Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.088 0.208 -9999.0 0.0 -0.645 26.0 26.0 IHH -0.153 0.312 -9999.0 0.0 -0.697 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.053 0.158 -9999.0 0.0 -0.391 83.0 83.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.156 0.389 83.0 -9999.0 0.0 83.0 SMO/beta Arrestin2 -0.075 0.205 -9999.0 0.0 -0.521 16.0 16.0 SMO -0.096 0.207 -9999.0 0.0 -0.437 113.0 113.0 AKT1 -0.016 0.105 -9999.0 0.0 -0.607 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.089 -9999.0 0.0 -0.67 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.094 0.204 -9999.0 0.0 -0.431 113.0 113.0 STIL -0.065 0.158 -9999.0 0.0 -0.54 10.0 10.0 DHH N/PTCH2 -0.051 0.205 -9999.0 0.0 -0.507 80.0 80.0 DHH N/PTCH1 -0.076 0.188 -9999.0 0.0 -0.499 19.0 19.0 PIK3CA 0.023 0.055 -9999.0 0.0 -0.67 3.0 3.0 DHH 0.021 0.063 -9999.0 0.0 -0.67 4.0 4.0 PTHLH -0.137 0.308 -9999.0 0.0 -1.062 30.0 30.0 determination of left/right symmetry -0.094 0.204 -9999.0 0.0 -0.431 113.0 113.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.135 0.304 -9999.0 0.0 -1.043 30.0 30.0 IHH N/Hhip -0.29 0.33 -9999.0 0.0 -0.589 252.0 252.0 DHH N/Hhip -0.17 0.264 -9999.0 0.0 -0.503 185.0 185.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.094 0.204 -9999.0 0.0 -0.431 113.0 113.0 pancreas development -0.246 0.329 -9999.0 0.0 -0.667 184.0 184.0 HHAT 0.024 0.032 -9999.0 0.0 -0.67 1.0 1.0 PI3K 0.036 0.043 -9999.0 0.0 -0.505 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.101 0.262 -9999.0 0.0 -0.626 94.0 94.0 somite specification -0.094 0.204 -9999.0 0.0 -0.431 113.0 113.0 SHH Np/Cholesterol/PTCH1 -0.07 0.159 -9999.0 0.0 -0.495 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.044 0.15 -9999.0 0.0 -0.389 73.0 73.0 SHH Np/Cholesterol/Megalin -0.08 0.178 -9999.0 0.0 -0.377 124.0 124.0 SHH -0.005 0.029 -9999.0 0.0 -0.505 1.0 1.0 catabolic process -0.094 0.202 -9999.0 0.0 -0.417 117.0 117.0 SMO/Vitamin D3 -0.076 0.182 -9999.0 0.0 -0.542 12.0 12.0 SHH Np/Cholesterol/Hhip -0.136 0.199 -9999.0 0.0 -0.405 166.0 166.0 LRP2 -0.155 0.304 -9999.0 0.0 -0.657 129.0 129.0 receptor-mediated endocytosis -0.14 0.208 -9999.0 0.0 -0.613 37.0 37.0 SHH Np/Cholesterol/BOC 0.014 0.056 -9999.0 0.0 -0.369 9.0 9.0 SHH Np/Cholesterol/CDO -0.094 0.184 -9999.0 0.0 -0.406 116.0 116.0 mesenchymal cell differentiation 0.135 0.198 0.402 166.0 -9999.0 0.0 166.0 mol:Vitamin D3 -0.065 0.166 -9999.0 0.0 -0.525 11.0 11.0 IHH N/PTCH2 -0.17 0.286 -9999.0 0.0 -0.532 175.0 175.0 CDON -0.176 0.316 -9999.0 0.0 -0.667 142.0 142.0 IHH N/PTCH1 -0.091 0.207 -9999.0 0.0 -0.42 121.0 121.0 Megalin/LRPAP1 -0.102 0.237 -9999.0 0.0 -0.493 129.0 129.0 PTCH2 -0.086 0.256 -9999.0 0.0 -0.666 79.0 79.0 SHH Np/Cholesterol 0.01 0.023 -9999.0 0.0 -0.4 1.0 1.0 PTCH1 -0.094 0.202 -9999.0 0.0 -0.418 117.0 117.0 HHIP -0.246 0.33 -9999.0 0.0 -0.668 184.0 184.0