0.583	1.000
139	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1)	1263898	1	1	1	1	0	1	0	0	0	0	0.956	0.595	1.000
140	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	1183547	1	1	1	1	1	0	0	0	0	0	0.914	0.596	1.000
141	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), PNMT(1), TPH1(1)	2291254	3	3	3	0	1	1	1	0	0	0	0.381	0.599	1.000
142	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	755394	1	1	1	1	1	0	0	0	0	0	0.931	0.599	1.000
143	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1)	985463	1	1	1	0	1	0	0	0	0	0	0.693	0.608	1.000
144	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(3), MAPK1(1), PRKCA(1)	3344886	5	5	5	1	3	1	0	1	0	0	0.426	0.611	1.000
145	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO2(1), ACSS1(1), FH(1), IDH1(4)	4975474	7	6	5	2	4	0	1	2	0	0	0.506	0.612	1.000
146	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	1819908	2	2	2	1	0	1	0	0	1	0	0.800	0.616	1.000
147	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1)	1452430	1	1	1	0	0	0	0	0	1	0	1.000	0.625	1.000
148	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), IGF1R(2), KLK2(1), MAPK1(1), PDGFRA(3), RAF1(1), RPS6KA1(1), RPS6KA5(3), SHC1(2), SOS1(1), STAT3(6)	12400482	30	28	30	6	7	11	6	3	3	0	0.192	0.626	1.000
149	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2RL3(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(2), MAPK1(1), PLA2G4A(2), PLCB1(2), PRKCA(1), PTGS1(1), PTK2(2), RAF1(1), SYK(2)	9144684	19	15	19	3	8	6	4	1	0	0	0.111	0.627	1.000
150	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY1(1), CRY2(2), PER1(2)	3208066	5	4	5	0	0	2	1	1	1	0	0.238	0.629	1.000
151	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR18(1), GPR39(1), GPR68(1), GPR75(1)	3658359	5	5	5	0	3	1	0	1	0	0	0.154	0.630	1.000
152	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGAL(3), ITGAM(2), ITGB2(2), SELE(1), SELP(2)	5979913	10	9	10	2	5	2	2	1	0	0	0.304	0.634	1.000
153	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	CPOX(1), HMBS(3)	2826730	4	4	4	0	3	0	1	0	0	0	0.271	0.635	1.000
154	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(1), HEXB(1), HK2(1), HK3(2), PGM3(1)	6363560	7	7	7	1	2	1	0	1	3	0	0.402	0.638	1.000
155	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BIRC2(1), CASP7(1), FASLG(1), MAP2K4(1), MAP3K1(1), MAPK10(1), MCL1(1), MDM2(1), NFKB1(2), PARP1(2), RELA(1), RIPK1(1), TNF(1), TP53(20), TRAF1(1), TRAF2(2)	14065007	39	33	36	9	10	13	7	2	7	0	0.209	0.641	1.000
156	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), HRAS(2), KLK2(1), MAPK1(1), RAF1(1)	3098548	6	6	6	2	3	0	2	0	1	0	0.705	0.646	1.000
157	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS1(2), DHRS7(1), DHRSX(1), PON1(1), PON2(1), RDH12(1)	3386138	8	7	8	2	2	2	3	0	1	0	0.404	0.663	1.000
158	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(2), SHC1(2), SOS1(1)	3304499	5	5	5	2	3	1	1	0	0	0	0.685	0.664	1.000
159	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), HRAS(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(1), NFATC1(2), NFATC2(1), PAK2(1), PIK3CA(9), PIK3R1(2), PLA2G4A(2), PLCG1(1), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2)	16111142	37	31	37	8	15	7	7	7	1	0	0.136	0.673	1.000
160	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(2), PANK1(1), PANK2(1), PANK3(1)	5240111	12	12	12	4	2	4	2	2	2	0	0.666	0.675	1.000
161	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), MARS(1), MARS2(2), MAT1A(1), PAPSS2(1), SEPHS1(1)	4648418	8	7	8	2	2	3	1	0	2	0	0.483	0.685	1.000
162	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B3(1)	3027615	3	3	3	1	1	1	1	0	0	0	0.709	0.687	1.000
163	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(1), CDC25B(1), SHH(2)	3246524	4	4	4	1	3	0	1	0	0	0	0.544	0.688	1.000
164	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGTR1(2), NOS3(1)	3748323	6	5	6	1	2	1	1	1	1	0	0.535	0.689	1.000
165	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPNS1(1), EP300(4), MEF2D(2), NFATC1(2), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1)	9154563	16	13	16	2	8	2	3	3	0	0	0.0827	0.690	1.000
166	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO2(1), FH(1), IDH1(4), PC(1), SUCLG1(1)	7701718	8	8	6	1	3	0	1	2	2	0	0.226	0.692	1.000
167	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3)	5622957	12	12	12	3	3	5	1	0	3	0	0.488	0.698	1.000
168	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3)	5622957	12	12	12	3	3	5	1	0	3	0	0.488	0.698	1.000
169	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3)	5622957	12	12	12	3	3	5	1	0	3	0	0.488	0.698	1.000
170	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BIK(1), BIRC2(1), CASP7(1), DFFA(1), ENDOG(1)	5100083	6	6	6	0	1	3	0	1	1	0	0.246	0.701	1.000
171	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(1), CHN1(1), LIMK1(1), MAP3K1(1), MYL2(1), MYLK(4), NCF2(4), PDGFRA(3), PIK3CA(9), PIK3R1(2), PLD1(2), RAC1(1), RALBP1(1), TRIO(4), VAV1(2)	13097406	37	31	37	9	14	6	8	5	4	0	0.221	0.707	1.000
172	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), ILVBL(1), LARS(1), LARS2(1), PDHA2(1), VARS(2), VARS2(2)	6990242	10	9	10	2	2	2	2	2	2	0	0.447	0.711	1.000
173	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(1)	1218711	1	1	1	1	1	0	0	0	0	0	0.910	0.712	1.000
174	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	SQLE(1)	1587683	1	1	1	1	1	0	0	0	0	0	0.916	0.717	1.000
175	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MAPKAPK5(1), NFKB1(2), PIK3CA(9), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(2), TRAF5(1)	12725984	25	19	25	3	8	7	3	4	3	0	0.0600	0.717	1.000
176	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH6(1)	2104922	2	2	2	0	1	1	0	0	0	0	0.488	0.718	1.000
177	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(4), CASP7(1), DFFA(1), LMNA(1)	7255592	10	10	10	2	3	4	1	2	0	0	0.381	0.719	1.000
178	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(1), BAD(1), BCR(1), BTK(1), CD81(1), CSK(1), DAG1(2), GSK3A(1), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(3), ITPR3(1), MAP4K1(1), MAPK1(1), NFATC1(2), NFATC2(1), PDK1(1), PIK3CA(9), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(3), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(2)	27834581	52	46	52	9	21	10	8	6	7	0	0.0301	0.720	1.000
179	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), MUT(1)	1841743	2	2	2	0	1	0	0	0	1	0	0.676	0.722	1.000
180	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), ATG7(1), IFNA10(1), IFNA13(1), PIK3R4(1), PRKAA2(3), ULK3(1)	7938397	10	10	10	2	5	0	1	3	1	0	0.380	0.724	1.000
181	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(1), POLR1C(2), POLR2A(2), POLR3A(2), POLR3B(1)	8785302	12	11	12	1	3	6	0	2	1	0	0.127	0.724	1.000
182	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), PPARG(1), TNF(1)	2170252	3	3	3	2	1	0	1	0	1	0	0.855	0.727	1.000
183	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1B(1), PLCB1(2), TRH(1)	4189204	5	5	5	0	2	1	1	0	1	0	0.184	0.734	1.000
184	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO2(1), HAO1(2), MTHFD1(1), MTHFD1L(1)	4789886	5	5	5	0	1	3	1	0	0	0	0.195	0.735	1.000
185	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1R(2), TNF(1)	2465229	3	3	3	1	3	0	0	0	0	0	0.617	0.744	1.000
186	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	HBB(1), HMBS(3)	2916074	4	4	4	1	3	1	0	0	0	0	0.551	0.752	1.000
187	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACSL1(1), ACSL4(1), EHHADH(3), SLC25A20(1)	6312550	8	7	7	0	3	2	2	0	1	0	0.0923	0.753	1.000
188	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(3), AGTR1(2), CMA1(1), CTSA(1), ENPEP(1), MAS1(1), MME(2), THOP1(1)	7942417	12	10	12	2	4	5	2	1	0	0	0.217	0.753	1.000
189	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1), CES1(3)	4051026	5	5	5	0	0	5	0	0	0	0	0.261	0.756	1.000
190	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCG2(1), BCHE(1), CES1(3), UGT1A1(3)	8533513	9	9	9	0	2	4	1	0	2	0	0.0618	0.758	1.000
191	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(1), B3GALT5(1), FUT1(1), FUT2(1), HEXB(1), NAGA(1), ST3GAL1(1), ST8SIA1(1)	4034701	10	10	10	4	4	3	0	1	2	0	0.686	0.758	1.000
192	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(2), GOT1(1), SULT4A1(1)	4708776	4	4	4	1	2	0	0	1	1	0	0.685	0.760	1.000
193	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	HRAS(2), MAPK1(1), NFKB1(2), PLCB1(2), PRKCA(1), RAF1(1), RELA(1), TNF(1)	5829081	11	9	11	3	4	4	2	1	0	0	0.408	0.761	1.000
194	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGDH(1), UGT1A1(3), UGT2B15(2)	6581978	6	6	6	1	1	2	1	1	1	0	0.441	0.762	1.000
195	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), RDH12(1)	1805942	2	2	2	0	1	1	0	0	0	0	0.456	0.763	1.000
196	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHB(1), MECR(1)	3177337	3	3	3	1	1	0	1	0	1	0	0.700	0.763	1.000
197	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C6(2), C9(1)	4696127	4	4	4	1	1	1	0	0	2	0	0.570	0.770	1.000
198	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO2(1), HAO1(2), MTHFD1(1), MTHFD1L(1)	5018030	5	5	5	0	1	3	1	0	0	0	0.194	0.774	1.000
199	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGFR(3), HRAS(2), MAPK1(1), PTPRB(3), RAF1(1), SHC1(2), SOS1(1), SPRY3(1)	9350036	15	13	15	4	6	5	2	1	1	0	0.441	0.774	1.000
200	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AKT1(1), AKT2(1), APAF1(1), ATM(12), BAD(1), BIRC2(1), CASP7(1), DFFA(1), ENDOG(1), FASLG(1), IL1RAP(2), IL3RA(2), IRAK1(1), IRAK2(1), IRAK4(1), NFKB1(2), NTRK1(3), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), RELA(1), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TP53(20), TRAF2(2)	31439189	86	65	83	17	21	27	17	10	11	0	0.0284	0.776	1.000
201	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), RPN1(1), UBE2A(1), UBE3A(1)	4829815	5	5	5	0	3	1	0	1	0	0	0.201	0.782	1.000
202	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11B2(1), HSD11B1(1)	2591236	2	2	2	1	0	0	0	0	2	0	0.816	0.789	1.000
203	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	HRAS(2), IL3RA(2), JAK2(2), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1)	6629291	12	9	12	4	4	5	3	0	0	0	0.533	0.789	1.000
204	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), CASP7(1), DFFA(1), SCAP(1), SREBF2(3)	6911296	8	8	8	2	2	3	1	2	0	0	0.499	0.789	1.000
205	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), TPO(1)	3150428	3	3	3	1	1	2	0	0	0	0	0.634	0.790	1.000
206	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT3(2), B4GALT7(1), CHPF(1), CHST11(1), CHSY1(1), UST(1), XYLT1(4)	5305208	12	12	12	3	6	4	0	0	2	0	0.288	0.793	1.000
207	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST6GALNAC2(1), ST8SIA1(1)	2119498	4	4	4	2	2	1	0	0	1	0	0.738	0.793	1.000
208	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FHL5(1), FSHR(1), GNAS(2)	3580468	5	4	5	2	0	2	2	1	0	0	0.810	0.794	1.000
209	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS7(1), DHRSX(1), ESCO1(5)	6194142	9	9	9	2	2	1	1	1	4	0	0.467	0.798	1.000
210	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(2), RELA(1), TNF(1)	3709613	4	4	4	1	1	3	0	0	0	0	0.535	0.799	1.000
211	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(1), AOC2(1), CES1(3), DDHD1(3), ESCO1(5)	9482813	14	12	14	2	3	5	2	1	3	0	0.211	0.800	1.000
212	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(1), ENPP1(2), ENPP3(2), NNMT(1), NNT(2), NT5M(1)	5458678	11	10	11	4	2	4	2	0	3	0	0.600	0.807	1.000
213	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR3(1), NTRK1(3), RAC1(1), WASF2(1), WASF3(1)	5706997	7	7	7	2	1	3	1	2	0	0	0.626	0.808	1.000
214	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR3(1), RAC1(1)	3033339	2	2	2	0	0	0	1	1	0	0	0.626	0.815	1.000
215	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(3), PDHA2(1)	2635642	5	5	5	2	1	1	0	1	2	0	0.627	0.818	1.000
216	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(1), MBTPS2(1), SCAP(1), SREBF2(3)	4534438	8	8	8	3	3	1	1	1	2	0	0.707	0.820	1.000
217	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(2), JAK2(2), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), STAT5A(1), STAT5B(1)	11226739	31	22	31	8	9	9	8	4	1	0	0.308	0.825	1.000
218	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	GRM1(4), PLCB1(2), PPP1CA(1), PPP3CA(1), PRKAR1A(1), PRKAR1B(1)	6019049	10	10	9	3	3	1	1	3	2	0	0.528	0.832	1.000
219	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(1), EGFR(3), MET(1), PDGFRA(3), PRKCA(1), SH3GLB2(1)	7283828	11	10	11	3	4	3	2	1	1	0	0.506	0.834	1.000
220	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	NFKB1(2), RELA(1), TNFSF11(1)	4166141	4	4	4	0	0	3	0	1	0	0	0.349	0.834	1.000
221	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), HRAS(2), KLK2(1), PIK3CA(9), PIK3R1(2), PLCG1(1), RAF1(1), SHC1(2), SOS1(1)	7135676	20	18	20	6	8	4	5	2	1	0	0.485	0.834	1.000
222	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(1)	1866943	1	1	1	0	0	0	0	1	0	0	0.846	0.838	1.000
223	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1)	2088119	1	1	1	0	0	0	0	0	1	0	1.000	0.841	1.000
224	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(2), HRAS(2), IRS1(2), JAK2(2), MAPK1(1), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), RPS6KA1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1)	12407065	29	23	29	7	10	9	5	4	1	0	0.274	0.841	1.000
225	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), FUT8(1), ST3GAL1(1)	2967521	8	7	8	3	4	3	0	0	1	0	0.622	0.843	1.000
226	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX3(1), ELOVL6(1), FADS1(1), FADS2(2), FASN(1), SCD(1)	5454421	9	9	9	3	1	4	2	1	1	0	0.572	0.844	1.000
227	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), EGFR(3), HRAS(2), NFKB1(2), PLCG1(1), PRKCA(1), RELA(1)	7704042	12	11	12	3	2	7	1	2	0	0	0.379	0.846	1.000
228	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), AKT1(1), BAD(1), IGF1R(2), IL3RA(2), PIK3CA(9), PIK3R1(2), PRKAR1A(1), PRKAR1B(1)	8244935	20	17	20	5	4	7	6	3	0	0	0.356	0.847	1.000
