Correlation between copy number variation genes (focal events) and selected clinical features
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
15 January 2014  |  analyses__2014_01_15
Maintainer Information
Citation Information
doi:10.7908/C1M61HR5
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): Correlation between copy number variation genes (focal events) and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1M61HR5
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.

Summary

Testing the association between copy number variation 98 focal events and 5 clinical features across 472 patients, 176 significant findings detected with Q value < 0.25.

  • amp_1p35.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1p34.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1q21.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1q22 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_1q42.3 cnv correlated to 'AGE'.

  • amp_2p24.3 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_2q13 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_3p25.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_3p14.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_3q26.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_3q26.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_4p16.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_5p15.33 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_5q35.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_6p24.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_6q25.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_7q22.1 cnv correlated to 'Time to Death'.

  • amp_8p11.21 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_8q24.21 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_8q24.21 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • amp_9p24.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_9q34.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_11p11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_11q13.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_11q22.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_12p12.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_12q13.11 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_12q13.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_13q34 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_14q24.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • amp_16p11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_17q11.2 cnv correlated to 'AGE',  'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.

  • amp_17q12 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • amp_17q25.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_18p11.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_18q11.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • amp_19p13.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_19p13.11 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_19q12 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_20p13 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_20q11.21 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • amp_20q13.12 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_20q13.33 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • amp_22q12.2 cnv correlated to 'Time to Death',  'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.

  • del_1p36.11 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_2q22.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • del_2q37.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_3p14.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_3q13.31 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_4p16.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_4p15.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_4q22.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_4q34.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_5q11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_6q26 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_7p22.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_7q11.22 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_7q31.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_7q36.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_8p23.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_8p21.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_9p23 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_9q21.2 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_9q34.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_10q23.31 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_11p15.5 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_11q14.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_11q25 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_12q23.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_12q24.33 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_13q11 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_13q14.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_14q13.1 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_15q15.1 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_15q23 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_16p13.3 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_16q21 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_16q23.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_17p13.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_17p11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_17p11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_17q11.2 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_17q21.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_18q21.2 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_18q23 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_19p13.3 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

  • del_19p12 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_19q13.43 cnv correlated to 'HISTOLOGICAL.TYPE'.

