Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	57.0	399.0	7.0	-0.053	-0.0	1000.0	-1000.0	-0.0	-1000.0
E-cadherin signaling events	50.0	251.0	5.0	-0.065	0.028	1000.0	-1000.0	0.015	-1000.0
TCR signaling in naïve CD8+ T cells	46.0	4358.0	93.0	-0.226	0.116	1000.0	-1000.0	-0.03	-1000.0
IL23-mediated signaling events	41.0	2488.0	60.0	-0.315	0.028	1000.0	-1000.0	-0.057	-1000.0
IL4-mediated signaling events	40.0	3675.0	91.0	-0.509	0.372	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	40.0	3156.0	78.0	-0.19	0.062	1000.0	-1000.0	-0.025	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	38.0	2854.0	74.0	-0.065	0.063	1000.0	-1000.0	-0.041	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	37.0	2529.0	68.0	-0.3	0.082	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in the nascent adherens junction	36.0	2757.0	76.0	-0.117	0.043	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	36.0	3225.0	88.0	-0.199	0.037	1000.0	-1000.0	-0.044	-1000.0
Syndecan-1-mediated signaling events	35.0	1205.0	34.0	-0.05	0.028	1000.0	-1000.0	-0.014	-1000.0
IL12-mediated signaling events	34.0	3044.0	87.0	-0.291	0.064	1000.0	-1000.0	-0.037	-1000.0
BCR signaling pathway	34.0	3435.0	99.0	-0.157	0.033	1000.0	-1000.0	-0.046	-1000.0
Signaling events regulated by Ret tyrosine kinase	33.0	2783.0	82.0	-0.051	0.028	1000.0	-1000.0	-0.03	-1000.0
Endothelins	33.0	3204.0	96.0	-0.118	0.048	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling in keratinocytes	29.0	1287.0	43.0	-0.067	0.03	1000.0	-1000.0	-0.014	-1000.0
Nectin adhesion pathway	28.0	1822.0	63.0	-0.088	0.043	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	28.0	2946.0	102.0	-0.08	0.032	1000.0	-1000.0	-0.045	-1000.0
TCGA08_retinoblastoma	28.0	229.0	8.0	-0.007	0.049	1000.0	-1000.0	-0.004	-1000.0
Signaling mediated by p38-alpha and p38-beta	25.0	1135.0	44.0	-0.06	0.028	1000.0	-1000.0	-0.013	-1000.0
Integrins in angiogenesis	25.0	2134.0	84.0	-0.112	0.049	1000.0	-1000.0	-0.024	-1000.0
Glypican 1 network	24.0	1163.0	48.0	-0.038	0.039	1000.0	-1000.0	-0.016	-1000.0
S1P4 pathway	24.0	623.0	25.0	-0.037	0.036	1000.0	-1000.0	-0.01	-1000.0
Thromboxane A2 receptor signaling	23.0	2458.0	105.0	-0.088	0.034	1000.0	-1000.0	-0.029	-1000.0
Glucocorticoid receptor regulatory network	23.0	2669.0	114.0	-0.248	0.127	1000.0	-1000.0	-0.034	-1000.0
FAS signaling pathway (CD95)	23.0	1126.0	47.0	-0.037	0.036	1000.0	-1000.0	-0.027	-1000.0
Glypican 2 network	23.0	92.0	4.0	0.01	0.014	1000.0	-1000.0	0.015	-1000.0
Calcium signaling in the CD4+ TCR pathway	23.0	725.0	31.0	-0.089	0.029	1000.0	-1000.0	-0.029	-1000.0
EGFR-dependent Endothelin signaling events	23.0	491.0	21.0	-0.036	0.04	1000.0	-1000.0	-0.029	-1000.0
a4b1 and a4b7 Integrin signaling	22.0	112.0	5.0	-0.003	0.016	1000.0	-1000.0	0.015	-1000.0
EPHB forward signaling	22.0	1926.0	85.0	-0.053	0.055	1000.0	-1000.0	-0.041	-1000.0