229	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1)	3274110	2	2	2	0	0	1	0	1	0	0	0.625	0.850	1.000
230	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD8A(1), IL6(1)	2316921	2	2	2	4	0	1	0	0	1	0	0.990	0.850	1.000
231	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CRY1(1), CRY2(2), DAZAP2(1), EIF4G2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(2), NCOA4(2), NR1D2(1), PER1(2), PER2(1), SF3A3(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(1), ZFR(1)	13714085	23	18	23	4	3	7	4	4	5	0	0.251	0.851	1.000
232	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(2), CAMK1(2), HDAC5(2), IGF1R(2), MEF2C(2), MEF2D(2), NFATC1(2), NFATC2(1), PIK3CA(9), PIK3R1(2), PPP3CA(1), PPP3CC(1), SYT1(1)	13095921	30	22	30	5	13	5	6	5	1	0	0.0653	0.852	1.000
233	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGTR1(2), CMA1(1), COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1)	9403173	9	8	9	1	4	2	2	1	0	0	0.154	0.852	1.000
234	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), ENPP2(2), PAFAH2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLD1(2), PPAP2B(1)	8717176	17	15	17	4	7	2	2	3	3	0	0.338	0.853	1.000
235	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMD1(1), PSMD2(1), PSMD6(1)	5994365	5	5	5	0	1	1	1	2	0	0	0.279	0.856	1.000
236	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(2), GRIN1(1), JAK2(2), NFKB1(2), RELA(1), SOD2(1)	4771465	10	7	10	3	4	4	0	0	2	0	0.628	0.862	1.000
237	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	2349839	1	1	1	0	0	0	0	1	0	0	0.845	0.862	1.000
238	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFA(1), ENDOG(1), TOP2A(1), TOP2B(1)	3397370	5	5	5	2	2	2	0	0	1	0	0.826	0.863	1.000
239	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(3), ANAPC1(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), ATM(12), BUB1(1), BUB1B(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(1), CDC25A(1), CDC25B(1), CDC27(1), CDC6(2), CDC7(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CHEK2(1), CREBBP(5), E2F3(1), EP300(4), ESPL1(1), FZR1(3), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), MDM2(1), PLK1(2), PRKDC(8), RB1(3), RBL1(2), RBL2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMC1B(1), TGFB1(1), TGFB2(1), TP53(20), YWHAQ(1)	50919565	116	79	113	17	33	29	21	10	22	1	0.00118	0.864	1.000
240	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(2), CREBBP(5), CSNK2A1(1), CTNNB1(9), DVL1(1), FZD1(2), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(1), WIF1(2)	11061247	28	26	26	7	7	5	8	3	5	0	0.365	0.866	1.000
241	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(5), EP300(4), NFKB1(2), RELA(1), RIPK1(1), TNF(1)	8416946	14	14	14	4	5	5	2	1	1	0	0.478	0.867	1.000
242	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), DAXX(1), FASLG(1), MAPKAPK3(1), TNF(1)	4252687	5	5	5	2	1	1	2	0	1	0	0.840	0.869	1.000
243	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(1)	1758982	2	2	2	3	1	0	0	0	1	0	0.970	0.872	1.000
244	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY1(1), CRY2(2), NPAS2(1), PER1(2), PER2(1), PER3(3)	6412615	10	8	10	2	1	3	1	3	2	0	0.361	0.872	1.000
245	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND3(1), CDC25A(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), RB1(3), RBL1(2)	6058319	16	12	16	5	5	4	1	0	5	1	0.647	0.874	1.000
246	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(1), HRAS(2), JAK2(2), MAP2K4(1), MAP3K1(1), PIK3CA(9), PIK3R1(2), RAF1(1), SOS1(1), STAT1(1), STAT5A(1), STAT5B(1)	10552175	24	20	24	7	6	8	7	3	0	0	0.421	0.874	1.000
247	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), IL12RB2(4), IL4(1), IL4R(1)	4746697	7	6	7	3	2	4	0	0	1	0	0.782	0.877	1.000
248	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT2(1), ST8SIA1(1)	2304587	4	4	4	4	0	3	0	0	1	0	0.950	0.879	1.000
249	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(6), CREB3(1), EEF2K(3), MAPK1(1), NFKB1(2), RPS6KA1(1), SHC1(2), SOS1(1)	11073645	18	16	17	4	5	7	2	2	2	0	0.340	0.881	1.000
250	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(5), EP300(4), MAP3K7(2), NFKB1(2), RELA(1), TGFBR1(2), TNF(1)	11156944	17	14	17	3	7	5	2	1	2	0	0.212	0.885	1.000
251	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), GNAS(2), HRAS(2), MAPK1(1), PIK3CA(9), PIK3R1(2), PRKAR1A(1), PRKAR1B(1), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(1)	10945089	29	26	29	7	8	8	7	6	0	0	0.321	0.886	1.000
252	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(2), JAK2(2), STAT1(1)	3067494	5	4	5	2	1	2	2	0	0	0	0.735	0.886	1.000
253	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPT(2), ENPP1(2), ENPP3(2), RFK(1)	5632656	8	8	8	3	2	2	1	1	2	0	0.679	0.888	1.000
254	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD2(4)	2168850	4	4	4	3	1	2	0	0	1	0	0.882	0.889	1.000
255	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), LIMK1(1), MAPK1(1), MYL2(1), PLCB1(2), PRKCA(1), PTK2(2), RAF1(1), ROCK2(1)	9389555	17	13	17	3	5	6	3	2	1	0	0.268	0.891	1.000
256	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD8A(1), ITGAL(3), ITGB2(2), PTPRC(3)	4022813	9	8	9	4	3	2	1	2	1	0	0.697	0.892	1.000
257	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(1), CCR4(1), CCR7(1), IL12RB2(4), IL4(1), IL4R(1), TGFB1(1), TGFB2(1)	7473809	11	10	11	3	2	7	1	0	1	0	0.420	0.892	1.000
258	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSE(2), CYP11B2(1), CYP19A1(2), HSD11B1(1), HSD17B3(1), METTL6(1), PRMT3(1), PRMT5(1), STS(2), SULT1E1(2), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1)	18806170	32	26	32	6	6	9	3	5	9	0	0.137	0.893	1.000
259	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(1), PRKCA(1)	2512828	2	2	2	1	1	0	0	1	0	0	0.850	0.893	1.000
260	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BTK(1), CAD(3), DAXX(1), DEDD2(1), DFFA(1), EGFR(3), EPHB2(3), FAF1(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MET(1), NFKB1(2), PFN2(2), PTPN13(2), RALBP1(1), RIPK1(1), ROCK1(4), TNFRSF6B(1), TP53(20), TPX2(1), TRAF2(2)	27385787	60	48	57	10	21	14	10	3	12	0	0.0267	0.895	1.000
261	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(2), CYP1A2(1), CYP2C19(1), CYP2C8(2), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), RDH12(1)	8971775	14	12	14	3	4	3	5	1	1	0	0.312	0.897	1.000
262	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), RB1(3)	3196386	4	4	4	2	0	2	1	0	0	1	0.792	0.900	1.000
263	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), JAK1(2), JAK2(2), JAK3(2), STAT1(1), STAT3(6), STAT5A(1), STAT5B(1), TYK2(1)	6936076	19	15	19	6	3	7	5	1	3	0	0.505	0.900	1.000
264	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(1), FUT2(1), HEXB(1), NAGA(1), ST3GAL1(1), ST8SIA1(1)	3802566	8	8	8	4	3	3	0	0	2	0	0.789	0.901	1.000
265	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(1), ANKRD6(1), APC(2), AXIN2(2), CTNNB1(9), DACT1(3), DKK2(2), DVL1(1), GSK3A(1), GSK3B(1), LRP1(3), NKD2(1), PSEN1(1), PTPRA(3), WIF1(2)	15198791	34	26	32	7	10	8	7	5	4	0	0.155	0.901	1.000
266	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), DAG1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), PDE6B(1), PDE6C(1), SLC6A13(1), TF(2)	13460423	17	16	17	3	6	5	1	1	4	0	0.245	0.903	1.000
267	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(3)	5988132	12	12	12	4	3	5	1	0	3	0	0.665	0.904	1.000
268	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), SYT1(1)	4353453	7	7	7	3	3	2	0	1	1	0	0.738	0.906	1.000
269	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS1(1), GSK3B(1)	3482831	2	2	2	0	0	0	1	0	1	0	0.545	0.907	1.000
270	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(2), CREBBP(5), CTNNB1(9), DVL1(1), EP300(4), FZD1(2), GSK3B(1), LEF1(1), PITX2(1), TRRAP(2)	12475379	28	27	26	7	8	6	7	3	4	0	0.266	0.909	1.000
271	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), GNA12(1), PRKAG1(2)	3782013	4	4	4	2	0	2	2	0	0	0	0.799	0.911	1.000
272	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	GSTA2(1), GSTM3(1), GSTM4(2), IDH1(4)	6793441	8	7	6	2	4	2	0	2	0	0	0.498	0.911	1.000
273	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	GSTA2(1), GSTM3(1), GSTM4(2), IDH1(4), OPLAH(2)	8302043	10	9	8	2	5	2	0	2	1	0	0.327	0.912	1.000
274	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), AKT1(1), DAG1(2), DGKA(2), ETFA(1), ITGA9(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NR1I3(1), PDE3B(1), PIK3CA(9), PIK3CD(1), PIK3R1(2)	18304924	31	28	31	6	10	8	3	4	6	0	0.153	0.913	1.000
275	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(1), PC(1)	3475105	2	2	2	1	0	1	0	0	1	0	0.761	0.913	1.000
276	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(3)	4569710	8	8	8	3	1	4	2	1	0	0	0.668	0.920	1.000
277	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGAL(3), ITGB2(2), SELE(1)	4531714	6	5	6	2	3	1	1	1	0	0	0.628	0.922	1.000
278	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(3), SIRT2(1)	4441263	5	5	5	2	1	2	1	1	0	0	0.740	0.923	1.000
279	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), FCGR3A(1), TGFB1(1), TGFB2(1), TNF(1), TNFSF8(1)	4978500	8	7	8	2	3	2	2	1	0	0	0.413	0.925	1.000
280	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(1)	2568403	1	1	1	0	1	0	0	0	0	0	0.691	0.927	1.000
281	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), CD38(1), ENPP1(2), ENPP3(2), NADK(2), NNMT(1), NNT(2), NT5C2(2), NT5M(1), NUDT12(1)	8082188	16	13	16	5	4	6	2	0	4	0	0.506	0.933	1.000
282	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	RB1(3)	3087197	3	3	3	2	0	1	1	0	0	1	0.871	0.933	1.000
283	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), FH(1)	3518720	2	2	2	0	0	0	1	1	0	0	0.655	0.934	1.000
284	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(1), BAD(1), BCR(1), BTK(1), CSK(1), DAG1(2), EPHB2(3), ITPKB(2), MAPK1(1), NFKB1(2), PIK3CA(9), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(2)	19850070	38	33	38	8	16	10	6	3	3	0	0.104	0.934	1.000
285	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRB(1), COX15(1), CP(1), CPOX(1), EPRS(2), HMBS(3), HMOX1(1), HMOX2(1), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1)	15792103	27	23	27	5	10	6	3	4	4	0	0.142	0.935	1.000
286	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(1), DHFR(1)	2483012	5	5	5	6	2	1	0	1	1	0	0.990	0.935	1.000
287	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), HRAS(2), IGF1R(2), IRS1(2), PIK3CA(9), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1)	9268113	22	19	22	7	7	5	6	3	1	0	0.551	0.935	1.000
288	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(2), JAK3(2), MAPK1(1), STAT3(6), TYK2(1)	4435960	14	13	14	6	3	5	3	1	2	0	0.755	0.937	1.000
289	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(1), GOT1(1)	2918230	2	2	2	5	1	0	0	0	1	0	0.999	0.937	1.000
290	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12RB2(4), JAK2(2), STAT4(3), TYK2(1)	5505928	10	8	10	5	1	4	2	0	3	0	0.831	0.937	1.000
291	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT2(1), BAD(1), CDKN1B(4), CDKN2A(1), CREB3(1), ERBB4(1), GSK3A(1), GSK3B(1), INPPL1(1), IRS1(2), IRS2(2), IRS4(3), MET(1), PAK2(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(9), PIK3CD(1), PPP1R13B(1), PTEN(13), PTK2(2), PTPN1(1), RPS6KA1(1), SHC1(2), SOS1(1), TSC2(2), YWHAQ(1)	29072394	59	46	59	10	11	14	5	5	24	0	0.155	0.937	1.000
292	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(1), GSK3B(1), PPP1CA(1)	4309892	6	6	6	3	1	0	1	2	2	0	0.862	0.939	1.000
293	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	JAK1(2), STAT1(1), TYK2(1)	4068031	4	4	4	2	0	1	2	0	1	0	0.839	0.939	1.000
294	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(2), GOT1(1), PAH(1), YARS2(1)	3255049	5	4	5	2	4	0	0	0	1	0	0.644	0.939	1.000
295	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL6(1), IL9(1), TGFB1(1), TGFB2(1)	3112731	5	5	5	4	0	2	2	0	1	0	0.958	0.944	1.000
296	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGDIB(1), CASP1(4)	4828216	6	6	6	3	2	2	1	1	0	0	0.804	0.945	1.000
297	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1B(1), ADH6(1), DHRS1(2), DHRS7(1), DHRSX(1), ESCO1(5)	9352191	11	10	11	2	3	2	1	1	4	0	0.309	0.945	1.000
298	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(3), HADHB(1), IVD(1), MUT(1)	13491963	23	20	22	5	6	9	5	1	2	0	0.203	0.946	1.000
299	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(1), MAP3K1(1), NFKB1(2), RELA(1), TNFAIP3(1)	6807310	6	5	6	1	0	5	0	0	1	0	0.414	0.947	1.000
300	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRA(1), IL4(1), IL6(1), LTA(1), TGFB1(1), TGFB2(1), TNF(1)	4996431	7	6	7	3	3	3	1	0	0	0	0.687	0.949	1.000
301	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(3), L1CAM(3), SELP(2)	5899183	9	8	9	3	4	1	2	0	2	0	0.632	0.949	1.000
302	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(1)	2950135	1	1	1	0	0	0	0	0	1	0	0.672	0.949	1.000
303	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), FPR1(1), GNB1(1), GNGT1(1), HRAS(2), MAP3K1(1), MAPK1(1), NCF1(1), NCF2(4), NFATC1(2), NFATC2(1), NFKB1(2), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1), SYT1(1)	14328243	27	20	27	5	9	9	4	4	1	0	0.111	0.949	1.000
304	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(1)	2983406	3	3	3	2	2	0	0	0	1	0	0.901	0.952	1.000
305	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(2)	3153629	2	2	2	1	0	1	0	0	1	0	0.937	0.953	1.000
306	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(4), NCOA1(1), PPARG(1)	6923846	11	10	11	4	5	2	2	1	1	0	0.635	0.956	1.000
307	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), TYK2(1)	3935776	7	6	7	3	1	3	2	0	1	0	0.743	0.956	1.000
308	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), TYK2(1)	3935776	7	6	7	3	1	3	2	0	1	0	0.743	0.956	1.000
309	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(1), LTA(1), MAP3K1(1), NFKB1(2), RELA(1), RIPK1(1), TNFAIP3(1), TRAF1(1), TRAF2(2)	8430806	11	8	11	2	1	8	1	0	1	0	0.276	0.957	1.000
