SNP6 Copy number analysis (GISTIC2)
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
15 January 2014  |  analyses__2014_01_15
Maintainer Information
Citation Information
Maintained by Dan DiCara (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): SNP6 Copy number analysis (GISTIC2). Broad Institute of MIT and Harvard. doi:10.7908/C1VQ315V
Overview
Introduction

GISTIC identifies genomic regions that are significantly gained or lost across a set of tumors. The pipeline first filters out normal samples from the segmented copy-number data by inspecting the TCGA barcodes and then executes GISTIC version 2.0.20 (Firehose task version: 126).

Summary

There were 514 tumor samples used in this analysis: 28 significant arm-level results, 48 significant focal amplifications, and 50 significant focal deletions were found.

Results
Focal results

Figure 1.  Genomic positions of amplified regions: the X-axis represents the normalized amplification signals (top) and significance by Q value (bottom). The green line represents the significance cutoff at Q value=0.25.

Table 1.  Get Full Table Amplifications Table - 48 significant amplifications found. Click the link in the last column to view a comprehensive list of candidate genes. If no genes were identified within the peak, the nearest gene appears in brackets.

Cytoband Q value Residual Q value Wide Peak Boundaries # Genes in Wide Peak
19q12 6.9583e-38 8.4806e-38 chr19:30304858-30358071 1
3q26.2 1.692e-54 1.4256e-35 chr3:168605367-168677467 0 [EGFEM1P]
8q24.21 2.8363e-44 1.2409e-25 chr8:129543557-129554481 0 [MIR1208]
17q12 5.6932e-32 6.782e-19 chr17:37827871-37904210 5
10q22.2 7.6287e-13 7.6287e-13 chr10:77001334-77071885 1
2q13 1.303e-12 1.303e-12 chr2:114050324-114109976 0 [PAX8]
8q24.21 1.8702e-36 1.4354e-12 chr8:128739772-128781734 1
1p22.3 5.3498e-13 2.8418e-11 chr1:85979933-86002734 1
6p24.2 8.0746e-11 8.0746e-11 chr6:11383458-11435364 0 [NEDD9]
8p11.21 3.1024e-10 3.1024e-10 chr8:41701319-42077182 4
1q21.3 4.7085e-23 4.8977e-10 chr1:150516762-150919620 11
19p13.2 3.2509e-14 2.7938e-08 chr19:10841050-10892007 2
3p25.1 3.6396e-09 5.1651e-08 chr3:13714839-13726839 1
1q22 1.3612e-21 4.5946e-07 chr1:155822941-156146725 15
3q26.2 2.0715e-37 6.7865e-07 chr3:169257885-169521059 5
12q13.2 2.1988e-09 7.712e-07 chr12:56481350-56491606 1
17q25.1 2.4649e-10 3.1022e-06 chr17:73568926-73774242 9
4p16.3 3.7659e-05 3.7659e-05 chr4:1629690-1881446 7
5p15.33 5.5057e-05 5.5057e-05 chr5:1-1425066 26
20q11.21 6.1161e-08 5.8684e-05 chr20:30731473-30921695 6
11q13.2 7.7931e-06 0.00019491 chr11:67093861-67224838 12
2p24.3 0.00038017 0.00038017 chr2:15808766-16358714 2
16p11.2 0.00042287 0.00042287 chr16:30854953-30989870 9
19p13.11 2.1463e-08 0.00066028 chr19:15293986-18123964 78
6q25.1 0.00077392 0.00077392 chr6:151933176-152042501 2
18q11.2 0.00091829 0.00091829 chr18:23844490-24065368 2
1q42.3 9.3866e-07 0.0011391 chr1:234932633-235266458 0 [TOMM20]
9p24.2 0.0018046 0.0018046 chr9:3631009-3867341 1
20q13.12 1.7173e-06 0.0035961 chr20:45921681-46076395 2
1p34.2 0.00039302 0.0070467 chr1:41317021-41507861 5
14q24.3 0.0146 0.0146 chr14:77354977-77546298 1
Xq28 0.016276 0.016276 chrX:153029080-153392575 18
Xp11.23 0.022265 0.022265 chrX:46547716-47356397 14
11q22.2 0.0074556 0.033662 chr11:102404131-102417951 0 [MMP7]
12p12.1 0.034613 0.038297 chr12:24643054-25683946 9
1p35.2 0.0023208 0.05069 chr1:31354381-31376674 1
12q13.11 7.7989e-05 0.054272 chr12:48107006-48305012 5
22q12.2 0.061404 0.061404 chr22:30270268-31676489 34
3p14.1 0.0059073 0.076272 chr3:66724129-66740563 0 [LRIG1]
17q11.2 1.1805e-05 0.083225 chr17:26704253-27113673 25
18p11.31 0.093412 0.093412 chr18:3532757-3739936 2
7q22.1 0.097941 0.097941 chr7:99538700-99827234 23
11p11.2 0.10178 0.10178 chr11:46300642-46711489 12
13q34 0.10889 0.10889 chr13:109144777-114923884 39
20p13 0.11926 0.11926 chr20:2698775-4359815 38
20q13.33 0.00036119 0.15742 chr20:62147281-63025520 41
9q34.3 0.17419 0.17419 chr9:139812578-139951370 13
5q35.3 0.20056 0.20056 chr5:176740997-176957671 13
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 19q12.

Table S1.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CCNE1
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 17q12.

Table S2.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ERBB2
GRB7
MIEN1
PGAP3
MIR4728
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 10q22.2.

Table S3.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ZNF503-AS1
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 8q24.21.

Table S4.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
MYC
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 1p22.3.

Table S5.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
DDAH1
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 8p11.21.

Table S6.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ANK1
PLAT
KAT6A
AP3M2
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 1q21.3.

Table S7.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ARNT
hsa-mir-4257
CTSK
CTSS
ENSA
MCL1
SETDB1
ADAMTSL4
GOLPH3L
HORMAD1
MIR4257
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 19p13.2.

Table S8.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
DNM2
MIR4748
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 3p25.1.

Table S9.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LOC285375
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 1q22.

Table S10.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LMNA
RIT1
SSR2
ARHGEF2
KIAA0907
SYT11
LAMTOR2
GON4L
UBQLN4
RAB25
SEMA4A
MEX3A
RXFP4
SCARNA4
SNORA42
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 3q26.2.

Table S11.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
MECOM
TERC
MYNN
ARPM1
LRRC34
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 12q13.2.

Table S12.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ERBB3
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 17q25.1.

Table S13.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
GALK1
H3F3B
ITGB4
LLGL2
RECQL5
SAP30BP
MYO15B
C17orf109
C17orf110
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 4p16.3.

Table S14.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
FGFR3
WHSC1
LETM1
SLBP
TACC3
TMEM129
FAM53A
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 5p15.33.

Table S15.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
SDHA
SLC6A3
SLC9A3
TERT
TRIP13
PDCD6
SLC12A7
TPPP
EXOC3
PP7080
CEP72
AHRR
BRD9
ZDHHC11
CLPTM1L
NKD2
C5orf55
CCDC127
PLEKHG4B
SLC6A19
SLC6A18
LRRC14B
LOC100506688
MIR4457
MIR4456
MIR4635
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 20q11.21.

Table S16.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-1825
PLAGL2
KIF3B
TM9SF4
POFUT1
TSPY26P
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 11q13.2.

Table S17.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
PPP1CA
PTPRCAP
RAD9A
RPS6KB2
CLCF1
CABP4
CORO1B
CARNS1
POLD4
TBC1D10C
GPR152
LOC100130987
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 2p24.3.

Table S18.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
MYCN
MYCNOS
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 16p11.2.

Table S19.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-762
CTF1
BCL7C
SETD1A
FBXL19
ORAI3
FBXL19-AS1
MIR762
MIR4519
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 19p13.11.

Table S20.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
JAK3
TPM4
BRD4
hsa-mir-1470
BST2
NR2F6
INSL3
KCNN1
CYP4F3
RAB8A
MYO9B
NOTCH3
RPL18A
SLC5A5
CYP4F2
AP1M1
F2RL3
MED26
AKAP8
B3GNT3
KLF2
CHERP
CYP4F8
UNC13A
FCHO1
SIN3B
PGLS
FAM32A
OR10H3
OR10H2
OR10H1
SNORA68
AKAP8L
ARRDC2
CPAMD8
BABAM1
MAP1S
USE1
ANO8
CYP4F11
EPS15L1
WIZ
RASAL3
MRPL34
CYP4F12
DDA1
TMEM38A
C19orf42
ABHD8
OCEL1
GLT25D1
EPHX3
SLC35E1
PLVAP
USHBP1
C19orf44
GTPBP3
HSH2D
HAUS8
FAM125A
PGLYRP2
CCDC124
NXNL1
CIB3
CALR3
CYP4F22
LOC126536
OR10H4
ANKLE1
FLJ25328
FAM129C
OR10H5
NWD1
SLC27A1
CYP4F24P
UCA1
TMEM221
MIR1470
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 6q25.1.

Table S21.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ESR1
C6orf97
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 18q11.2.

Table S22.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
TAF4B
KCTD1
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 9p24.2.

Table S23.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
GLIS3
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 20q13.12.

Table S24.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ZMYND8
LOC100131496
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 1p34.2.

Table S25.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CTPS
SCMH1
CITED4
SLFNL1
LOC100507178
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 14q24.3.

Table S26.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
IRF2BPL
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for Xq28.

Table S27.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-718
ARHGAP4
AVPR2
HCFC1
IDH3G
IRAK1
L1CAM
MECP2
PLXNB3
RENBP
SSR4
NAA10
TMEM187
SRPK3
PDZD4
MIR718
MIR3202-2
MIR3202-1
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for Xp11.23.

Table S28.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CDK16
RP2
UBA1
ZNF41
ZNF157
USP11
RBM10
INE1
RGN
PHF16
NDUFB11
SLC9A7
CXorf31
SNORA11C
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 12p12.1.

Table S29.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
KRAS
BCAT1
LRMP
SOX5
CASC1
LINC00477
LYRM5
IFLTD1
C12orf77
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 1p35.2.

Table S30.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
SDC3
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 12q13.11.

Table S31.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
VDR
ENDOU
RAPGEF3
HDAC7
SLC48A1
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 22q12.2.