IL27-mediated signaling events	22.0	1171.0	51.0	-0.152	0.102	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	21.0	1560.0	74.0	-0.063	0.041	1000.0	-1000.0	-0.024	-1000.0
Osteopontin-mediated events	21.0	826.0	38.0	-0.049	0.03	1000.0	-1000.0	-0.022	-1000.0
p75(NTR)-mediated signaling	21.0	2737.0	125.0	-0.051	0.071	1000.0	-1000.0	-0.044	-1000.0
BMP receptor signaling	21.0	1760.0	81.0	-0.051	0.048	1000.0	-1000.0	-0.022	-1000.0
JNK signaling in the CD4+ TCR pathway	20.0	348.0	17.0	-0.086	0.038	1000.0	-1000.0	-0.02	-1000.0
HIF-1-alpha transcription factor network	20.0	1595.0	76.0	-0.019	0.065	1000.0	-1000.0	-0.011	-1000.0
Wnt signaling	20.0	146.0	7.0	-0.028	0.02	1000.0	-1000.0	-0.003	-1000.0
Signaling events mediated by the Hedgehog family	19.0	988.0	52.0	-0.047	0.043	1000.0	-1000.0	-0.016	-1000.0
Noncanonical Wnt signaling pathway	19.0	512.0	26.0	-0.036	0.027	1000.0	-1000.0	-0.023	-1000.0
Ceramide signaling pathway	19.0	1466.0	76.0	-0.039	0.039	1000.0	-1000.0	-0.026	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	19.0	878.0	45.0	-0.051	0.058	1000.0	-1000.0	-0.024	-1000.0
Plasma membrane estrogen receptor signaling	19.0	1640.0	86.0	-0.12	0.089	1000.0	-1000.0	-0.026	-1000.0
Arf6 signaling events	18.0	1174.0	62.0	-0.03	0.058	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PTP1B	18.0	1394.0	76.0	-0.058	0.042	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	18.0	306.0	17.0	-0.035	0.032	1000.0	-1000.0	-0.003	-1000.0
Ephrin B reverse signaling	18.0	866.0	48.0	-0.046	0.039	1000.0	-1000.0	-0.027	-1000.0
Syndecan-4-mediated signaling events	18.0	1256.0	67.0	-0.045	0.036	1000.0	-1000.0	-0.026	-1000.0
Fc-epsilon receptor I signaling in mast cells	17.0	1659.0	97.0	-0.048	0.048	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	17.0	1000.0	56.0	-0.027	0.059	1000.0	-1000.0	-0.017	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	927.0	52.0	-0.055	0.058	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by PI3K	17.0	1023.0	58.0	-0.099	0.041	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events	17.0	1305.0	73.0	-0.092	0.049	1000.0	-1000.0	-0.021	-1000.0
Class IB PI3K non-lipid kinase events	17.0	51.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	16.0	1444.0	85.0	-0.035	0.037	1000.0	-1000.0	-0.036	-1000.0
amb2 Integrin signaling	16.0	1384.0	82.0	-0.032	0.041	1000.0	-1000.0	-0.019	-1000.0
TRAIL signaling pathway	16.0	785.0	48.0	-0.025	0.043	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	16.0	789.0	49.0	-0.027	0.04	1000.0	-1000.0	-0.021	-1000.0
Effects of Botulinum toxin	16.0	418.0	26.0	-0.017	0.039	1000.0	-1000.0	-0.002	-1000.0
Ras signaling in the CD4+ TCR pathway	16.0	272.0	17.0	-0.024	0.049	1000.0	-1000.0	-0.02	-1000.0
IFN-gamma pathway	15.0	1057.0	68.0	-0.032	0.036	1000.0	-1000.0	-0.042	-1000.0
S1P1 pathway	15.0	541.0	36.0	-0.077	0.028	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	14.0	169.0	12.0	-0.041	0.006	1000.0	-1000.0	-0.015	-1000.0
TCGA08_p53	14.0	98.0	7.0	-0.013	0.023	1000.0	-1000.0	-0.003	-1000.0
