E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.038 0.142 -9999.0 0.0 -0.308 20.0 20.0 KLHL20 -0.009 0.08 0.174 5.0 -0.185 3.0 8.0 CYFIP2 0.024 0.011 -9999.0 0.0 0.0 18.0 18.0 Rac1/GDP 0.004 0.1 0.24 3.0 -0.213 7.0 10.0 ENAH -0.037 0.14 -9999.0 0.0 -0.297 22.0 22.0 AP1M1 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 RAP1B 0.025 0.01 -9999.0 0.0 0.0 15.0 15.0 RAP1A 0.029 0.003 -9999.0 0.0 0.0 1.0 1.0 CTNNB1 0.029 0.003 -9999.0 0.0 0.0 1.0 1.0 CDC42/GTP -0.014 0.056 0.125 2.0 -9999.0 0.0 2.0 ABI1/Sra1/Nap1 -0.029 0.039 -9999.0 0.0 -0.125 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.075 -9999.0 0.0 -0.146 12.0 12.0 RAPGEF1 -0.03 0.134 0.217 4.0 -0.286 17.0 21.0 CTNND1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.037 0.15 -9999.0 0.0 -0.302 24.0 24.0 CRK -0.029 0.128 -9999.0 0.0 -0.299 17.0 17.0 E-cadherin/gamma catenin/alpha catenin 0.025 0.075 -9999.0 0.0 -0.155 14.0 14.0 alphaE/beta7 Integrin 0.03 0.033 -9999.0 0.0 -0.17 2.0 2.0 IQGAP1 0.027 0.007 -9999.0 0.0 0.0 6.0 6.0 NCKAP1 0.029 0.003 -9999.0 0.0 0.0 1.0 1.0 Rap1/GTP/I-afadin 0.044 0.028 -9999.0 0.0 -0.14 1.0 1.0 DLG1 -0.04 0.144 -9999.0 0.0 -0.308 21.0 21.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.034 -9999.0 0.0 -0.116 8.0 8.0 MLLT4 0.027 0.007 -9999.0 0.0 0.0 6.0 6.0 ARF6/GTP/NME1/Tiam1 0.036 0.053 -9999.0 0.0 -0.138 8.0 8.0 PI3K -0.026 0.044 -9999.0 0.0 -0.145 8.0 8.0 ARF6 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.003 0.073 -9999.0 0.0 -0.181 14.0 14.0 TIAM1 0.025 0.01 -9999.0 0.0 0.0 15.0 15.0 E-cadherin(dimer)/Ca2+ 0.038 0.069 -9999.0 0.0 -0.136 12.0 12.0 AKT1 -0.006 0.046 0.115 3.0 -9999.0 0.0 3.0 PIK3R1 0.028 0.004 -9999.0 0.0 0.0 2.0 2.0 CDH1 0.015 0.014 -9999.0 0.0 0.0 48.0 48.0 RhoA/GDP 0.003 0.105 0.231 4.0 -0.211 8.0 12.0 actin cytoskeleton organization -0.002 0.07 0.171 6.0 -0.147 2.0 8.0 CDC42/GDP 0.004 0.104 0.231 4.0 -0.213 8.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.003 0.069 -9999.0 0.0 -0.172 14.0 14.0 ITGB7 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 RAC1 0.026 0.009 -9999.0 0.0 0.0 10.0 10.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.041 0.074 -9999.0 0.0 -0.146 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.026 0.061 -9999.0 0.0 -0.131 12.0 12.0 mol:GDP -0.01 0.109 0.233 4.0 -0.238 8.0 12.0 CDC42/GTP/IQGAP1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.005 -9999.0 0.0 0.0 3.0 3.0 p120 catenin/RhoA/GDP 0.01 0.11 0.237 4.0 -0.217 8.0 12.0 RAC1/GTP/IQGAP1 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 0.0 2.0 2.0 CDC42 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 CTNNA1 0.028 0.005 -9999.0 0.0 0.0 3.0 3.0 positive regulation of S phase of mitotic cell cycle -0.007 0.056 0.139 3.0 -0.122 10.0 13.0 NME1 0.028 0.004 -9999.0 0.0 0.0 2.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.14 -9999.0 0.0 -0.304 20.0 20.0 regulation of cell-cell adhesion -0.018 0.043 -9999.0 0.0 -0.13 8.0 8.0 WASF2 -0.006 0.036 0.078 7.0 -0.075 4.0 11.0 Rap1/GTP -0.007 0.066 0.169 3.0 -9999.0 0.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.041 0.082 -9999.0 0.0 -0.139 14.0 14.0 CCND1 -0.01 0.066 0.158 3.0 -0.148 10.0 13.0 VAV2 -0.038 0.171 -9999.0 0.0 -0.576 3.0 3.0 RAP1/GDP 0.01 0.08 0.221 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.035 0.137 -9999.0 0.0 -0.296 20.0 20.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 PIP5K1C 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 regulation of heterotypic cell-cell adhesion 0.026 0.073 0.186 1.0 -0.138 14.0 15.0 E-cadherin/beta catenin -0.009 0.082 -9999.0 0.0 -0.252 10.0 10.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.146 -9999.0 0.0 -0.299 24.0 24.0 PIK3CA 0.028 0.005 -9999.0 0.0 0.0 3.0 3.0 Rac1/GTP -0.045 0.089 -9999.0 0.0 -0.288 4.0 4.0 E-cadherin/beta catenin/alpha catenin 0.029 0.072 -9999.0 0.0 -0.157 12.0 12.0 ITGAE 0.025 0.01 -9999.0 0.0 0.0 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.038 0.153 -9999.0 0.0 -0.308 24.0 24.0