Table S32.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-3200
LIF
LIMK2
OSM
SMTN
TCN2
MTMR3
GAL3ST1
SF3A1
MORC2
PES1
SEC14L2
OSBP2
INPP5J
PLA2G3
MTFP1
TUG1
TBC1D10A
KIAA1656
RNF185
SELM
HORMAD2
DUSP18
MORC2-AS1
RNF215
SEC14L3
SEC14L4
SLC35E4
SDC4P
CCDC157
GATSL3
SEC14L6
MIR3200
MIR3928
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 17q11.2.

Table S33.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ALDOC
RPL23A
SDF2
SUPT6H
FOXN1
SLC13A2
UNC119
TRAF4
KIAA0100
SPAG5
SARM1
SNORD4B
SNORD4A
SNORD42B
SNORD42A
C17orf63
RAB34
PIGS
SLC46A1
TLCD1
SGK494
PROCA1
NEK8
SPAG5-AS1
RAB34
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 18p11.31.

Table S34.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
DLGAP1
FLJ35776
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 7q22.1.

Table S35.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-106b
AZGP1
MCM7
TAF6
ZNF3
ZKSCAN1
ZSCAN21
AP4M1
STAG3
COPS6
C7orf43
PVRIG
GAL3ST4
GPC2
CNPY4
MBLAC1
GATS
C7orf59
MIR106B
MIR25
MIR93
AZGP1P1
MIR4658
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 11p11.2.

Table S36.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CREB3L1
hsa-mir-3160-2
ARHGAP1
CHRM4
MDK
DGKZ
ATG13
AMBRA1
HARBI1
MIR3160-2
MIR3160-1
MIR4688
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 13q34.

Table S37.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ATP4B
COL4A1
COL4A2
F7
F10
GAS6
ING1
LAMP1
GRK1
SOX1
TFDP1
CUL4A
IRS2
PROZ
ARHGEF7
TUBGCP3
RASA3
MYO16
ATP11A
MCF2L
TMCO3
DCUN1D2
ANKRD10
RAB20
CARKD
PCID2
CARS2
GRTP1
ADPRHL1
TEX29
SPACA7
LINC00346
FAM70B
C13orf35
FLJ44054
FLJ41484
LINC00552
MCF2L-AS1
LOC100506394
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 20p13.

Table S38.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-103-2-as
ADRA1D
AVP
CDC25B
CENPB
GNRH2
ITPA
OXT
PTPRA
SIGLEC1
ATRN
ProSAPiP1
RNF24
UBOX5
SPEF1
C20orf194
SMOX
C20orf27
C20orf29
CPXM1
MAVS
EBF4
FASTKD5
GFRA4
VPS16
FAM113A
MRPS26
DDRGK1
PANK2
ADAM33
SLC4A11
HSPA12B
C20orf141
MIR103A2
LOC728228
LOC100134015
TMEM239
MIR103B2
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 20q13.33.

Table S39.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-647
NPBWR2
MYT1
OPRL1
PTK6
SRMS
TCEA2
TPD52L2
TNFRSF6B
ARFRP1
RGS19
PRPF6
GMEB2
STMN3
RTEL1
SOX18
LIME1
UCKL1
PCMTD2
SLC2A4RG
ZNF512B
C20orf195
PPDPF
DNAJC5
ZGPAT
PRIC285
ZBTB46
SAMD10
ABHD16B
LINC00266-1
C20orf201
LINC00176
MIR647
UCKL1-AS1
MIR941-1
MIR941-4
MIR941-2
MIR941-3
MIR1914
LOC100505815
RTEL1-TNFRSF6B
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 9q34.3.

Table S40.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ABCA2
C8G
ENTPD2
FUT7
PTGDS
TRAF2
CLIC3
FBXW5
NPDC1
LCN12
C9orf142
LCNL1
C9orf139
Genes in Wide Peak

This is the comprehensive list of amplified genes in the wide peak for 5q35.3.

Table S41.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
DBN1
F12
GRK6
SLC34A1
PDLIM7
RGS14
LMAN2
DDX41
FAM193B
DOK3
PRR7
LOC340037
PFN3

Figure 2.  Genomic positions of deleted regions: the X-axis represents the normalized deletion signals (top) and significance by Q value (bottom). The green line represents the significance cutoff at Q value=0.25.

Table 2.  Get Full Table Deletions Table - 50 significant deletions found. Click the link in the last column to view a comprehensive list of candidate genes. If no genes were identified within the peak, the nearest gene appears in brackets.

Cytoband Q value Residual Q value Wide Peak Boundaries # Genes in Wide Peak
19p13.3 2.5911e-43 1.2155e-42 chr19:3054758-3143282 1
5q11.2 3.4983e-31 3.4983e-31 chr5:58260298-59787985 3
4q34.3 5.0477e-32 5.9536e-25 chr4:178911874-183060693 1
10q23.31 6.821e-21 6.821e-21 chr10:89617158-90034038 2
1p36.11 5.4343e-18 5.4343e-18 chr1:26900639-27322419 9
Xp21.2 7.7345e-18 7.6653e-18 chrX:30870233-34644819 4
2q22.1 7.6653e-18 1.1669e-16 chr2:139655617-143637838 1
16q23.1 3.6636e-16 2.8743e-14 chr16:78129058-79627770 1
22q13.32 5.3353e-18 5.4628e-11 chr22:48668761-51304566 46
6q26 2.353e-09 2.3638e-09 chr6:161693099-163153207 1
3p14.2 1.0321e-07 1.0999e-07 chr3:59034763-61547330 1
11p15.5 8.8647e-07 8.7442e-07 chr11:1-3679657 114
12q23.1 2.3608e-08 9.8439e-07 chr12:99124001-100107912 2
17q11.2 1.6945e-08 2.0915e-06 chr17:29326736-29722618 5
8p23.2 1.0812e-08 1.063e-05 chr8:1-6262191 15
15q15.1 9.1559e-08 1.8662e-05 chr15:28096454-47478056 204
13q14.2 1.5163e-06 6.0775e-05 chr13:48833767-49281290 3
7p22.3 0.00010326 0.00010501 chr7:1-5515694 57
11q25 1.0123e-06 0.00010501 chr11:121183812-135006516 117
18q23 4.8612e-06 0.00026229 chr18:64271112-78077248 44
20p12.1 0.0002584 0.00026229 chr20:14302876-16252980 3
16p13.3 0.0003737 0.00036116 chr16:3764793-4013466 1
4p15.31 0.00011182 0.00087104 chr4:20527762-21845560 4
11q14.1 0.00045001 0.0019297 chr11:82995735-85348794 2
19q13.43 0.0034736 0.0033755 chr19:57359801-59128983 71
9p24.1 0.0047645 0.0049588 chr9:7799607-12693402 1
22q13.31 1.0965e-20 0.0057247 chr22:47571204-48018269 1
8p21.2 4.6194e-09 0.0064541 chr8:22106166-28561777 67
16q21 2.3285e-05 0.007823 chr16:51183223-69367995 179
4q22.1 0.00010933 0.013672 chr4:90844993-94753878 3
14q13.1 0.015693 0.016129 chr14:33301849-34394000 1
7q31.1 5.6687e-05 0.016981 chr7:109599468-111366370 2
4p16.3 0.00045449 0.02166 chr4:1-1511830 31
2q37.3 0.00046755 0.025884 chr2:223169842-243199373 189
17q21.31 0.00032712 0.035366 chr17:38253229-45885314 227
12q24.33 0.00058343 0.043979 chr12:121015462-133851895 126
17p13.3 0.0028891 0.043979 chr17:1-1201203 17
3q13.31 0.066886 0.064853 chr3:116161663-118620828 1
7q36.1 0.00010558 0.064853 chr7:120389649-159138663 335
9q34.2 0.034522 0.064853 chr9:116359544-141213431 381
17p11.2 0.00026747 0.080097 chr17:9693062-18289032 93
18q21.2 0.010185 0.095493 chr18:44216759-65175647 104
22q12.1 0.070654 0.1299 chr22:29192671-29455701 1
7q11.22 0.0027815 0.13771 chr7:66780207-70601215 1
9q21.2 0.068359 0.13771 chr9:38619152-108424830 298
15q23 0.00032438 0.14829 chr15:71406546-72105142 1
13q11 0.0012218 0.15988 chr13:1-24043829 30
2p25.3 0.17187 0.17187 chr2:1-27196298 142
19p12 0.00027908 0.18366 chr19:23939307-28240493 4
17p11.2 0.00079145 0.1991 chr17:19651612-25270516 19
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 19p13.3.

Table S42.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
GNA11
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 5q11.2.

Table S43.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-582
PDE4D
PART1
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 4q34.3.

Table S44.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LINC00290
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 10q23.31.

Table S45.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
PTEN
KLLN
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 1p36.11.

Table S46.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ARID1A
SFN
NR0B2
NUDC
GPN2
PIGV
GPATCH3
ZDHHC18
C1orf172
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for Xp21.2.

Table S47.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-548f-5
DMD
FTHL17
FAM47A
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 2q22.1.

Table S48.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LRP1B
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 16q23.1.

Table S49.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
WWOX
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 22q13.32.

Table S50.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-3201
ACR
ARSA
CHKB
CPT1B
TYMP
MAPK11
MAPK12
SBF1
PPP6R2
ZBED4
SCO2
RABL2B
MLC1
MAPK8IP2
PLXNB2
BRD1
FAM19A5
NCAPH2
MOV10L1
MIOX
PANX2
ALG12
CRELD2
ADM2
TRABD
SELO
HDAC10
SHANK3
TUBGCP6
LOC90834
LMF2
KLHDC7B
LOC284933
RPL23AP82
C22orf34
CHKB-CPT1B
IL17REL
FAM116B
PIM3
ODF3B
SYCE3
LOC100128946
LOC100144603
MIR3201
MIR4535
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 6q26.

Table S51.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
PARK2
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 3p14.2.

Table S52.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
FHIT
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 11p15.5.