  • del_20p12.1 cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • del_22q12.1 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_22q13.31 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_22q13.32 cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • del_xp21.1 cnv correlated to 'Time to Death',  'AGE', and 'HISTOLOGICAL.TYPE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 98 focal events and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 176 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		COMPLETENESS
OF
RESECTION
nCNV (%) nWild-Type logrank test t-test Fisher's exact test Fisher's exact test Fisher's exact test
amp 14q24 3 57 (12%) 415 0.000418
(0.139) 		0.000361
(0.122) 		1.41e-12
(6.08e-10) 		0.0599
(1.00) 		0.331
(1.00)
amp 17q11 2 62 (13%) 410 0.00951
(1.00) 		0.000546
(0.179) 		4.47e-21
(2.08e-18) 		0.454
(1.00) 		0.000564
(0.183)
amp 17q12 62 (13%) 410 0.000509
(0.168) 		5.07e-05
(0.0184) 		1.01e-19
(4.64e-17) 		1
(1.00) 		0.129
(1.00)
amp 20q11 21 121 (26%) 351 0.000363
(0.122) 		7.39e-08
(2.91e-05) 		5.78e-24
(2.77e-21) 		0.0267
(1.00) 		0.0454
(1.00)
amp 22q12 2 53 (11%) 419 0.000717
(0.228) 		0.00124
(0.381) 		2.09e-21
(9.79e-19) 		0.108
(1.00) 		0.000661
(0.212)
del 7p22 3 63 (13%) 409 0.000142
(0.05) 		7.03e-05
(0.0253) 		5.11e-15
(2.24e-12) 		0.294
(1.00) 		0.188
(1.00)
del 9q21 2 107 (23%) 365 0.000125
(0.0444) 		7.01e-11
(2.97e-08) 		7.76e-21
(3.61e-18) 		0.277
(1.00) 		0.136
(1.00)
del 11q25 79 (17%) 393 0.000655
(0.211) 		0.000548
(0.179) 		6.24e-17
(2.82e-14) 		0.00922
(1.00) 		0.228
(1.00)
del 15q15 1 116 (25%) 356 0.00067
(0.214) 		5.52e-08
(2.19e-05) 		1.92e-23
(9.16e-21) 		0.0332
(1.00) 		0.0216
(1.00)
del 17p13 3 100 (21%) 372 0.0007
(0.223) 		0.000207
(0.0715) 		3.33e-21
(1.56e-18) 		0.107
(1.00) 		0.152
(1.00)
del 19p13 3 129 (27%) 343 3.63e-06
(0.00138) 		1.49e-11
(6.32e-09) 		1.19e-49
(5.83e-47) 		0.137
(1.00) 		0.00302
(0.855)
del xp21 1 72 (15%) 400 0.000547
(0.179) 		0.000291
(0.0996) 		3.23e-16
(1.45e-13) 		0.206
(1.00) 		0.0801
(1.00)
amp 1p35 2 48 (10%) 424 0.113
(1.00) 		0.000489
(0.162) 		5.6e-13
(2.44e-10) 		1
(1.00) 		0.677
(1.00)
amp 1p34 2 61 (13%) 411 0.0483
(1.00) 		0.000195
(0.0681) 		1.32e-16
(5.93e-14) 		0.363
(1.00) 		0.0276
(1.00)
amp 1q21 3 211 (45%) 261 0.0559
(1.00) 		1.58e-05
(0.00584) 		0.000518
(0.17) 		0.413
(1.00) 		0.77
(1.00)
amp 1q22 225 (48%) 247 0.00845
(1.00) 		5.9e-07
(0.000228) 		5.18e-07
(0.000201) 		0.308
(1.00) 		0.391
(1.00)
amp 2q13 100 (21%) 372 0.000826
(0.258) 		0.000311
(0.105) 		1.72e-17
(7.82e-15) 		0.618
(1.00) 		0.11
(1.00)
amp 3p25 1 67 (14%) 405 0.07
(1.00) 		0.000252
(0.087) 		3.34e-10
(1.4e-07) 		0.0804
(1.00) 		0.59
(1.00)
amp 3p14 1 52 (11%) 420 0.000389
(0.13) 		0.0126
(1.00) 		0.000196
(0.0682) 		0.0332
(1.00) 		0.2
(1.00)
amp 3q26 2 144 (31%) 328 0.00929
(1.00) 		1.17e-10
(4.92e-08) 		3.79e-27
(1.84e-24) 		0.0771
(1.00) 		0.128
(1.00)
amp 3q26 2 136 (29%) 336 0.01
(1.00) 		2.01e-08
(8.08e-06) 		9.93e-27
(4.8e-24) 		0.0914
(1.00) 		0.0926
(1.00)
amp 4p16 3 46 (10%) 426 0.242
(1.00) 		2.21e-05
(0.00814) 		2.67e-12
(1.15e-09) 		0.606
(1.00) 		0.193
(1.00)
amp 5q35 3 47 (10%) 425 0.188
(1.00) 		0.00029
(0.0996) 		2.13e-09
(8.74e-07) 		0.173
(1.00) 		0.422
(1.00)
amp 6p24 2 97 (21%) 375 0.415
(1.00) 		4.83e-06
(0.00182) 		2.19e-18
(1e-15) 		0.102
(1.00) 		0.494
(1.00)
amp 8p11 21 143 (30%) 329 0.000292
(0.0996) 		0.363
(1.00) 		2.5e-07
(9.77e-05) 		0.0197
(1.00) 		0.00267
(0.782)
amp 8q24 21 178 (38%) 294 0.000322
(0.109) 		0.45
(1.00) 		4.36e-14
(1.91e-11) 		0.0155
(1.00) 		0.0961
(1.00)
amp 8q24 21 187 (40%) 285 0.00078
(0.246) 		0.173
(1.00) 		1.44e-15
(6.38e-13) 		0.005
(1.00) 		0.00333
(0.935)
amp 9q34 3 33 (7%) 439 0.00773
(1.00) 		0.000205
(0.0712) 		7.46e-07
(0.000288) 		0.843
(1.00) 		0.316
(1.00)
amp 11p11 2 44 (9%) 428 0.0168
(1.00) 		3.49e-05
