Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.023 0.113 -9999.0 0.0 -0.55 5.0 5.0 IHH 0.013 0.05 -9999.0 0.0 -0.4 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.165 0.226 -9999.0 0.0 -0.461 55.0 55.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.164 0.224 0.458 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.003 0.084 -9999.0 0.0 -0.44 2.0 2.0 SMO -0.009 0.087 -9999.0 0.0 -0.466 2.0 2.0 AKT1 0.011 0.05 -9999.0 0.0 -0.294 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.009 0.075 -9999.0 0.0 -0.282 11.0 11.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.009 0.086 -9999.0 0.0 -0.459 2.0 2.0 STIL -0.107 0.192 -9999.0 0.0 -0.36 55.0 55.0 DHH N/PTCH2 0.006 0.058 -9999.0 0.0 -0.541 1.0 1.0 DHH N/PTCH1 0.021 0.073 -9999.0 0.0 -0.378 3.0 3.0 PIK3CA 0.01 0.023 -9999.0 0.0 -0.282 1.0 1.0 DHH -0.0 0.056 -9999.0 0.0 -0.282 6.0 6.0 PTHLH 0.016 0.147 -9999.0 0.0 -0.694 6.0 6.0 determination of left/right symmetry -0.009 0.086 -9999.0 0.0 -0.459 2.0 2.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.016 0.145 -9999.0 0.0 -0.687 6.0 6.0 IHH N/Hhip -0.008 0.083 -9999.0 0.0 -0.402 2.0 2.0 DHH N/Hhip -0.014 0.072 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.009 0.086 -9999.0 0.0 -0.459 2.0 2.0 pancreas development -0.022 0.094 -9999.0 0.0 -0.282 18.0 18.0 HHAT 0.01 0.023 -9999.0 0.0 -0.282 1.0 1.0 PI3K 0.016 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.049 0.128 -9999.0 0.0 -0.296 31.0 31.0 somite specification -0.009 0.086 -9999.0 0.0 -0.459 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.115 0.202 -9999.0 0.0 -0.382 55.0 55.0 SHH Np/Cholesterol/PTCH2 -0.139 0.214 -9999.0 0.0 -0.429 55.0 55.0 SHH Np/Cholesterol/Megalin -0.175 0.244 -9999.0 0.0 -0.463 62.0 62.0 SHH -0.178 0.267 -9999.0 0.0 -0.544 54.0 54.0 catabolic process 0.023 0.072 -9999.0 0.0 -0.436 2.0 2.0 SMO/Vitamin D3 -0.101 0.191 -9999.0 0.0 -0.453 4.0 4.0 SHH Np/Cholesterol/Hhip -0.152 0.213 -9999.0 0.0 -0.438 54.0 54.0 LRP2 -0.054 0.2 -9999.0 0.0 -0.717 13.0 13.0 receptor-mediated endocytosis -0.11 0.195 -9999.0 0.0 -0.524 9.0 9.0 SHH Np/Cholesterol/BOC -0.146 0.216 -9999.0 0.0 -0.438 54.0 54.0 SHH Np/Cholesterol/CDO -0.137 0.215 -9999.0 0.0 -0.431 54.0 54.0 mesenchymal cell differentiation 0.151 0.211 0.435 54.0 -9999.0 0.0 54.0 mol:Vitamin D3 -0.113 0.202 -9999.0 0.0 -0.38 55.0 55.0 IHH N/PTCH2 0.014 0.058 -9999.0 0.0 -0.587 1.0 1.0 CDON 0.01 0.023 -9999.0 0.0 -0.282 1.0 1.0 IHH N/PTCH1 0.026 0.073 -9999.0 0.0 -0.44 2.0 2.0 Megalin/LRPAP1 -0.033 0.153 -9999.0 0.0 -0.541 13.0 13.0 PTCH2 0.007 0.058 -9999.0 0.0 -0.717 1.0 1.0 SHH Np/Cholesterol -0.142 0.212 -9999.0 0.0 -0.434 54.0 54.0 PTCH1 0.023 0.072 -9999.0 0.0 -0.438 2.0 2.0 HHIP -0.022 0.094 -9999.0 0.0 -0.282 18.0 18.0