Table S53.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CARS
HRAS
hsa-mir-483
hsa-mir-675
hsa-mir-4298
hsa-mir-210
AP2A2
ASCL2
CD81
CD151
CDKN1C
CTSD
DRD4
DUSP8
IGF2
INS
IRF7
KCNQ1
LSP1
MUC2
MUC6
NAP1L4
SLC22A18
SLC22A18AS
POLR2L
PSMD13
RNH1
MRPL23
RPLP2
SCT
TALDO1
TH
TSPAN4
TNNI2
TNNT3
TRPC2
PHLDA2
ZNF195
RASSF7
IFITM1
BRSK2
TSPAN32
TSSC4
IFITM3
DEAF1
IFITM2
OR7E12P
KCNQ1OT1
PKP3
SIRT3
C11orf21
TRPM5
IGF2-AS1
BET1L
CEND1
CDHR5
TOLLIP
PIDD
KCNQ1DN
PNPLA2
PHRF1
SIGIRR
RIC8A
EPS8L2
CHID1
SLC25A22
ATHL1
PTDSS2
MOB2
SYT8
ODF3
OSBPL5
LRRC56
MRGPRE
ART5
LOC143666
SCGB1C1
NLRP6
NS3BP
LOC255512
C11orf35
H19
EFCAB4A
TMEM80
C11orf36
ANO9
LOC338651
B4GALNT4
PDDC1
MRGPRG
KRTAP5-1
KRTAP5-3
KRTAP5-4
IFITM5
FAM99A
IFITM10
MIR210
KRTAP5-5
KRTAP5-2
KRTAP5-6
MIR483
SNORA52
LOC650368
LOC653486
SNORA54
INS-IGF2
MUC5B
MIR675
FAM99B
LOC100133161
MRPL23-AS1
MIR4298
MIR210HG
MIR4686
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 12q23.1.

Table S54.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ANKS1B
FAM71C
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 17q11.2.

Table S55.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
NF1
EVI2A
EVI2B
OMG
MIR4733
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 8p23.2.

Table S56.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-596
CLN8
MYOM2
DLGAP2
ARHGEF10
KBTBD11
FBXO25
CSMD1
C8orf42
ERICH1
ZNF596
LOC286083
OR4F21
RPL23AP53
MIR596
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 15q15.1.

Table S57.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
BUB1B
C15orf55
hsa-mir-147b
hsa-mir-1282
hsa-mir-627
hsa-mir-4310
hsa-mir-626
hsa-mir-1233-2
hsa-mir-1233-1
hsa-mir-211
ACTC1
APBA2
B2M
CAPN3
CHRM5
CHRNA7
CKMT1B
EPB42
GANC
GATM
GCHFR
PDIA3
ITPKA
IVD
LTK
MAP1A
MEIS2
MFAP1
TRPM1
PLCB2
RAD51
RYR3
SCG5
SORD
SPINT1
SRP14
THBS1
TJP1
TP53BP1
TYRO3
SLC30A4
EIF3J
JMJD7-PLA2G4B
SNAP23
HERC2
SLC28A2
TGM5
PPIP5K1
AQR
ARHGAP11A
LCMT2
SLC12A6
RASGRP1
SERF2
GPR176
CHP
OIP5
BAHD1
FAN1
MAPKBP1
GOLGA8A
RTF1
MGA
VPS39
FAM189A1
CCNDBP1
C15orf63
TMEM87A
RPAP1
DKFZP434L187
PLDN
GREM1
RPUSD2
TUBGCP4
EHD4
DUOX2
NDUFAF1
NUSAP1
TMEM85
SPTBN5
CTDSPL2
KLF13
DUOX1
DLL4
INO80
PPP1R14D
MTMR10
ZNF770
HAUS2
FAM82A2
DNAJC17
NOP10
NDNL2
C15orf24
PAK6
CASC5
AVEN
GJD2
STARD9
VPS18
SQRDL
ZFP106
SPATA5L1
CHAC1
C15orf29
WDR76
TMEM62
SPG11
ELL3
C15orf48
C15orf41
ZFYVE19
FRMD5
DISP2
CHRFAM7A
ULK4P3
ULK4P1
ARHGAP11B
ATPBD4
C15orf57
C15orf23
BMF
SHF
DUOXA1
CHST14
CASC4
TGM7
CATSPER2
PLA2G4E
TRIM69
C15orf43
LOC145663
LOC145845
TMCO5A
ZSCAN29
TTBK2
CDAN1
STRC
CSNK1A1P1
OTUD7A
SPRED1
PGBD4
ADAL
EXD1
FSIP1
RHOV
UBR1
PATL2
LPCAT4
PLA2G4F
LRRC57
HMGN2P46
LOC283710
FAM98B
PLA2G4D
GOLGA8G
FMN1
MRPL42P5
C15orf52
C15orf53
C15orf54
DUOXA2
MIR211
HERC2P9
WHAMMP2
GOLGA8B
EIF2AK4
CATSPER2P1
CKMT1A
SERINC4
C15orf62
C15orf56
PHGR1
LOC645212
LOC646278
LOC653075
MIR626
MIR627
ANP32AP1
LOC728758
OIP5-AS1
MIR147B
LOC100131089
ANKRD63
GOLGA8F
JMJD7
PLA2G4B
ULK4P2
LOC100288615
LOC100288637
LOC100289656
MIR1233-1
MIR1282
MIR1233-2
MIR4310
MIR3942
LOC100505648
LOC100507466
SERF2-C15ORF63
MIR4509-1
MIR4509-2
MIR4510
MIR4509-3
TMCO5B
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 13q14.2.

Table S58.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
RB1
RCBTB2
LPAR6
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 7p22.3.

Table S59.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CARD11
hsa-mir-339
GNA12
GPER
LFNG
NUDT1
PDGFA
PRKAR1B
MAFK
MAD1L1
EIF3B
KIAA0415
ADAP1
IQCE
SUN1
WIPI2
INTS1
SNX8
FTSJ2
GET4
CYP2W1
HEATR2
CHST12
RADIL
PAPOLB
FAM20C
RBAK
MICALL2
TTYH3
PSMG3
C7orf50
TNRC18
ZFAND2A
COX19
KIAA1908
GPR146
AMZ1
TMEM184A
BRAT1
SDK1
FOXK1
MMD2
SLC29A4
TFAMP1
UNCX
LOC389458
ELFN1
RNF216P1
FLJ44511
LOC442497
MIR339
ZNF890P
LOC100288524
RBAK-LOC389458
MIR4648
MIR4655
MIR4656
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 11q25.

Table S60.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
FLI1
hsa-mir-3167
hsa-mir-100
ACRV1
APLP2
CHEK1
ETS1
HSPA8
STT3A
KCNJ1
KCNJ5
VWA5A
NFRKB
NRGN
OPCML
ST3GAL4
SORL1
SRPR
ST14
ZNF202
BARX2
EI24
FEZ1
ARHGAP32
ADAMTS8
IGSF9B
NCAPD3
VSIG2
OR8G2
OR8B8
OR8G1
OR8B2
ACAD8
B3GAT1
DCPS
ZBTB44
THYN1
DDX25
NTM
CDON
SPA17
SIAE
ROBO4
FOXRED1
SCN3B
CRTAM
PRDM10
GRAMD1B
PKNOX2
TP53AIP1
ROBO3
FAM118B
C11orf61
CLMP
C11orf63
CCDC15
PUS3
JAM3
KIRREL3
RPUSD4
TBRG1
UBASH3B
GLB1L2
ESAM
VPS26B
GLB1L3
TIRAP
PANX3
TMEM45B
PATE1
ADAMTS15
C11orf45
HYLS1
TMEM218
SLC37A2
OR8B12
OR8G5
OR10G8
OR10G9
OR10S1
OR6T1
OR4D5
SPATA19
HEPACAM
OR8D1
OR8D2
OR8B4
KIRREL3-AS3
LOC283174
LOC283177
TMEM225
OR8D4
LOC341056
BSX
OR6X1
OR6M1
OR10G4
OR10G7
OR8B3
OR8A1
MIR100HG
PATE2
PATE4
FLJ39051
SNX19
MIRLET7A2
MIR100
MIR125B1
BLID
LINC00167
HEPN1
LOC100128239
PATE3
MIR3167
LOC100507392
MIR4697
MIR4493
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 18q23.

Table S61.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CYB5A
GALR1
MBP
NFATC1
ZNF236
CTDP1
SOCS6
ZNF516
TSHZ1
CD226
TXNL4A
ADNP2
RTTN
KCNG2
SALL3
TIMM21
TMX3
ZNF407
CNDP2
CCDC102B
RBFA
PQLC1
NETO1
PARD6G
CNDP1
DSEL
FAM69C
CBLN2
FBXO15
DOK6
ZADH2
C18orf62
LOC284276
LOC339298
ATP9B
LOC400655
LOC400657
HSBP1L1
LOC643542
C18orf63
LOC100130522
LOC100131655
LOC100505776
LOC100505817
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 20p12.1.

Table S62.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
FLRT3
MACROD2
MACROD2-AS1
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 16p13.3.

Table S63.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CREBBP
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 4p15.31.

Table S64.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-218-1
KCNIP4
PACRGL
MIR218-1
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 11q14.1.

Table S65.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
DLG2
TMEM126B
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 19q13.43.

Table S66.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-1274b
A1BG
FKBP1AP1
RPS5
AURKC
ZNF8
ZNF17
MZF1
ZNF132
ZNF134
ZNF135
ZNF154
UBE2M
ZNF264
TRIM28
ZNF256
ZNF211
TRAPPC2P1
ZNF274
ZNF460
SLC27A5
ZNF324
CHMP2A
ZNF544
ZNF586
ZNF416
ZNF446
VN1R1
ZNF304
USP29
ZSCAN18
MGC2752
ZNF329
ZNF419
ZNF552
ZNF671
ZNF606
ZBTB45
ZNF587
ZNF551
ZIM3
ZNF837
ZNF543
C19orf18
ZNF418
ZNF417
ZNF548
ZNF497
ZNF550
ZNF584
ZSCAN4
ZNF549
ZNF547
ZIK1
ZNF776
ZSCAN1
ZSCAN22
ZNF530
ZNF773
ZNF749
ZNF324B
ZNF805
ZNF772
A1BG-AS1
DUXA
LOC646862
ZNF814
LOC100128398
LOC100131691
ZNF587B
MIR4754
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 9p24.1.

Table S67.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
PTPRD
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 22q13.31.

Table S68.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LOC339685
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 8p21.2.

Table S69.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-4288
hsa-mir-4287
hsa-mir-548h-4
ADRA1A
BNIP3L
CHRNA2
CLU
DPYSL2
EGR3
EPHX2
PTK2B
GNRH1
LOXL2
NEFM
NEFL
NKX3-1
PNOC
PPP2R2A
PPP3CC
STC1
FZD3
ADAM7
TNFRSF10D
TNFRSF10C
TNFRSF10B
TNFRSF10A
ENTPD4
SORBS3
PNMA2
ADAM28
TRIM35
RHOBTB2
SLC39A14
ADAMDEC1
SLC25A37
SCARA3
KCTD9
PIWIL2
ELP3
CCDC25
PBK
ZNF395
BIN3
KIAA1967
PDLIM2
EBF2
DOCK5
FLJ14107
STMN4
CHMP7
NKX2-6
PEBP4
CDCA2
ESCO2
FBXO16
R3HCC1
LOC254896
LOC286059
SCARA5
LOC389641
C8orf80
C8orf58
MIR4287
MIR4288
MIR3622A
MIR3622B
LOC100507156
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 16q21.

