E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.093 0.189 -9999.0 0.0 -0.389 81.0 81.0 KLHL20 -0.018 0.082 -9999.0 0.0 -0.207 13.0 13.0 CYFIP2 -0.011 0.098 -9999.0 0.0 -0.391 17.0 17.0 Rac1/GDP -0.034 0.118 -9999.0 0.0 -0.218 77.0 77.0 ENAH -0.097 0.194 -9999.0 0.0 -0.398 81.0 81.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.016 -9999.0 0.0 -0.248 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.043 0.063 -9999.0 0.0 -0.275 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.046 -9999.0 0.0 -0.149 18.0 18.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.058 0.126 -9999.0 0.0 -0.228 90.0 90.0 RAPGEF1 -0.071 0.168 -9999.0 0.0 -0.335 81.0 81.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.099 0.194 -9999.0 0.0 -0.404 81.0 81.0 CRK -0.082 0.18 -9999.0 0.0 -0.365 81.0 81.0 E-cadherin/gamma catenin/alpha catenin -0.063 0.124 -9999.0 0.0 -0.245 81.0 81.0 alphaE/beta7 Integrin 0.001 0.073 -9999.0 0.0 -0.291 16.0 16.0 IQGAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.023 -9999.0 0.0 -0.214 2.0 2.0 DLG1 -0.092 0.189 -9999.0 0.0 -0.389 81.0 81.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.033 0.048 -9999.0 0.0 -0.184 4.0 4.0 MLLT4 0.01 0.04 -9999.0 0.0 -0.364 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.012 0.056 -9999.0 0.0 -0.214 16.0 16.0 PI3K -0.041 0.061 -9999.0 0.0 -0.236 4.0 4.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.086 0.145 -9999.0 0.0 -0.266 105.0 105.0 TIAM1 -0.012 0.102 -9999.0 0.0 -0.412 17.0 17.0 E-cadherin(dimer)/Ca2+ -0.041 0.102 -9999.0 0.0 -0.195 81.0 81.0 AKT1 -0.024 0.036 -9999.0 0.0 -0.142 3.0 3.0 PIK3R1 0.01 0.036 -9999.0 0.0 -0.422 2.0 2.0 CDH1 -0.129 0.197 -9999.0 0.0 -0.389 100.0 100.0 RhoA/GDP -0.035 0.118 -9999.0 0.0 -0.218 77.0 77.0 actin cytoskeleton organization -0.012 0.062 -9999.0 0.0 -0.152 13.0 13.0 CDC42/GDP -0.035 0.118 -9999.0 0.0 -0.218 77.0 77.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.052 0.105 -9999.0 0.0 -0.212 81.0 81.0 ITGB7 -0.013 0.103 -9999.0 0.0 -0.403 18.0 18.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.044 0.11 -9999.0 0.0 -0.208 81.0 81.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.048 0.101 -9999.0 0.0 -0.2 81.0 81.0 mol:GDP -0.048 0.132 -9999.0 0.0 -0.252 81.0 81.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.005 0.052 -9999.0 0.0 -0.291 8.0 8.0 p120 catenin/RhoA/GDP -0.035 0.12 -9999.0 0.0 -0.221 77.0 77.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.006 0.048 -9999.0 0.0 -0.145 9.0 9.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.095 0.19 -9999.0 0.0 -0.391 81.0 81.0 regulation of cell-cell adhesion -0.038 0.056 -9999.0 0.0 -0.242 1.0 1.0 WASF2 -0.017 0.025 -9999.0 0.0 -0.107 2.0 2.0 Rap1/GTP -0.022 0.09 -9999.0 0.0 -0.314 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.052 0.122 -9999.0 0.0 -0.214 90.0 90.0 CCND1 -0.008 0.057 -9999.0 0.0 -0.178 9.0 9.0 VAV2 -0.092 0.203 -9999.0 0.0 -0.387 86.0 86.0 RAP1/GDP -0.027 0.1 -9999.0 0.0 -0.276 2.0 2.0 adherens junction assembly -0.092 0.185 -9999.0 0.0 -0.378 82.0 82.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.045 0.117 -9999.0 0.0 -0.354 12.0 12.0 E-cadherin/beta catenin -0.084 0.143 -9999.0 0.0 -0.307 81.0 81.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.092 0.19 -9999.0 0.0 -0.391 81.0 81.0 PIK3CA 0.006 0.054 -9999.0 0.0 -0.387 5.0 5.0 Rac1/GTP -0.067 0.099 -9999.0 0.0 -0.335 13.0 13.0 E-cadherin/beta catenin/alpha catenin -0.058 0.119 -9999.0 0.0 -0.237 81.0 81.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.102 0.198 -9999.0 0.0 -0.413 81.0 81.0