(0.0128) 		7.84e-10
(3.26e-07) 		0.726
(1.00) 		0.268
(1.00)
amp 11q22 2 47 (10%) 425 0.0304
(1.00) 		0.000141
(0.0498) 		1.32e-09
(5.45e-07) 		0.612
(1.00) 		0.0847
(1.00)
amp 13q34 51 (11%) 421 0.567
(1.00) 		8.86e-07
(0.00034) 		3.55e-15
(1.56e-12) 		1
(1.00) 		0.02
(1.00)
amp 16p11 2 55 (12%) 417 0.00325
(0.916) 		0.000287
(0.0987) 		3.46e-13
(1.51e-10) 		0.637
(1.00) 		0.0594
(1.00)
amp 17q25 1 87 (18%) 385 0.00747
(1.00) 		0.000108
(0.0384) 		1.2e-17
(5.48e-15) 		0.694
(1.00) 		0.165
(1.00)
amp 18p11 31 79 (17%) 393 0.0526
(1.00) 		0.000107
(0.0384) 		8.84e-22
(4.17e-19) 		0.0409
(1.00) 		0.00493
(1.00)
amp 19p13 2 77 (16%) 395 0.19
(1.00) 		2.6e-11
(1.1e-08) 		1.46e-20
(6.76e-18) 		0.214
(1.00) 		0.458
(1.00)
amp 19p13 11 80 (17%) 392 0.108
(1.00) 		1.55e-10
(6.51e-08) 		6.02e-23
(2.85e-20) 		0.041
(1.00) 		0.0914
(1.00)
amp 19q12 96 (20%) 376 0.000804
(0.253) 		3.84e-09
(1.57e-06) 		2.79e-38
(1.36e-35) 		0.312
(1.00) 		0.0968
(1.00)
amp 20p13 99 (21%) 373 0.284
(1.00) 		1.67e-05
(0.00616) 		4.63e-13
(2.02e-10) 		0.0796
(1.00) 		0.371
(1.00)
amp 20q13 12 126 (27%) 346 0.00461
(1.00) 		2.24e-08
(8.96e-06) 		5.62e-23
(2.66e-20) 		0.00565
(1.00) 		0.0284
(1.00)
amp 20q13 33 122 (26%) 350 0.0152
(1.00) 		1.11e-07
(4.36e-05) 		2.06e-18
(9.47e-16) 		0.00247
(0.728) 		0.0195
(1.00)
del 1p36 11 69 (15%) 403 0.0275
(1.00) 		9.44e-06
(0.00351) 		3.64e-16
(1.63e-13) 		0.474
(1.00) 		0.0359
(1.00)
del 2q22 1 42 (9%) 430 6.83e-10
(2.85e-07) 		0.0036
(1.00) 		2.4e-08
(9.56e-06) 		0.00364
(1.00) 		0.00494
(1.00)
del 2q37 3 46 (10%) 426 0.0444
(1.00) 		0.000512
(0.169) 		0.000772
(0.245) 		0.173
(1.00) 		0.0831
(1.00)
del 3p14 2 66 (14%) 406 0.161
(1.00) 		0.000135
(0.0477) 		1.22e-15
(5.42e-13) 		0.305
(1.00) 		0.642
(1.00)
del 4p16 3 75 (16%) 397 0.00291
(0.829) 		6.95e-05
(0.0251) 		5.77e-16
(2.57e-13) 		0.404
(1.00) 		0.756
(1.00)
del 4p15 31 77 (16%) 395 0.00269
(0.784) 		4.23e-05
(0.0154) 		2.77e-15
(1.22e-12) 		0.214
(1.00) 		0.293
(1.00)
del 4q22 1 86 (18%) 386 0.00778
(1.00) 		5.21e-06
(0.00195) 		4.46e-26
(2.15e-23) 		0.238
(1.00) 		0.0379
(1.00)
del 4q34 3 107 (23%) 365 0.0249
(1.00) 		5.33e-06
(0.00199) 		2.67e-27
(1.3e-24) 		0.277
(1.00) 		0.069
(1.00)
del 5q11 2 92 (19%) 380 0.00876
(1.00) 		5.45e-05
(0.0197) 		5.26e-25
(2.53e-22) 		0.442
(1.00) 		0.411
(1.00)
del 7q11 22 37 (8%) 435 0.857
(1.00) 		2.81e-05
(0.0103) 		3.51e-08
(1.39e-05) 		0.448
(1.00) 		0.667
(1.00)
del 7q31 1 46 (10%) 426 0.0897
(1.00) 		7.81e-07
(0.000301) 		3.2e-18
(1.46e-15) 		1
(1.00) 		0.263
(1.00)
del 7q36 1 56 (12%) 416 0.0209
(1.00) 		1.37e-09
(5.65e-07) 		3.41e-21
(1.59e-18) 		0.754
(1.00) 		0.144
(1.00)
del 8p23 2 97 (21%) 375 0.00251
(0.737) 		0.000167
(0.0583) 		4.8e-31
(2.34e-28) 		0.258
(1.00) 		0.0208
(1.00)
del 8p21 2 94 (20%) 378 0.0105
(1.00) 		6.56e-06
(0.00245) 		5.41e-39
(2.65e-36) 		0.373
(1.00) 		0.0617
(1.00)
del 9q34 2 109 (23%) 363 0.00117
(0.363) 		1.37e-09
(5.65e-07) 		4.24e-19
(1.96e-16) 		0.148
(1.00) 		0.119
(1.00)
del 11p15 5 84 (18%) 388 0.0101
(1.00) 		1.59e-06
(0.000607) 		1.36e-18
(6.26e-16) 		0.0335
(1.00) 		0.0662
(1.00)
del 11q14 1 57 (12%) 415 0.00455
(1.00) 		4.63e-05
(0.0169) 		2.88e-15
(1.27e-12) 		0.212
(1.00) 		0.474
(1.00)
del 12q24 33 51 (11%) 421 0.0951
(1.00) 		9.72e-05
(0.0349) 		1.49e-15
(6.62e-13) 		0.0722
(1.00) 		0.0113
(1.00)
del 13q14 2 84 (18%) 388 0.00352
(0.983) 		0.000363
(0.122) 		2.28e-07
(8.91e-05) 		0.0335
(1.00) 		0.316
(1.00)
del 15q23 97 (21%) 375 0.0228
(1.00) 		1.86e-05
(0.00685) 		2.51e-23
(1.19e-20) 		0.102
(1.00) 		0.25
(1.00)
del 16p13 3 75 (16%) 397 0.00778
(1.00) 		6.91e-08
(2.73e-05) 		1.26e-21
(5.91e-19) 		0.265
(1.00) 		0.096
(1.00)
del 16q21 130 (28%) 342 0.0224
(1.00) 		1.79e-08
(7.2e-06) 		5.9e-24
(2.82e-21) 		0.172
(1.00) 		0.107
(1.00)
del 16q23 1 139 (29%) 333 0.00642
(1.00) 		2.53e-07
(9.84e-05) 		1.3e-26
