Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.032 0.18 -9999.0 0.0 -0.524 27.0 27.0 IHH -0.002 0.054 -9999.0 0.0 -0.262 5.0 5.0 SHH Np/Cholesterol/GAS1 0.003 0.052 -9999.0 0.0 -0.23 10.0 10.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.003 0.051 0.228 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.033 0.146 -9999.0 0.0 -0.435 19.0 19.0 SMO -0.041 0.153 -9999.0 0.0 -0.416 25.0 25.0 AKT1 -0.006 0.085 -9999.0 0.0 -0.418 2.0 2.0 ARRB2 0.013 0.016 -9999.0 0.0 -0.248 1.0 1.0 BOC -0.014 0.095 -9999.0 0.0 -0.324 23.0 23.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.04 0.151 -9999.0 0.0 -0.41 25.0 25.0 STIL -0.008 0.099 -9999.0 0.0 -0.335 14.0 14.0 DHH N/PTCH2 -0.022 0.092 -9999.0 0.0 -0.293 19.0 19.0 DHH N/PTCH1 -0.03 0.132 -9999.0 0.0 -0.346 27.0 27.0 PIK3CA 0.006 0.054 -9999.0 0.0 -0.387 5.0 5.0 DHH -0.035 0.118 -9999.0 0.0 -0.299 44.0 44.0 PTHLH -0.047 0.237 -9999.0 0.0 -0.771 23.0 23.0 determination of left/right symmetry -0.04 0.151 -9999.0 0.0 -0.41 25.0 25.0 PIK3R1 0.01 0.036 -9999.0 0.0 -0.422 2.0 2.0 skeletal system development -0.046 0.235 -9999.0 0.0 -0.762 23.0 23.0 IHH N/Hhip -0.003 0.058 -9999.0 0.0 -0.199 18.0 18.0 DHH N/Hhip -0.028 0.092 -9999.0 0.0 -0.199 58.0 58.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.04 0.151 -9999.0 0.0 -0.41 25.0 25.0 pancreas development -0.007 0.063 -9999.0 0.0 -0.247 18.0 18.0 HHAT 0.006 0.057 -9999.0 0.0 -0.422 5.0 5.0 PI3K 0.013 0.051 -9999.0 0.0 -0.341 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.005 0.059 -9999.0 0.0 -0.393 6.0 6.0 somite specification -0.04 0.151 -9999.0 0.0 -0.41 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.012 0.104 -9999.0 0.0 -0.299 23.0 23.0 SHH Np/Cholesterol/PTCH2 0.001 0.051 -9999.0 0.0 -0.22 10.0 10.0 SHH Np/Cholesterol/Megalin -0.095 0.108 -9999.0 0.0 -0.236 81.0 81.0 SHH -0.001 0.052 -9999.0 0.0 -0.199 17.0 17.0 catabolic process -0.014 0.124 -9999.0 0.0 -0.375 23.0 23.0 SMO/Vitamin D3 -0.024 0.123 -9999.0 0.0 -0.389 19.0 19.0 SHH Np/Cholesterol/Hhip -0.003 0.053 -9999.0 0.0 -0.238 8.0 8.0 LRP2 -0.182 0.184 -9999.0 0.0 -0.334 159.0 159.0 receptor-mediated endocytosis -0.089 0.149 -9999.0 0.0 -0.448 26.0 26.0 SHH Np/Cholesterol/BOC -0.007 0.065 -9999.0 0.0 -0.235 14.0 14.0 SHH Np/Cholesterol/CDO 0.005 0.046 -9999.0 0.0 -0.218 8.0 8.0 mesenchymal cell differentiation 0.003 0.053 0.237 8.0 -9999.0 0.0 8.0 mol:Vitamin D3 -0.009 0.106 -9999.0 0.0 -0.3 23.0 23.0 IHH N/PTCH2 0.004 0.059 -9999.0 0.0 -0.262 10.0 10.0 CDON 0.009 0.045 -9999.0 0.0 -0.422 3.0 3.0 IHH N/PTCH1 -0.011 0.126 -9999.0 0.0 -0.377 23.0 23.0 Megalin/LRPAP1 -0.117 0.131 -9999.0 0.0 -0.223 159.0 159.0 PTCH2 0.002 0.063 -9999.0 0.0 -0.318 10.0 10.0 SHH Np/Cholesterol 0.001 0.039 -9999.0 0.0 -0.225 5.0 5.0 PTCH1 -0.014 0.124 -9999.0 0.0 -0.376 23.0 23.0 HHIP -0.007 0.063 -9999.0 0.0 -0.248 18.0 18.0