Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Reelin signaling pathway	32.0	1846.0	56.0	-0.224	0.074	1000.0	-1000.0	-0.035	-1000.0
TCGA08_retinoblastoma	26.0	213.0	8.0	-0.06	0.047	1000.0	-1000.0	-0.005	-1000.0
Signaling events regulated by Ret tyrosine kinase	23.0	1940.0	82.0	-0.104	0.036	1000.0	-1000.0	-0.048	-1000.0
Ephrin A  reverse signaling	21.0	150.0	7.0	-0.052	0.017	1000.0	-1000.0	-0.017	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	20.0	1124.0	54.0	-0.199	0.036	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	20.0	1854.0	91.0	-0.61	0.45	1000.0	-1000.0	-0.141	-1000.0
Glypican 1 network	18.0	890.0	48.0	-0.131	0.053	1000.0	-1000.0	-0.03	-1000.0
Fc-epsilon receptor I signaling in mast cells	16.0	1647.0	97.0	-0.133	0.05	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by the Hedgehog family	15.0	798.0	52.0	-0.07	0.061	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1193.0	78.0	-0.199	0.052	1000.0	-1000.0	-0.053	-1000.0
p75(NTR)-mediated signaling	14.0	1753.0	125.0	-0.327	0.07	1000.0	-1000.0	-0.064	-1000.0
HIF-1-alpha transcription factor network	13.0	995.0	76.0	-0.414	0.034	1000.0	-1000.0	-0.139	-1000.0
IL1-mediated signaling events	13.0	847.0	62.0	-0.068	0.096	1000.0	-1000.0	-0.055	-1000.0
FOXA2 and FOXA3 transcription factor networks	12.0	556.0	46.0	-0.41	0.03	1000.0	-1000.0	-0.124	-1000.0
BCR signaling pathway	12.0	1218.0	99.0	-0.145	0.03	1000.0	-1000.0	-0.049	-1000.0
BMP receptor signaling	11.0	901.0	81.0	-0.082	0.051	1000.0	-1000.0	-0.045	-1000.0
PDGFR-beta signaling pathway	11.0	1084.0	97.0	-0.101	0.092	1000.0	-1000.0	-0.055	-1000.0
Visual signal transduction: Rods	11.0	574.0	52.0	-0.089	0.04	1000.0	-1000.0	-0.032	-1000.0
Syndecan-1-mediated signaling events	10.0	355.0	34.0	-0.303	0.036	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	10.0	414.0	38.0	-0.057	0.041	1000.0	-1000.0	-0.026	-1000.0
TCGA08_p53	10.0	76.0	7.0	-0.057	0.028	1000.0	-1000.0	-0.011	-1000.0
LPA receptor mediated events	10.0	1030.0	102.0	-0.142	0.035	1000.0	-1000.0	-0.047	-1000.0
Syndecan-2-mediated signaling events	9.0	657.0	69.0	-0.141	0.045	1000.0	-1000.0	-0.043	-1000.0
Plasma membrane estrogen receptor signaling	9.0	839.0	86.0	-0.276	0.08	1000.0	-1000.0	-0.047	-1000.0
VEGFR1 specific signals	9.0	544.0	56.0	-0.002	0.104	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	9.0	862.0	88.0	-0.087	0.042	1000.0	-1000.0	-0.062	-1000.0
Endothelins	8.0	774.0	96.0	-0.274	0.061	1000.0	-1000.0	-0.054	-1000.0
Nongenotropic Androgen signaling	8.0	436.0	52.0	-0.112	0.052	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	7.0	540.0	76.0	-0.168	0.067	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	119.0	17.0	-0.128	0.05	1000.0	-1000.0	-0.027	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	448.0	61.0	-0.167	0.086	1000.0	-1000.0	-0.036	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	682.0	93.0	-0.043	0.043	1000.0	-1000.0	-0.044	-1000.0
Canonical Wnt signaling pathway	7.0	381.0	51.0	-0.167	0.097	1000.0	-1000.0	-0.04	-1000.0
EPHB forward signaling	7.0	621.0	85.0	-0.042	0.086	1000.0	-1000.0	-0.06	-1000.0
Effects of Botulinum toxin	7.0	193.0	26.0	-0.065	0.049	1000.0	-1000.0	-0.01	-1000.0
Wnt signaling	7.0	54.0	7.0	-0.048	0.023	1000.0	-1000.0	-0.015	-1000.0
IGF1 pathway	7.0	423.0	57.0	-0.038	0.052	1000.0	-1000.0	-0.053	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	130.0	17.0	-0.058	0.045	1000.0	-1000.0	-0.027	-1000.0
amb2 Integrin signaling	6.0	535.0	82.0	-0.084	0.037	1000.0	-1000.0	-0.032	-1000.0
Nectin adhesion pathway	6.0	380.0	63.0	-0.279	0.071	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	287.0	44.0	-0.032	0.035	1000.0	-1000.0	-0.027	-1000.0
IL23-mediated signaling events	6.0	407.0	60.0	-0.171	0.04	1000.0	-1000.0	-0.096	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	750.0	120.0	-0.077	0.074	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by PRL	6.0	233.0	34.0	-0.064	0.087	1000.0	-1000.0	-0.036	-1000.0
