E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.096 0.185 0.229 1.0 -0.371 85.0 86.0 KLHL20 -0.029 0.094 0.185 6.0 -0.217 26.0 32.0 CYFIP2 0.012 0.073 -9999.0 0.0 -0.331 12.0 12.0 Rac1/GDP -0.046 0.118 0.239 1.0 -0.234 63.0 64.0 ENAH -0.09 0.184 0.223 2.0 -0.384 74.0 76.0 AP1M1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.082 -9999.0 0.0 -0.16 53.0 53.0 ABI1/Sra1/Nap1 -0.04 0.055 -9999.0 0.0 -0.146 32.0 32.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.119 -9999.0 0.0 -0.185 85.0 85.0 RAPGEF1 -0.077 0.166 0.227 2.0 -0.336 75.0 77.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.093 0.195 -9999.0 0.0 -0.378 88.0 88.0 CRK -0.084 0.175 0.216 1.0 -0.357 77.0 78.0 E-cadherin/gamma catenin/alpha catenin -0.013 0.116 -9999.0 0.0 -0.199 76.0 76.0 alphaE/beta7 Integrin 0.027 0.057 -9999.0 0.0 -0.227 13.0 13.0 IQGAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.027 -9999.0 0.0 -0.164 2.0 2.0 DLG1 -0.096 0.186 -9999.0 0.0 -0.37 87.0 87.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.04 0.049 -9999.0 0.0 -0.126 57.0 57.0 MLLT4 0.022 0.031 -9999.0 0.0 -0.331 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.049 -9999.0 0.0 -0.174 13.0 13.0 PI3K -0.05 0.062 -9999.0 0.0 -0.159 57.0 57.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.031 0.128 -9999.0 0.0 -0.236 77.0 77.0 TIAM1 0.011 0.075 0.121 1.0 -0.331 13.0 14.0 E-cadherin(dimer)/Ca2+ 0.001 0.105 -9999.0 0.0 -0.167 76.0 76.0 AKT1 -0.025 0.049 0.146 1.0 -0.138 3.0 4.0 PIK3R1 0.024 0.031 -9999.0 0.0 -0.331 2.0 2.0 CDH1 -0.065 0.165 0.121 18.0 -0.331 77.0 95.0 RhoA/GDP -0.042 0.127 0.273 3.0 -0.234 67.0 70.0 actin cytoskeleton organization -0.02 0.071 0.153 6.0 -0.159 26.0 32.0 CDC42/GDP -0.043 0.127 0.273 3.0 -0.234 67.0 70.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.039 0.097 -9999.0 0.0 -0.194 78.0 78.0 ITGB7 0.012 0.076 0.121 2.0 -0.331 13.0 15.0 RAC1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.002 0.112 -9999.0 0.0 -0.179 76.0 76.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.096 -9999.0 0.0 -0.164 76.0 76.0 mol:GDP -0.06 0.135 0.279 3.0 -0.265 67.0 70.0 CDC42/GTP/IQGAP1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.033 -9999.0 0.0 -0.331 2.0 2.0 p120 catenin/RhoA/GDP -0.038 0.131 0.255 2.0 -0.24 64.0 66.0 RAC1/GTP/IQGAP1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.041 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.055 0.129 9.0 -0.109 27.0 36.0 NME1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.098 0.187 -9999.0 0.0 -0.375 86.0 86.0 regulation of cell-cell adhesion -0.025 0.066 -9999.0 0.0 -0.143 56.0 56.0 WASF2 -0.014 0.04 0.089 3.0 -0.089 15.0 18.0 Rap1/GTP -0.019 0.095 0.253 3.0 -0.211 4.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.0 0.122 -9999.0 0.0 -0.178 84.0 84.0 CCND1 -0.013 0.066 0.147 9.0 -0.133 27.0 36.0 VAV2 -0.117 0.248 0.358 1.0 -0.451 85.0 86.0 RAP1/GDP -0.024 0.108 0.301 2.0 -0.235 8.0 10.0 adherens junction assembly -0.095 0.182 -9999.0 0.0 -0.364 86.0 86.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.112 0.206 3.0 -0.175 83.0 86.0 E-cadherin/beta catenin -0.065 0.131 -9999.0 0.0 -0.282 75.0 75.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.092 0.182 0.224 1.0 -0.372 80.0 81.0 PIK3CA 0.022 0.043 -9999.0 0.0 -0.331 4.0 4.0 Rac1/GTP -0.073 0.127 -9999.0 0.0 -0.343 29.0 29.0 E-cadherin/beta catenin/alpha catenin -0.012 0.113 -9999.0 0.0 -0.195 76.0 76.0 ITGAE 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.095 0.198 -9999.0 0.0 -0.386 88.0 88.0