310	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(5), EP300(4), IL7R(1), JAK1(2), JAK3(2), PIK3CA(9), PIK3R1(2), STAT5A(1), STAT5B(1)	10493419	27	23	27	8	9	9	5	3	1	0	0.475	0.959	1.000
311	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(2), PTPRU(3), STAT1(1), TYK2(1)	4704281	7	7	7	3	3	1	2	0	1	0	0.726	0.960	1.000
312	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BAD(1), CBL(1), HRAS(2), IRS1(2), JAK1(2), JAK3(2), MAPK1(1), PIK3CA(9), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1), SYK(2)	13578141	31	27	31	9	12	9	6	3	1	0	0.399	0.961	1.000
313	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(1), DHRS1(2), DHRS7(1), DHRSX(1), EHHADH(3), ESCO1(5), FN3K(1)	9721211	15	13	15	4	3	5	2	1	4	0	0.431	0.962	1.000
314	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGTR1(2), ATF2(1), EGFR(3), HRAS(2), MAP2K4(1), MAP3K1(1), MAPK1(1), MEF2C(2), MEF2D(2), PRKCA(1), PTK2(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1)	12538042	24	21	24	6	10	6	5	3	0	0	0.255	0.964	1.000
315	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(2), JAK2(2), PLA2G2A(1), PTPRU(3), STAT1(1)	4299247	9	7	9	3	4	2	2	1	0	0	0.604	0.966	1.000
316	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(1), INPP4A(1), INPP5B(2), INPP5E(1), INPPL1(1), IPMK(1), ITPK1(2), ITPKB(2), OCRL(2), PI4KA(1), PI4KB(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIP5K1C(2), PLCB1(2), PLCB4(2), PLCD3(1), PLCD4(1), PLCG1(1), PLCG2(1), PLCZ1(2), PTEN(13), SYNJ1(2), SYNJ2(2)	27932493	60	48	60	12	14	16	10	7	13	0	0.101	0.969	1.000
317	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), CDC27(1), CUL2(3), CUL3(3), FBXW11(1), FZR1(3), TCEB2(1), UBA1(1), VHL(1), WWP1(1)	15012867	23	22	23	5	3	4	10	1	5	0	0.277	0.969	1.000
318	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C6(2), IL6(1), ITGAL(3), ITGB2(2), SELP(2), SELPLG(1), TNF(1), VCAM1(1)	9275960	14	12	14	4	6	4	1	2	1	0	0.383	0.969	1.000
319	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(3), GNA12(1), GNB1(1), GNGT1(1), MYL2(1), MYLK(4), PLCB1(2), PRKCA(1), ROCK1(4)	7733826	18	16	18	5	4	6	3	3	2	0	0.503	0.970	1.000
320	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN3(1), BCAR1(1), BCR(1), CAPNS1(1), CSK(1), HRAS(2), MAPK1(1), PTK2(2), PXN(1), RAF1(1), ROCK1(4), SHC1(2), SOS1(1), TLN1(2)	17736887	21	19	21	4	7	3	6	1	4	0	0.244	0.970	1.000
321	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1), P4HB(1), SLC23A2(1)	9359629	8	7	8	1	3	3	0	1	1	0	0.236	0.971	1.000
322	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(1), C3(1), C6(2), C8B(1), C9(1), MASP1(1)	7787995	7	7	7	2	2	1	2	0	2	0	0.531	0.971	1.000
323	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	RIPK1(1), TNF(1), TRAF2(2)	3163115	4	3	4	2	1	2	1	0	0	0	0.766	0.972	1.000
324	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), HEXB(1), LCT(3)	5405412	7	6	7	3	3	2	1	0	1	0	0.719	0.972	1.000
325	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1B(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), CYP7A1(3), HADHB(1), SOAT2(1)	8717159	17	16	17	5	3	7	4	2	1	0	0.418	0.973	1.000
326	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(3), ITGB2(2), PTPRC(3)	4218689	8	7	8	4	3	2	1	2	0	0	0.775	0.974	1.000
327	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(1), GCK(1), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKFB4(1), PFKM(1), PFKP(1), PMM1(1), TPI1(1)	8996540	12	12	12	4	2	4	2	2	2	0	0.543	0.974	1.000
328	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2)	5074663	3	3	3	0	2	0	0	1	0	0	0.402	0.974	1.000
329	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN3(1), CAPNS1(1), PTK2(2), PXN(1), RAC1(1), SPTAN1(1), TLN1(2)	10735196	9	9	9	1	2	3	2	0	2	0	0.231	0.975	1.000
330	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	DHFR(1), POLG(1), RRM1(2)	4737517	4	4	4	6	0	2	0	0	2	0	0.997	0.975	1.000
331	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PGM1(1), PYGL(2), TPI1(1)	5041735	7	7	7	3	2	4	1	0	0	0	0.643	0.977	1.000
332	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	FBL(2)	3355765	2	2	2	1	2	0	0	0	0	0	0.783	0.977	1.000
333	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), NFATC1(2), NFATC2(1), PRKAR1A(1), PRKAR1B(1)	4588449	6	6	6	3	2	0	2	2	0	0	0.815	0.979	1.000
334	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MARS(1), MARS2(2), MAT1A(1)	6538480	9	8	9	5	1	3	2	0	3	0	0.874	0.980	1.000
335	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(2), JAK2(2), JAK3(2), PIAS3(2), PTPRU(3), STAT3(6)	5752927	18	14	18	6	6	6	4	1	1	0	0.536	0.980	1.000
336	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CMAS(1), CYB5R1(1), GFPT2(2), GNPNAT1(1), HEXB(1), HK2(1), HK3(2), NAGK(1), PGM3(1)	10771898	11	10	11	3	4	1	1	2	3	0	0.571	0.981	1.000
337	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BAD(1), BIRC2(1), CASP1(4), CASP7(1), DFFA(1), FASLG(1), IRF2(2), IRF3(1), IRF4(3), IRF6(1), LTA(1), MAP2K4(1), MAP3K1(1), MAPK10(1), MDM2(1), NFKB1(2), RELA(1), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF21(1), TP53(20), TRAF1(1), TRAF2(2)	21651898	52	43	49	11	13	16	9	3	11	0	0.140	0.981	1.000
338	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(4), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(3), MUT(1), SUCLG1(1)	12411285	17	14	17	4	3	7	4	1	2	0	0.337	0.982	1.000
339	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(2), IL12RB2(4), JAK2(2), STAT4(3), TYK2(1)	6986044	12	10	12	7	2	5	2	0	3	0	0.894	0.983	1.000
340	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(2), DHRS7(1), DHRSX(1), METTL6(1), PRMT3(1), PRMT5(1)	5646678	7	7	7	6	1	1	1	1	3	0	0.969	0.984	1.000
341	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(3), MAP3K1(1), NCOR2(1), THRA(2)	6521453	7	7	7	2	2	4	0	0	1	0	0.440	0.984	1.000
342	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(2), ILVBL(1), PANK1(1), PANK2(1), PANK3(1)	6508610	13	13	13	5	2	5	2	2	2	0	0.738	0.984	1.000
343	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(1), C3(1), C6(2), C9(1)	6553759	5	5	5	2	1	1	1	0	2	0	0.703	0.985	1.000
344	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	METTL6(1), PRMT3(1), PRMT5(1)	5278061	3	3	3	4	0	0	0	1	2	0	0.993	0.985	1.000
345	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(2), TPI1(1)	3502329	3	3	3	4	1	1	0	0	1	0	0.980	0.986	1.000
346	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IRAK1(1), MAP3K1(1), MAP3K7(2), NFKB1(2), RELA(1), RIPK1(1), TNF(1), TNFAIP3(1)	9136954	10	9	10	3	3	4	1	0	2	0	0.547	0.986	1.000
347	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	EPN1(1), EPS15(2), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(2), SYT1(1)	8183671	11	11	11	4	1	2	2	3	3	0	0.738	0.986	1.000
348	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	HLA-DRA(1), ITK(1), PIK3CA(9), PIK3R1(2)	4788770	13	12	13	5	6	2	3	2	0	0	0.731	0.987	1.000
349	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(3), FASN(1), OXSM(1)	6025892	9	9	9	4	3	4	1	1	0	0	0.723	0.987	1.000
350	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), TPO(1)	3628981	3	3	3	2	1	2	0	0	0	0	0.826	0.987	1.000
351	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(1), SNAP25(1), VAMP1(1), VAMP5(1), VAMP7(1), VTI1A(1)	6295674	7	6	7	2	3	0	1	1	2	0	0.634	0.988	1.000
352	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2A(1), UBE2I(1), UBE3A(1)	3948117	3	3	3	2	2	1	0	0	0	0	0.825	0.988	1.000
353	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP7(1), DAXX(1), DFFA(1), FAF1(2), LMNA(1), MAP2K4(1), MAP3K1(1), MAP3K7(2), PAK2(1), PRKDC(8), PTPN13(2), RB1(3), RIPK2(2), SPTAN1(1)	15304477	28	21	28	6	10	9	4	2	2	1	0.192	0.988	1.000
354	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), ASAH1(2), CERK(1), CREB3(1), DAG1(2), EPHB2(3), ITPKB(2), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8IP3(2)	10769696	19	16	19	5	10	3	0	1	5	0	0.461	0.989	1.000
355	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	NOTCH1(2), PSEN1(1)	3578052	3	3	3	2	1	1	1	0	0	0	0.841	0.989	1.000
356	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10A(1), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL8(1), RPS11(2)	8577259	11	11	11	3	3	2	1	2	3	0	0.737	0.989	1.000
357	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1)	3005508	5	5	5	3	1	2	1	1	0	0	0.862	0.990	1.000
358	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1)	3005508	5	5	5	3	1	2	1	1	0	0	0.862	0.990	1.000
359	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(3), DBH(1), DDC(1), GAD2(4), PAH(1), PNMT(1), TPH1(1)	5442300	13	13	13	7	4	4	1	1	3	0	0.795	0.990	1.000
360	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(2), HEXB(1), LCT(3), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1), ST8SIA1(1)	6171525	12	10	12	8	8	2	0	0	2	0	0.902	0.991	1.000
361	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT1(2), B4GALT2(2), FUT1(1), FUT2(1), FUT3(1), FUT6(1), ST8SIA1(1)	6085220	13	12	13	5	4	5	0	2	1	1	0.643	0.991	1.000
362	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLAT(1), FH(1), PC(1), PDHA2(1), PDHX(1), PDK1(1), PDK4(1), PDP2(1), SUCLG1(1)	10607244	10	10	10	3	0	5	1	1	3	0	0.493	0.991	1.000
363	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA3(1)	4481726	1	1	1	0	0	0	0	0	1	0	0.668	0.991	1.000
364	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B2(1), EIF2B3(1), FLT1(1), FLT4(2), HRAS(2), KDR(5), NOS3(1), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(2), PXN(1), SHC1(2), VHL(1)	12768413	33	24	33	8	15	7	4	3	4	0	0.247	0.992	1.000
365	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), MAP2K4(1), MAP3K7(2), NFKB1(2), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TRAF2(2)	10257453	12	11	12	4	2	4	1	2	3	0	0.642	0.992	1.000
366	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(5), DFFA(1), GZMA(1)	3983773	7	7	7	4	3	2	0	1	1	0	0.879	0.992	1.000
367	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(1), GNAS(2), GNB1(1), GNGT1(1), NFKB1(2), NOS3(1), NPPA(1), PIK3CA(9), PIK3R1(2), RELA(1), SYT1(1)	6750683	23	20	23	7	5	11	3	3	1	0	0.583	0.992	1.000
368	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), PPP1CA(1), PRKAG1(2)	6786625	7	7	7	4	1	1	2	1	2	0	0.874	0.993	1.000
369	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(12), CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CDC25A(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CREB3(1), CREB3L3(1), E2F3(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), MDM2(1), MYT1(1), POLE(4), RB1(3), RBL1(2), RPA1(1), RPA2(1), TFDP2(1), TNXB(7), TP53(20)	29004935	77	53	74	16	24	18	12	8	14	1	0.0772	0.993	1.000
370	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), AGXT(1), ASL(1), CAD(3), GAD2(4), GOT1(1), PC(1)	9786827	13	13	13	8	5	3	0	0	5	0	0.902	0.993	1.000
371	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT1(2), B4GALT2(2), B4GALT5(1), FUT8(1), MAN1A1(2), MGAT1(1), MGAT5(1), RPN1(1), ST6GAL1(1)	7505229	12	11	12	4	6	5	0	0	1	0	0.445	0.993	1.000
372	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MARS(1), MARS2(2), MAT1A(1)	7803846	9	8	9	6	1	3	2	0	3	0	0.935	0.993	1.000
373	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CD74(1), CD8A(1), CD8B(1), CIITA(1), CTSL1(1), HLA-DRA(1), HLA-F(1), HLA-G(4), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), KIR2DL1(1), KIR3DL2(1), KIR3DL3(1), LTA(1), NFYA(1), NFYC(2), PSME2(1), RFXANK(1), TAP1(1), TAP2(1)	17422941	29	20	29	7	5	12	5	3	4	0	0.196	0.993	1.000
374	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1)	4137006	2	2	2	2	0	1	0	0	1	0	0.892	0.994	1.000
375	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(1), F2(1), FGA(2), PLAT(1), PLAU(2), PLG(2), SERPINB2(1)	5011961	11	10	11	7	2	2	3	3	1	0	0.976	0.994	1.000
376	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(1), CASP7(1), DFFA(1), LMNA(1), NFKB1(2), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(2)	12567213	14	12	14	3	1	10	1	1	1	0	0.295	0.994	1.000
377	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ADH1B(1), ADH6(1), AKR1B10(1), AKR1C4(1), AKR1D1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), CYP7A1(3), HADHB(1), RDH12(1), SOAT2(1)	11908480	18	16	17	5	5	7	4	1	1	0	0.332	0.994	1.000
378	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F3(1), F5(5), F7(1), FGA(2), PROS1(2)	6128475	13	12	13	5	3	6	3	1	0	0	0.699	0.995	1.000
379	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), HRAS(2), MAP3K1(1), MAPK1(1), MAPK8IP3(2), PAPPA(3), RAC1(1), RPS6KA1(1), SHC1(2), SOS1(1), SYK(2), VAV1(2), VAV2(1), VAV3(4)	12029925	25	22	24	8	8	6	5	2	4	0	0.544	0.995	1.000
380	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(1), ASAH1(2), BRAF(6), DAG1(2), EGFR(3), EPHB2(3), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(2), MAPK1(1), PIK3CB(2), PITX2(1), PLCB1(2), PLCB4(2), RAF1(1), RGS20(1), SHC1(2), SOS1(1), STAT3(6), TERF2IP(1)	21978332	48	42	47	11	15	15	6	3	9	0	0.157	0.995	1.000
381	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CBS(1), MARS(1), MARS2(2), MAT1A(1), METTL6(1), PAPSS2(1), PRMT3(1), PRMT5(1), SEPHS1(1), SEPHS2(3)	9367323	14	13	14	6	3	3	2	2	4	0	0.798	0.995	1.000
382	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), DNMT1(1), MTNR1A(1), MTNR1B(1), PTGER2(1), TBXA2R(2)	4230328	7	7	7	4	3	2	1	0	1	0	0.770	0.995	1.000
383	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(1), ABCC1(1), ABCC3(2)	5356072	8	8	8	5	3	2	1	1	1	0	0.881	0.996	1.000
384	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), IL4(1), MAP3K1(1), MAP3K5(1), NFKB1(2), RELA(1), TRAF2(2)	7271898	9	7	9	4	2	6	0	1	0	0	0.745	0.996	1.000
385	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(1), C3(1), C6(2), C9(1), MASP1(1), MASP2(1)	7986099	7	7	7	3	1	1	2	1	2	0	0.744	0.996	1.000