(6.26e-24) 		0.316
(1.00) 		0.00361
(1.00)
del 17p11 2 107 (23%) 365 0.000927
(0.289) 		1.14e-06
(0.000437) 		7.52e-27
(3.64e-24) 		0.115
(1.00) 		0.617
(1.00)
del 17p11 2 101 (21%) 371 0.00112
(0.349) 		3.16e-06
(0.0012) 		2.66e-20
(1.23e-17) 		0.264
(1.00) 		0.768
(1.00)
del 17q11 2 87 (18%) 385 0.0499
(1.00) 		4.33e-06
(0.00163) 		6.21e-12
(2.65e-09) 		0.148
(1.00) 		0.189
(1.00)
del 17q21 31 86 (18%) 386 0.0119
(1.00) 		0.0001
(0.0359) 		6.14e-13
(2.66e-10) 		0.149
(1.00) 		0.296
(1.00)
del 20p12 1 30 (6%) 442 0.000152
(0.0535) 		0.195
(1.00) 		0.000574
(0.186) 		1
(1.00) 		0.119
(1.00)
del 22q12 1 79 (17%) 393 0.236
(1.00) 		0.000589
(0.19) 		1.76e-08
(7.1e-06) 		0.0409
(1.00) 		0.655
(1.00)
del 22q13 31 114 (24%) 358 0.00172
(0.518) 		3.83e-09
(1.57e-06) 		4.25e-23
(2.02e-20) 		0.075
(1.00) 		0.671
(1.00)
del 22q13 32 118 (25%) 354 0.00166
(0.502) 		9.91e-08
(3.9e-05) 		1.53e-22
(7.21e-20) 		0.0252
(1.00) 		0.251
(1.00)
amp 1q42 3 199 (42%) 273 0.209
(1.00) 		0.000791
(0.249) 		0.214
(1.00) 		0.471
(1.00) 		0.859
(1.00)
amp 2p24 3 105 (22%) 367 0.0018
(0.538) 		0.0175
(1.00) 		1.13e-11
(4.8e-09) 		0.0143
(1.00) 		0.596
(1.00)
amp 5p15 33 74 (16%) 398 0.00153
(0.464) 		0.0012
(0.369) 		4.79e-18
(2.18e-15) 		0.265
(1.00) 		0.0714
(1.00)
amp 6q25 1 73 (15%) 399 0.354
(1.00) 		0.013
(1.00) 		4.16e-06
(0.00157) 		0.325
(1.00) 		0.166
(1.00)
amp 7q22 1 78 (17%) 394 0.000301
(0.102) 		0.0531
(1.00) 		0.0049
(1.00) 		0.0996
(1.00) 		0.646
(1.00)
amp 9p24 2 56 (12%) 416 0.0087
(1.00) 		0.00301
(0.855) 		1.19e-09
(4.96e-07) 		0.155
(1.00) 		0.178
(1.00)
amp 11q13 2 65 (14%) 407 0.00673
(1.00) 		0.00174
(0.523) 		8.78e-09
(3.56e-06) 		1
(1.00) 		0.0454
(1.00)
amp 12p12 1 76 (16%) 396 0.975
(1.00) 		0.235
(1.00) 		2.25e-08
(8.99e-06) 		0.491
(1.00) 		0.753
(1.00)
amp 12q13 11 75 (16%) 397 0.692
(1.00) 		0.773
(1.00) 		5.72e-09
(2.33e-06) 		0.163
(1.00) 		0.511
(1.00)
amp 12q13 2 85 (18%) 387 0.803
(1.00) 		0.156
(1.00) 		3.11e-08
(1.24e-05) 		0.0334
(1.00) 		0.18
(1.00)
amp 18q11 2 60 (13%) 412 0.0133
(1.00) 		0.00159
(0.483) 		1.31e-16
(5.89e-14) 		0.363
(1.00) 		0.0144
(1.00)
del 3q13 31 27 (6%) 445 0.856
(1.00) 		0.00592
(1.00) 		2.41e-06
(0.000919) 		0.518
(1.00) 		0.593
(1.00)
del 6q26 40 (8%) 432 0.363
(1.00) 		0.00273
(0.791) 		1.2e-10
(5.05e-08) 		0.716
(1.00) 		0.971
(1.00)
del 9p23 61 (13%) 411 0.14
(1.00) 		0.00229
(0.678) 		2.23e-12
(9.61e-10) 		0.224
(1.00) 		0.176
(1.00)
del 10q23 31 63 (13%) 409 0.0541
(1.00) 		0.00282
(0.812) 		6.21e-09
(2.53e-06) 		0.0164
(1.00) 		0.0995
(1.00)
del 12q23 1 40 (8%) 432 0.00393
(1.00) 		0.00537
(1.00) 		4.5e-12
(1.93e-09) 		0.273
(1.00) 		0.00833
(1.00)
del 13q11 79 (17%) 393 0.00339
(0.95) 		0.00129
(0.395) 		8.99e-13
(3.89e-10) 		0.0771
(1.00) 		0.112
(1.00)
del 14q13 1 59 (12%) 413 0.0029
(0.829) 		0.00496
(1.00) 		9.63e-11
(4.06e-08) 		0.645
(1.00) 		0.944
(1.00)
del 18q21 2 75 (16%) 397 0.332
(1.00) 		0.002
(0.593) 		5.91e-12
(2.53e-09) 		0.018
(1.00) 		0.112
(1.00)
del 18q23 81 (17%) 391 0.00459
(1.00) 		0.00289
(0.829) 		1.79e-16
(8.05e-14) 		0.00273
(0.791) 		0.00761
(1.00)
del 19p12 44 (9%) 428 0.0027
(0.786) 		0.0444
(1.00) 		7.94e-09
(3.22e-06) 		0.118
(1.00) 		0.134
(1.00)
del 19q13 43 54 (11%) 418 0.00102
(0.317) 		0.00149
(0.454) 		4.05e-17
(1.83e-14) 		0.75
(1.00) 		0.0523
(1.00)
amp 1p22 3 83 (18%) 389 0.409
(1.00) 		0.00179
(0.535) 		0.00519
(1.00) 		0.69
(1.00) 		0.941
(1.00)
amp 10q22 2 129 (27%) 343 0.229
(1.00) 		0.494
(1.00) 		0.0194
(1.00) 		0.568
(1.00) 		0.537
(1.00)
amp xp11 23 77 (16%) 395 0.242
(1.00) 		0.196
(1.00) 		0.00557
(1.00) 		0.0276
(1.00) 		0.435
(1.00)
amp xq28 77 (16%) 395 0.0043
(1.00) 		0.158
(1.00) 		0.00401
(1.00) 		0.89
(1.00) 		0.123
(1.00)
del 2p25 3 23 (5%) 449 0.0182
(1.00) 		0.107
(1.00) 		0.00499
(1.00) 		0.102
(1.00) 		0.235
(1.00)
'amp_1p35.2' versus 'AGE'