Table S70.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
CBFB
CDH1
CDH11
HERPUD1
hsa-mir-328
hsa-mir-138-2
AGRP
AMFR
BBS2
CA7
CDH3
CDH5
CDH8
CDH16
CES1
CETP
CNGB1
CSNK2A2
CTRL
DYNC1LI2
E2F4
GNAO1
GOT2
HAS3
HSD11B2
HSF4
KIFC3
LCAT
MMP2
MMP15
MT1A
MT1B
MT1E
MT1F
MT1G
MT1H
MT1JP
MT1M
MT1L
MT1X
MT2A
MT3
NFATC3
POLR2C
PSKH1
PSMB10
RBL2
RRAD
CCL17
CCL22
CX3CL1
SLC6A2
SLC9A5
SLC12A3
SLC12A4
SNTB2
TK2
TRADD
CES2
NAE1
NOL3
SLC7A6
ATP6V0D1
GPR56
NUP93
NUTF2
IRX5
KATNB1
CTCF
NUDT21
CNOT1
RPGRIP1L
CES3
ARL2BP
EDC4
PLA2G15
PLEKHG4
DKFZP434H168
LRRC29
VPS4A
TOX3
CCDC113
TMEM208
C16orf80
FHOD1
ZDHHC1
PARD6A
PLLP
CKLF
FAM96B
TPPP3
CES1P1
PRMT7
DUS2L
CHTF8
LPCAT2
SLC38A7
OGFOD1
LRRC36
FBXL8
SMPD3
DOK4
DDX28
TSNAXIP1
COQ9
CIAPIN1
THAP11
PDP2
ZNF319
RANBP10
PDF
DPEP2
DPEP3
AKTIP
GINS3
NDRG4
ACD
FTO
IRX6
IRX3
FAM65A
TMCO7
C16orf57
ELMO3
SETD6
ESRP2
FAM192A
CENPT
CHD9
C16orf70
GFOD2
C16orf48
SLC7A6OS
NLRC5
CCDC135
CAPNS2
MT4
B3GNT9
CIRH1A
RSPRY1
CCDC102A
CMTM1
NRN1L
CMTM3
ZFP90
RLTPR
KCTD19
CMTM4
CMTM2
BEAN1
CPNE2
GPR114
PRSS54
CES5A
GPR97
CCDC79
CES4A
EXOC3L1
LOC283856
LOC283867
MT1DP
TEPP
LOC388276
C16orf86
CES1P2
MIR138-2
MIR328
LOC643714
LOC643802
CRNDE
MT1IP
LOC644649
KIAA0895L
SNORA46
SNORA50
MIR3935
LOC100505619
LOC100505865
CKLF-CMTM1
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 4q22.1.

Table S71.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ATOH1
GRID2
FAM190A
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 14q13.1.

Table S72.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
NPAS3
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 7q31.1.

Table S73.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LRRN3
IMMP2L
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 4p16.3.

Table S74.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-571
ATP5I
CTBP1
DGKQ
GAK
IDUA
MYL5
PDE6B
ZNF141
MAEA
PCGF3
SPON2
CPLX1
SLC26A1
FGFRL1
PIGG
KIAA1530
ABCA11P
MFSD7
TMEM175
C4orf42
ZNF595
ZNF721
ZNF718
CRIPAK
RNF212
ZNF876P
ZNF732
LOC100129917
LOC100130872
TMED11P
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 2q37.3.

Table S75.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ACSL3
hsa-mir-3133
hsa-mir-149
hsa-mir-4269
hsa-mir-562
hsa-mir-1471
hsa-mir-1244-1
AGXT
ALPI
ALPP
ALPPL2
KIF1A
BOK
CHRND
CHRNG
COL4A3
COL4A4
COL6A3
DTYMK
GBX2
GPC1
GPR35
HDLBP
AGFG1
HTR2B
SP110
INPP5D
IRS1
KCNJ13
NCL
NDUFA10
SEPT2
NEU2
NPPC
PDCD1
PDE6D
SERPINE2
PPP1R7
PSMD1
PTMA
SNORD20
SAG
CCL20
SP100
SPP2
SCG2
CUL3
DGKD
PER2
LRRFIP1
GPR55
TRIP12
ECEL1
EIF4E2
HDAC4
FARP2
FARSB
ARL4C
RAMP1
NMUR1
STK25
COPS8
CAPN10
SP140
PASK
ATG4B
SH3BP4
KCNE4
NGEF
SNORD82
SNED1
GIGYF2
TRAF3IP1
ANO7
PRLH
THAP4
ANKMY1
SCLY
ASB1
CAB39
UGT1A10
UGT1A8
UGT1A7
UGT1A6
UGT1A5
UGT1A9
UGT1A4
UGT1A1
UGT1A3
PID1
ATG16L1
USP40
HJURP
HES6
DOCK10
C2orf83
MFF
CXCR7
RNPEPL1
WDFY1
NYAP2
GAL3ST2
RAB17
COPS7B
MRPL44
TRPM8
MLPH
IQCA1
FAM124B
TM4SF20
C2orf54
ARMC9
EFHD1
SPHKAP
SLC19A3
ILKAP
ITM2C
RHBDD1
ING5
MGC16025
DNER
B3GNT7
SP140L
MOGAT1
AGAP1
TWIST2
DIS3L2
NEU4
AP1S3
SGPP2
SPATA3
FBXO36
MTERFD2
UBE2F
OTOS
MYEOV2
OR6B3
LOC150935
LOC151171
LOC151174
SLC16A14
LOC151475
LINC00471
LOC151484
MSL3P1
WDR69
C2orf57
TIGD1
LOC200772
C2orf72
CXXC11
DUSP28
ESPNL
ECEL1P2
LOC348761
RBM44
AQP12A
KLHL30
C2orf82
OR6B2
ASB18
FLJ43879
MIR149
DNAJB3
LOC643387
PRR21
LOC646736
PRSS56
AQP12B
SNORA75
SCARNA6
SCARNA5
D2HGDH
LOC728323
PP14571
LOC100286922
MIR1471
MIR1244-1
BOK-AS1
MIR1244-3
MIR1244-2
MIR4269
UBE2F-SCLY
MIR4439
MIR4777
MIR2467
MIR4440
MIR4786
MIR4441
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 17q21.31.

Table S76.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
BRCA1
ETV4
RARA
hsa-mir-4315-1
hsa-mir-2117
ACLY
AOC2
ARL4D
ATP6V0A1
FMNL1
CDC6
CDC27
CCR7
CNP
CRHR1
DHX8
DUSP3
EZH1
GAST
FZD2
G6PC
KAT2A
GFAP
CCR10
GRN
HCRT
HSD17B1
IFI35
IGFBP4
ITGA2B
ITGB3
JUP
KPNB1
KRT9
KRT10
KRT12
KRT13
KRT14
KRT15
KRT16
KRT17
KRT19
KRT31
KRT32
KRT33A
KRT33B
KRT34
KRT35
NBR1
MAPT
ADAM11
MEOX1
MPP2
MPP3
MYL4
NAGLU
NMT1
NSF
PPY
PYY
RAB5C
RPL27
SLC4A1
SMARCE1
STAT3
STAT5A
STAT5B
MLX
TOP2A
DNAJC7
TUBG1
UBTF
WNT3
WNT9B
RND2
CNTNAP1
AOC3
BECN1
KRT38
KRT37
KRT36
HAP1
MAP3K14
EFTUD2
NPEPPS
GOSR2
TBKBP1
PLEKHM1
LRRC37A
HDAC5
GJC1
PSME3
EIF1
NBR2
RAMP2
VAT1
LEPREL4
HEXIM1
C1QL1
RUNDC3A
CASC3
GPATCH8
KCNH4
FAM215A
KRT23
TUBG2
NKIRAS2
CCDC56
PSMC3IP
TBX21
SOST
RAPGEFL1
ARL17A
SLC25A39
HIGD1B
KRT20
LRRC37A4
KLHL11
ATXN7L3
FKBP10
WNK4
C17orf53
TMUB2
DHX58
ACBD4
DCAKD
PLEKHH3
DBF4B
COASY
AARSD1
KRTAP1-3
KRTAP1-1
KRTAP9-9
KRTAP4-6
KRTAP2-1
TTC25
KRTAP4-12
KRTAP1-5
KRTAP3-1
KRTAP3-2
KRTAP9-2
KRTAP9-3
KRTAP9-8
KRTAP17-1
VPS25
TMEM101
GHDC
KRTAP4-4
TNS4
KRTAP9-4
KRTAP4-1
KRTAP4-5
KRTAP4-3
KRTAP4-2
KRTAP3-3
KRTAP2-4
AOC4
G6PC3
ASB16
HSPB9
PLCD3
TMEM106A
NT5C3L
C17orf46
HEXIM2
LSM12
CCDC43
CNTD1
C17orf57
GJD3
KRT222
KRT40
CD300LG
KIF18B
RUNDC1
C17orf69
LOC147093
WIPF2
KRT25
TMEM99
NAGS
FAM134C
IMP5
KRT28
KRT24
ARHGAP27
ZNF385C
STH
KIAA1267
C17orf105
FAM171A2
C17orf104
KRT42P
PTRF
KLHL10
C17orf65
MSL1
KRT27
KRT26
LOC388387
CCDC103
RPRML
KRT39
MGC57346
LRRC37A2
LOC644172
LOC644246
KRTAP4-11
MRPL45P2
KRTAP4-8
KRTAP2-2
KRTAP9-1
NSFP1
LOC730755
LOC100128977
LOC100130148
LOC100130581
KRTAP4-9
KRTAP4-7
LOC100133991
LOC100190938
MIR2117
MIR4315-2
MIR4315-1
KRTAP16-1
LOC100505782
ARL17B
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 12q24.33.