Caspase cascade in apoptosis	5.0	376.0	74.0	-0.066	0.061	1000.0	-1000.0	-0.033	-1000.0
Osteopontin-mediated events	5.0	205.0	38.0	-0.063	0.039	1000.0	-1000.0	-0.048	-1000.0
Thromboxane A2 receptor signaling	5.0	573.0	105.0	-0.094	0.053	1000.0	-1000.0	-0.048	-1000.0
Ceramide signaling pathway	5.0	425.0	76.0	-0.032	0.069	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	276.0	52.0	-0.125	0.06	1000.0	-1000.0	-0.038	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	165.0	31.0	-0.169	0.027	1000.0	-1000.0	-0.038	-1000.0
Regulation of Androgen receptor activity	5.0	378.0	70.0	-0.228	0.051	1000.0	-1000.0	-0.046	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	167.0	34.0	-0.023	0.061	1000.0	-1000.0	-0.027	-1000.0
IL12-mediated signaling events	4.0	366.0	87.0	-0.067	0.054	1000.0	-1000.0	-0.076	-1000.0
Noncanonical Wnt signaling pathway	4.0	128.0	26.0	-0.048	0.048	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	4.0	297.0	62.0	-0.041	0.062	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	4.0	379.0	85.0	-0.009	0.057	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	280.0	68.0	-0.056	0.068	1000.0	-1000.0	-0.032	-1000.0
S1P5 pathway	4.0	69.0	17.0	-0.071	0.059	1000.0	-1000.0	-0.014	-1000.0
HIF-2-alpha transcription factor network	4.0	193.0	43.0	-0.209	0.1	1000.0	-1000.0	-0.069	-1000.0
S1P1 pathway	4.0	153.0	36.0	-0.071	0.032	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	4.0	163.0	35.0	-0.141	0.07	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	4.0	393.0	84.0	-0.081	0.063	1000.0	-1000.0	-0.046	-1000.0
EGFR-dependent Endothelin signaling events	4.0	99.0	21.0	-0.037	0.038	1000.0	-1000.0	-0.037	-1000.0
Syndecan-4-mediated signaling events	4.0	325.0	67.0	-0.122	0.065	1000.0	-1000.0	-0.033	-1000.0
S1P3 pathway	4.0	207.0	42.0	-0.07	0.044	1000.0	-1000.0	-0.032	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	142.0	33.0	-0.058	0.063	1000.0	-1000.0	-0.026	-1000.0
S1P4 pathway	4.0	103.0	25.0	-0.07	0.044	1000.0	-1000.0	-0.023	-1000.0
Aurora B signaling	4.0	332.0	67.0	-0.42	0.1	1000.0	-1000.0	-0.034	-1000.0
ErbB2/ErbB3 signaling events	3.0	202.0	65.0	-0.034	0.039	1000.0	-1000.0	-0.053	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	511.0	136.0	-0.276	0.054	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by PTP1B	3.0	272.0	76.0	-0.104	0.049	1000.0	-1000.0	-0.034	-1000.0
EPO signaling pathway	3.0	214.0	55.0	-0.011	0.062	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	3.0	171.0	53.0	-0.065	0.034	1000.0	-1000.0	-0.033	-1000.0
Glucocorticoid receptor regulatory network	3.0	389.0	114.0	-0.165	0.105	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	3.0	150.0	48.0	-0.023	0.036	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	3.0	178.0	47.0	-0.026	0.044	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	58.0	15.0	-0.063	0.026	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	3.0	226.0	58.0	-0.137	0.049	1000.0	-1000.0	-0.037	-1000.0
Regulation of p38-alpha and p38-beta	3.0	174.0	54.0	-0.05	0.052	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	233.0	76.0	-0.014	0.089	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events	3.0	284.0	73.0	-0.035	0.04	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	2.0	97.0	39.0	-0.019	0.032	1000.0	-1000.0	-0.018	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	219.0	85.0	-0.021	0.06	1000.0	-1000.0	-0.041	-1000.0
Insulin-mediated glucose transport	2.0	85.0	32.0	-0.134	0.045	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	2.0	102.0	44.0	-0.013	0.066	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	2.0	167.0	68.0	-0.043	0.045	1000.0	-1000.0	-0.053	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	87.0	37.0	-0.014	0.064	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class III	2.0	95.0	40.0	-0.048	0.051	1000.0	-1000.0	-0.026	-1000.0