386	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH6(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2)	4975333	6	6	5	3	3	2	1	0	0	0	0.737	0.996	1.000
387	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT7(1), B4GALT1(2), B4GALT2(2), CHST4(1), FUT8(1), ST3GAL1(1)	4697675	9	7	9	4	5	4	0	0	0	0	0.694	0.997	1.000
388	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), HMGCS1(2), SQLE(1)	4953106	4	3	4	5	2	1	0	0	1	0	0.983	0.997	1.000
389	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), CHAT(3), DGKA(2), DGKB(1), DGKD(2), DGKI(2), DGKQ(2), DGKZ(1), ESCO1(5), ETNK1(1), ETNK2(1), GNPAT(1), GPAM(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLD1(2), PPAP2B(1), PTDSS1(1)	24643723	40	34	40	9	12	6	5	5	12	0	0.188	0.997	1.000
390	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ACADS(2), ACAT1(1), ACSM1(1), AKR1B10(1), ALDH1A3(1), ALDH1B1(1), ALDH5A1(1), ALDH7A1(2), DDHD1(3), EHHADH(3), GAD2(4), HMGCS1(2), HMGCS2(1), ILVBL(1), PDHA2(1), RDH12(1)	15241847	27	25	25	8	9	11	4	0	3	0	0.287	0.998	1.000
391	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), ACY3(1), AGXT(1), ASL(1), CAD(3), DARS2(1), DLAT(1), GAD2(4), GOT1(1), NARS2(1), PC(1), PDHA2(1)	14211877	18	17	18	8	7	4	0	0	7	0	0.707	0.998	1.000
392	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(1), EP300(4), NOS3(1), P4HB(1), VHL(1)	6381939	9	7	9	4	4	3	1	0	1	0	0.780	0.998	1.000
393	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), ATP7B(2), NDUFA10(2), NDUFB7(1), NDUFV1(1), SHMT1(3), UQCRC1(1), UQCRFS1(1)	14308094	21	19	21	5	4	9	4	1	3	0	0.343	0.998	1.000
394	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), HEXB(1), LCT(3), SPAM1(1)	7692969	8	7	8	4	3	3	1	0	1	0	0.801	0.998	1.000
395	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CITED2(1), CREBBP(5), EHHADH(3), EP300(4), FABP1(2), HSPA1A(1), MAPK1(1), ME1(1), NCOA1(1), NCOR1(5), NCOR2(1), NR1H3(1), NR2F1(1), NRIP1(1), PIK3CA(9), PIK3R1(2), PPARA(2), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PTGS2(3), RB1(3), RELA(1), SP1(1), STAT5A(1), STAT5B(1), TNF(1)	23774557	55	39	55	13	17	18	8	5	6	1	0.105	0.998	1.000
396	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3), PIGT(1)	8940781	9	8	9	4	3	2	2	0	2	0	0.808	0.998	1.000
397	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT2(1), DAG1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), NFKB1(2), PDK1(1), PHKA2(1), PIK3CB(2), PITX2(1), PLD1(2), VN1R1(2)	16891093	24	22	24	6	8	8	2	0	6	0	0.297	0.998	1.000
398	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), HRAS(2), IRS1(2), PIK3CA(9), PIK3R1(2), RAF1(1), SHC1(2), SOS1(1)	9539916	20	18	20	8	7	4	5	3	1	0	0.736	0.998	1.000
399	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP6(1), ARHGEF1(3), ARHGEF11(3), ARHGEF5(1), CFL1(1), DIAPH1(1), GSN(2), LIMK1(1), MYL2(1), MYLK(4), ROCK1(4), TLN1(2)	16938665	25	22	25	7	4	4	5	3	9	0	0.546	0.998	1.000
400	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), HEXB(1), LCT(3), NEU1(1)	6250370	6	5	6	4	2	2	1	0	1	0	0.912	0.998	1.000
401	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	CASP1(4), CASP7(1), RERE(3), WWP1(1)	9002558	9	9	9	4	3	3	2	1	0	0	0.733	0.999	1.000
402	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(3), EHMT2(1), PLOD1(2), PLOD3(1), SHMT1(3), SHMT2(1)	13919674	22	18	22	6	4	8	5	1	4	0	0.362	0.999	1.000
403	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(2), ACAA2(1), ACADS(2), ACAT1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(3), HADHB(1), HMGCS1(2), HMGCS2(1), IVD(1), MUT(1)	16125223	23	21	21	6	8	9	4	0	2	0	0.290	0.999	1.000
404	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4(1), IL4R(1), IRS1(2), JAK1(2), JAK3(2), SHC1(2), STAT6(1)	5563479	12	12	12	5	4	5	1	1	1	0	0.786	0.999	1.000
405	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1B(1), ADH6(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(1), DDC(1), FAH(1), GOT1(1), HGD(1), HPD(1), PNMT(1), TPO(1)	11888382	16	15	16	7	5	5	1	0	5	0	0.700	0.999	1.000
406	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), HRAS(2), MAP3K1(1), NFATC1(2), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2)	14312616	21	19	21	6	9	4	4	4	0	0	0.354	0.999	1.000
407	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), ELTD1(1), EMR2(4), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(2), LPHN3(6), SCTR(1), VIPR1(1)	10044219	22	21	21	9	7	4	3	4	4	0	0.715	0.999	1.000
408	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(1), GOT1(1), ME1(1), ME3(1), PGK2(1), TKT(1), TKTL1(1), TPI1(1)	7579616	8	8	8	4	2	3	1	2	0	0	0.790	0.999	1.000
409	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACPT(2), ALPI(1), ALPP(2), ALPPL2(1), CMBL(1), CYP3A7(1), DHRS1(2), DHRS7(1), DHRSX(1), PON1(1), PON2(1)	6779171	15	12	15	7	5	2	4	1	3	0	0.702	0.999	1.000
410	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAD(1), BCL2A1(1), CASP1(4), CASP7(1), DAXX(1), DFFA(1), FASLG(1), LTA(1), MCL1(1), NFKB1(2), NTRK1(3), PTPN13(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(2)	16377195	25	20	25	5	5	15	4	1	0	0	0.136	0.999	1.000
411	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GRM1(4), GRM3(1), GRM4(2), GRM5(2), GRM7(1), GRM8(1)	7861781	13	13	12	6	8	2	1	0	2	0	0.606	0.999	1.000
412	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ACADS(2), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH5A1(1), EHHADH(3), GAD2(4), PDHA2(1)	9688531	17	17	16	7	5	7	2	1	2	0	0.624	0.999	1.000
413	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(1), H6PD(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(1), RBKS(2), TKT(1)	7686173	12	12	12	5	3	1	3	3	2	0	0.841	0.999	1.000
414	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), EPRS(2), GARS(1), HARS(1), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(2), QARS(2), TARS(1), WARS(1)	11975625	17	14	17	5	5	5	3	1	3	0	0.589	0.999	1.000
415	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), DDC(1), EPX(1), ESCO1(5), GOT1(1), HPD(1), LPO(1), TPO(1)	12800775	15	14	15	6	5	3	1	1	5	0	0.756	0.999	1.000
416	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGFR(3), HRAS(2), JAK1(2), MAP2K4(1), MAP3K1(1), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), STAT5A(1)	14014076	35	28	35	10	8	12	9	5	1	0	0.394	0.999	1.000
417	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPT(2), ALPI(1), ALPP(2), ALPPL2(1), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(1), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP2F1(1), CYP3A7(1), CYP4F8(1), PON1(1)	11016535	22	20	22	8	11	2	6	1	2	0	0.590	0.999	1.000
418	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG2(1), ASL(1), CKB(1), CKMT2(2), PYCR1(1)	6596731	7	7	7	8	2	2	1	1	1	0	0.993	1.000	1.000
419	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), ETV3(3), HDAC5(2), HRAS(2), NCOR2(1), RBL1(2), RBL2(1), SIN3B(1)	9817724	13	11	13	6	3	2	3	0	5	0	0.828	1.000	1.000
420	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(1), ACADSB(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(1), CNDP1(2), DPYD(3), DPYS(1), EHHADH(3), GAD2(4)	10901478	22	19	22	8	5	10	4	1	2	0	0.529	1.000	1.000
421	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX15(2), CYP4F2(1), EPX(1), LPO(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PTGS1(1), PTGS2(3), TPO(1)	10512331	15	14	15	5	4	8	2	1	0	0	0.474	1.000	1.000
422	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), CYP2C19(1), DHRS1(2), DHRS7(1), DHRSX(1), EHHADH(3), ESCO1(5)	11581488	18	13	17	6	5	5	3	1	4	0	0.543	1.000	1.000
423	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR3(1), AKT1(1), AKT2(1), ARHGEF11(3), BTK(1), CFL1(1), CFL2(1), INPPL1(1), ITPR1(2), ITPR2(3), ITPR3(1), LIMK1(1), MYLK(4), MYLK2(2), PAK2(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(9), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(1), PPP1R13B(1), PTEN(13), ROCK1(4), ROCK2(1)	26292735	62	50	62	16	13	14	9	6	20	0	0.473	1.000	1.000
424	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	PLCG1(1), PRKCA(1), SYT1(1)	5163384	3	3	3	2	2	0	0	1	0	0	0.853	1.000	1.000
425	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT(1), AMT(1), AOC2(1), CBS(1), CHDH(2), DAO(2), GARS(1), GCAT(1), GLDC(2), PLCG1(1), PLCG2(1), SARDH(2), SHMT1(3), SHMT2(1), TARS(1)	15774209	22	19	22	9	7	5	2	1	7	0	0.808	1.000	1.000
426	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(6), CACNA1A(9), GNA12(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GRIA1(4), GRIA2(3), GRIA3(1), GRID2(4), GRM1(4), GRM5(2), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), HRAS(2), IGF1R(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NOS1(2), NOS3(1), NPR2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCB1(2), PLCB4(2), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PRKCA(1), RAF1(1), RYR1(7)	41436757	88	69	86	18	36	15	11	10	16	0	0.0257	1.000	1.000
427	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(1), BRAF(6), DDIT4(1), MAPK1(1), PDPK1(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PRKAA2(3), RPS6KA1(1), RPS6KA6(1), TSC2(2), ULK3(1), VEGFA(2)	20015951	41	32	40	10	14	8	7	6	6	0	0.258	1.000	1.000
428	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), DDC(1), EPX(1), GOT1(1), HPD(1), LPO(1), TPO(1)	8238325	10	9	10	6	4	3	1	0	2	0	0.886	1.000	1.000
429	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(2), BRAF(6), CREB3(1), CREBBP(5), DAG1(2), EGR1(1), EGR3(1), FRS2(1), MAP1B(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), NTRK1(3), OPN1LW(1), PIK3CA(9), PIK3CD(1), PIK3R1(2), SHC1(2), TERF2IP(1)	19339825	46	38	45	12	16	11	6	7	6	0	0.287	1.000	1.000
430	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	IRAK1(1), MAP2K4(1), MAP3K1(1), MAP3K7(2), NFKB1(2), PPARA(2), RELA(1), TLR10(1), TLR7(1), TLR9(1)	13657130	13	9	13	3	7	4	0	1	1	0	0.320	1.000	1.000
431	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(3), CANT1(1), CTPS2(1), DHODH(1), DPYD(3), DPYS(1), ENTPD6(1), ENTPD8(1), NT5C2(2), NT5M(1), PNPT1(1), POLA1(1), POLD3(1), POLE(4), POLR1A(4), POLR1B(1), POLR1C(2), POLR2A(2), POLR3A(2), POLR3B(1), RRM1(2), RRM2B(1), TXNRD1(1), UCK2(1), UPP1(2)	30377669	41	30	41	8	13	15	4	2	7	0	0.0483	1.000	1.000
432	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1RAP(2), IL6(1), IRAK1(1), IRAK2(1), MAP3K1(1), MAP3K7(2), NFKB1(2), RELA(1), TGFB1(1), TGFB2(1), TNF(1)	11128489	14	12	14	5	5	6	1	0	2	0	0.569	1.000	1.000
433	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), HEXB(1), LCT(3), NEU1(1)	7698374	6	5	6	5	2	2	1	0	1	0	0.953	1.000	1.000
434	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(1), H6PD(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(1), RBKS(2), TKT(1), TKTL1(1)	9145868	13	13	13	5	4	1	3	3	2	0	0.785	1.000	1.000
435	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CSK(1), DAG1(2), EPHB2(3), ITK(1), ITPKB(2), LCP2(1), MAPK1(1), NFKB1(2), PAK2(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(3), RAF1(1), SOS1(1), VAV1(2), ZAP70(1)	21022186	26	21	26	6	10	10	2	3	1	0	0.210	1.000	1.000
436	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX15(2), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP4F2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PTGS1(1), PTGS2(3)	14648515	18	17	18	5	5	6	5	1	1	0	0.377	1.000	1.000
437	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), MAP2K4(1), MAP3K1(1), MAPK1(1), NFKB1(2), NSMAF(1), RAF1(1), RELA(1), RIPK1(1), TRAF2(2)	7721023	12	9	12	5	1	8	2	1	0	0	0.728	1.000	1.000
438	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(1), BTK(1), FCER1A(1), GAB2(5), HRAS(2), IL4(1), INPP5D(2), LCP2(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), PDK1(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCG1(1), PLCG2(1), PRKCA(1), RAC1(1), RAC2(2), RAF1(1), SOS1(1), SYK(2), TNF(1), VAV1(2), VAV2(1), VAV3(4)	27140102	63	53	62	16	23	13	12	7	8	0	0.188	1.000	1.000
439	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(1), DHCR7(1), GGCX(1), NQO1(1), SQLE(1), TM7SF2(1)	7241099	7	7	7	6	4	1	1	0	1	0	0.974	1.000	1.000
440	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	CAMK2A(1), CAMK2D(1), CLCA2(1), CNGA3(3), CNGA4(3), GNAL(1), GUCA1A(1), PDE1C(1), PRKACA(1), PRKX(2)	11447446	15	14	15	7	5	2	4	1	3	0	0.725	1.000	1.000
441	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG12(1), ALG14(1), B4GALT1(2), B4GALT2(2), DOLPP1(1), FUT8(1), GANAB(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT1(1), MGAT5(1), MGAT5B(3), RPN1(1), ST6GAL1(1)	15894462	20	17	20	5	10	5	1	0	4	0	0.320	1.000	1.000
442	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOC2(1), CNDP1(2), DPYD(3), DPYS(1), EHHADH(3), GAD2(4)	10141857	19	17	18	8	6	9	3	0	1	0	0.620	1.000	1.000
443	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF2(1), EEF2K(3), EIF2AK3(3), EIF2B2(1), EIF2B3(1), EIF4A1(1), EIF4G1(2), EIF4G3(2), EIF5B(1), KIAA0664(1)	16464667	18	17	18	6	5	1	2	4	6	0	0.729	1.000	1.000
444	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), CANT1(1), CTPS2(1), DHODH(1), DPYD(3), DPYS(1), NT5M(1), POLE(4), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), RRM1(2), TXNRD1(1), UCK2(1), UPP1(2)	21559922	29	22	29	7	11	7	4	3	4	0	0.174	1.000	1.000
445	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLD3(1), POLE(4), POLG(1), POLL(1), POLM(1), POLQ(3), REV1(1), REV3L(2)	15171314	15	13	15	8	3	3	2	2	5	0	0.963	1.000	1.000
446	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CAP1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), MAPK1(1), MYT1(1), PRKAR1A(1), PRKAR1B(1), RPS6KA1(1)	7730668	14	14	14	8	2	5	3	3	1	0	0.945	1.000	1.000
447	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(5), EP300(4), PRKAR1A(1), PRKAR1B(1)	7764412	11	10	11	8	4	2	2	2	1	0	0.964	1.000	1.000
448	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), DFFA(1), LMNA(1), MADD(2), MAP2K4(1), MAP3K1(1), MAP3K7(2), PAK2(1), PRKDC(8), RB1(3), RIPK1(1), SPTAN1(1), TNF(1), TRAF2(2)	14548244	26	20	26	8	10	9	2	2	2	1	0.441	1.000	1.000