Table S77.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
BCL7A
hsa-mir-4304
ACADS
SCARB1
EIF2B1
STX2
GOLGA3
GTF2H3
HPD
MMP17
P2RX4
P2RX7
POLE
PSMD9
PXMP2
RAN
CLIP1
SFSWAP
HNF1A
UBC
ZNF10
ZNF26
ZNF84
ZNF140
CDK2AP1
ULK1
DENR
OASL
HCAR3
HIP1R
PIWIL1
CABP1
NCOR2
KNTC1
MLEC
MPHOSPH9
CAMKK2
ZNF268
TMED2
SNRNP35
FZD10
MLXIP
P2RX2
SETD1B
ANKLE2
ABCB9
RIMBP2
ATP6V0A2
HCAR1
GALNT9
ARL6IP4
POP5
ANAPC5
RHOF
SBNO1
ZCCHC8
CHFR
DIABLO
PITPNM2
EP400
DHX37
FBRSL1
DDX55
C12orf43
VPS33A
RSRC2
AACS
NOC4L
B3GNT4
OGFOD2
VPS37B
TCTN2
RNF34
CCDC92
PUS1
CCDC62
KDM2B
UNC119B
ORAI1
C12orf65
TMEM132C
TMEM132B
LOC116437
TMEM132D
SLC15A4
SPPL3
BRI3BP
FAM101A
ZNF664
TMEM120B
WDR66
GLT1D1
PGAM5
RILPL2
DNAH10
LRRC43
GPR133
MORN3
HNF1A-AS1
DDX51
HCAR2
LOC338799
EP400NL
RILPL1
IL31
SETD8
LOC387895
LOC400084
FLJ37505
LOC440117
FLJ31485
LOC647589
SNORA49
LOC100128554
LOC100130238
LOC100190940
ZNF605
MIR4304
MIR3612
MIR3908
LOC100507055
LOC100507066
LOC100507091
LOC100507206
ZNF664-FAM101A
MIR4700
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 17p13.3.

Table S78.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
hsa-mir-3183
ABR
DOC2B
RPH3AL
TIMM22
GEMIN4
GLOD4
RNMTL1
VPS53
NXN
FAM57A
FAM101B
C17orf97
BHLHA9
DBIL5P
MIR3183
LOC100506388
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 3q13.31.

Table S79.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
LSAMP-AS3
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 7q36.1.

Table S80.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
BRAF
EZH2
SMO
KIAA1549
MLL3
CREB3L2
hsa-mir-595
hsa-mir-153-2
hsa-mir-671
hsa-mir-1975
hsa-mir-548f-4
hsa-mir-490
hsa-mir-29b-1
hsa-mir-335
hsa-mir-183
hsa-mir-129-1
hsa-mir-593
hsa-mir-592
ABP1
AKR1B1
ARF5
OPN1SW
BPGM
CALD1
CALU
CASP2
CDK5
CHRM2
CLCN1
CPA1
CPA2
DPP6
EN2
EPHA1
EPHB6
FLNC
GBX1
GPR37
GRM8
MNX1
HTR5A
IMPDH1
INSIG1
IRF5
KCNH2
KEL
LEP
MEST
MKLN1
NDUFA5
NDUFB2
NOS3
CNOT4
NRF1
PAX4
PIP
PODXL
PRSS1
PRSS2
TAS2R38
PTN
PTPRN2
PTPRZ1
RARRES2
RHEB
SHH
SLC4A2
SLC13A1
SMARCD3
SPAM1
AKR1D1
SSBP1
TBXAS1
UBE2H
VIPR2
XRCC2
ZYX
ARHGEF5
ZNF212
ZNF282
CUL1
TRIM24
MGAM
WASL
DGKI
ATP6V1F
ACCN3
PDIA4
UBE3C
FAM131B
FAM115A
DNAJB6
ABCF2
AASS
FAM3C
FASTK
ABCB8
PAXIP1
KLHDC10
SSPO
NUP205
AHCYL2
TNPO3
HYAL4
TSPAN12
CLEC5A
MKRN1
POT1
CNTNAP2
HYALP1
GIMAP2
OR2F1
SLC13A4
COPG2
TPK1
SND1
SND1-IT1
DENND2A
ZNF777
TMEM176B
HIPK2
WDR91
REPIN1
HILPDA
FSCN3
ATP6V0A4
TAS2R3
TAS2R4
TAS2R16
CPA4
WNT16
PRKAG2
ZC3HC1
LUC7L2
MRPS33
NUB1
TAS2R5
CHPF2
ING3
NCAPG2
CHCHD3
WDR60
RBM28
TMEM140
GIMAP4
GIMAP5
TMEM176A
TRPV6
AGK
METTL2B
TRPV5
ZC3HAV1
AKR1B10
ACTR3B
KIAA1147
FAM40B
ESYT2
ZNF398
EXOC4
GALNT11
LRRC4
LMBR1
LINC00244
NOM1
CCDC136
PARP12
LRRC61
C7orf49
GCC1
ZNF767
C7orf58
TTC26
JHDM1D
TMUB1
SLC37A3
KRBA1
FAM71F1
SLC35B4
TMEM209
OR6W1P
ADCK2
PLXNA4
ZC3HAV1L
LOC93432
CADPS2
CPA5
CEP41
C7orf29
TSGA13
AGAP3
C7orf13
OR9A4
OR9A2
C7orf34
TMEM139
NOBOX
OR2A14
OR6B1
OR2F2
ZNF786
PRSS37
KLF14
C7orf45
SVOPL
MTPN
LRGUK
ASB10
PRSS58
RNF32
ASB15
TRY6
LOC154761
CLEC2L
C7orf55
LOC154822
LOC154860
IQUB
LOC154872
TMEM213
GIMAP8
CRYGN
ZNF425
LOC155060
ZNF746
ATP6V0E2
RBM33
MGC27345
GALNTL5
RNF133
GIMAP7
ZNF467
ZNF800
GIMAP1
LOC202781
C7orf33
FABP5P3
UBN2
TAS2R39
TAS2R40
TAS2R41
CNPY1
LOC285889
FLJ40852
LOC285965
FAM115C
ZNF775
LOC285972
ATG9B
TPI1P2
FLJ40288
MESTIT1
TAS2R60
CTAGE6P
TSPAN33
AGBL3
OR6V1
OR2A12
OR2A1
FAM71F2
STRA8
KLRG2
WDR86
LOC349160
GSTK1
KCP
FLJ43663
RNF148
FEZF1
FAM180A
OR2A25
OR2A5
PRRT4
RAB19
OR2A7
OR2A20P
LOC401431
OR2A42
FLJ45340
MIR129-1
MIR153-2
MIR182
MIR183
MIR29A
MIR29B1
MIR96
LOC407835
AKR1B15
CTAGE15P
OR2A9P
OR2A2
LMOD2
MIR335
ARHGEF35
GIMAP6
WEE2
MIR490
ZNF862
LOC645249
LOC646329
C7orf73
ACTR3C
MIR592
MIR593
MIR595
LOC728377
LOC728743
TMEM229A
LOC730441
LUZP6
MIR671
LOC100124692
LOC100128264
CTAGE4
LOC100128822
LOC100129148
LOC100130705
LOC100130880
LOC100131176
LOC100132707
LOC100134229
LOC100134713
LOC100287482
MOXD2P
ZNF783
MIR548F3
MIR548I4
MIR548F4
MIR548T
MTRNR2L6
MIR3907
LOC100505483
LOC100506585
LOC100507421
GIMAP1-GIMAP5
MIR4468
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 9q34.2.

Table S81.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ABL1
NOTCH1
RALGDS
SET
TSC1
BRD3
NUP214
FNBP1
hsa-mir-602
hsa-mir-4292
hsa-mir-126
hsa-mir-219-2
hsa-mir-3154
hsa-mir-2861
hsa-mir-181b-2
hsa-mir-601
hsa-mir-600
hsa-mir-147
hsa-mir-455
ABCA2
ABO
AK1
AMBP
ASS1
C5
C8G
CACNA1B
CCBL1
TNFSF8
ENTPD2
CDK9
CEL
CELP
COL5A1
CRAT
DBC1
DBH
SARDH
DNM1
TOR1A
MEGF9
ENDOG
ENG
STOM
FCN1
FCN2
FPGS
NR5A1
FUT7
NR6A1
GGTA1P
GLE1
GOLGA1
GOLGA2
GPR21
RAPGEF1
GRIN1
GSN
HSPA5
TNC
LCN1
LCN2
LMX1B
NDUFA8
ODF2
ORM1
ORM2
PAEP
PAPPA
PDCL
PBX3
PPP2R4
PPP6C
PSMB7
PSMD5
PTGDS
PTGS1
RPL7A
RPL12
RXRA
SNAPC4
SPTAN1
STXBP1
SURF1
SURF2
SURF4
MED22
SURF6
TLR4
TRAF1
TRAF2
TTF1
VAV2
ZNF79
LHX3
GFI1B
SSNA1
EDF1
DPM2
FUBP3
CLIC3
GTF3C5
GTF3C4
LHX2
MED27
PTGES
ATP6V1G1
RALGPS1
ADAMTSL2
PPP1R26
SEC16A
TNFSF15
SH2D3C
RABEPK
LAMC3
TUBB4B
UBAC1
OLFM1
ZER1
AGPAT2
POMT1
ZBTB6
NEK6
SDCCAG3
NOXA1
USP20
SLC27A4
CNTRL
WDR5
C9orf9
ADAMTS13
C9orf7
SLC2A6
RPL35
MAN1B1
DOLK
TRIM32
SETX
ZBTB43
PMPCA
ASTN2
EXOSC2
NCS1
ANGPTL2
NUP188
RABGAP1
CIZ1
DFNB31
COBRA1
NELF
GPSM1
DKFZP434A062
GAPVD1
PHF19
FBXW2
OR1J4
GBGT1
LHX6
OR1L3
OR1L1
OR1J2
SNORA65
SNORD62A
SNORD36C
SNORD36B
SNORD36A
SNORD24
TRUB2
ST6GALNAC4
NDOR1
TOR1B
TOR2A
METTL11A
PHPT1
ANAPC2
PKN3
DPP7
SLC2A8
OBP2B
OBP2A
ST6GALNAC6
DEC1
MRPS2
COQ4
CERCAM
EGFL7
PRRX2
C9orf114
RAB14
C9orf78
FBXW5
RC3H2
TBC1D13
C9orf167
EXD3
STRBP
C9orf86
CDK5RAP2
LRRC8A
INPP5E
NPDC1
BARHL1
SH3GLB2
REXO4
DOLPP1
KCNT1
ZBTB26
DENND1A
GPR107
LINC00474
PRDM12
CARD9
DDX31
FAM129B
MRPL41
C9orf16
MAPKAP1
EHMT1
PTGES2
AKNA
MIR600HG
URM1
ARPC5L
AIF1L
UCK1
GARNL3
NTNG2
PRRC2B
PPAPDC3
ZDHHC12
FAM73B
FIBCD1
KIAA1984
SNHG7
TMEM141
C9orf37
COL27A1
FAM125B
WDR34
SAPCD2
C9orf69
LRSAM1
UAP1L1
MRRF
RBM18
ARRDC1
WDR85
TMEM203
KIF12
SLC25A25
ZNF618
ZMYND19
NACC2
C9orf116
LCN8
FAM69B
PTRH1
PIP5KL1
OR1L8
OR1N2
OR1N1
ASB6
SLC34A3
DAB2IP
CAMSAP1
C9orf163
MAMDC4
LCN6
AK8
OR1Q1
TTLL11
TTC16
C9orf96
OLFML2A
QSOX2
C9orf91
NAIF1
LOC253039
PHYHD1
MORN5
OR1L4
LINC00094
CRB2
SCAI
C9orf117
LCN12
C9orf142
TPRN
FAM78A
GPR144
QRFP
OR1J1
OR1B1
GLT6D1
SWI5
C9orf50
PNPLA7
C9orf169
ENTPD8
LOC389791
IER5L
C9orf171
LCN15
C9orf172
LRRC26
TMEM8C
OR1L6
OR5C1
OR1K1
LCN9
FAM102A
WDR38
LOC401557
LCNL1
C9orf139
FAM166A
SOHLH1
ZBTB34
MIR126
MIR147A
MIR181A2
MIR181B2
MIR199B
MIR219-2
C9orf106
LCN10
C9orf173
NRARP
MIR455
NRON
FAM163B
FLJ40292
TUBBP5
RNF224
SNORA17
SNORA43
SNORD62B
SNORD90
MIR600
MIR601
MIR602
RNF208
DNLZ
SNORA70C
LOC100128505
LOC100128593
LOC100129034
LOC100129722
LOC100130954
LOC100131193
FAM157B
RNU6ATAC
LOC100272217
LOC100288842
LOC100289019
LOC100289341
MIR181A2HG
MIR4292
MIR3154
MIR2861
MIR3621
MIR3689A
MIR3911
MIR3689B
LOC100505478
LOC100506100
LOC100506190
LOC100506599
MIR3689D1
MIR3689F
MIR4669
MIR4673
MIR3960
MIR4674
MIR4478
MIR3689C
MIR2964A
MIR3689D2
MIR4672
MIR3689E
MIR4479
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 17p11.2.