P value = 0.000489 (t-test), Q value = 0.16

Table S1.  Gene #1: 'amp_1p35.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 1(1P35.2) MUTATED 48 68.5 (9.2)
AMP PEAK 1(1P35.2) WILD-TYPE 423 63.3 (11.4)

Figure S1.  Get High-res Image Gene #1: 'amp_1p35.2' versus Clinical Feature #2: 'AGE'

'amp_1p35.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.6e-13 (Fisher's exact test), Q value = 2.4e-10

Table S2.  Gene #1: 'amp_1p35.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 1(1P35.2) MUTATED 14 5 29
AMP PEAK 1(1P35.2) WILD-TYPE 346 14 64

Figure S2.  Get High-res Image Gene #1: 'amp_1p35.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1p34.2' versus 'AGE'

P value = 0.000195 (t-test), Q value = 0.068

Table S3.  Gene #2: 'amp_1p34.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 2(1P34.2) MUTATED 61 68.5 (10.0)
AMP PEAK 2(1P34.2) WILD-TYPE 410 63.1 (11.3)

Figure S3.  Get High-res Image Gene #2: 'amp_1p34.2' versus Clinical Feature #2: 'AGE'

'amp_1p34.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.32e-16 (Fisher's exact test), Q value = 5.9e-14

Table S4.  Gene #2: 'amp_1p34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 2(1P34.2) MUTATED 18 7 36
AMP PEAK 2(1P34.2) WILD-TYPE 342 12 57

Figure S4.  Get High-res Image Gene #2: 'amp_1p34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1q21.3' versus 'AGE'

P value = 1.58e-05 (t-test), Q value = 0.0058

Table S5.  Gene #4: 'amp_1q21.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 4(1Q21.3) MUTATED 211 66.2 (10.5)
AMP PEAK 4(1Q21.3) WILD-TYPE 260 61.8 (11.5)

Figure S5.  Get High-res Image Gene #4: 'amp_1q21.3' versus Clinical Feature #2: 'AGE'

'amp_1q21.3' versus 'HISTOLOGICAL.TYPE'

P value = 0.000518 (Fisher's exact test), Q value = 0.17

Table S6.  Gene #4: 'amp_1q21.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 4(1Q21.3) MUTATED 144 9 58
AMP PEAK 4(1Q21.3) WILD-TYPE 216 10 35

Figure S6.  Get High-res Image Gene #4: 'amp_1q21.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1q22' versus 'AGE'

P value = 5.9e-07 (t-test), Q value = 0.00023

Table S7.  Gene #5: 'amp_1q22' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 5(1Q22) MUTATED 225 66.5 (10.5)
AMP PEAK 5(1Q22) WILD-TYPE 246 61.3 (11.4)

Figure S7.  Get High-res Image Gene #5: 'amp_1q22' versus Clinical Feature #2: 'AGE'

'amp_1q22' versus 'HISTOLOGICAL.TYPE'

P value = 5.18e-07 (Fisher's exact test), Q value = 2e-04

Table S8.  Gene #5: 'amp_1q22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 5(1Q22) MUTATED 149 9 67
AMP PEAK 5(1Q22) WILD-TYPE 211 10 26

Figure S8.  Get High-res Image Gene #5: 'amp_1q22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_1q42.3' versus 'AGE'

