Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.151 0.123 -9999.0 0.0 -0.237 46.0 46.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.15 0.122 0.236 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 0.046 0.052 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.007 0.107 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.128 -9999.0 0.0 -0.422 6.0 6.0 ADRBK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.0 0.075 0.353 1.0 -9999.0 0.0 1.0 DHH N/PTCH2 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.051 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.031 0.159 -9999.0 0.0 -0.333 15.0 15.0 DHH N/Hhip -0.03 0.144 -9999.0 0.0 -0.303 15.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.066 0.187 -9999.0 0.0 -0.422 15.0 15.0 HHAT 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.048 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.297 0.203 -9999.0 0.0 -0.422 50.0 50.0 somite specification 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.031 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.025 0.02 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.024 0.024 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.016 0.016 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.029 0.033 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.031 0.112 -9999.0 0.0 -0.242 15.0 15.0 LRP2 0.03 0.023 -9999.0 0.0 -0.157 1.0 1.0 receptor-mediated endocytosis 0.024 0.028 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.008 0.075 -9999.0 0.0 -0.259 5.0 5.0 SHH Np/Cholesterol/CDO 0.017 0.049 -9999.0 0.0 -0.234 2.0 2.0 mesenchymal cell differentiation 0.031 0.112 0.241 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 0.043 0.06 0.375 1.0 -9999.0 0.0 1.0 IHH N/PTCH2 0.053 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.019 0.076 -9999.0 0.0 -0.422 2.0 2.0 IHH N/PTCH1 0.048 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.066 0.188 -9999.0 0.0 -0.422 15.0 15.0