Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.03 0.129 -9999.0 0.0 -0.471 11.0 11.0 IHH -0.028 0.143 -9999.0 0.0 -0.384 35.0 35.0 SHH Np/Cholesterol/GAS1 -0.01 0.083 -9999.0 0.0 -0.198 42.0 42.0 LRPAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.083 0.197 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.022 0.134 -9999.0 0.0 -0.403 16.0 16.0 SMO -0.034 0.13 -9999.0 0.0 -0.355 32.0 32.0 AKT1 -0.021 0.136 -9999.0 0.0 -0.463 17.0 17.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.09 -9999.0 0.0 -0.352 16.0 16.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.032 0.129 -9999.0 0.0 -0.35 32.0 32.0 STIL -0.058 0.121 0.186 7.0 -0.316 28.0 35.0 DHH N/PTCH2 0.01 0.081 -9999.0 0.0 -0.206 33.0 33.0 DHH N/PTCH1 -0.01 0.109 -9999.0 0.0 -0.334 12.0 12.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.054 -9999.0 0.0 -0.338 6.0 6.0 PTHLH -0.043 0.168 -9999.0 0.0 -0.638 13.0 13.0 determination of left/right symmetry -0.032 0.129 -9999.0 0.0 -0.35 32.0 32.0 PIK3R1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.043 0.167 -9999.0 0.0 -0.632 13.0 13.0 IHH N/Hhip -0.071 0.166 -9999.0 0.0 -0.31 81.0 81.0 DHH N/Hhip -0.04 0.133 -9999.0 0.0 -0.262 70.0 70.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.032 0.129 -9999.0 0.0 -0.35 32.0 32.0 pancreas development -0.07 0.169 -9999.0 0.0 -0.368 66.0 66.0 HHAT 0.024 0.034 -9999.0 0.0 -0.368 2.0 2.0 PI3K 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.093 -9999.0 0.0 -0.343 18.0 18.0 somite specification -0.032 0.129 -9999.0 0.0 -0.35 32.0 32.0 SHH Np/Cholesterol/PTCH1 -0.031 0.108 -9999.0 0.0 -0.305 20.0 20.0 SHH Np/Cholesterol/PTCH2 -0.017 0.082 -9999.0 0.0 -0.172 57.0 57.0 SHH Np/Cholesterol/Megalin -0.028 0.091 -9999.0 0.0 -0.176 69.0 69.0 SHH -0.018 0.086 -9999.0 0.0 -0.259 30.0 30.0 catabolic process -0.021 0.111 -9999.0 0.0 -0.273 34.0 34.0 SMO/Vitamin D3 -0.035 0.124 -9999.0 0.0 -0.361 19.0 19.0 SHH Np/Cholesterol/Hhip -0.049 0.122 -9999.0 0.0 -0.23 78.0 78.0 LRP2 -0.029 0.12 -9999.0 0.0 -0.288 48.0 48.0 receptor-mediated endocytosis -0.053 0.124 -9999.0 0.0 -0.356 22.0 22.0 SHH Np/Cholesterol/BOC -0.009 0.084 -9999.0 0.0 -0.201 41.0 41.0 SHH Np/Cholesterol/CDO -0.004 0.074 -9999.0 0.0 -0.201 29.0 29.0 mesenchymal cell differentiation 0.049 0.121 0.229 78.0 -9999.0 0.0 78.0 mol:Vitamin D3 -0.028 0.113 0.2 7.0 -0.317 18.0 25.0 IHH N/PTCH2 -0.023 0.114 -9999.0 0.0 -0.232 56.0 56.0 CDON 0.017 0.055 -9999.0 0.0 -0.317 7.0 7.0 IHH N/PTCH1 -0.014 0.115 -9999.0 0.0 -0.275 34.0 34.0 Megalin/LRPAP1 -0.003 0.09 -9999.0 0.0 -0.196 47.0 47.0 PTCH2 -0.005 0.094 -9999.0 0.0 -0.282 28.0 28.0 SHH Np/Cholesterol -0.008 0.067 -9999.0 0.0 -0.194 30.0 30.0 PTCH1 -0.021 0.111 -9999.0 0.0 -0.275 33.0 33.0 HHIP -0.07 0.169 -9999.0 0.0 -0.368 66.0 66.0