449	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), HRAS(2), JAK1(2), MAP2K4(1), MAP3K1(1), PDGFRA(3), PIK3CA(9), PIK3R1(2), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), STAT5A(1)	13053141	35	27	35	11	10	9	9	5	2	0	0.511	1.000	1.000
450	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA4(1), HSD11B1(1), PLA2G4A(2), PTGER2(1), PTGS1(1), PTGS2(3), SCGB1A1(1)	7746933	12	12	12	6	3	4	4	0	1	0	0.829	1.000	1.000
451	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(5), EP300(4), ERCC3(3), ESR1(1), GRIP1(3), GTF2A1(1), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(1), NRIP1(1), PELP1(1), POLR2A(2)	17299830	30	21	29	8	13	7	3	2	5	0	0.241	1.000	1.000
452	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPNS1(1), EGFR(3), HRAS(2), MAPK1(1), MYL2(1), MYLK(4), PRKAR1A(1), PRKAR1B(1), PTK2(2), PXN(1), TLN1(2)	12278448	19	18	19	7	6	6	4	2	1	0	0.564	1.000	1.000
453	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ACOX3(1), ACSL1(1), ACSL4(1), ACSL6(2), ADH1B(1), ADH6(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), CPT1C(2), EHHADH(3), HADHB(1)	18367655	25	17	23	6	10	7	6	0	2	0	0.206	1.000	1.000
454	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADH6(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DGAT1(1), DGKA(2), DGKB(1), DGKD(2), DGKQ(2), DGKZ(1), GK(1), LCT(3), LIPG(3), PNLIP(1), PNLIPRP1(1), PPAP2B(1)	18145380	31	25	31	9	10	9	3	4	5	0	0.339	1.000	1.000
455	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR3(1), MAP3K1(1), NFATC1(2), NFATC2(1), NFKB1(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RELA(1), SYT1(1)	10499173	14	12	14	6	3	5	2	3	1	0	0.732	1.000	1.000
456	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(2), B4GALT2(2), GAA(2), GALK1(1), GANAB(1), GCK(1), HK2(1), HK3(2), LCT(3), MGAM(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1)	12267561	20	17	20	9	9	4	2	2	3	0	0.738	1.000	1.000
457	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB3(1), EEF2K(3), MAP2K4(1), MAP3K10(4), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPKAPK5(1), NFKB1(2)	12539160	17	13	17	8	7	4	1	2	3	0	0.846	1.000	1.000
458	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(1), INPPL1(1), ITPKB(2), OCRL(2), PIK3C2A(1), PIK3C2B(2), PIK3CA(9), PIK3CB(2), PIK3CG(3), PLCB1(2), PLCB4(2), PLCG1(1), PLCG2(1)	16804473	30	24	30	9	11	9	6	2	2	0	0.364	1.000	1.000
459	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK3(2), CPSF2(1), CPSF3(1), CSTF2T(1), CSTF3(1), DHX15(1), DHX38(1), DHX8(1), LOC440563(2), METTL3(1), PHF5A(1), POLR2A(2), PPM1G(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(3), PTBP1(2), PTBP2(1), RBM17(1), RBM5(1), SF3A1(2), SF3A3(1), SF3B1(2), SF3B5(1), SNRPA(1), SNRPD2(1), SNRPD3(1), SNRPN(1), SPOP(24), SUPT5H(2)	39650091	65	57	51	13	10	10	28	8	9	0	0.0935	1.000	1.000
460	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(4), ACACB(3), ACAT1(1), ACSS1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), EHHADH(3), MUT(1), SUCLG1(1)	14887839	18	15	17	6	7	6	3	1	1	0	0.486	1.000	1.000
461	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DLAT(1), ME1(1), ME3(1), PC(1), PDHA2(1)	13876266	15	15	15	5	2	7	2	2	2	0	0.535	1.000	1.000
462	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP5A1(2), ATP6V0A1(1), ATP6V0A2(4), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), CYC1(1), NDUFA10(2), NDUFB10(1), NDUFB7(1), NDUFB9(1), NDUFS3(1), NDUFV1(1), UQCRC1(1), UQCRFS1(1)	20981873	28	24	28	8	5	10	7	2	4	0	0.494	1.000	1.000
463	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(1), GALNT4(1), GALNTL2(1), GALNTL5(3), OGT(1), ST3GAL1(1), WBSCR17(2)	12077253	15	13	15	8	5	2	3	3	2	0	0.922	1.000	1.000
464	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), MCM10(1), MCM3(1), MCM4(1), MCM5(1), MCM6(2), MCM7(3), POLD3(1), POLE(4), RFC3(1), RPA1(1), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1)	18963565	26	19	26	7	7	10	4	1	4	0	0.324	1.000	1.000
465	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO2(1), FH(1), IDH1(4), PC(1), PCK2(2), SUCLG1(1)	11168288	10	9	8	5	4	0	2	2	2	0	0.756	1.000	1.000
466	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1), F10(1), F11(1), F12(1), F2(1), F5(5), F8(2), FGA(2), KLKB1(1), PROS1(2)	16591849	22	20	22	8	6	11	2	2	1	0	0.675	1.000	1.000
467	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN3(1), DMD(4), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH6(4), MYH7(4), MYH8(3), MYL1(1), MYL2(1), MYOM1(2), NEB(5), TCAP(2), TNNT2(1), TPM1(1), TTN(46)	50666427	83	61	83	14	31	15	17	5	14	1	0.00986	1.000	1.000
468	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(3), ACAT1(1), ACOT12(1), ACSS1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), DLAT(1), ME1(1), ME3(1), PC(1), PCK2(2), PDHA2(1)	17563180	21	19	20	7	8	6	3	2	2	0	0.436	1.000	1.000
469	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), ARHGDIB(1), BIRC2(1), CASP7(1), DAXX(1), DFFA(1), GSN(2), LMNA(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MDM2(1), NFKB1(2), PAK2(1), PRKDC(8), PSEN1(1), PTK2(2), RB1(3), RELA(1), RIPK1(1), SPTAN1(1), TNF(1), TRAF1(1), TRAF2(2)	25974757	38	24	38	8	12	16	3	2	4	1	0.107	1.000	1.000
470	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	HRAS(2), MAP2K4(1), MAP3K1(1), NFATC1(2), NFATC2(1), NFKB1(2), PIK3CA(9), PIK3R1(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RAF1(1), RELA(1), SHC1(2), SOS1(1), SYT1(1), VAV1(2), ZAP70(1)	17911801	34	28	34	10	11	9	7	7	0	0	0.366	1.000	1.000
471	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(1), ACVR1C(1), ACVRL1(1), BMP5(2), BMP6(1), BMP7(3), BMPR2(1), CHRD(1), COMP(1), CREBBP(5), EP300(4), FST(1), GDF6(1), GDF7(1), INHBA(2), INHBC(1), LTBP1(3), MAPK1(1), PITX2(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), RBL1(2), RBL2(1), ROCK1(4), ROCK2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SP1(1), TGFB1(1), TGFB2(1), TGFBR1(2), THBS1(4), THBS3(1), THBS4(1), TNF(1), ZFYVE16(1), ZFYVE9(1)	37291297	68	52	68	15	19	19	13	10	7	0	0.0906	1.000	1.000
472	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(3), F2(1), F2RL3(1), MAPK1(1), PLD1(2), PTK2(2), RAF1(1), RASAL1(2), VAV1(2)	10319616	17	14	17	8	9	5	1	1	1	0	0.764	1.000	1.000
473	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(1), ALDOC(1), FUK(1), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKFB4(1), PFKM(1), PFKP(1), PGM2(2), PMM1(1), RDH12(1), TPI1(1), TSTA3(2)	14006127	18	16	18	6	5	6	3	2	2	0	0.460	1.000	1.000
474	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(1), DLAT(1), ENO1(2), GCK(1), GOT1(1), HK2(1), HK3(2), PC(1), PDHA2(1), PDHX(1), PFKM(1), PFKP(1), PGK2(1), TPI1(1)	15954776	16	16	16	8	4	5	2	1	4	0	0.782	1.000	1.000
475	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), HRAS(2), MAP2K4(1), MAP3K1(1), MAPK1(1), PLCG1(1), PRKCA(1), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1)	10685284	14	11	14	6	6	2	3	2	1	0	0.784	1.000	1.000
476	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDOC(1), DLAT(1), ENO1(2), GCK(1), HK2(1), HK3(2), PDHA2(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), TPI1(1)	18329997	23	21	23	8	5	7	3	4	4	0	0.593	1.000	1.000
477	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDOC(1), DLAT(1), ENO1(2), GCK(1), HK2(1), HK3(2), PDHA2(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), TPI1(1)	18329997	23	21	23	8	5	7	3	4	4	0	0.593	1.000	1.000
478	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AKT1(1), CAMK1(2), CAMK4(2), CREBBP(5), F2(1), GSK3B(1), HRAS(2), LIF(1), MAPK1(1), MEF2C(2), MYH2(1), NFATC1(2), NFATC2(1), NPPA(1), PIK3CA(9), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RAF1(1), SYT1(1)	19070972	40	31	40	13	13	9	8	7	3	0	0.460	1.000	1.000
479	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(6), EGFR(3), ERBB2(1), ERBB4(1), ETV6(1), FMN2(3), MAPK1(1), NOTCH1(2), NOTCH2(3), NOTCH3(3), NOTCH4(2), PIWIL1(3), PIWIL2(1), PIWIL3(2), RAF1(1), SOS1(1)	19747541	34	32	33	10	8	10	6	2	8	0	0.482	1.000	1.000
480	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	APOA4(1), CETP(1), CYP7A1(3), DGAT1(1), LDLR(1), LRP1(3), SCARB1(2)	10280384	12	12	12	7	5	4	1	1	1	0	0.871	1.000	1.000
481	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(2), ATF2(1), BMP5(2), BMP7(3), BMPR2(1), CHRD(1), CTNNB1(9), DVL1(1), FZD1(2), GSK3B(1), MAP3K7(2), MEF2C(2), MYL2(1), NPPA(1), NPPB(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1)	13692529	35	28	33	12	10	6	11	4	4	0	0.537	1.000	1.000
482	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(2), ASAH1(2), B4GALT6(1), CERK(1), DEGS2(2), LCT(3), NEU1(1), PPAP2B(1), SGMS1(2), SMPD4(1)	13470895	16	12	16	7	7	4	3	0	2	0	0.608	1.000	1.000
483	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), CHAT(3), DGKA(2), DGKB(1), DGKD(2), DGKQ(2), DGKZ(1), ETNK1(1), GNPAT(1), PAFAH2(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCG1(1), PLCG2(1), PPAP2B(1)	18809943	26	23	26	8	8	4	6	4	4	0	0.481	1.000	1.000
484	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), GALNS(2), HEXB(1), LCT(3), NEU1(1), SPAM1(1)	13002685	10	9	10	6	4	3	2	0	1	0	0.880	1.000	1.000
485	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(1), IARS(1), IL13RA1(1), IL4(1), IL4R(1), INPP5D(2), JAK1(2), JAK2(2), JAK3(2), PIK3CA(9), PPP1R13B(1), SHC1(2), SOS1(1), STAT6(1), TYK2(1)	13877654	29	25	29	10	9	9	6	2	3	0	0.567	1.000	1.000
486	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(1), BAD(1), HRAS(2), KDR(5), MAPK1(1), MAPKAPK3(1), NFATC1(2), NFATC2(1), NOS3(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(1), PTGS2(3), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAF1(1), SH2D2A(2), SHC2(1), VEGFA(2)	27175036	62	44	62	16	21	15	12	6	8	0	0.150	1.000	1.000
487	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1B(1), ADH6(1), AKR1C3(1), AKR1C4(1), ALDH1A3(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP2F1(1), CYP2S1(1), CYP3A7(1), EPHX1(1), GSTA2(1), GSTM3(1), GSTM4(2), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1)	21490238	37	30	37	10	9	12	6	5	5	0	0.340	1.000	1.000
488	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), DOT1L(2), EHMT2(1), EZH1(1), EZH2(1), JMJD4(1), KDM6A(6), MEN1(1), MLL(2), MLL2(13), MLL3(10), MLL5(1), NSD1(1), OGT(1), PAXIP1(2), PPP1CA(1), PRDM9(2), PRMT1(1), PRMT5(1), RBBP5(2), SETD1A(3), SETD2(6), SETDB1(2), STK38(1), SUV420H2(1), WHSC1(1), WHSC1L1(3)	44583150	71	53	71	16	17	14	7	7	25	1	0.338	1.000	1.000
489	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACOX3(1), ACSL1(1), ACSL4(1), ACSL6(2), CPT1C(2), CYP7A1(3), EHHADH(3), FABP1(2), FABP2(1), FABP4(1), FADS2(2), GK(1), HMGCS2(1), ME1(1), NR1H3(1), PCK2(2), PDPK1(1), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRB(1), RXRG(1), SCD(1), SLC27A1(1), SLC27A4(1), SLC27A6(1), SORBS1(2), UBC(1)	24569663	43	31	43	11	14	14	7	3	5	0	0.211	1.000	1.000
490	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E2(1), GTF2I(1), GTF2IRD1(1), TAF1L(3), TAF4(1), TAF5(1), TAF7L(2)	13466026	11	9	11	7	3	5	1	1	1	0	0.965	1.000	1.000
491	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(4), ARAF(1), ATF4(1), BRAF(6), CACNA1C(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CREBBP(5), EP300(4), GRIA1(4), GRIA2(3), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRM1(4), GRM5(2), HRAS(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), PLCB1(2), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), RPS6KA1(1), RPS6KA6(1)	37369585	75	62	73	21	24	19	7	11	14	0	0.281	1.000	1.000
492	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH6(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), DGAT1(1), DGKA(2), DGKB(1), DGKD(2), DGKI(2), DGKQ(2), DGKZ(1), GK(1), GPAM(3), LCT(3), LIPG(3), MGLL(1), PNLIP(1), PNLIPRP1(1), PPAP2B(1)	22072330	40	32	39	12	13	11	3	4	9	0	0.357	1.000	1.000
493	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTG1(1), ACTN3(1), ACVR1B(1), ACVR1C(1), CDH1(3), CREBBP(5), CSNK2A1(1), CSNK2A2(1), CTNNA2(4), CTNNA3(1), CTNNB1(9), EGFR(3), EP300(4), ERBB2(1), IGF1R(2), IQGAP1(3), LEF1(1), LMO7(2), MAP3K7(2), MAPK1(1), MET(1), MLLT4(2), NLK(1), PTPN1(1), PTPRB(3), PTPRF(1), PVRL1(1), RAC1(1), RAC2(2), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(2), TJP1(4), WASF2(1), WASF3(1)	44915681	80	61	78	21	21	20	15	13	11	0	0.207	1.000	1.000
494	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	DGKA(2), DGKB(1), DGKD(2), DGKI(2), DGKQ(2), DGKZ(1), FN3K(1), IMPA1(1), INPP4A(1), INPP5B(2), INPP5D(2), INPP5E(1), INPPL1(1), ITPK1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), OCRL(2), PI4KA(1), PI4KB(1), PIK3C2A(1), PIK3C2B(2), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PLCB1(2), PLCB4(2), PLCD3(1), PLCD4(1), PLCG1(1), PLCG2(1), PLCZ1(2), PRKCA(1), PTEN(13), SYNJ1(2), SYNJ2(2)	46857953	86	60	86	21	25	20	11	8	22	0	0.185	1.000	1.000
495	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(1), AKT1(1), AKT2(1), ARAF(1), BAD(1), BRAF(6), CAMK2A(1), CAMK2D(1), CBL(1), CDKN1A(2), CDKN1B(4), CRK(1), EGFR(3), ERBB2(1), ERBB3(4), ERBB4(1), GSK3B(1), HRAS(2), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), NRG1(1), NRG2(1), NRG3(2), PAK2(1), PAK6(1), PAK7(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(1), PTK2(2), RAF1(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), STAT5A(1), STAT5B(1)	38681176	80	55	79	20	24	20	12	7	17	0	0.147	1.000	1.000
496	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(1), DUSP8(2), GCK(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(4), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAPK10(1), PAPPA(3), SHC1(2), TP53(20)	18942472	44	37	41	13	17	7	7	2	11	0	0.430	1.000	1.000