P value = 0.000791 (t-test), Q value = 0.25

Table S9.  Gene #6: 'amp_1q42.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 6(1Q42.3) MUTATED 199 65.8 (10.4)
AMP PEAK 6(1Q42.3) WILD-TYPE 272 62.3 (11.7)

Figure S9.  Get High-res Image Gene #6: 'amp_1q42.3' versus Clinical Feature #2: 'AGE'

'amp_2p24.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.13e-11 (Fisher's exact test), Q value = 4.8e-09

Table S10.  Gene #7: 'amp_2p24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 7(2P24.3) MUTATED 52 7 46
AMP PEAK 7(2P24.3) WILD-TYPE 308 12 47

Figure S10.  Get High-res Image Gene #7: 'amp_2p24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_2q13' versus 'AGE'

P value = 0.000311 (t-test), Q value = 0.11

Table S11.  Gene #8: 'amp_2q13' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 8(2Q13) MUTATED 99 67.1 (9.4)
AMP PEAK 8(2Q13) WILD-TYPE 372 62.9 (11.6)

Figure S11.  Get High-res Image Gene #8: 'amp_2q13' versus Clinical Feature #2: 'AGE'

'amp_2q13' versus 'HISTOLOGICAL.TYPE'

P value = 1.72e-17 (Fisher's exact test), Q value = 7.8e-15

Table S12.  Gene #8: 'amp_2q13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 8(2Q13) MUTATED 43 5 52
AMP PEAK 8(2Q13) WILD-TYPE 317 14 41

Figure S12.  Get High-res Image Gene #8: 'amp_2q13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3p25.1' versus 'AGE'

P value = 0.000252 (t-test), Q value = 0.087

Table S13.  Gene #9: 'amp_3p25.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 9(3P25.1) MUTATED 67 68.5 (10.9)
AMP PEAK 9(3P25.1) WILD-TYPE 404 63.0 (11.2)

Figure S13.  Get High-res Image Gene #9: 'amp_3p25.1' versus Clinical Feature #2: 'AGE'

'amp_3p25.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.34e-10 (Fisher's exact test), Q value = 1.4e-07

Table S14.  Gene #9: 'amp_3p25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 9(3P25.1) MUTATED 31 1 35
AMP PEAK 9(3P25.1) WILD-TYPE 329 18 58

Figure S14.  Get High-res Image Gene #9: 'amp_3p25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3p14.1' versus 'Time to Death'

P value = 0.000389 (logrank test), Q value = 0.13

Table S15.  Gene #10: 'amp_3p14.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 10(3P14.1) MUTATED 51 14 0.1 - 191.8 (20.0)
AMP PEAK 10(3P14.1) WILD-TYPE 418 43 0.0 - 185.8 (21.0)

Figure S15.  Get High-res Image Gene #10: 'amp_3p14.1' versus Clinical Feature #1: 'Time to Death'

'amp_3p14.1' versus 'HISTOLOGICAL.TYPE'

P value = 0.000196 (Fisher's exact test), Q value = 0.068

Table S16.  Gene #10: 'amp_3p14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 10(3P14.1) MUTATED 28 2 22
AMP PEAK 10(3P14.1) WILD-TYPE 332 17 71

Figure S16.  Get High-res Image Gene #10: 'amp_3p14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3q26.2' versus 'AGE'

P value = 1.17e-10 (t-test), Q value = 4.9e-08

Table S17.  Gene #11: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 11(3Q26.2) MUTATED 144 68.5 (9.4)
AMP PEAK 11(3Q26.2) WILD-TYPE 327 61.7 (11.4)

Figure S17.  Get High-res Image Gene #11: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

'amp_3q26.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.79e-27 (Fisher's exact test), Q value = 1.8e-24

Table S18.  Gene #11: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 11(3Q26.2) MUTATED 64 8 72
AMP PEAK 11(3Q26.2) WILD-TYPE 296 11 21

Figure S18.  Get High-res Image Gene #11: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_3q26.2' versus 'AGE'

P value = 2.01e-08 (t-test), Q value = 8.1e-06

Table S19.  Gene #12: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 12(3Q26.2) MUTATED 136 68.0 (9.5)
AMP PEAK 12(3Q26.2) WILD-TYPE 335 62.1 (11.5)

Figure S19.  Get High-res Image Gene #12: 'amp_3q26.2' versus Clinical Feature #2: 'AGE'

'amp_3q26.2' versus 'HISTOLOGICAL.TYPE'

P value = 9.93e-27 (Fisher's exact test), Q value = 4.8e-24

Table S20.  Gene #12: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 12(3Q26.2) MUTATED 59 7 70
AMP PEAK 12(3Q26.2) WILD-TYPE 301 12 23

Figure S20.  Get High-res Image Gene #12: 'amp_3q26.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_4p16.3' versus 'AGE'

P value = 2.21e-05 (t-test), Q value = 0.0081

Table S21.  Gene #13: 'amp_4p16.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 13(4P16.3) MUTATED 46 69.8 (9.1)
AMP PEAK 13(4P16.3) WILD-TYPE 425 63.1 (11.3)