ErbB2/ErbB3 signaling events	13.0	902.0	65.0	-0.03	0.04	1000.0	-1000.0	-0.063	-1000.0
Syndecan-2-mediated signaling events	13.0	957.0	69.0	-0.016	0.042	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	13.0	851.0	62.0	-0.028	0.066	1000.0	-1000.0	-0.019	-1000.0
Signaling mediated by p38-gamma and p38-delta	13.0	197.0	15.0	-0.02	0.027	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by STAT5	13.0	302.0	22.0	-0.04	0.028	1000.0	-1000.0	-0.012	-1000.0
S1P3 pathway	13.0	572.0	42.0	-0.034	0.044	1000.0	-1000.0	-0.022	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1654.0	120.0	-0.078	0.067	1000.0	-1000.0	-0.037	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	12.0	650.0	54.0	-0.019	0.039	1000.0	-1000.0	-0.018	-1000.0
EPO signaling pathway	12.0	694.0	55.0	-0.002	0.047	1000.0	-1000.0	-0.012	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	451.0	37.0	-0.034	0.044	1000.0	-1000.0	-0.014	-1000.0
IGF1 pathway	12.0	711.0	57.0	-0.029	0.057	1000.0	-1000.0	-0.017	-1000.0
PDGFR-beta signaling pathway	12.0	1203.0	97.0	-0.054	0.063	1000.0	-1000.0	-0.033	-1000.0
Cellular roles of Anthrax toxin	11.0	432.0	39.0	-0.03	0.027	1000.0	-1000.0	-0.016	-1000.0
PDGFR-alpha signaling pathway	11.0	506.0	44.0	-0.019	0.053	1000.0	-1000.0	-0.022	-1000.0
Paxillin-dependent events mediated by a4b1	11.0	428.0	36.0	-0.034	0.046	1000.0	-1000.0	-0.026	-1000.0
Regulation of p38-alpha and p38-beta	11.0	596.0	54.0	-0.055	0.057	1000.0	-1000.0	-0.034	-1000.0
IL6-mediated signaling events	11.0	873.0	75.0	-0.034	0.07	1000.0	-1000.0	-0.026	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1383.0	136.0	-0.284	0.071	1000.0	-1000.0	-0.03	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	290.0	28.0	-0.035	0.042	1000.0	-1000.0	-0.02	-1000.0
FOXA2 and FOXA3 transcription factor networks	10.0	467.0	46.0	-0.144	0.036	1000.0	-1000.0	-0.053	-1000.0
Nongenotropic Androgen signaling	10.0	567.0	52.0	-0.054	0.043	1000.0	-1000.0	-0.017	-1000.0
Regulation of Androgen receptor activity	10.0	765.0	70.0	-0.094	0.036	1000.0	-1000.0	-0.03	-1000.0
Hedgehog signaling events mediated by Gli proteins	9.0	607.0	65.0	-0.053	0.065	1000.0	-1000.0	-0.022	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	597.0	61.0	-0.011	0.071	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class III	9.0	360.0	40.0	-0.053	0.044	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	9.0	552.0	58.0	-0.047	0.052	1000.0	-1000.0	-0.022	-1000.0
Atypical NF-kappaB pathway	9.0	297.0	31.0	-0.018	0.033	1000.0	-1000.0	-0.016	-1000.0
Canonical Wnt signaling pathway	9.0	491.0	51.0	-0.022	0.063	1000.0	-1000.0	-0.023	-1000.0
Visual signal transduction: Rods	9.0	511.0	52.0	-0.011	0.046	1000.0	-1000.0	-0.012	-1000.0
mTOR signaling pathway	8.0	460.0	53.0	-0.025	0.032	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	8.0	381.0	43.0	-0.106	0.109	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	713.0	83.0	-0.032	0.052	1000.0	-1000.0	-0.01	-1000.0