Table S82.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
MAP2K4
GAS7
hsa-mir-33b
hsa-mir-1288
hsa-mir-548h-3
hsa-mir-744
ADORA2B
COX10
DNAH9
DRG2
FLII
LLGL1
MEIS3P1
MYH1
MYH2
MYH3
MYH4
MYH8
PMP22
RCVRN
SCO1
SHMT1
SREBF1
TOP3A
UBB
ZNF18
COPS3
MYH13
GLP2R
PIGL
NCOR1
CCDC144A
ARHGAP44
HS3ST3B1
HS3ST3A1
PEMT
TRIM16
RAI1
MPRIP
TNFRSF13B
SNORD49A
MYO15A
TRPV2
RASD1
ALKBH5
TTC19
MED9
NT5M
C17orf48
ZNF286A
ZNF287
ZNF624
ELAC2
TEKT3
C17orf39
LRRC48
MGC12916
ATPAF2
MYOCD
CDRT7
CDRT15P1
C17orf76-AS1
ZSWIM7
SMCR7
SMCR5
SMCR8
SMCR9
TOM1L2
CDRT15
USP32P1
FAM18B2
CENPV
FLCN
PLD6
FLJ34690
CDRT4
TBC1D26
CDRT1
TMEM220
SHISA6
FAM211A
KRT16P2
PIRT
CDRT15P2
SNORD49B
SNORD65
MIR33B
MIR744
FAM106CP
LOC100289255
MIR1288
FAM18B2-CDRT4
MIR4731
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 18q21.2.

Table S83.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
BCL2
MALT1
hsa-mir-122
hsa-mir-4320
hsa-mir-1539
CDH7
DCC
FECH
KDSR
GRP
LMAN1
SMAD2
SMAD4
SMAD7
MBD1
MC4R
ME2
MYO5B
NARS
SERPINB2
ATP8B1
SERPINB5
SERPINB8
SERPINB10
SERPINB13
PMAIP1
MAPK4
RAB27B
RPL17
SERPINB3
SERPINB4
TCF4
SERPINB7
TNFRSF11A
MBD2
PIAS2
TXNL1
LIPG
ONECUT2
VPS4B
CTIF
ACAA2
POLI
PHLPP1
NEDD4L
WDR7
PIGN
SNORD58B
SNORD58A
CDH20
CDH19
ST8SIA5
RAX
CXXC1
ST8SIA3
IER3IP1
TCEB3B
MEX3C
DYM
ZCCHC2
ZNF532
ELAC1
KIAA1468
CCDC68
KATNAL2
MRO
HDHD2
SERPINB12
SERPINB11
SEC11C
ALPK2
STARD6
CCBE1
C18orf54
TCEB3C
ZBTB7C
SKA1
CCDC11
RNF152
LINC00305
C18orf26
BOD1P
HMSD
LOC284294
CPLX4
LOC390858
LOC400654
MIR122
C18orf32
SCARNA17
SNORA37
TCEB3CL
SNORD58C
LOC100287225
MIR1539
MIR4320
LOC100505474
LOC100505549
LOC100506888
RPL17-C18ORF32
MIR4529
MIR3591
MIR4743
MIR4744
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 22q12.1.

Table S84.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ZNRF3
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 7q11.22.

Table S85.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
AUTS2
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 9q21.2.

Table S86.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
FANCC
GNAQ
OMD
SYK
XPA
NR4A3
hsa-mir-1302-8
hsa-mir-24-1
hsa-mir-2278
hsa-let-7d
hsa-mir-4291
hsa-mir-4290
hsa-mir-3153
hsa-mir-4289
hsa-mir-7-1
hsa-mir-204
hsa-mir-1299
ABCA1
ALDH1A1
ALDOB
ANXA1
APBA1
AUH
BAAT
KLF9
CKS2
COL15A1
CTSL1
CTSL2
CTSL1P8
CYLC2
DAPK1
ECM2
S1PR3
FBP1
FKTN
FOXE1
FXN
GAS1
GCNT1
HNRNPK
HSD17B3
IARS
NCBP1
NFIL3
NINJ1
NTRK2
ROR2
OGN
PCSK5
PGM5
PHF2
PPP3R2
PRKACG
PTCH1
RORB
TGFBR1
TLE1
TLE4
TMOD1
CORO2A
ZNF189
ZFAND5
PIP5K1B
CDC14B
TMEFF1
FBP2
FAM189A2
TJP2
GABBR2
GDA
GNA14
TRIM14
SEMA4D
ANP32B
SPTLC1
SMC2
GADD45G
SPIN1
SEC61B
SLC35D2
ZNF510
HABP4
ERP44
SMC5
FAM120A
VPS13A
AGTPBP1
BICD2
TDRD7
SLC44A1
CDK20
TMEM2
NIPSNAP3A
ZNF658
FAM75A7
OSTF1
INVS
PSAT1
UBQLN1
PCA3
FAM108B1
GOLM1
C9orf156
SHC3
NANS
MRPL50
FAM22F
DIRAS2
ASPN
TEX10
LPPR1
C9orf95
STX17
NOL8
C9orf40
RFK
NIPSNAP3B
TBC1D2
HEMGN
KIF27
BARX1
RNF20
BDAG1
NAA35
SLC28A3
IPPK
WNK2
SECISBP2
ZCCHC6
GALNT12
CNTNAP3
RMI1
TRPM3
GKAP1
ISCA1
ZNF484
FSD1L
CEP78
ANKRD20A1
C9orf64
C9orf89
HIATL2
C9orf125
HIATL1
C9orf3
ALG2
FGD3
C9orf30
FAM122A
GRIN3A
TMC1
C9orf41
C9orf57
C9orf85
C9orf135
PTPDC1
ANKRD19P
OR13C5
OR13C8
OR13C3
OR13C4
OR13F1
TRPM6
NXNL2
RASEF
FAM201A
LOC158257
FAM120AOS
LINC00475
TSTD2
ZNF782
LOC158434
LOC158435
PRUNE2
C9orf71
ZNF169
C9orf21
ZNF367
ANKS6
SUSD3
CBWD5
MAMDC2
FRMD3
C9orf47
C9orf79
LOC286238
LOC286297
LOC286359
OR13C9
OR13D1
LOC286367
LOC286370
FOXD4L3
LOC340508
LOC340515
FAM75D5
MURC
FOXD4L4
AQP7P1
PTAR1
C9orf102
KGFLP1
FAM75A6
MGC21881
FAM75D4
FAM75D3
FAM75D1
LOC389765
C9orf153
CTSL3
LOC392364
OR13C2
FAM74A1
FAM74A4
ZNF658B
C9orf170
CENPP
MIRLET7A1
MIRLET7D
MIRLET7F1
MIR204
MIR23B
MIR24-1
MIR27B
MIR7-1
C9orf103
LOC440173
LOC440896
ANKRD20A3
ANKRD20A2
AQP7P3
FAM75C1
LOC441454
LOC441455
FAM22G
LOC441461
LOC442421
FOXB2
CBWD3
C9orf129
LOC494127
LOC494558
FAM27A
LOC572558
PGM5P2
LOC642236
FAM75A2
FAM75A4
LOC642929
LOC643648
CBWD6
FAM75C2
FAM75A1
FAM74A2
RPSAP9
FOXD4L6
FOXD4L5
LOC653501
KGFLP2
FAM75A3
FAM75A5
FAM74A3
CNTNAP3B
ANKRD20A4
FOXD4L2
SNORA84
LOC100128076
LOC100128361
LINC00476
UNQ6494
LOC100129316
LOC100132077
LOC100132352
LOC100132781
FAM27C
FAM95B1
FAM27B
LOC100133920
LINC00092
LOC100286938
MIR548H3
MIR2278
MIR3074
MIR4291
MIR3153
MIR4290
MIR4289
C9orf174
LOC100499484
MIR3910-1
MIR3910-2
MIR3651
LOC100507244
LOC100507299
LOC100507346
C9orf30-TMEFF1
MIR4670
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 15q23.

Table S87.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
THSD4
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 13q11.