497	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN3(1), BCAR1(1), CDH5(4), CLDN15(2), CLDN9(2), CTNNA2(4), CTNNA3(1), CTNNB1(9), CYBB(1), ESAM(1), GNAI1(1), GNAI2(1), ITGAL(3), ITGAM(2), ITGB2(2), ITK(1), JAM2(1), MLLT4(2), MMP2(1), MMP9(1), MSN(1), MYL2(1), MYL5(1), NCF1(1), NCF2(4), NCF4(1), NOX3(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(1), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAPGEF4(1), RASSF5(1), RHOH(1), ROCK1(4), ROCK2(1), SIPA1(1), TXK(1), VAV1(2), VAV2(1), VAV3(4), VCAM1(1)	46689040	98	69	95	26	34	16	17	16	15	0	0.186	1.000	1.000
498	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), BCAR1(1), CAPN11(2), CAPN3(1), CAPNS1(1), CAV3(1), CRK(1), CSK(1), GIT2(2), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAD(2), ITGAL(3), ITGAM(2), ITGAV(2), ITGAX(1), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), MAPK10(1), MYLK2(2), PAK2(1), PAK6(1), PDPK1(1), PIK3R2(2), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAPGEF1(3), ROCK1(4), ROCK2(1), SHC1(2), SHC3(1), SORBS1(2), SOS1(1), TLN1(2), TNS1(6), VAV2(1), VAV3(4)	50465141	82	59	81	20	27	25	11	9	10	0	0.0840	1.000	1.000
499	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(2), GAA(2), GANAB(1), GBE1(2), GCK(1), HK2(1), HK3(2), MGAM(1), PGM1(1), PGM3(1), PYGL(2), UGDH(1), UGT1A1(3), UGT2B15(2)	21350908	30	29	30	10	7	9	5	2	7	0	0.617	1.000	1.000
500	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(1), BMP7(3), BMPR2(1), CCL28(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CD27(1), CNTF(2), CSF1R(1), CSF2RA(2), CSF3R(1), CXCL16(1), CXCL9(1), CXCR6(1), EDA(1), EGFR(3), FASLG(1), FLT1(1), FLT3(1), FLT4(2), GH2(1), GHR(2), HGF(2), IFNA10(1), IFNA13(1), IFNW1(1), IL10RA(3), IL11RA(1), IL12RB2(4), IL13RA1(1), IL17A(1), IL17RA(3), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL23A(1), IL25(1), IL28A(1), IL3RA(2), IL4(1), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(1), IL9(1), INHBA(2), INHBC(1), KDR(5), LEPR(1), LIF(1), LIFR(2), LTA(1), LTBR(3), MET(1), PDGFRA(3), PDGFRB(1), PF4(1), RELT(1), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(2), TNFRSF13B(3), TNFRSF18(1), TNFRSF19(1), TNFRSF21(1), TNFRSF4(2), TNFRSF6B(1), TNFSF11(1), TNFSF14(1), TNFSF8(1), TPO(1), VEGFA(2), XCL1(1), XCR1(1)	66622196	117	69	117	28	31	43	19	7	17	0	0.0242	1.000	1.000
501	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(5), DLL3(3), DLL4(1), DTX1(2), DTX2(1), DTX4(1), DVL1(1), DVL2(2), DVL3(1), EP300(4), JAG2(3), MAML1(1), MAML2(1), MAML3(1), NCOR2(1), NOTCH1(2), NOTCH2(3), NOTCH3(3), NOTCH4(2), NUMB(1), NUMBL(1), PSEN1(1), RBPJL(1), SNW1(2)	26345507	44	35	44	13	13	10	8	2	11	0	0.428	1.000	1.000
502	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(1), BTK(1), CARD11(1), CD81(1), FCGR2B(1), GSK3B(1), HRAS(2), INPP5D(2), LILRB3(1), NFATC1(2), NFATC2(1), NFKB1(2), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(2), SYK(2), VAV1(2), VAV2(1), VAV3(4)	28010104	53	43	52	17	20	10	10	6	7	0	0.369	1.000	1.000
503	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(3), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CXCR6(1), FPR1(1), FSHR(1), GNRHR(3), LHCGR(1), MC4R(1), NPY1R(1), NPY2R(1), SSTR1(1), SSTR2(1), SSTR3(1), TACR1(1), TACR3(1), TRHR(1), TSHR(1)	19623854	31	27	31	12	9	9	3	4	6	0	0.547	1.000	1.000
504	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTR3(1), AKT1(1), AKT2(1), ARHGEF6(1), BCAR1(1), BRAF(6), CDKN2A(1), CRK(1), EPHB2(3), GRB7(1), ITGA10(1), ITGA11(1), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), MAP2K4(1), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MRAS(1), MYLK(4), MYLK2(2), P4HB(1), PAK2(1), PAK6(1), PAK7(1), PIK3CA(9), PIK3CB(2), PLCG1(1), PLCG2(1), PTEN(13), PTK2(2), RAF1(1), ROCK1(4), ROCK2(1), SHC1(2), SOS1(1), TERF2IP(1), TLN1(2), TLN2(2)	45981734	88	62	87	24	15	25	15	11	22	0	0.380	1.000	1.000
505	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(1), CBL(1), CCND3(1), CNTF(2), CREBBP(5), CSF2RA(2), CSF3R(1), EP300(4), GH2(1), GHR(2), IFNA10(1), IFNA13(1), IFNW1(1), IL10RA(3), IL11RA(1), IL12RB2(4), IL13RA1(1), IL20(1), IL20RA(1), IL21(1), IL23A(1), IL28A(1), IL3RA(2), IL4(1), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(1), IL9(1), JAK1(2), JAK2(2), JAK3(2), LEPR(1), LIF(1), LIFR(2), PIAS3(2), PIAS4(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), SOCS5(1), SOS1(1), SPRED2(1), SPRY3(1), STAT1(1), STAT3(6), STAT4(3), STAT5A(1), STAT5B(1), STAT6(1), TPO(1), TYK2(1)	54568719	100	66	100	27	25	35	20	6	14	0	0.153	1.000	1.000
506	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(4), ACACB(3), AKT1(1), AKT2(1), ARAF(1), BAD(1), BRAF(6), CBL(1), CRK(1), EXOC7(1), FASN(1), GCK(1), GSK3B(1), HRAS(2), INPP5D(2), IRS1(2), IRS2(2), IRS4(3), MAPK1(1), MAPK10(1), PCK2(2), PDE3B(1), PDPK1(1), PFKM(1), PFKP(1), PHKA1(1), PHKA2(1), PHKB(2), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(3), PPP1R3B(1), PRKAA2(3), PRKACA(1), PRKAG1(2), PRKAG2(1), PRKAG3(1), PRKAR1A(1), PRKAR1B(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(1), PYGL(2), RAF1(1), RAPGEF1(3), SHC1(2), SHC2(1), SHC3(1), SORBS1(2), SOS1(1), TSC2(2)	60372489	104	74	103	27	35	22	19	15	13	0	0.0954	1.000	1.000
507	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BRAF(6), CD48(2), FASLG(1), FCGR3A(1), FCGR3B(1), HLA-G(4), HRAS(2), IFNA10(1), IFNA13(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL2(1), LCP2(1), MAPK1(1), MICB(1), NCR1(1), NFATC1(2), NFATC2(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(1), RAC1(1), RAC2(2), RAF1(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), ULBP3(1), VAV1(2), VAV2(1), VAV3(4), ZAP70(1)	42597630	83	58	81	25	28	18	16	12	9	0	0.282	1.000	1.000
508	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BAD(1), CABIN1(2), CAMK4(2), CD69(1), CDKN1A(2), CEBPB(1), CNR1(1), CREBBP(5), CSNK2A1(1), EGR3(1), EP300(4), FCER1A(1), FCGR3A(1), GSK3A(1), GSK3B(1), HRAS(2), IL4(1), IL6(1), ITK(1), KPNA5(2), MAP2K7(1), MEF2D(2), NFATC1(2), NFATC2(1), NPPB(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(1), SP1(1), SP3(2), TGFB1(1), TNF(1), TRAF2(2), VAV1(2), VAV2(1), VAV3(4), XPO5(1)	34233584	60	48	59	21	21	17	7	5	10	0	0.526	1.000	1.000
509	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(3), ACSL1(1), ACSL4(1), ACSL6(2), ADIPOR1(1), ADIPOR2(1), AKT1(1), AKT2(1), CPT1C(2), IRS1(2), IRS2(2), IRS4(3), JAK1(2), JAK2(2), JAK3(2), LEPR(1), MAPK10(1), NFKB1(2), PCK2(2), POMC(1), PPARA(2), PPARGC1A(2), PRKAA2(3), PRKAG1(2), PRKAG2(1), PRKAG3(1), RELA(1), RXRB(1), RXRG(1), STAT3(6), TNF(1), TRAF2(2), TYK2(1)	31279103	57	40	57	19	19	18	7	5	8	0	0.423	1.000	1.000
510	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG12(1), ALG14(1), B3GNT1(1), B3GNT7(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), B4GALT7(1), CHPF(1), CHST11(1), CHST4(1), CHSY1(1), EXT1(1), EXT2(2), EXTL1(3), EXTL3(2), FUT8(1), GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(1), GALNT4(1), GALNTL2(1), GALNTL5(3), GANAB(1), HS2ST1(1), HS3ST2(1), HS6ST1(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT1(1), MGAT5(1), MGAT5B(3), NDST1(3), NDST2(1), NDST4(4), OGT(1), RPN1(1), ST3GAL1(1), ST6GAL1(1), UST(1), WBSCR17(2), XYLT1(4)	41374662	66	47	66	19	24	19	9	6	8	0	0.256	1.000	1.000
511	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(1), ACTN3(1), AKT1(1), AKT2(1), BAD(1), BCAR1(1), BIRC2(1), BRAF(6), CAV3(1), CCND3(1), COL11A1(6), COL11A2(5), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(5), COL5A2(1), COL5A3(2), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), CRK(1), CTNNB1(9), DIAPH1(1), EGFR(3), ERBB2(1), FLNB(1), FLNC(2), FLT1(1), FN1(2), GSK3B(1), HGF(2), HRAS(2), IGF1R(2), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), KDR(5), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(3), LAMB2(3), LAMB3(1), LAMB4(1), LAMC1(1), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MET(1), MYL2(1), MYL5(1), MYLK(4), MYLK2(2), PAK2(1), PAK6(1), PAK7(1), PARVB(1), PARVG(2), PDGFRA(3), PDGFRB(1), PDPK1(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PRKCA(1), PTEN(13), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAF1(1), RAPGEF1(3), RELN(3), ROCK1(4), ROCK2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), THBS1(4), THBS3(1), THBS4(1), TLN1(2), TLN2(2), TNC(3), TNN(1), TNR(1), TNXB(7), VAV1(2), VAV2(1), VAV3(4), VEGFA(2), VWF(7)	139576371	257	129	253	80	82	72	33	24	46	0	0.177	1.000	1.000
512	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(3), ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(2), ADRA2C(1), ADRB1(1), ADRB2(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(3), CCKBR(1), CHRM3(1), CHRM4(1), CNR1(1), CYSLTR2(1), F2(1), F2RL3(1), FPR1(1), FSHR(1), GABBR2(1), GABRA3(1), GABRB1(3), GABRB2(1), GABRD(1), GABRE(2), GABRG1(4), GABRR2(2), GH2(1), GHR(2), GLP2R(2), GLRA1(2), GLRA2(2), GNRHR(3), GPR156(2), GPR35(1), GPR50(2), GPR83(2), GRIA1(4), GRIA2(3), GRIA3(1), GRIA4(1), GRID1(2), GRID2(4), GRIK1(1), GRIK2(1), GRIK3(2), GRIK4(3), GRIK5(1), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRIN3A(1), GRIN3B(2), GRM1(4), GRM3(1), GRM4(2), GRM5(2), GRM7(1), GRM8(1), GZMA(1), HCRTR2(3), HRH2(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1), LEPR(1), LHCGR(1), MAS1(1), MC4R(1), MCHR1(1), MCHR2(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), P2RX5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY4(2), P2RY6(1), P2RY8(1), PTGER2(1), PTH2R(2), RXFP1(2), RXFP2(1), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR5(1), TAAR1(1), TAAR5(1), TAAR6(1), TAAR9(1), TACR1(1), TACR3(1), TBXA2R(2), THRA(2), TRHR(1), TSHR(1), VIPR1(1)	83349599	179	117	176	56	83	40	14	18	24	0	0.0332	1.000	1.000
513	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY4(2), ADCY7(1), ADCY8(4), ADCY9(2), ADORA2A(1), ADRA1A(1), ADRA1D(1), ADRB1(1), ADRB2(1), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2B1(1), ATP2B2(3), ATP2B3(2), ATP2B4(3), AVPR1B(1), BDKRB1(1), CACNA1A(9), CACNA1B(1), CACNA1C(1), CACNA1D(3), CACNA1E(8), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(2), CACNA1S(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CCKAR(3), CCKBR(1), CD38(1), CHRM3(1), CYSLTR2(1), EGFR(3), ERBB2(1), ERBB3(4), ERBB4(1), GNAL(1), GNAS(2), GRIN1(1), GRIN2A(6), GRIN2C(1), GRM1(4), GRM5(2), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), LHCGR(1), MYLK(4), MYLK2(2), NOS1(2), NOS3(1), P2RX5(2), PDE1B(1), PDE1C(1), PDGFRA(3), PDGFRB(1), PHKA1(1), PHKA2(1), PHKB(2), PLCB1(2), PLCB4(2), PLCD3(1), PLCD4(1), PLCG1(1), PLCG2(1), PLCZ1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKCA(1), PRKX(2), RYR1(7), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(2), TACR1(1), TACR3(1), TBXA2R(2), TRHR(1), VDAC1(1)	101276069	187	115	186	85	76	42	13	17	39	0	0.944	1.000	1.000
514	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN3(1), APC(2), APC2(1), ARAF(1), ARHGEF1(3), ARHGEF6(1), ARPC5(1), ARPC5L(1), BCAR1(1), BDKRB1(1), BRAF(6), CFL1(1), CFL2(1), CHRM3(1), CHRM4(1), CRK(1), CSK(1), CYFIP1(2), CYFIP2(4), DIAPH1(1), DIAPH3(2), EGFR(3), F2(1), FGD1(1), FGD3(1), FGF10(2), FGF13(1), FGF16(1), FGF23(2), FGF3(1), FGF5(1), FGF9(3), FGFR2(3), FGFR3(1), FN1(2), GNA12(1), GSN(2), HRAS(2), IQGAP1(3), IQGAP2(1), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAD(2), ITGAL(3), ITGAM(2), ITGAV(2), ITGAX(1), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), LIMK1(1), LIMK2(3), MAPK1(1), MRAS(1), MSN(1), MYH10(4), MYH9(2), MYL2(1), MYL5(1), MYLK(4), MYLK2(2), NCKAP1L(2), PAK2(1), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(1), PFN2(2), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PTK2(2), PXN(1), RAC1(1), RAC2(2), RAF1(1), ROCK1(4), ROCK2(1), RRAS2(1), SOS1(1), SSH2(6), SSH3(2), TIAM1(3), TIAM2(2), VAV1(2), VAV2(1), VAV3(4), WASF2(1)	103973228	186	114	184	38	61	46	27	24	28	0	0.00183	1.000	1.000
515	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(1), ACVR1C(1), AKT1(1), AKT2(1), ATF2(1), ATF4(1), BRAF(6), CACNA1A(9), CACNA1B(1), CACNA1C(1), CACNA1D(3), CACNA1E(8), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(2), CACNA1S(2), CACNA2D3(1), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNB4(1), CACNG3(1), CACNG4(1), CACNG7(2), CACNG8(1), CDC25B(1), CRK(1), DAXX(1), DUSP16(1), DUSP7(1), DUSP8(2), EGFR(3), FASLG(1), FGF10(2), FGF13(1), FGF16(1), FGF23(2), FGF3(1), FGF5(1), FGF9(3), FGFR2(3), FGFR3(1), FLNB(1), FLNC(2), GNA12(1), HRAS(2), JUND(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(4), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK8IP3(2), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MRAS(1), NF1(1), NFATC2(1), NFKB1(2), NLK(1), NTRK1(3), PAK2(1), PDGFRA(3), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PPP5C(2), PRKACA(1), PRKCA(1), PRKX(2), PTPN5(2), RAC1(1), RAC2(2), RAF1(1), RAPGEF2(1), RASGRF1(2), RASGRF2(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(1), SOS1(1), STK4(2), TAOK1(1), TAOK2(3), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TP53(20), TRAF2(2)	107655946	189	107	185	54	67	38	36	15	33	0	0.141	1.000	1.000
516	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), COL11A1(6), COL11A2(5), COL17A1(1), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(5), COL5A2(1), COL5A3(2), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(3), FN1(2), GJA1(1), GJA4(1), GJA5(2), GJA8(3), GJB5(1), GJC2(1), ITGA6(2), ITGB4(2), KRT1(1), KRT14(1), KRT15(2), KRT16(1), KRT18(1), KRT23(2), KRT24(1), KRT25(3), KRT27(1), KRT31(1), KRT33A(1), KRT38(2), KRT39(1), KRT4(1), KRT6A(1), KRT6C(3), KRT7(1), KRT73(1), KRT75(1), KRT77(1), KRT78(3), KRT79(1), KRT82(1), KRT83(2), KRT84(1), KRT85(1), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(3), LAMB2(3), LAMB3(1), LAMB4(1), LAMC1(1), LAMC2(3), LAMC3(1), LMNA(1), NES(3), RELN(3), THBS1(4), THBS3(1), THBS4(1), TNC(3), TNN(1), TNR(1), TNXB(7), VWF(7)	93616894	159	96	159	55	73	41	13	11	21	0	0.278	1.000	1.000