TCGA08_rtk_signaling	8.0	232.0	26.0	-0.021	0.06	1000.0	-1000.0	-0.008	-1000.0
Insulin Pathway	8.0	641.0	74.0	-0.067	0.068	1000.0	-1000.0	-0.028	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	286.0	33.0	-0.004	0.06	1000.0	-1000.0	-0.021	-1000.0
Rapid glucocorticoid signaling	8.0	168.0	20.0	-0.011	0.028	1000.0	-1000.0	-0.001	-1000.0
FOXM1 transcription factor network	8.0	442.0	51.0	-0.02	0.075	1000.0	-1000.0	-0.048	-1000.0
Aurora B signaling	8.0	575.0	67.0	-0.074	0.063	1000.0	-1000.0	-0.019	-1000.0
Coregulation of Androgen receptor activity	7.0	607.0	76.0	-0.064	0.047	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	7.0	504.0	69.0	-0.071	0.065	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	7.0	324.0	43.0	-0.038	0.047	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	7.0	915.0	125.0	-0.02	0.066	1000.0	-1000.0	-0.018	-1000.0
Regulation of Telomerase	7.0	746.0	102.0	-0.08	0.056	1000.0	-1000.0	-0.034	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	211.0	34.0	-0.04	0.069	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Cones	6.0	256.0	38.0	-0.016	0.049	1000.0	-1000.0	-0.017	-1000.0
PLK1 signaling events	6.0	512.0	85.0	-0.01	0.048	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	6.0	438.0	64.0	-0.19	0.041	1000.0	-1000.0	-0.019	-1000.0
Syndecan-3-mediated signaling events	6.0	222.0	35.0	0.0	0.071	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PRL	6.0	213.0	34.0	-0.026	0.047	1000.0	-1000.0	-0.03	-1000.0
BARD1 signaling events	5.0	297.0	57.0	-0.052	0.057	1000.0	-1000.0	-0.041	-1000.0
Insulin-mediated glucose transport	5.0	180.0	32.0	-0.022	0.048	1000.0	-1000.0	-0.016	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	383.0	68.0	-0.04	0.05	1000.0	-1000.0	-0.019	-1000.0
VEGFR1 specific signals	5.0	321.0	56.0	-0.028	0.054	1000.0	-1000.0	-0.023	-1000.0
p38 MAPK signaling pathway	5.0	235.0	44.0	-0.04	0.046	1000.0	-1000.0	-0.012	-1000.0
Canonical NF-kappaB pathway	4.0	185.0	39.0	-0.007	0.057	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	-0.016	-1000.0	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class I	4.0	428.0	104.0	-0.051	0.065	1000.0	-1000.0	-0.034	-1000.0
Aurora A signaling	3.0	229.0	60.0	-0.025	0.056	1000.0	-1000.0	-0.014	-1000.0
Arf6 trafficking events	3.0	240.0	71.0	-0.039	0.051	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	2.0	194.0	75.0	-0.029	0.069	1000.0	-1000.0	-0.019	-1000.0
Circadian rhythm pathway	2.0	50.0	22.0	-0.008	0.042	1000.0	-1000.0	-0.018	-1000.0
Aurora C signaling	2.0	18.0	7.0	-0.0	0.045	1000.0	-1000.0	-0.006	-1000.0
Arf1 pathway	2.0	126.0	54.0	-0.001	0.045	1000.0	-1000.0	-0.01	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	17.0	23.0	0.003	0.055	1000.0	-1000.0	-0.014	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.011	0.065	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.07	1000.0	-1000.0	0.0	-1000.0
Total	2103	124489	7203	-8.06372673947	-993.387095705	131000	-131000	-3.04126135927	-131000