Table S88.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
FGF9
GJA3
GJB2
SGCG
TUBA3C
ZMYM2
IFT88
ZMYM5
SAP18
GJB6
SACS
LATS2
CRYL1
IL17D
MPHOSPH8
PSPC1
XPO4
MRP63
TPTE2
N6AMT2
SKA3
EFHA1
ZDHHC20
PHF2P1
ANKRD20A9P
LINC00442
BASP1P1
ANKRD26P3
LINC00421
MIR4499
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 2p25.3.

Table S89.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
DNMT3A
MYCN
NCOA1
hsa-mir-1301
hsa-mir-3125
hsa-mir-4262
hsa-mir-548s
hsa-mir-4261
ACP1
ADCY3
APOB
RHOB
CENPA
DDX1
DTNB
E2F6
FKBP1B
HADHA
HADHB
HPCAL1
ID2
KCNF1
KCNK3
KCNS3
KIF3C
MATN3
ODC1
POMC
RPS7
RRM2
SDC1
SOX11
ADAM17
TPO
TSSC1
VSNL1
PXDN
KLF11
ASAP2
TAF1B
ITGB1BP1
OTOF
ROCK2
TP53I3
GREB1
LAPTM4A
RNF144A
PDIA6
MYCNOS
RAB10
YWHAQ
EFR3B
MYT1L
LPIN1
PUM2
NTSR2
SH3YL1
TRIB2
GRHL1
ITSN2
TRAPPC12
DNAJC27
NBAS
SF3B14
CPSF3
SNTG2
ATAD2B
C2orf18
ASXL2
ADI1
ALLC
DPYSL5
KIDINS220
WDR35
RDH14
C2orf43
HS1BP3
COLEC11
CENPO
SMC6
NOL10
C2orf44
FAM49A
EPT1
RSAD2
CCDC164
NT5C1B
KLHL29
CMPK2
MBOAT2
TMEM18
CIB4
OSR1
TTC32
C2orf50
PQLC3
LOC150622
FAM59B
FAM84A
GDF7
GPR113
UBXN2A
CYS1
ATP6V1C2
RNASEH1
FAM150B
IAH1
FLJ33534
C2orf70
LOC339788
LINC00299
LOC339822
MSGN1
GEN1
C2orf48
PFN4
LOC375190
LOC386597
MFSD2B
PTRHD1
LOC400940
LINC00487
FLJ12334
FAM110C
LOC645949
C2orf84
LOC727982
RAD51AP2
DNAJC27-AS1
LOC730811
MIR1301
SNORA80B
MIR4261
MIR3125
MIR4262
LOC100505964
LOC100506054
LOC100506274
LOC100506474
NT5C1B-RDH14
MIR4757
MIR4429
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 19p12.

Table S90.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
ZNF254
RPSAP58
ZNF726
LOC100101266
Genes in Wide Peak

This is the comprehensive list of deleted genes in the wide peak for 17p11.2.

Table S91.  Genes in bold are cancer genes as defined by The Sanger Institute's Cancer Gene Census [7].

Genes
KCNJ12
MAP2K3
TMEM11
ULK2
AKAP10
USP22
DHRS7B
SPECC1
CDRT15L2
C17orf103
FAM27L
FLJ36000
LGALS9B
CCDC144NL
C17orf51
CCDC144C
KRT16P3
KCNJ18
MTRNR2L1
Arm-level results

Table 3.  Get Full Table Arm-level significance table - 28 significant results found. The significance cutoff is at Q value=0.25.

Arm # Genes Amp Frequency Amp Z score Amp Q value Del Frequency Del Z score Del Q value
1p 2121 0.09 -0.307 1 0.05 -3.07 1
1q 1955 0.34 18.6 0 0.06 -2.36 1
2p 924 0.17 3.94 0.000203 0.03 -5.65 1
2q 1556 0.14 2.92 0.00774 0.04 -4.62 1
3p 1062 0.09 -1.64 1 0.11 -0.466 1
3q 1139 0.15 2.47 0.0246 0.08 -2 1
4p 489 0.02 -6.15 1 0.20 5.1 6.31e-07
4q 1049 0.02 -6.04 1 0.19 5.62 4.86e-08
5p 270 0.10 -1.87 1 0.12 -0.279 1
5q 1427 0.04 -4.7 1 0.15 3.29 0.00143
6p 1173 0.15 2.48 0.0246 0.04 -4.67 1
6q 839 0.12 0.246 0.948 0.05 -4.26 1
7p 641 0.13 0.356 0.902 0.10 -1.28 1
7q 1277 0.13 1.3 0.297 0.09 -1.23 1
8p 580 0.23 7 1.05e-11 0.21 5.76 2.36e-08
8q 859 0.30 12.8 0 0.07 -2.56 1
9p 422 0.03 -5.54 1 0.21 5.88 1.34e-08
9q 1113 0.02 -5.92 1 0.23 8.82 0
10p 409 0.23 6.85 2.51e-11 0.11 -1.03 1
10q 1268 0.21 7.35 9.88e-13 0.10 -0.599 1
11p 862 0.05 -4.52 1 0.15 2.05 0.05
11q 1515 0.04 -4.23 1 0.14 2.46 0.0183
12p 575 0.13 0.798 0.607 0.10 -1.59 1
12q 1447 0.10 -0.0398 1 0.08 -2.07 1
13q 654 0.07 -3.5 1 0.18 3.83 0.000216
14q 1341 0.08 -1.92 1 0.12 1.16 0.259
15q 1355 0.02 -5.57 1 0.20 7.08 7.46e-12
16p 872 0.05 -4.08 1 0.19 5.18 4.39e-07
16q 702 0.03 -5.6 1 0.27 10.1 0
17p 683 0.03 -5.75 1 0.24 8.44 0
17q 1592 0.06 -2.65 1 0.18 5.58 5.39e-08
18p 143 0.12 -0.798 1 0.14 0.534 0.565
18q 446 0.08 -3.05 1 0.15 1.55 0.134
19p 995 0.10 -0.688 1 0.13 1 0.317
19q 1709 0.11 0.684 0.658 0.12 1.65 0.115
20p 355 0.21 5.41 1.81e-07 0.05 -4.45 1
20q 753 0.24 8.49 0 0.03 -5.4 1
21q 509 0.08 -2.98 1 0.11 -1.1 1
22q 921 0.08 -2.5 1 0.22 7.03 8.17e-12
Xq 1312 0.13 1.74 0.137 0.16 3.34 0.00131
Methods & Data
Input
Description
  • Segmentation File: The segmentation file contains the segmented data for all the samples identified by GLAD, CBS, or some other segmentation algorithm. (See GLAD file format in the Genepattern file formats documentation.) It is a six column, tab-delimited file with an optional first line identifying the columns. Positions are in base pair units.The column headers are: (1) Sample (sample name), (2) Chromosome (chromosome number), (3) Start Position (segment start position, in bases), (4) End Position (segment end position, in bases), (5) Num markers (number of markers in segment), (6) Seg.CN (log2() -1 of copy number).

  • Markers File: The markers file identifies the marker names and positions of the markers in the original dataset (before segmentation). It is a three column, tab-delimited file with an optional header. The column headers are: (1) Marker Name, (2) Chromosome, (3) Marker Position (in bases).

  • Reference Genome: The reference genome file contains information about the location of genes and cytobands on a given build of the genome. Reference genome files are created in Matlab and are not viewable with a text editor.

  • CNV Files: There are two options for the cnv file. The first option allows CNVs to be identified by marker name. The second option allows the CNVs to be identified by genomic location. Option #1: A two column, tab-delimited file with an optional header row. The marker names given in this file must match the marker names given in the markers file. The CNV identifiers are for user use and can be arbitrary. The column headers are: (1) Marker Name, (2) CNV Identifier. Option #2: A 6 column, tab-delimited file with an optional header row. The 'CNV Identifier' is for user use and can be arbitrary. 'Narrow Region Start' and 'Narrow Region End' are also not used. The column headers are: (1) CNV Identifier, (2) Chromosome, (3) Narrow Region Start, (4) Narrow Region End, (5) Wide Region Start, (6) Wide Region End

  • Amplification Threshold: Threshold for copy number amplifications. Regions with a log2 ratio above this value are considered amplified.

  • Deletion Threshold: Threshold for copy number deletions. Regions with a log2 ratio below the negative of this value are considered deletions.

  • Cap Values: Minimum and maximum cap values on analyzed data. Regions with a log2 ratio greater than the cap are set to the cap value; regions with a log2 ratio less than -cap value are set to -cap. Values must be positive.

  • Broad Length Cutoff: Threshold used to distinguish broad from focal events, given in units of fraction of chromosome arm.

  • Remove X-Chromosome: Flag indicating whether to remove data from the X-chromosome before analysis. Allowed values= {1,0} (1: Remove X-Chromosome, 0: Do not remove X-Chromosome.

  • Confidence Level: Confidence level used to calculate the region containing a driver.

  • Join Segment Size: Smallest number of markers to allow in segments from the segmented data. Segments that contain fewer than this number of markers are joined to the neighboring segment that is closest in copy number.

  • Arm Level Peel Off: Flag set to enable arm-level peel-off of events during peak definition. The arm-level peel-off enhancement to the arbitrated peel-off method assigns all events in the same chromosome arm of the same sample to a single peak. It is useful when peaks are split by noise or chromothripsis. Allowed values= {1,0} (1: Use arm level peel off, 0: Use normal arbitrated peel-off).

  • Maximum Sample Segments: Maximum number of segments allowed for a sample in the input data. Samples with more segments than this threshold are excluded from the analysis.

  • Gene GISTIC: When enabled (value = 1), this option causes GISTIC to analyze deletions using genes instead of array markers to locate the lesion. In this mode, the copy number assigned to a gene is the lowest copy number among the markers that represent the gene.

Values

List of inputs used for this run of GISTIC2. All files listed should be included in the archived results.

  • Segmentation File = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_MergeDataFilesPipeline/UCEC-TP/5949731/GDAC_MergeDataFiles_5954423/UCEC-TP.snp__genome_wide_snp_6__broad_mit_edu__Level_3__segmented_scna_minus_germline_cnv_hg19__seg.seg.txt

  • Markers File = /xchip/cga/reference/gistic2/genome.info.6.0_hg19.na31_minus_frequent_nan_probes_sorted_2.1.txt

  • Reference Genome = /xchip/cga/reference/gistic2/hg19_with_miR_20120227.mat

  • CNV Files = /xchip/cga/reference/gistic2/CNV.hg19.bypos.111213.txt

  • Amplification Threshold = 0.1

  • Deletion Threshold = 0.1

  • Cap Values = 1.5

  • Broad Length Cutoff = 0.7

  • Remove X-Chromosome = 0

  • Confidence Level = 0.99

  • Join Segment Size = 4

  • Arm Level Peel Off = 1

  • Maximum Sample Segments = 2000

  • Gene GISTIC = 1

Table 4.  Get Full Table First 10 out of 514 Input Tumor Samples.

