E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.127 -9999.0 0.0 -0.363 13.0 13.0 KLHL20 -0.011 0.07 -9999.0 0.0 -0.188 5.0 5.0 CYFIP2 -0.028 0.102 -9999.0 0.0 -0.268 15.0 15.0 Rac1/GDP -0.006 0.079 -9999.0 0.0 -0.2 13.0 13.0 ENAH -0.039 0.128 -9999.0 0.0 -0.363 13.0 13.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.008 0.033 -9999.0 0.0 -0.224 2.0 2.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.024 0.041 -9999.0 0.0 -0.19 1.0 1.0 ABI1/Sra1/Nap1 -0.028 0.041 -9999.0 0.0 -0.127 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.035 0.082 -9999.0 0.0 -0.178 16.0 16.0 RAPGEF1 -0.025 0.112 -9999.0 0.0 -0.313 13.0 13.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.042 0.13 -9999.0 0.0 -0.377 13.0 13.0 CRK -0.031 0.12 -9999.0 0.0 -0.34 13.0 13.0 E-cadherin/gamma catenin/alpha catenin -0.041 0.085 -9999.0 0.0 -0.194 15.0 15.0 alphaE/beta7 Integrin 0.006 0.049 -9999.0 0.0 -0.169 7.0 7.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.02 0.025 -9999.0 0.0 -0.174 1.0 1.0 DLG1 -0.037 0.127 -9999.0 0.0 -0.363 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.018 0.031 -9999.0 0.0 -0.136 1.0 1.0 MLLT4 0.009 0.036 -9999.0 0.0 -0.356 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.006 0.055 -9999.0 0.0 -0.174 8.0 8.0 PI3K -0.022 0.038 -9999.0 0.0 -0.172 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.06 0.1 -9999.0 0.0 -0.177 41.0 41.0 TIAM1 -0.021 0.103 -9999.0 0.0 -0.329 10.0 10.0 E-cadherin(dimer)/Ca2+ -0.024 0.071 -9999.0 0.0 -0.158 13.0 13.0 AKT1 0.005 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.01 0.023 -9999.0 0.0 -0.224 1.0 1.0 CDH1 -0.094 0.141 -9999.0 0.0 -0.268 39.0 39.0 RhoA/GDP -0.005 0.079 -9999.0 0.0 -0.199 13.0 13.0 actin cytoskeleton organization -0.007 0.053 -9999.0 0.0 -0.138 5.0 5.0 CDC42/GDP -0.005 0.079 -9999.0 0.0 -0.199 13.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.028 0.07 -9999.0 0.0 -0.184 15.0 15.0 ITGB7 -0.004 0.067 -9999.0 0.0 -0.268 6.0 6.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.025 0.076 -9999.0 0.0 -0.169 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.03 0.069 -9999.0 0.0 -0.162 13.0 13.0 mol:GDP -0.013 0.088 -9999.0 0.0 -0.231 13.0 13.0 CDC42/GTP/IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.005 0.051 -9999.0 0.0 -0.356 2.0 2.0 p120 catenin/RhoA/GDP -0.005 0.08 -9999.0 0.0 -0.202 13.0 13.0 RAC1/GTP/IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.058 -9999.0 0.0 -0.153 12.0 12.0 NME1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.037 0.127 -9999.0 0.0 -0.363 13.0 13.0 regulation of cell-cell adhesion -0.022 0.037 -9999.0 0.0 -0.169 1.0 1.0 WASF2 -0.012 0.024 -9999.0 0.0 -0.1 1.0 1.0 Rap1/GTP -0.007 0.061 -9999.0 0.0 -0.215 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.079 -9999.0 0.0 -0.161 18.0 18.0 CCND1 -0.015 0.071 -9999.0 0.0 -0.188 12.0 12.0 VAV2 -0.027 0.121 -9999.0 0.0 -0.337 13.0 13.0 RAP1/GDP -0.007 0.067 -9999.0 0.0 -0.233 1.0 1.0 adherens junction assembly -0.036 0.123 -9999.0 0.0 -0.353 13.0 13.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.025 0.075 -9999.0 0.0 -0.205 2.0 2.0 E-cadherin/beta catenin -0.046 0.094 -9999.0 0.0 -0.275 13.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.037 0.127 -9999.0 0.0 -0.363 13.0 13.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.047 0.091 -9999.0 0.0 -0.287 6.0 6.0 E-cadherin/beta catenin/alpha catenin -0.037 0.082 -9999.0 0.0 -0.194 13.0 13.0 ITGAE 0.01 0.023 -9999.0 0.0 -0.224 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.043 0.133 -9999.0 0.0 -0.385 13.0 13.0