Figure S21.  Get High-res Image Gene #13: 'amp_4p16.3' versus Clinical Feature #2: 'AGE'

'amp_4p16.3' versus 'HISTOLOGICAL.TYPE'

P value = 2.67e-12 (Fisher's exact test), Q value = 1.1e-09

Table S22.  Gene #13: 'amp_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 13(4P16.3) MUTATED 15 1 30
AMP PEAK 13(4P16.3) WILD-TYPE 345 18 63

Figure S22.  Get High-res Image Gene #13: 'amp_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_5p15.33' versus 'HISTOLOGICAL.TYPE'

P value = 4.79e-18 (Fisher's exact test), Q value = 2.2e-15

Table S23.  Gene #14: 'amp_5p15.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 14(5P15.33) MUTATED 26 3 45
AMP PEAK 14(5P15.33) WILD-TYPE 334 16 48

Figure S23.  Get High-res Image Gene #14: 'amp_5p15.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_5q35.3' versus 'AGE'

P value = 0.00029 (t-test), Q value = 0.1

Table S24.  Gene #15: 'amp_5q35.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 15(5Q35.3) MUTATED 47 69.4 (10.5)
AMP PEAK 15(5Q35.3) WILD-TYPE 424 63.2 (11.2)

Figure S24.  Get High-res Image Gene #15: 'amp_5q35.3' versus Clinical Feature #2: 'AGE'

'amp_5q35.3' versus 'HISTOLOGICAL.TYPE'

P value = 2.13e-09 (Fisher's exact test), Q value = 8.7e-07

Table S25.  Gene #15: 'amp_5q35.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 15(5Q35.3) MUTATED 18 2 27
AMP PEAK 15(5Q35.3) WILD-TYPE 342 17 66

Figure S25.  Get High-res Image Gene #15: 'amp_5q35.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_6p24.2' versus 'AGE'

P value = 4.83e-06 (t-test), Q value = 0.0018

Table S26.  Gene #16: 'amp_6p24.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 16(6P24.2) MUTATED 97 68.3 (10.2)
AMP PEAK 16(6P24.2) WILD-TYPE 374 62.6 (11.3)

Figure S26.  Get High-res Image Gene #16: 'amp_6p24.2' versus Clinical Feature #2: 'AGE'

'amp_6p24.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.19e-18 (Fisher's exact test), Q value = 1e-15

Table S27.  Gene #16: 'amp_6p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 16(6P24.2) MUTATED 40 5 52
AMP PEAK 16(6P24.2) WILD-TYPE 320 14 41

Figure S27.  Get High-res Image Gene #16: 'amp_6p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_6q25.1' versus 'HISTOLOGICAL.TYPE'

P value = 4.16e-06 (Fisher's exact test), Q value = 0.0016

Table S28.  Gene #17: 'amp_6q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 17(6Q25.1) MUTATED 40 2 31
AMP PEAK 17(6Q25.1) WILD-TYPE 320 17 62

Figure S28.  Get High-res Image Gene #17: 'amp_6q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_7q22.1' versus 'Time to Death'

P value = 0.000301 (logrank test), Q value = 0.1

Table S29.  Gene #18: 'amp_7q22.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 18(7Q22.1) MUTATED 77 17 0.0 - 125.4 (15.4)
AMP PEAK 18(7Q22.1) WILD-TYPE 392 40 0.1 - 191.8 (23.3)

Figure S29.  Get High-res Image Gene #18: 'amp_7q22.1' versus Clinical Feature #1: 'Time to Death'

'amp_8p11.21' versus 'Time to Death'

P value = 0.000292 (logrank test), Q value = 0.1

Table S30.  Gene #19: 'amp_8p11.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 19(8P11.21) MUTATED 142 27 0.0 - 125.4 (17.9)
AMP PEAK 19(8P11.21) WILD-TYPE 327 30 0.1 - 191.8 (23.5)

Figure S30.  Get High-res Image Gene #19: 'amp_8p11.21' versus Clinical Feature #1: 'Time to Death'

'amp_8p11.21' versus 'HISTOLOGICAL.TYPE'

P value = 2.5e-07 (Fisher's exact test), Q value = 9.8e-05

Table S31.  Gene #19: 'amp_8p11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 19(8P11.21) MUTATED 86 7 50
AMP PEAK 19(8P11.21) WILD-TYPE 274 12 43

Figure S31.  Get High-res Image Gene #19: 'amp_8p11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_8q24.21' versus 'Time to Death'

P value = 0.000322 (logrank test), Q value = 0.11

Table S32.  Gene #20: 'amp_8q24.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 20(8Q24.21) MUTATED 177 32 0.0 - 191.8 (17.9)
AMP PEAK 20(8Q24.21) WILD-TYPE 292 25 0.1 - 185.8 (24.1)

Figure S32.  Get High-res Image Gene #20: 'amp_8q24.21' versus Clinical Feature #1: 'Time to Death'

'amp_8q24.21' versus 'HISTOLOGICAL.TYPE'

P value = 4.36e-14 (Fisher's exact test), Q value = 1.9e-11

Table S33.  Gene #20: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 20(8Q24.21) MUTATED 102 9 67
AMP PEAK 20(8Q24.21) WILD-TYPE 258 10 26

