Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.043 0.1 -9999.0 0.0 -0.199 81.0 81.0 epithelial cell differentiation -0.043 0.1 -9999.0 0.0 -0.194 81.0 81.0 CYFIP2 -0.011 0.098 -9999.0 0.0 -0.391 17.0 17.0 ENAH -0.015 0.081 -9999.0 0.0 -0.232 10.0 10.0 EGFR -0.022 0.102 -9999.0 0.0 -0.297 32.0 32.0 EPHA2 0.001 0.066 -9999.0 0.0 -0.335 10.0 10.0 MYO6 -0.045 0.1 -9999.0 0.0 -0.186 87.0 87.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.013 0.059 -9999.0 0.0 -0.237 14.0 14.0 AQP5 -0.039 0.095 -9999.0 0.0 -0.524 2.0 2.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.038 0.093 -9999.0 0.0 -0.178 81.0 81.0 regulation of calcium-dependent cell-cell adhesion -0.049 0.102 -9999.0 0.0 -0.191 86.0 86.0 EGF -0.088 0.173 -9999.0 0.0 -0.369 75.0 75.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.054 0.143 -9999.0 0.0 -0.482 19.0 19.0 cortical microtubule organization -0.043 0.1 -9999.0 0.0 -0.194 81.0 81.0 GO:0000145 -0.038 0.088 -9999.0 0.0 -0.17 81.0 81.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.041 0.102 -9999.0 0.0 -0.195 81.0 81.0 MLLT4 0.01 0.04 -9999.0 0.0 -0.364 3.0 3.0 ARF6/GDP -0.049 0.069 -9999.0 0.0 -0.254 5.0 5.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.037 -9999.0 0.0 -0.208 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.03 0.09 -9999.0 0.0 -0.207 2.0 2.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.039 0.096 -9999.0 0.0 -0.183 81.0 81.0 ARF6/GTP 0.032 0.034 -9999.0 0.0 -0.188 5.0 5.0 CDH1 -0.129 0.197 -9999.0 0.0 -0.389 100.0 100.0 EGFR/EGFR/EGF/EGF -0.108 0.127 -9999.0 0.0 -0.333 49.0 49.0 RhoA/GDP -0.037 0.094 -9999.0 0.0 -0.179 81.0 81.0 actin cytoskeleton organization -0.04 0.098 -9999.0 0.0 -0.18 82.0 82.0 IGF-1R heterotetramer 0.01 0.04 -9999.0 0.0 -0.363 3.0 3.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.04 -9999.0 0.0 -0.364 3.0 3.0 IGF1 -0.024 0.119 -9999.0 0.0 -0.383 27.0 27.0 DIAPH1 -0.023 0.129 -9999.0 0.0 -0.583 14.0 14.0 Wnt receptor signaling pathway 0.043 0.1 0.194 81.0 -9999.0 0.0 81.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.069 -9999.0 0.0 -0.254 5.0 5.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.041 0.099 -9999.0 0.0 -0.183 82.0 82.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.035 0.091 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.059 0.082 -9999.0 0.0 -0.247 8.0 8.0 SEC6/SEC8 -0.049 0.068 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.05 0.103 -9999.0 0.0 -0.194 86.0 86.0 HGF/MET -0.091 0.114 -9999.0 0.0 -0.317 36.0 36.0 HGF -0.019 0.102 -9999.0 0.0 -0.316 28.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.043 0.101 -9999.0 0.0 -0.2 81.0 81.0 actin cable formation -0.004 0.08 -9999.0 0.0 -0.23 6.0 6.0 KIAA1543 -0.07 0.115 -9999.0 0.0 -0.295 29.0 29.0 KIFC3 -0.039 0.094 -9999.0 0.0 -0.18 82.0 82.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.016 -9999.0 0.0 -0.248 1.0 1.0 ACTN1 -0.041 0.095 -9999.0 0.0 -0.18 85.0 85.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.043 0.1 -9999.0 0.0 -0.194 81.0 81.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.038 0.094 -9999.0 0.0 -0.18 81.0 81.0 PIP5K1C -0.038 0.094 -9999.0 0.0 -0.18 81.0 81.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.018 0.082 -9999.0 0.0 -0.224 5.0 5.0 adherens junction assembly -0.054 0.114 -9999.0 0.0 -0.337 15.0 15.0 IGF-1R heterotetramer/IGF1 -0.071 0.094 -9999.0 0.0 -0.19 96.0 96.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.028 -9999.0 0.0 -0.246 3.0 3.0 MET -0.046 0.143 -9999.0 0.0 -0.371 44.0 44.0 PLEKHA7 -0.049 0.105 -9999.0 0.0 -0.193 89.0 89.0 mol:GTP 0.027 0.036 -9999.0 0.0 -0.207 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.018 0.085 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.043 0.1 -9999.0 0.0 -0.199 81.0 81.0 regulation of cell-cell adhesion -0.04 0.098 -9999.0 0.0 -0.18 82.0 82.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.043 0.101 -9999.0 0.0 -0.2 81.0 81.0