Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.028 -9999.0 0.0 -0.19 4.0 4.0 epithelial cell differentiation 0.048 0.035 -9999.0 0.0 -0.184 4.0 4.0 CYFIP2 0.021 0.045 -9999.0 0.0 -0.346 4.0 4.0 ENAH -0.004 0.055 0.216 6.0 -0.231 1.0 7.0 EGFR 0.012 0.069 -9999.0 0.0 -0.358 9.0 9.0 EPHA2 0.024 0.031 -9999.0 0.0 -0.323 2.0 2.0 MYO6 -0.004 0.044 0.178 11.0 -9999.0 0.0 11.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.036 -9999.0 0.0 -0.203 4.0 4.0 AQP5 -0.116 0.187 -9999.0 0.0 -0.398 77.0 77.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.005 0.042 0.176 10.0 -9999.0 0.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.008 0.046 0.176 10.0 -9999.0 0.0 10.0 EGF -0.012 0.104 -9999.0 0.0 -0.295 32.0 32.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.008 0.088 -9999.0 0.0 -0.415 8.0 8.0 cortical microtubule organization 0.048 0.035 -9999.0 0.0 -0.184 4.0 4.0 GO:0000145 -0.005 0.039 0.164 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.037 -9999.0 0.0 -0.186 4.0 4.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.028 -9999.0 0.0 -0.31 1.0 1.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.039 -9999.0 0.0 -0.199 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.005 0.038 0.175 8.0 -9999.0 0.0 8.0 PVRL2 0.025 0.02 -9999.0 0.0 -0.278 1.0 1.0 ZYX -0.004 0.044 0.178 11.0 -9999.0 0.0 11.0 ARF6/GTP 0.061 0.042 -9999.0 0.0 -0.186 1.0 1.0 CDH1 0.02 0.048 -9999.0 0.0 -0.368 4.0 4.0 EGFR/EGFR/EGF/EGF 0.012 0.073 -9999.0 0.0 -0.231 3.0 3.0 RhoA/GDP 0.049 0.035 -9999.0 0.0 -0.177 3.0 3.0 actin cytoskeleton organization -0.006 0.04 0.165 10.0 -9999.0 0.0 10.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.019 0.117 -9999.0 0.0 -0.31 37.0 37.0 DIAPH1 0.01 0.153 -9999.0 0.0 -0.535 12.0 12.0 Wnt receptor signaling pathway -0.048 0.035 0.184 4.0 -9999.0 0.0 4.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.027 -9999.0 0.0 -0.294 1.0 1.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.007 0.041 0.166 10.0 -9999.0 0.0 10.0 EFNA1 0.022 0.037 -9999.0 0.0 -0.278 4.0 4.0 LPP -0.011 0.045 0.172 8.0 -0.242 2.0 10.0 Ephrin A1/EPHA2 0.038 0.044 -9999.0 0.0 -0.334 1.0 1.0 SEC6/SEC8 -0.015 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.008 0.046 0.177 10.0 -9999.0 0.0 10.0 HGF/MET 0.02 0.064 -9999.0 0.0 -0.243 1.0 1.0 HGF 0.021 0.041 -9999.0 0.0 -0.278 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.028 -9999.0 0.0 -0.191 4.0 4.0 actin cable formation 0.018 0.081 0.263 13.0 -0.29 2.0 15.0 KIAA1543 -0.005 0.041 0.167 11.0 -9999.0 0.0 11.0 KIFC3 -0.007 0.039 0.177 8.0 -9999.0 0.0 8.0 NCK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.046 0.178 11.0 -9999.0 0.0 11.0 NCK1/GIT1 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.035 -9999.0 0.0 -0.184 4.0 4.0 EXOC4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.006 0.041 0.178 9.0 -9999.0 0.0 9.0 PIP5K1C -0.005 0.042 0.177 10.0 -9999.0 0.0 10.0 LIMA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.002 0.069 0.306 5.0 -0.265 1.0 6.0 adherens junction assembly -0.008 0.091 0.278 2.0 -0.541 4.0 6.0 IGF-1R heterotetramer/IGF1 0.018 0.071 -9999.0 0.0 -0.184 14.0 14.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.019 -9999.0 0.0 -0.19 1.0 1.0 MET -0.007 0.094 -9999.0 0.0 -0.278 29.0 29.0 PLEKHA7 -0.004 0.044 0.178 11.0 -9999.0 0.0 11.0 mol:GTP 0.056 0.038 -9999.0 0.0 -0.198 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.015 0.08 0.287 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.019 0.028 -9999.0 0.0 -0.19 4.0 4.0 regulation of cell-cell adhesion -0.006 0.04 0.165 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.028 -9999.0 0.0 -0.191 4.0 4.0