Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.022 0.079 0.46 11.0 -9999.0 0.0 11.0 EGFR 0.021 0.063 -9999.0 0.0 -0.67 4.0 4.0 EPHA2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.031 0.066 0.422 11.0 -9999.0 0.0 11.0 CTNNB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.003 0.11 -9999.0 0.0 -0.535 18.0 18.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.047 0.377 7.0 -9999.0 0.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.054 0.395 5.0 -9999.0 0.0 5.0 EGF -0.074 0.243 -9999.0 0.0 -0.665 70.0 70.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.042 0.171 -9999.0 0.0 -0.527 49.0 49.0 cortical microtubule organization 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.012 0.047 0.367 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.012 0.031 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.067 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.009 0.143 -9999.0 0.0 -0.354 71.0 71.0 RhoA/GDP 0.057 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.021 0.051 0.384 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.128 0.287 -9999.0 0.0 -0.667 107.0 107.0 DIAPH1 0.05 0.05 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.051 0.386 8.0 -9999.0 0.0 8.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.01 0.059 0.354 3.0 -0.355 8.0 11.0 Ephrin A1/EPHA2 0.047 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.011 0.055 0.398 5.0 -9999.0 0.0 5.0 HGF/MET -0.005 0.145 -9999.0 0.0 -0.371 63.0 63.0 HGF -0.073 0.243 -9999.0 0.0 -0.67 69.0 69.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.066 0.133 0.496 29.0 -0.327 1.0 30.0 KIAA1543 0.013 0.053 0.366 8.0 -0.349 1.0 9.0 KIFC3 0.021 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.038 0.355 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.047 0.38 7.0 -9999.0 0.0 7.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.044 0.103 0.44 22.0 -9999.0 0.0 22.0 adherens junction assembly 0.026 0.086 0.457 12.0 -0.563 1.0 13.0 IGF-1R heterotetramer/IGF1 -0.037 0.165 -9999.0 0.0 -0.354 101.0 101.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.028 0.071 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.026 0.053 0.376 8.0 -0.366 1.0 9.0 mol:GTP 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.032 0.067 0.482 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.021 0.051 0.384 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0