517	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(2), APC2(1), AXIN2(2), CACYBP(1), CAMK2A(1), CAMK2D(1), CCND3(1), CHD8(1), CREBBP(5), CSNK1A1L(1), CSNK2A1(1), CSNK2A2(1), CTNNB1(9), DAAM2(3), DKK2(2), DVL1(1), DVL2(2), DVL3(1), EP300(4), FBXW11(1), FZD1(2), FZD10(1), FZD2(4), FZD4(2), FZD5(1), FZD6(2), FZD9(1), GSK3B(1), LEF1(1), LRP5(1), LRP6(1), MAP3K7(2), MAPK10(1), NFATC1(2), NFATC2(1), NKD2(1), NLK(1), PLCB1(2), PLCB4(2), PPARD(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(2), PRKACA(1), PRKCA(1), PRKX(2), PSEN1(1), RAC1(1), RAC2(2), ROCK1(4), ROCK2(1), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(1), TP53(20), VANGL2(2), WIF1(2), WNT2(2), WNT5A(1), WNT6(2)	61044720	137	93	132	45	43	33	26	14	21	0	0.441	1.000	1.000
518	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTG1(1), ACTN3(1), AKT1(1), AKT2(1), ASH1L(4), CDK4(1), CGN(1), CLDN15(2), CLDN9(2), CSNK2A1(1), CSNK2A2(1), CTNNA2(4), CTNNA3(1), CTNNB1(9), EPB41L1(1), EPB41L2(1), EPB41L3(8), GNAI1(1), GNAI2(1), HRAS(2), INADL(3), JAM2(1), LLGL2(1), MAGI3(1), MLLT4(2), MPDZ(3), MRAS(1), MYH1(4), MYH10(4), MYH13(4), MYH15(1), MYH2(1), MYH4(5), MYH6(4), MYH7(4), MYH7B(4), MYH8(3), MYH9(2), MYL2(1), MYL5(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(1), PRKCH(1), PRKCZ(2), PTEN(13), RRAS2(1), SPTAN1(1), TJAP1(1), TJP1(4), TJP2(3), TJP3(2), VAPA(1)	72895712	133	87	131	31	43	30	18	15	27	0	0.0319	1.000	1.000
519	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ADRA1A(1), ADRA1D(1), ADRB1(1), ADRB2(1), ATP2A2(1), ATP2B1(1), ATP2B2(3), ATP2B3(2), CACNA1A(9), CACNA1B(1), CACNA1C(1), CACNA1D(3), CACNA1E(8), CACNA1S(2), CACNB1(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CHRM3(1), CHRM4(1), GJA1(1), GJA4(1), GJA5(2), GJB5(1), GNAI2(1), GNAO1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(2), GNGT1(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNB1(3), KCNJ5(2), MIB1(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RGS10(1), RGS11(1), RGS16(2), RGS20(1), RGS6(1), RGS7(1), RGS9(2), RYR1(7), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(2), YWHAQ(1)	70583989	125	83	125	68	55	26	12	9	23	0	0.994	1.000	1.000
520	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), COL11A1(6), COL11A2(5), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(5), COL5A2(1), COL5A3(2), COL6A1(2), COL6A3(7), COL6A6(2), DAG1(2), FN1(2), FNDC1(2), FNDC3A(1), GP5(2), HSPG2(6), ITGA10(1), ITGA11(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(1), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(2), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(3), LAMB2(3), LAMB3(1), LAMB4(1), LAMC1(1), LAMC2(3), LAMC3(1), RELN(3), SDC3(1), SV2A(1), SV2B(1), THBS1(4), THBS3(1), THBS4(1), TNC(3), TNN(1), TNR(1), TNXB(7), VWF(7)	84502110	135	81	135	51	57	38	10	8	22	0	0.505	1.000	1.000
521	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(2), CFL1(1), CFL2(1), DCC(3), DPYSL2(1), DPYSL5(1), EFNB3(1), EPHA3(3), EPHA4(1), EPHA5(1), EPHA6(2), EPHA7(3), EPHB1(3), EPHB2(3), EPHB3(3), FES(2), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(2), L1CAM(3), LIMK1(1), LIMK2(3), LRRC4C(1), MAPK1(1), MET(1), NFATC1(2), NFATC2(1), NGEF(1), NTN1(1), NTNG1(4), PAK2(1), PAK6(1), PAK7(1), PLXNA1(1), PLXNB1(1), PLXNB2(1), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(2), RAC1(1), RAC2(2), RHOD(1), ROBO1(3), ROBO2(3), ROBO3(2), ROCK1(4), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4C(3), SEMA4D(1), SEMA4F(1), SEMA5A(1), SEMA5B(1), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(1), SRGAP1(3), SRGAP3(1), UNC5A(2), UNC5B(4), UNC5D(1)	74203966	122	77	122	34	50	24	17	19	12	0	0.0970	1.000	1.000
522	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM3(2), CD226(1), CD276(1), CD6(1), CD8A(1), CD8B(1), CDH1(3), CDH2(4), CDH3(2), CDH4(3), CDH5(4), CLDN15(2), CLDN9(2), CNTN2(1), CNTNAP1(6), CNTNAP2(1), ESAM(1), GLG1(2), HLA-DRA(1), HLA-F(1), HLA-G(4), ICAM3(1), ITGA6(2), ITGA9(1), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB8(2), JAM2(1), L1CAM(3), MADCAM1(1), MAG(1), NCAM1(1), NCAM2(3), NEO1(1), NFASC(1), NLGN1(2), NRCAM(2), NRXN1(2), NRXN2(3), NRXN3(2), PDCD1(1), PTPRC(3), PTPRF(1), PVRL1(1), SDC3(1), SELE(1), SELP(2), SELPLG(1), SIGLEC1(5), VCAM1(1), VCAN(3)	55452202	102	71	100	31	38	27	11	11	15	0	0.205	1.000	1.000
523	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA1D(1), ADRA2A(2), ADRA2C(1), ADRB1(1), ADRB2(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(3), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CHRM3(1), CHRM4(1), CMKLR1(2), CNR1(1), F2RL3(1), FPR1(1), FSHR(1), GPR17(1), GPR174(1), GPR27(1), GPR35(1), GPR37L1(2), GPR4(1), GPR50(2), GPR83(2), GPR87(1), HCRTR2(3), HRH2(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), OR1F1(1), OR1Q1(1), OR7A5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY6(1), PTGER2(1), SSTR1(1), SSTR2(1), SSTR3(1), TBXA2R(2), TRHR(1)	45682649	89	69	89	33	35	26	9	9	10	0	0.298	1.000	1.000
524	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ATF2(1), ATF4(1), ATP2A2(1), CAMK2A(1), CAMK2D(1), CORIN(2), CREB3(1), DGKZ(1), GJA1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(2), GNGT1(1), GUCY1A3(2), IL6(1), ITPR1(2), ITPR2(3), ITPR3(1), MIB1(1), MYL2(1), MYLK2(2), NFKB1(2), NOS1(2), NOS3(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RAMP2(1), RGS10(1), RGS11(1), RGS16(2), RGS20(1), RGS6(1), RGS7(1), RGS9(2), RYR1(7), RYR2(10), RYR3(5), SLC8A1(1), SP1(1), TNXB(7), YWHAQ(1)	65228068	99	66	99	66	38	23	8	7	23	0	1.000	1.000	1.000
525	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ADRB1(1), EGFR(3), GJA1(1), GNAI1(1), GNAI2(1), GNAS(2), GRM1(4), GRM5(2), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), HRAS(2), HTR2A(3), HTR2B(1), HTR2C(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NPR2(1), PDGFRA(3), PDGFRB(1), PLCB1(2), PLCB4(2), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), SOS1(1), TJP1(4), TUBA1A(1), TUBA3C(3), TUBA3E(2), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(1)	49650221	83	62	82	30	31	17	6	10	19	0	0.581	1.000	1.000
526	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), AK5(1), AMPD1(1), AMPD2(1), AMPD3(1), ATIC(3), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(2), ENTPD6(1), ENTPD8(1), FHIT(1), GART(1), GMPR(1), GMPR2(1), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), NPR2(1), NT5C2(2), NT5M(1), PAPSS2(1), PDE10A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE7A(1), PDE8A(1), PDE8B(1), PNPT1(1), POLA1(1), POLD3(1), POLE(4), POLR1A(4), POLR1B(1), POLR1C(2), POLR2A(2), POLR3A(2), POLR3B(1), PRPS1L1(1), RRM1(2), RRM2B(1)	61319959	79	59	79	39	23	25	6	9	16	0	0.935	1.000	1.000
527	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), CAMK2A(1), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(1), CREBBP(5), CTNNB1(9), DVL1(1), DVL2(2), DVL3(1), EP300(4), FZD1(2), FZD10(1), FZD2(4), FZD4(2), FZD5(1), FZD6(2), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GSK3B(1), HRAS(2), LEF1(1), MAPK1(1), PLCB1(2), PLCB4(2), POMC(1), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), TCF7L1(1), TCF7L2(1), TYRP1(1), WNT2(2), WNT5A(1), WNT6(2)	41069664	80	59	78	43	22	23	14	12	9	0	0.981	1.000	1.000
528	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2A(1), AMY2B(2), ASCC3(1), DDX47(4), DDX50(1), DDX51(1), ENPP1(2), ENPP3(2), ENTPD7(1), ERCC2(2), ERCC3(3), GAA(2), GBE1(2), GCK(1), HK2(1), HK3(2), MGAM(1), PGM1(1), PGM3(1), PYGL(2), RAD54L(1), RUVBL2(1), SETX(1), SKIV2L2(3), SMARCA2(1), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(3), UGT2A1(1), UGT2A3(1), UGT2B10(3), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(1)	46378456	64	52	63	22	14	20	10	7	13	0	0.649	1.000	1.000
529	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), AK5(1), AMPD1(1), AMPD2(1), AMPD3(1), ATIC(3), ATP5A1(2), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(2), FHIT(1), GART(1), GUCY1A2(3), GUCY1A3(2), GUCY2C(2), GUCY2F(2), NPR2(1), NT5M(1), PAPSS2(1), PDE4A(1), PDE4C(1), PDE6B(1), PDE6C(1), PDE8A(1), POLE(4), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), PRPS1L1(1), RRM1(2)	48188590	60	50	60	29	17	15	7	10	11	0	0.926	1.000	1.000
530	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL2(3), CSNK2A1(1), CSNK2A2(1), DGKA(2), DGKB(1), DGKD(2), DGKQ(2), DGKZ(1), IMPA1(1), INPP4A(1), INPPL1(1), ITPKB(2), MAP3K10(4), NEK1(2), OCRL(2), PIK3C2A(1), PIK3C2B(2), PIK3CA(9), PIK3CB(2), PIK3CG(3), PLCB1(2), PLCB4(2), PLCG1(1), PLCG2(1), PLK3(4), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RAF1(1), RPS6KA1(1), RPS6KA4(2), TGFBR1(2), VRK1(1)	42507538	75	49	75	23	22	21	17	6	9	0	0.303	1.000	1.000
531	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), ATF4(1), CACNA1C(1), CACNA1D(3), CACNA1F(1), CACNA1S(2), CAMK2A(1), CAMK2D(1), EGFR(3), GNAS(2), GNRHR(3), HRAS(2), ITPR1(2), ITPR2(3), ITPR3(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(1), MAPK10(1), MMP2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G5(1), PLCB1(2), PLCB4(2), PLD1(2), PRKACA(1), PRKCA(1), PRKX(2), RAF1(1), SOS1(1)	47728612	61	48	61	34	18	18	7	6	12	0	0.991	1.000	1.000
532	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY4(2), ADCY6(2), ADCY7(1), ADCY8(4), ADCY9(2), AKAP1(1), AKAP11(1), AKAP12(4), AKAP3(1), AKAP4(1), AKAP6(2), AKAP8(1), AKAP9(4), ARHGEF1(3), GNA12(1), GNAI2(1), GNAL(1), GNAO1(1), GNB1(1), GNB3(1), GNB5(2), GNGT1(1), HRAS(2), ITPR1(2), PDE1B(1), PDE1C(1), PDE4A(1), PDE4C(1), PDE7A(1), PDE8A(1), PDE8B(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), PRKD3(1)	43927605	62	47	62	35	19	13	9	10	11	0	0.988	1.000	1.000
533	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(1), CARD11(1), CBL(1), CD8A(1), CD8B(1), CDK4(1), HRAS(2), IL4(1), ITK(1), LCP2(1), NFATC1(2), NFATC2(1), NFKB1(2), PAK2(1), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTPRC(3), SOS1(1), TNF(1), VAV1(2), VAV2(1), VAV3(4), ZAP70(1)	38130122	59	44	58	21	19	16	10	7	7	0	0.548	1.000	1.000
534	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA12(3), ABCA13(7), ABCA3(2), ABCA4(5), ABCA5(5), ABCA9(2), ABCB1(4), ABCB10(1), ABCB11(1), ABCB5(2), ABCB6(1), ABCB7(1), ABCC1(1), ABCC10(1), ABCC11(3), ABCC12(2), ABCC3(2), ABCC4(3), ABCC5(2), ABCC6(1), ABCC9(1), ABCD2(1), ABCD3(1), ABCG1(1), ABCG2(1), CFTR(1), TAP1(1), TAP2(1)	44205252	57	43	57	35	16	18	9	6	8	0	0.991	1.000	1.000
535	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(1), C1S(1), C3(1), C3AR1(1), C6(2), C8B(1), C9(1), CD46(2), CD55(1), CFB(3), CFH(6), CPB2(1), CR1(1), F10(1), F11(1), F12(1), F13A1(1), F13B(2), F2(1), F3(1), F5(5), F7(1), F8(2), FGA(2), KLKB1(1), MASP1(1), MASP2(1), PLAT(1), PLAU(2), PLG(2), PROS1(2), SERPIND1(2), VWF(7)	33903267	61	42	61	22	15	21	9	8	8	0	0.707	1.000	1.000
536	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), CCKBR(1), CCR2(1), CELSR1(2), CELSR2(4), CELSR3(4), CHRM3(1), EMR2(4), FSHR(1), GNRHR(3), GPR116(1), GPR132(2), GPR133(2), GPR17(1), GPR18(1), GPR55(1), GPR56(1), GPR84(2), GRM1(4), LPHN2(2), LPHN3(6), OR2M4(1), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2)	25073193	51	40	48	21	23	11	6	6	5	0	0.547	1.000	1.000
537	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(6), DAXX(1), HRAS(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(4), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MEF2D(2), NFKB1(2), PAK2(1), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), SHC1(2), SP1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(2)	35896875	57	39	56	17	18	11	13	7	8	0	0.408	1.000	1.000
538	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(2), CCND3(1), CTNNB1(9), DVL1(1), DVL2(2), DVL3(1), FZD1(2), FZD10(1), FZD2(4), FZD5(1), FZD6(2), FZD9(1), GSK3B(1), LDLR(1), MAPK10(1), PLAU(2), PPP2R5E(1), PRKCA(1), PRKCH(1), PRKCZ(2), PRKD1(2), RAC1(1), WNT2(2), WNT5A(1), WNT6(2)	22662838	45	37	43	19	11	10	11	7	6	0	0.800	1.000	1.000
539	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(1), CXCL9(1), IFNA10(1), IFNA13(1), IL6(1), IRAK1(1), IRAK4(1), IRF3(1), MAP2K4(1), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(1), NFKB1(2), PIK3CA(9), PIK3CB(2), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R3(1), RAC1(1), RELA(1), RIPK1(1), STAT1(1), TLR7(1), TLR9(1), TNF(1)	33732716	44	35	44	19	15	10	9	5	5	0	0.842	1.000	1.000
540	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(9), CACNA1B(1), GNAS(2), GNB1(1), GNB3(1), GRM4(2), ITPR3(1), KCNB1(3), PRKACA(1), PRKX(2), SCNN1B(2), TAS1R2(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R46(1), TAS2R5(1), TRPM5(1)	21466902	42	33	42	19	19	7	4	5	7	0	0.826	1.000	1.000
541	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP5(2), BMP6(1), BMP7(3), CSNK1A1L(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(4), GLI2(2), GLI3(1), GSK3B(1), HHIP(2), LRP2(3), PRKACA(1), PRKX(2), PTCH1(2), PTCH2(4), SHH(2), STK36(1), SUFU(1), WNT2(2), WNT5A(1), WNT6(2)	22934510	42	32	42	24	15	10	6	6	5	0	0.949	1.000	1.000
542	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	CD1B(2), CD1C(1), CD1E(1), CD38(1), CD55(1), CD8A(1), CD8B(1), CR1(1), CSF1R(1), CSF2RA(2), CSF3R(1), FCER2(1), FLT3(1), GP5(2), HLA-DRA(1), IL11RA(1), IL3RA(2), IL4(1), IL4R(1), IL5RA(1), IL6(1), IL7R(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGAM(2), MME(2), TNF(1), TPO(1)	30608575	39	32	39	17	12	15	3	2	7	0	0.746	1.000	1.000
543	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(1), CYP2B6(2), CYP2C19(1), CYP2C8(2), CYP2F1(1), CYP3A7(1), CYP4F8(1), DDC(1), EHHADH(3), KMO(1), KYNU(2), TDO2(1), TPH1(1), WARS(1)	20628695	37	31	37	15	10	11	9	1	6	0	0.735	1.000	1.000