TRAIL signaling pathway	2.0	98.0	48.0	-0.017	0.051	1000.0	-1000.0	-0.027	-1000.0
ceramide signaling pathway	2.0	113.0	49.0	-0.001	0.041	1000.0	-1000.0	-0.029	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	181.0	83.0	-0.096	0.066	1000.0	-1000.0	-0.036	-1000.0
FoxO family signaling	2.0	140.0	64.0	-0.025	0.071	1000.0	-1000.0	-0.058	-1000.0
Atypical NF-kappaB pathway	2.0	64.0	31.0	-0.011	0.058	1000.0	-1000.0	-0.025	-1000.0
Glypican 2 network	2.0	9.0	4.0	0.022	0.032	1000.0	-1000.0	0.012	-1000.0
IL6-mediated signaling events	2.0	183.0	75.0	-0.039	0.116	1000.0	-1000.0	-0.064	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	2.0	176.0	68.0	-0.169	0.035	1000.0	-1000.0	-0.096	-1000.0
Arf6 trafficking events	2.0	207.0	71.0	-0.047	0.048	1000.0	-1000.0	-0.026	-1000.0
FOXM1 transcription factor network	2.0	131.0	51.0	-0.12	0.048	1000.0	-1000.0	-0.178	-1000.0
LPA4-mediated signaling events	1.0	15.0	12.0	-0.013	-0.0	1000.0	-1000.0	-0.018	-1000.0
ErbB4 signaling events	1.0	111.0	69.0	-0.11	0.076	1000.0	-1000.0	-0.041	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	42.0	28.0	-0.064	0.044	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	5.0	5.0	0.026	0.037	1000.0	-1000.0	0.01	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	71.0	65.0	-0.066	0.047	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	1.0	75.0	43.0	-0.028	0.041	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class I	1.0	136.0	104.0	-0.052	0.063	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	1.0	103.0	58.0	-0.009	0.042	1000.0	-1000.0	-0.043	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	84.0	45.0	-0.016	0.067	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	200.0	125.0	-0.016	0.096	1000.0	-1000.0	-0.053	-1000.0
IL27-mediated signaling events	1.0	64.0	51.0	-0.042	0.062	1000.0	-1000.0	-0.052	-1000.0
TCGA08_rtk_signaling	1.0	47.0	26.0	-0.024	0.061	1000.0	-1000.0	-0.018	-1000.0
Regulation of Telomerase	1.0	201.0	102.0	-0.152	0.064	1000.0	-1000.0	-0.063	-1000.0
Insulin Pathway	1.0	130.0	74.0	-0.016	0.085	1000.0	-1000.0	-0.052	-1000.0
Rapid glucocorticoid signaling	1.0	22.0	20.0	-0.015	0.031	1000.0	-1000.0	-0.013	-1000.0
p38 MAPK signaling pathway	1.0	67.0	44.0	-0.007	0.056	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	1.0	101.0	54.0	-0.006	0.05	1000.0	-1000.0	-0.018	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	0.009	0.035	1000.0	-1000.0	-0.024	-1000.0
Canonical NF-kappaB pathway	0.0	22.0	39.0	-0.011	0.055	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class II	0.0	51.0	75.0	-0.015	0.07	1000.0	-1000.0	-0.028	-1000.0
BARD1 signaling events	0.0	34.0	57.0	-0.056	0.072	1000.0	-1000.0	-0.036	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.014	0.026	1000.0	-1000.0	-0.03	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.008	0.058	1000.0	-1000.0	-0.028	-1000.0
Aurora A signaling	0.0	22.0	60.0	-0.008	0.074	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.043	1000.0	-1000.0	-0.011	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.051	0.054	1000.0	-1000.0	-0.031	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	67.0	74.0	-0.053	0.065	1000.0	-1000.0	-0.061	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.016	0.048	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by STAT5	0.0	15.0	22.0	-0.006	0.033	1000.0	-1000.0	-0.033	-1000.0
E-cadherin signaling in keratinocytes	0.0	21.0	43.0	-0.042	0.08	1000.0	-1000.0	-0.035	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.026	0.026	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.026	0.052	1000.0	-1000.0	0.009	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.073	1000.0	-1000.0	0.0	-1000.0
Total	694	44906	7203	-11.5500316688	7.56488569396	131000	-131000	-5.16071333489	-131000