Tumor Sample Names
TCGA-A5-A0G1-01A-11D-A120-01
TCGA-A5-A0G2-01A-11D-A042-01
TCGA-A5-A0G5-01A-11D-A042-01
TCGA-A5-A0G9-01A-11D-A042-01
TCGA-A5-A0GA-01A-11D-A042-01
TCGA-A5-A0GB-01A-11D-A042-01
TCGA-A5-A0GD-01A-11D-A042-01
TCGA-A5-A0GE-01A-11D-A042-01
TCGA-A5-A0GG-01A-11D-A120-01
TCGA-A5-A0GH-01A-21D-A042-01

Figure 3.  Segmented copy number profiles in the input data

Output
All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level)

The all lesions file summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.

Region Data

Columns 1-9 present the data about the significant regions as follows:

  1. Unique Name: A name assigned to identify the region.

  2. Descriptor: The genomic descriptor of that region.

  3. Wide Peak Limits: The 'wide peak' boundaries most likely to contain the targeted genes. These are listed in genomic coordinates and marker (or probe) indices.

  4. Peak Limits: The boundaries of the region of maximal amplification or deletion.

  5. Region Limits: The boundaries of the entire significant region of amplification or deletion.

  6. Q values: The Q value of the peak region.

  7. Residual Q values: The Q value of the peak region after removing ('peeling off') amplifications or deletions that overlap other, more significant peak regions in the same chromosome.

  8. Broad or Focal: Identifies whether the region reaches significance due primarily to broad events (called 'broad'), focal events (called 'focal'), or independently significant broad and focal events (called 'both').

  9. Amplitude Threshold: Key giving the meaning of values in the subsequent columns associated with each sample.

Sample Data

Each of the analyzed samples is represented in one of the columns following the lesion data (columns 10 through end). The data contained in these columns varies slightly by section of the file. The first section can be identified by the key given in column 9 - it starts in row 2 and continues until the row that reads 'Actual Copy Change Given.' This section contains summarized data for each sample. A '0' indicates that the copy number of the sample was not amplified or deleted beyond the threshold amount in that peak region. A '1' indicates that the sample had low-level copy number aberrations (exceeding the low threshold indicated in column 9), and a '2' indicates that the sample had high-level copy number aberrations (exceeding the high threshold indicated in column 9).The second section can be identified the rows in which column 9 reads 'Actual Copy Change Given.' The second section exactly reproduces the first section, except that here the actual changes in copy number are provided rather than zeroes, ones, and twos.The final section is similar to the first section, except that here only broad events are included. A 1 in the samples columns (columns 10+) indicates that the median copy number of the sample across the entire significant region exceeded the threshold given in column 9. That is, it indicates whether the sample had a geographically extended event, rather than a focal amplification or deletion covering little more than the peak region.

Amplification Genes File (amp_genes.conf_##.txt, where ## is the confidence level)

The amp genes file contains one column for each amplification peak identified in the GISTIC analysis. The first four rows are:

  1. Cytoband

  2. Q value

  3. Residual Q value

  4. Wide Peak Boundaries

These rows identify the lesion in the same way as the all lesions file.The remaining rows list the genes contained in each wide peak. For peaks that contain no genes, the nearest gene is listed in brackets.

Deletion Genes File (del_genes.conf_##.txt, where ## is the confidence level)

The del genes file contains one column for each deletion peak identified in the GISTIC analysis. The file format for the del genes file is identical to the format for the amp genes file.

Gistic Scores File (scores.gistic)

The scores file lists the Q values [presented as -log10(q)], G scores, average amplitudes among aberrant samples, and frequency of aberration, across the genome for both amplifications and deletions. The scores file is viewable with the Genepattern SNPViewer module and may be imported into the Integrated Genomics Viewer (IGV).

Segmented Copy Number (raw_copy_number.{fig|pdf|png} )

The segmented copy number is a pdf file containing a colormap image of the segmented copy number profiles in the input data.

Amplification Score GISTIC plot (amp_qplot.{fig|pdf|png|v2.pdf})

The amplification pdf is a plot of the G scores (top) and Q values (bottom) with respect to amplifications for all markers over the entire region analyzed.

Deletion Score GISTIC plot (del_qplot.{fig|pdf|png|v2.pdf})

The deletion pdf is a plot of the G scores (top) and Q values (bottom) with respect to deletions for all markers over the entire region analyzed.

Tables (table_{amp|del}.conf_##.txt, where ## is the confidence level)

Tables of basic information about the genomic regions (peaks) that GISTIC determined to be significantly amplified or deleted. These describe three kinds of peak boundaries, and list the genes contained in two of them. The region start and region end columns (along with the chromosome column) delimit the entire area containing the peak that is above the significance level. The region may be the same for multiple peaks. The peak start and end delimit the maximum value of the peak. The extended peak is the peak determined by robust, and is contained within the wide peak reported in {amp|del}_genes.txt by one marker.

Broad Significance Results (broad_significance_results.txt)

A table of per-arm statistical results for the data set. Each arm is a row in the table. The first column specifies the arm and the second column counts the number of genes known to be on the arm. For both amplification and deletion, the table has columns for the frequency of amplification or deletion of the arm, and a Z score and Q value.

Broad Values By Arm (broad_values_by_arm.txt)

A table of chromosome arm amplification levels for each sample. Each row is a chromosome arm, and each column a sample. The data are in units of absolute copy number -2.

All Data By Genes (all_data_by_genes.txt)

A gene-level table of copy number values for all samples. Each row is the data for a gene. The first three columns name the gene, its NIH locus ID, and its cytoband - the remaining columns are the samples. The copy number values in the table are in units of (copy number -2), so that no amplification or deletion is 0, genes with amplifications have positive values, and genes with deletions are negative values. The data are converted from marker level to gene level using the extreme method: a gene is assigned the greatest amplification or the least deletion value among the markers it covers.

Broad Data By Genes (broad_data_by_genes.txt)

A gene-level table of copy number data similar to the all_data_by_genes.txt output, but using only broad events with lengths greater than the broad length cutoff. The structure of the file and the methods and units used for the data analysis are otherwise identical to all_data_by_genes.txt.

Focal Data By Genes (focal_data_by_genes.txt)

A gene-level table of copy number data similar to the all_data_by_genes.txt output, but using only focal events with lengths greater than the focal length cutoff. The structure of the file and the methods and units used for the data analysis are otherwise identical to all_data_by_genes.txt.

All Thresholded By Genes (all_thresholded.by_genes.txt)

A gene-level table of discrete amplification and deletion indicators at for all samples. There is a row for each gene. The first three columns name the gene, its NIH locus ID, and its cytoband - the remaining columns are the samples. A table value of 0 means no amplification or deletion above the threshold. Amplifications are positive numbers: 1 means amplification above the amplification threshold; 2 means amplifications larger to the arm level amplifications observed for the sample. Deletions are represented by negative table values: -1 represents deletion beyond the threshold; -2 means deletions greater than the minimum arm-level deletion observed for the sample.

Sample Cutoffs (sample_cutoffs.txt)

A table of the per-sample threshold cutoffs (in units of absolute copy number -2) used to distinguish the high level amplifications (+/-2) from ordinary amplifications (+/-1) in the all_thresholded.by_genes.txt output file. The table contains three columns: the sample identifier followed by the low (deletion) and high (amplification) cutoff values. The cutoffs are calculated as the minimum arm-level amplification level less the deletion threshold for deletions and the maximum arm-level amplification plus the amplification threshold for amplifications.

Focal Input To Gistic (focal_input.seg.txt)

A list of copy number segments describing just the focal events present in the data. The segment amplification/deletion levels are in units of (copy number -2), with amplifications positive and deletions negative numbers. This file may be viewed with IGV.

Gene Counts vs. Copy Number Alteration Frequency (freqarms_vs_ngenes.{fig|pdf})

An image showing the correlation between gene counts and frequency of copy number alterations.

Confidence Intervals (regions_track.conf_##.bed, where ## is the confidence level)

A file indicating the position of the confidence intervals around GISTIC peaks that can be loaded as a track in a compatible viewer browser such as IGV or the UCSC genome browser.

GISTIC

GISTIC identifies genomic regions that are significantly gained or lost across a set of tumors. It takes segmented copy number ratios as input, separates arm-level events from focal events, and then performs two tests: (i) identifies significantly amplified/deleted chromosome arms; and (ii) identifies regions that are significantly focally amplified or deleted. For the focal analysis, the significance levels (Q values) are calculated by comparing the observed gains/losses at each locus to those obtained by randomly permuting the events along the genome to reflect the null hypothesis that they are all 'passengers' and could have occurred anywhere. The locus-specific significance levels are then corrected for multiple hypothesis testing. The arm-level significance is calculated by comparing the frequency of gains/losses of each arm to the expected rate given its size. The method outputs genomic views of significantly amplified and deleted regions, as well as a table of genes with gain or loss scores. A more in depth discussion of the GISTIC algorithm and its utility is given in [1], [3], and [5].

CNV Description

Regions of the genome that are prone to germ line variations in copy number are excluded from the GISTIC analysis using a list of germ line copy number variations (CNVs). A CNV is a DNA sequence that may be found at different copy numbers in the germ line of two different individuals. Such germ line variations can confound a GISTIC analysis, which finds significant somatic copy number variations in cancer. A more in depth discussion is provided in [6]. GISTIC currently uses two CNV exclusion lists. One is based on the literature describing copy number variation, and a second one comes from an analysis of significant variations among the blood normals in the TCGA data set.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Beroukhim et al, Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma, Proc Natl Acad Sci U S A. Vol. 104:50 (2007)
[3] Mermel et al, GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers, Genome Biology Vol. 12:4 (2011)
[5] Beroukhim et al., The landscape of somatic copy-number alteration across human cancers, Nature Vol. 463:7283 (2010)
[6] McCarroll, S. A. et al., Integrated detection and population-genetic analysis of SNPs and copy number variation, Nat Genet Vol. 40(10):1166-1174 (2008)