Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.002 0.067 -9999.0 0.0 -0.165 12.0 12.0 epithelial cell differentiation 0.033 0.066 -9999.0 0.0 -0.135 12.0 12.0 CYFIP2 0.024 0.011 -9999.0 0.0 0.0 18.0 18.0 ENAH -0.014 0.062 0.19 3.0 -9999.0 0.0 3.0 EGFR 0.025 0.009 -9999.0 0.0 0.0 12.0 12.0 EPHA2 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 MYO6 -0.008 0.064 0.19 3.0 -9999.0 0.0 3.0 CTNNB1 0.029 0.003 -9999.0 0.0 0.0 1.0 1.0 ABI1/Sra1/Nap1 0.049 0.04 -9999.0 0.0 -0.157 3.0 3.0 AQP5 -0.03 0.128 0.269 1.0 -0.366 11.0 12.0 CTNND1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.008 0.064 0.189 3.0 -9999.0 0.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.062 0.189 3.0 -9999.0 0.0 3.0 EGF 0.019 0.012 -9999.0 0.0 0.0 28.0 28.0 NCKAP1 0.029 0.003 -9999.0 0.0 0.0 1.0 1.0 AQP3 -0.012 0.092 0.269 1.0 -0.312 6.0 7.0 cortical microtubule organization 0.033 0.066 -9999.0 0.0 -0.135 12.0 12.0 GO:0000145 -0.011 0.057 0.174 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.038 0.069 -9999.0 0.0 -0.136 12.0 12.0 MLLT4 0.027 0.007 -9999.0 0.0 0.0 6.0 6.0 ARF6/GDP -0.034 0.039 -9999.0 0.0 -0.138 10.0 10.0 ARF6 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 Ephrin A1/EPHA2/NCK1/GIT1 0.064 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.011 0.065 0.191 2.0 -0.194 3.0 5.0 PVRL2 0.027 0.008 -9999.0 0.0 0.0 8.0 8.0 ZYX -0.008 0.064 0.19 3.0 -9999.0 0.0 3.0 ARF6/GTP 0.07 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.015 0.014 -9999.0 0.0 0.0 48.0 48.0 EGFR/EGFR/EGF/EGF -0.014 0.094 -9999.0 0.0 -0.158 27.0 27.0 RhoA/GDP 0.033 0.066 -9999.0 0.0 -0.132 12.0 12.0 actin cytoskeleton organization -0.014 0.06 0.174 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer 0.026 0.009 -9999.0 0.0 0.0 11.0 11.0 GIT1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.009 -9999.0 0.0 0.0 11.0 11.0 IGF1 0.023 0.012 -9999.0 0.0 0.0 22.0 22.0 DIAPH1 0.013 0.158 -9999.0 0.0 -0.52 7.0 7.0 Wnt receptor signaling pathway -0.033 0.066 0.135 12.0 -9999.0 0.0 12.0 RHOA 0.028 0.004 -9999.0 0.0 0.0 2.0 2.0 RhoA/GTP -0.035 0.039 -9999.0 0.0 -0.138 9.0 9.0 CTNNA1 0.028 0.005 -9999.0 0.0 0.0 3.0 3.0 VCL -0.014 0.061 0.175 3.0 -9999.0 0.0 3.0 EFNA1 0.026 0.008 -9999.0 0.0 0.0 9.0 9.0 LPP -0.022 0.071 0.188 2.0 -0.235 2.0 4.0 Ephrin A1/EPHA2 0.021 0.06 -9999.0 0.0 -0.135 10.0 10.0 SEC6/SEC8 -0.024 0.038 -9999.0 0.0 -0.138 7.0 7.0 MGAT3 -0.011 0.063 0.19 3.0 -9999.0 0.0 3.0 HGF/MET 0.019 0.071 -9999.0 0.0 -0.154 12.0 12.0 HGF 0.025 0.01 -9999.0 0.0 0.0 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.067 -9999.0 0.0 -0.166 12.0 12.0 actin cable formation -0.003 0.077 0.215 4.0 -0.275 1.0 5.0 KIAA1543 -0.015 0.061 0.175 3.0 -0.23 1.0 4.0 KIFC3 -0.012 0.067 0.19 3.0 -0.24 1.0 4.0 NCK1 0.028 0.004 -9999.0 0.0 0.0 2.0 2.0 EXOC3 0.025 0.009 -9999.0 0.0 0.0 12.0 12.0 ACTN1 -0.012 0.069 0.2 2.0 -0.24 2.0 4.0 NCK1/GIT1 0.042 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.033 0.066 -9999.0 0.0 -0.135 12.0 12.0 EXOC4 0.027 0.006 -9999.0 0.0 0.0 5.0 5.0 STX4 -0.011 0.065 0.19 3.0 -9999.0 0.0 3.0 PIP5K1C -0.009 0.064 0.19 3.0 -9999.0 0.0 3.0 LIMA1 0.027 0.006 -9999.0 0.0 0.0 5.0 5.0 ABI1 0.028 0.006 -9999.0 0.0 0.0 4.0 4.0 ROCK1 -0.01 0.071 0.211 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.022 0.093 0.227 1.0 -0.309 4.0 5.0 IGF-1R heterotetramer/IGF1 0.011 0.077 -9999.0 0.0 -0.145 17.0 17.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.026 -9999.0 0.0 -0.183 1.0 1.0 MET 0.026 0.009 -9999.0 0.0 0.0 11.0 11.0 PLEKHA7 -0.012 0.067 0.19 3.0 -0.24 1.0 4.0 mol:GTP 0.062 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.01 0.098 0.274 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization -0.002 0.067 -9999.0 0.0 -0.165 12.0 12.0 regulation of cell-cell adhesion -0.014 0.06 0.174 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.067 -9999.0 0.0 -0.166 12.0 12.0