Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.07 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.007 0.075 -9999.0 0.0 -0.816 4.0 4.0 EPHA2 0.011 0.026 -9999.0 0.0 -0.313 3.0 3.0 MYO6 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.038 0.129 -9999.0 0.0 -0.588 25.0 25.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.038 0.074 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.11 0.291 -9999.0 0.0 -0.777 76.0 76.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.073 0.193 -9999.0 0.0 -0.588 60.0 60.0 cortical microtubule organization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.0 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.048 0.036 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.001 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.065 0.151 -9999.0 0.0 -0.422 74.0 74.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.183 0.35 -9999.0 0.0 -0.816 113.0 113.0 DIAPH1 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.0 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.039 0.064 -9999.0 0.0 -0.424 9.0 9.0 Ephrin A1/EPHA2 -0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.038 0.074 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.101 0.162 -9999.0 0.0 -0.467 74.0 74.0 HGF -0.113 0.297 -9999.0 0.0 -0.816 74.0 74.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.085 0.022 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.047 0.021 -9999.0 0.0 -0.415 1.0 1.0 KIFC3 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.064 0.019 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.099 0.178 -9999.0 0.0 -0.422 113.0 113.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.106 0.157 -9999.0 0.0 -0.313 179.0 179.0 PLEKHA7 0.04 0.022 -9999.0 0.0 -0.443 1.0 1.0 mol:GTP -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.067 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0