Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.012 0.075 -9999.0 0.0 -0.405 4.0 4.0 IHH 0.03 0.021 -9999.0 0.0 -0.116 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.062 0.111 0.186 3.0 -0.179 66.0 69.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.061 0.11 0.178 66.0 -0.185 3.0 69.0 SMO/beta Arrestin2 0.014 0.071 -9999.0 0.0 -0.299 4.0 4.0 SMO -0.001 0.061 -9999.0 0.0 -0.303 5.0 5.0 AKT1 -0.005 0.101 -9999.0 0.0 -0.351 8.0 8.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.0 0.061 -9999.0 0.0 -0.3 5.0 5.0 STIL -0.031 0.097 0.192 10.0 -0.232 5.0 15.0 DHH N/PTCH2 0.029 0.046 -9999.0 0.0 -0.18 7.0 7.0 DHH N/PTCH1 0.025 0.063 -9999.0 0.0 -0.287 4.0 4.0 PIK3CA 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.004 0.108 -9999.0 0.0 -0.617 4.0 4.0 determination of left/right symmetry -0.0 0.061 -9999.0 0.0 -0.3 5.0 5.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.004 0.107 -9999.0 0.0 -0.611 4.0 4.0 IHH N/Hhip 0.011 0.081 -9999.0 0.0 -0.208 17.0 17.0 DHH N/Hhip 0.007 0.074 -9999.0 0.0 -0.173 22.0 22.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.0 0.061 -9999.0 0.0 -0.3 5.0 5.0 pancreas development 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.019 -9999.0 0.0 -0.174 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.019 0.028 -9999.0 0.0 -0.307 1.0 1.0 somite specification -0.0 0.061 -9999.0 0.0 -0.3 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.032 0.09 0.188 3.0 -0.23 6.0 9.0 SHH Np/Cholesterol/PTCH2 -0.036 0.094 0.186 3.0 -0.165 51.0 54.0 SHH Np/Cholesterol/Megalin -0.049 0.105 0.177 4.0 -0.179 57.0 61.0 SHH -0.07 0.118 0.34 4.0 -0.217 50.0 54.0 catabolic process 0.018 0.055 -9999.0 0.0 -0.289 4.0 4.0 SMO/Vitamin D3 -0.03 0.086 0.186 3.0 -0.274 4.0 7.0 SHH Np/Cholesterol/Hhip -0.05 0.099 0.186 3.0 -0.164 62.0 65.0 LRP2 -0.023 0.089 -9999.0 0.0 -0.307 13.0 13.0 receptor-mediated endocytosis -0.035 0.086 0.173 2.0 -0.281 5.0 7.0 SHH Np/Cholesterol/BOC -0.045 0.1 0.186 3.0 -0.169 56.0 59.0 SHH Np/Cholesterol/CDO -0.035 0.093 0.186 3.0 -0.164 50.0 53.0 mesenchymal cell differentiation 0.05 0.099 0.164 62.0 -0.185 3.0 65.0 mol:Vitamin D3 -0.025 0.103 0.206 10.0 -0.239 5.0 15.0 IHH N/PTCH2 0.034 0.04 -9999.0 0.0 -0.192 4.0 4.0 CDON 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.028 0.058 -9999.0 0.0 -0.291 4.0 4.0 Megalin/LRPAP1 0.014 0.07 -9999.0 0.0 -0.214 13.0 13.0 PTCH2 0.024 0.027 -9999.0 0.0 -0.307 1.0 1.0 SHH Np/Cholesterol -0.044 0.082 -9999.0 0.0 -0.16 50.0 50.0 PTCH1 0.018 0.055 -9999.0 0.0 -0.29 4.0 4.0 HHIP 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0