Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.109 0.257 -9999.0 0.0 -0.683 35.0 35.0 IHH -0.202 0.366 -9999.0 0.0 -0.837 121.0 121.0 SHH Np/Cholesterol/GAS1 -0.105 0.204 -9999.0 0.0 -0.512 97.0 97.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.104 0.203 0.508 97.0 -9999.0 0.0 97.0 SMO/beta Arrestin2 -0.095 0.24 -9999.0 0.0 -0.677 16.0 16.0 SMO -0.107 0.253 -9999.0 0.0 -0.511 124.0 124.0 AKT1 -0.027 0.124 -9999.0 0.0 -0.662 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.0 0.105 -9999.0 0.0 -0.816 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.105 0.249 -9999.0 0.0 -0.503 124.0 124.0 STIL -0.077 0.198 -9999.0 0.0 -0.593 18.0 18.0 DHH N/PTCH2 -0.107 0.241 -9999.0 0.0 -0.638 82.0 82.0 DHH N/PTCH1 -0.099 0.225 -9999.0 0.0 -0.45 128.0 128.0 PIK3CA 0.008 0.065 -9999.0 0.0 -0.816 3.0 3.0 DHH 0.006 0.075 -9999.0 0.0 -0.816 4.0 4.0 PTHLH -0.156 0.366 -9999.0 0.0 -1.161 35.0 35.0 determination of left/right symmetry -0.105 0.249 -9999.0 0.0 -0.503 124.0 124.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.153 0.359 -9999.0 0.0 -1.135 35.0 35.0 IHH N/Hhip -0.381 0.397 -9999.0 0.0 -0.731 258.0 258.0 DHH N/Hhip -0.248 0.309 -9999.0 0.0 -0.631 191.0 191.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.105 0.249 -9999.0 0.0 -0.503 124.0 124.0 pancreas development -0.312 0.401 -9999.0 0.0 -0.809 191.0 191.0 HHAT 0.012 0.038 -9999.0 0.0 -0.816 1.0 1.0 PI3K -0.004 0.049 -9999.0 0.0 -0.626 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.15 0.33 -9999.0 0.0 -0.816 96.0 96.0 somite specification -0.105 0.249 -9999.0 0.0 -0.503 124.0 124.0 SHH Np/Cholesterol/PTCH1 -0.087 0.202 -9999.0 0.0 -0.616 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.088 0.189 -9999.0 0.0 -0.509 81.0 81.0 SHH Np/Cholesterol/Megalin -0.141 0.228 -9999.0 0.0 -0.513 132.0 132.0 SHH 0.007 0.049 -9999.0 0.0 -0.626 1.0 1.0 catabolic process -0.113 0.248 -9999.0 0.0 -0.507 124.0 124.0 SMO/Vitamin D3 -0.091 0.222 -9999.0 0.0 -0.653 17.0 17.0 SHH Np/Cholesterol/Hhip -0.202 0.244 -9999.0 0.0 -0.506 190.0 190.0 LRP2 -0.209 0.368 -9999.0 0.0 -0.816 131.0 131.0 receptor-mediated endocytosis -0.198 0.233 -9999.0 0.0 -0.715 47.0 47.0 SHH Np/Cholesterol/BOC -0.014 0.074 -9999.0 0.0 -0.52 9.0 9.0 SHH Np/Cholesterol/CDO -0.154 0.232 -9999.0 0.0 -0.51 144.0 144.0 mesenchymal cell differentiation 0.2 0.242 0.502 190.0 -9999.0 0.0 190.0 mol:Vitamin D3 -0.086 0.206 -9999.0 0.0 -0.623 17.0 17.0 IHH N/PTCH2 -0.231 0.343 -9999.0 0.0 -0.658 180.0 180.0 CDON -0.23 0.378 -9999.0 0.0 -0.816 143.0 143.0 IHH N/PTCH1 -0.115 0.25 -9999.0 0.0 -0.514 124.0 124.0 Megalin/LRPAP1 -0.168 0.277 -9999.0 0.0 -0.626 131.0 131.0 PTCH2 -0.123 0.307 -9999.0 0.0 -0.816 80.0 80.0 SHH Np/Cholesterol -0.006 0.035 -9999.0 0.0 -0.507 1.0 1.0 PTCH1 -0.114 0.249 -9999.0 0.0 -0.509 124.0 124.0 HHIP -0.312 0.401 -9999.0 0.0 -0.811 191.0 191.0