544	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(1), APC(2), ASAH1(2), CAV3(1), DAG1(2), DLG4(1), EPHB2(3), GNAI1(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(2), MAPK1(1), PITX2(1), RAC1(1), RYR1(7)	17249114	32	30	32	12	18	4	2	1	7	0	0.618	1.000	1.000
545	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ATP6V0A1(1), ATP6V0A2(4), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), CSK(1), EGFR(3), JAM2(1), MAP2K4(1), MAPK10(1), MET(1), NFKB1(2), NOD1(1), PLCG1(1), PLCG2(1), RAC1(1), RELA(1), TJP1(4)	26362358	34	27	34	13	7	15	7	2	3	0	0.687	1.000	1.000
546	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), DAXX(1), HRAS(2), MAP2K4(1), MAP3K1(1), MAP3K5(1), MAP3K7(2), MAPKAPK5(1), MEF2C(2), MEF2D(2), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(2), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(2)	13726555	30	27	30	11	11	4	10	4	1	0	0.659	1.000	1.000
547	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(1), ASCC3(1), DDX47(4), DDX50(1), DDX51(1), DHFR(1), ENTPD7(1), ERCC2(2), ERCC3(3), RAD54L(1), RUVBL2(1), SETX(1), SKIV2L2(3), SMARCA2(1), SMARCA5(3)	23588428	28	26	27	15	8	8	4	3	5	0	0.951	1.000	1.000
548	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(2), B3GALNT1(1), B3GALT2(1), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(2), B4GALT6(1), FUT1(1), FUT2(1), FUT3(1), FUT6(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3), PIGT(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1), ST8SIA1(1)	18248225	33	26	33	14	16	6	2	4	4	1	0.747	1.000	1.000
549	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(1), F12(1), F13B(2), F2(1), F5(5), F7(1), F8(2), FGA(2), LPA(1), PLAT(1), PLAU(2), PLG(2), SERPINB2(1), VWF(7)	13200847	30	25	30	15	6	15	4	2	3	0	0.930	1.000	1.000
550	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(1), DDC(1), EHHADH(3), INMT(1), KMO(1), KYNU(2), METTL6(1), PRMT3(1), PRMT5(1), TDO2(1), TPH1(1), WARS(1)	22708350	29	25	28	21	5	11	5	1	7	0	0.995	1.000	1.000
551	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1D(1), ADRA2A(2), ADRA2C(1), ADRB1(1), ADRB2(1), CHRM3(1), CHRM4(1), HRH2(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), HTR7(1)	9659587	26	25	26	11	14	6	2	2	2	0	0.479	1.000	1.000
552	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(4), B3GALT4(1), CDR1(1), DGKI(2), IL6ST(2), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL5(1), RPL8(1), RPS11(2), RPS27A(2), RPS6KA1(1), RPS6KA6(1), UBB(1), UBC(1)	19686362	27	25	27	13	8	5	4	2	8	0	0.974	1.000	1.000
553	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTR3(1), AKT1(1), CFL1(1), CFL2(1), FLNC(2), FSCN2(1), FSCN3(4), LIMK1(1), MYH2(1), MYLK(4), MYLK2(2), PAK2(1), PAK6(1), PAK7(1), PFN2(2), ROCK1(4), ROCK2(1)	17955221	30	25	30	12	8	11	4	5	2	0	0.667	1.000	1.000
554	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), FLT1(1), FLT4(2), KDR(5), NOS3(1), PDE2A(1), PDE3B(1), PRKAR1A(1), PRKAR1B(1), RYR2(10), SYT1(1)	15254353	25	24	25	18	11	8	1	1	4	0	0.982	1.000	1.000
555	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2A(1), CAMK2D(1), F2(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(2), JAK2(2), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(1), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), STAT5A(1), SYT1(1)	15625952	30	23	30	11	9	10	7	3	1	0	0.576	1.000	1.000
556	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), ACAT1(1), AKR1B10(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), BBOX1(1), DOT1L(2), EHHADH(3), EHMT2(1), NSD1(1), PLOD1(2), PLOD3(1), RDH12(1), SETD1A(3), SETDB1(2), SHMT1(3), SHMT2(1)	21817975	28	23	27	12	9	9	4	1	5	0	0.746	1.000	1.000
557	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1B(1), ADH6(1), ALDH1A3(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(1), DDC(1), ESCO1(5), FAH(1), GOT1(1), HGD(1), HPD(1), METTL6(1), PNMT(1), PRMT3(1), PRMT5(1), TPO(1), TYRP1(1)	22283940	25	23	25	11	6	6	1	2	10	0	0.822	1.000	1.000
558	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	AR(1), ESR1(1), HNF4A(1), NR1D2(1), NR1H3(1), NR1I2(2), NR1I3(1), NR2E1(1), NR2F1(1), NR2F2(1), NR5A2(1), PGR(2), PPARA(2), PPARD(1), PPARG(1), RARB(2), ROR1(2), RXRB(1), RXRG(1), THRA(2), VDR(1)	15776963	27	23	27	10	14	4	3	2	4	0	0.514	1.000	1.000
559	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH4A1(1), AOC2(1), ARG2(1), ASL(1), CKB(1), CKMT2(2), DAO(2), GOT1(1), NOS1(2), NOS3(1), P4HA1(4), P4HA2(1), P4HB(1), PYCR1(1)	16632246	26	22	26	18	8	9	3	3	3	0	0.991	1.000	1.000
560	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY9(2), ARF4(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(4), ATP6V0D1(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(1), PRKCA(1), SEC61A1(1), SEC61A2(2), TRIM23(1)	13835611	26	22	26	11	8	7	5	3	3	0	0.767	1.000	1.000
561	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ADH1B(1), ADH6(1), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDH7A1(2), ALDOC(1), DLAT(1), ENO1(2), GCK(1), HK2(1), HK3(2), PDHA2(1), PFKM(1), PFKP(1), PGK2(1), PGM1(1), PGM3(1), TPI1(1)	21856932	24	21	23	11	7	6	4	3	4	0	0.794	1.000	1.000
562	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), CARS2(2), DARS2(1), EPRS(2), FARSB(2), GARS(1), HARS(1), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(2), NARS2(1), QARS(2), TARS(1), TARS2(1), VARS(2), VARS2(2), WARS(1), YARS2(1)	20336063	29	21	29	11	10	6	3	3	7	0	0.805	1.000	1.000
563	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(1), HRAS(2), IL6(1), IL6ST(2), JAK1(2), JAK2(2), JAK3(2), RAF1(1), SHC1(2), SOS1(1), STAT3(6)	8946647	23	21	23	10	5	8	5	1	4	0	0.848	1.000	1.000
564	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), SYT1(1)	9634646	20	20	20	11	6	7	1	5	1	0	0.888	1.000	1.000
565	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(1), ARHGEF11(3), DLG4(1), LPA(1), MAP2K4(1), MAP3K1(1), MAP3K5(1), NFKB1(2), PDK1(1), PHKA2(1), PIK3CB(2), PLD1(2), PTK2(2), ROCK1(4), ROCK2(1), TBXA2R(2)	18395826	27	20	27	14	7	9	3	2	6	0	0.915	1.000	1.000
566	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(1), B4GALT1(2), B4GALT2(2), GAA(2), GALK1(1), GCK(1), HK2(1), HK3(2), LCT(3), MGAM(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH12(1), UGP2(1)	14572472	22	19	22	11	10	5	2	3	2	0	0.788	1.000	1.000
567	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT(1), AKR1B10(1), AMT(1), AOC2(1), CBS(1), CHDH(2), DAO(2), GARS(1), GCAT(1), GLDC(2), RDH12(1), SARDH(2), SHMT1(3), SHMT2(1), TARS(1), TARS2(1)	16048427	23	19	23	10	7	7	1	1	7	0	0.831	1.000	1.000
568	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(1), CKB(1), CKMT2(2), DAO(2), EPRS(2), GOT1(1), NOS1(2), NOS3(1), P4HA1(4), P4HA2(1), PYCR1(1)	13532006	20	19	20	14	7	5	2	3	3	0	0.989	1.000	1.000
569	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ACY3(1), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), ALDH7A1(2), AMDHD1(1), AOC2(1), CNDP1(2), DDC(1), FTCD(1), HARS(1), METTL6(1), PRMT3(1), PRMT5(1), UROC1(3)	14855511	20	18	19	14	7	5	2	1	5	0	0.977	1.000	1.000
570	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(5), CSK(1), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(1)	8627894	18	17	18	12	5	6	2	4	1	0	0.978	1.000	1.000
571	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(5), CSK(1), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(1)	8627894	18	17	18	12	5	6	2	4	1	0	0.978	1.000	1.000
572	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(1), EGFR(3), HRAS(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MAPK1(1), NFKB1(2), PRKCA(1), PRKCH(1), RAF1(1), RELA(1), RIPK1(1), SP1(1), TNF(1), TRAF2(2)	18448692	22	17	22	12	4	10	4	2	2	0	0.906	1.000	1.000
573	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(2), NFATC1(2), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1), RAF1(1), SYT1(1)	13083355	19	16	19	9	4	5	5	5	0	0	0.845	1.000	1.000
574	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), ALDH5A1(1), CAD(3), EPRS(2), GAD2(4), GFPT2(2), GNPNAT1(1), GOT1(1), NAGK(1), QARS(2)	14841788	18	16	18	13	8	4	1	2	3	0	0.989	1.000	1.000
575	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), HRAS(2), JAK1(2), JAK3(2), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1), SYK(2)	8743300	15	15	15	9	6	6	3	0	0	0	0.904	1.000	1.000
576	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), ALDH5A1(1), CAD(3), EPRS(2), GAD2(4), GOT1(1), QARS(2)	12462936	14	14	14	12	6	4	1	1	2	0	0.993	1.000	1.000
577	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAA2(3), PRKAG1(2), PRKAG2(1), PRKAR1A(1), PRKAR1B(1)	5759092	13	12	13	7	3	5	2	3	0	0	0.902	1.000	1.000
578	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(3), GTF2E2(1), POLR1A(4), POLR1B(1), POLR2A(2), POLR3B(1), TAF5(1)	13121486	13	12	12	11	5	4	1	2	1	0	0.993	1.000	1.000
579	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(2), GLI3(1), GSK3B(1), PRKAR1A(1), PRKAR1B(1), SHH(2), SUFU(1)	6275582	12	11	12	11	2	1	2	5	2	0	0.993	1.000	1.000
580	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), HRAS(2), JAK2(2), PLCG1(1), RAF1(1), SHC1(2), SOS1(1), STAT5A(1), STAT5B(1)	8030205	12	10	12	8	5	5	2	0	0	0	0.919	1.000	1.000
581	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSE(2), ASAH1(2), LCT(3), NEU1(1), PPAP2B(1)	9103786	10	9	10	5	5	3	2	0	0	0	0.729	1.000	1.000
582	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDH3B1(1), AOC2(1), CNDP1(2), DDC(1), HARS(1)	9132942	12	9	12	10	3	5	1	1	2	0	0.984	1.000	1.000
583	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ALDH18A1(1), ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), AOC2(1), ARG2(1), ASL(1), SAT2(1)	11052917	10	9	9	11	5	2	1	1	1	0	0.996	1.000	1.000
584	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA1(1), CA14(1), CA2(2), CA3(1), CA6(1), CA8(2), CA9(1)	7951787	10	9	10	7	4	3	0	3	0	0	0.953	1.000	1.000
585	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA1(1), CA14(1), CA2(2), CA3(1), CA6(1), CA8(2), CA9(1)	7111673	10	9	10	7	4	3	0	3	0	0	0.954	1.000	1.000
586	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(2), JAK3(2), PIAS3(2), PTPRU(3)	5176325	11	9	11	5	6	3	2	0	0	0	0.751	1.000	1.000
587	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(4), POLG(1), POLL(1), POLQ(3)	6280018	9	8	9	5	3	3	1	2	0	0	0.864	1.000	1.000
588	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(1), PRKAR1B(1), PRKCA(1)	3605809	7	7	7	5	0	3	1	3	0	0	0.969	1.000	1.000
589	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1), CFTR(1), GNAS(2), PRKAR1A(1), PRKAR1B(1)	4906968	7	7	7	8	0	4	1	2	0	0	0.997	1.000	1.000
590	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(1)	2473523	7	7	7	5	0	4	2	1	0	0	0.959	1.000	1.000
591	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT3(1), GALNT4(1), ST3GAL1(1), WBSCR17(2)	5401342	7	7	7	5	3	1	1	2	0	0	0.942	1.000	1.000
592	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), GNAS(2), PRKAR1A(1), PRKAR1B(1), RAP2B(1)	5537557	7	7	7	7	0	4	1	2	0	0	0.991	1.000	1.000
593	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(1), NCOA1(1), NCOR2(1), POLR2A(2)	9394937	8	7	7	11	5	2	0	0	1	0	0.998	1.000	1.000
594	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	LTA(1), MAP2K4(1), MAP3K1(1), NFKB1(2), RELA(1), RIPK1(1), TNF(1), TRAF2(2)	9091469	10	7	10	6	1	7	1	1	0	0	0.880	1.000	1.000
595	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(1), GOT1(1), ME1(1), ME3(1), TKT(1), TPI1(1)	6783012	6	6	6	4	1	3	0	2	0	0	0.891	1.000	1.000
596	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(1), FUT2(1), FUT3(1)	2700700	6	6	6	4	0	3	0	3	0	0	0.908	1.000	1.000
597	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IL4(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1)	3972874	6	6	6	5	2	2	2	0	0	0	0.951	1.000	1.000
598	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(1), ALDH7A1(2), UGDH(1)	3210279	5	5	4	4	2	1	2	0	0	0	0.933	1.000	1.000
599	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	HLA-DRA(1), PTPRC(3), ZAP70(1)	3382320	5	5	5	4	2	1	1	1	0	0	0.930	1.000	1.000
600	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(1), FUT3(1), FUT6(1)	1906720	4	4	4	3	1	2	0	1	0	0	0.865	1.000	1.000
601	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	ITGAL(3), ITGB2(2)	3286869	5	4	5	5	3	1	0	1	0	0	0.941	1.000	1.000
602	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	IL4(1), ITGAX(1), TLR7(1), TLR9(1)	6968430	4	4	4	3	4	0	0	0	0	0	0.866	1.000	1.000
603	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), NQO1(1), SQLE(1)	4162143	3	3	3	4	3	0	0	0	0	0	0.972	1.000	1.000
604	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	POLR2A(2), PRKAR1A(1), PRKAR1B(1)	4842668	4	3	4	4	2	0	1	1	0	0	0.958	1.000	1.000
605	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(1), APOBEC3B(2)	2744812	3	3	3	3	2	1	0	0	0	0	0.959	1.000	1.000
606	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), IL6(1), LDLR(1)	1995104	3	3	3	3	1	2	0	0	0	0	0.945	1.000	1.000
607	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(1)	2041726	2	2	2	3	1	1	0	0	0	0	0.975	1.000	1.000
608	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGDH(1), UGP2(1)	1839977	2	2	2	2	0	0	1	1	0	0	0.959	1.000	1.000
609	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	689103	1	1	1	2	0	1	0	0	0	0	0.975	1.000	1.000
610	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	1159510	1	1	1	2	0	1	0	0	0	0	0.978	1.000	1.000
611	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1)	1446953	1	1	1	2	0	0	1	0	0	0	0.984	1.000	1.000
612	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		1706638	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		640187	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9		1587635	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		1200781	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		425984	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