Figure S33.  Get High-res Image Gene #20: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_8q24.21' versus 'Time to Death'

P value = 0.00078 (logrank test), Q value = 0.25

Table S34.  Gene #21: 'amp_8q24.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 21(8Q24.21) MUTATED 186 32 0.0 - 191.8 (17.8)
AMP PEAK 21(8Q24.21) WILD-TYPE 283 25 0.2 - 185.8 (25.0)

Figure S34.  Get High-res Image Gene #21: 'amp_8q24.21' versus Clinical Feature #1: 'Time to Death'

'amp_8q24.21' versus 'HISTOLOGICAL.TYPE'

P value = 1.44e-15 (Fisher's exact test), Q value = 6.4e-13

Table S35.  Gene #21: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 21(8Q24.21) MUTATED 108 8 71
AMP PEAK 21(8Q24.21) WILD-TYPE 252 11 22

Figure S35.  Get High-res Image Gene #21: 'amp_8q24.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_9p24.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.19e-09 (Fisher's exact test), Q value = 5e-07

Table S36.  Gene #22: 'amp_9p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 22(9P24.2) MUTATED 23 3 30
AMP PEAK 22(9P24.2) WILD-TYPE 337 16 63

Figure S36.  Get High-res Image Gene #22: 'amp_9p24.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_9q34.3' versus 'AGE'

P value = 0.000205 (t-test), Q value = 0.071

Table S37.  Gene #23: 'amp_9q34.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 23(9Q34.3) MUTATED 33 69.7 (8.4)
AMP PEAK 23(9Q34.3) WILD-TYPE 438 63.3 (11.4)

Figure S37.  Get High-res Image Gene #23: 'amp_9q34.3' versus Clinical Feature #2: 'AGE'

'amp_9q34.3' versus 'HISTOLOGICAL.TYPE'

P value = 7.46e-07 (Fisher's exact test), Q value = 0.00029

Table S38.  Gene #23: 'amp_9q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 23(9Q34.3) MUTATED 12 4 17
AMP PEAK 23(9Q34.3) WILD-TYPE 348 15 76

Figure S38.  Get High-res Image Gene #23: 'amp_9q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_11p11.2' versus 'AGE'

P value = 3.49e-05 (t-test), Q value = 0.013

Table S39.  Gene #25: 'amp_11p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 25(11P11.2) MUTATED 44 70.0 (9.4)
AMP PEAK 25(11P11.2) WILD-TYPE 427 63.2 (11.3)

Figure S39.  Get High-res Image Gene #25: 'amp_11p11.2' versus Clinical Feature #2: 'AGE'

'amp_11p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 7.84e-10 (Fisher's exact test), Q value = 3.3e-07

Table S40.  Gene #25: 'amp_11p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 25(11P11.2) MUTATED 15 4 25
AMP PEAK 25(11P11.2) WILD-TYPE 345 15 68

Figure S40.  Get High-res Image Gene #25: 'amp_11p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_11q13.2' versus 'HISTOLOGICAL.TYPE'

P value = 8.78e-09 (Fisher's exact test), Q value = 3.6e-06

Table S41.  Gene #26: 'amp_11q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 26(11Q13.2) MUTATED 30 3 32
AMP PEAK 26(11Q13.2) WILD-TYPE 330 16 61

Figure S41.  Get High-res Image Gene #26: 'amp_11q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_11q22.2' versus 'AGE'

P value = 0.000141 (t-test), Q value = 0.05

Table S42.  Gene #27: 'amp_11q22.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 27(11Q22.2) MUTATED 47 69.1 (9.2)
AMP PEAK 27(11Q22.2) WILD-TYPE 424 63.2 (11.3)

Figure S42.  Get High-res Image Gene #27: 'amp_11q22.2' versus Clinical Feature #2: 'AGE'

'amp_11q22.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.32e-09 (Fisher's exact test), Q value = 5.5e-07

Table S43.  Gene #27: 'amp_11q22.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 27(11Q22.2) MUTATED 17 4 26
AMP PEAK 27(11Q22.2) WILD-TYPE 343 15 67

Figure S43.  Get High-res Image Gene #27: 'amp_11q22.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_12p12.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.25e-08 (Fisher's exact test), Q value = 9e-06

Table S44.  Gene #28: 'amp_12p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 28(12P12.1) MUTATED 38 3 35
AMP PEAK 28(12P12.1) WILD-TYPE 322 16 58

Figure S44.  Get High-res Image Gene #28: 'amp_12p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_12q13.11' versus 'HISTOLOGICAL.TYPE'

P value = 5.72e-09 (Fisher's exact test), Q value = 2.3e-06

Table S45.  Gene #29: 'amp_12q13.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 29(12Q13.11) MUTATED 36 4 35
AMP PEAK 29(12Q13.11) WILD-TYPE 324 15 58

Figure S45.  Get High-res Image Gene #29: 'amp_12q13.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_12q13.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.11e-08 (Fisher's exact test), Q value = 1.2e-05

Table S46.  Gene #30: 'amp_12q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 30(12Q13.2) MUTATED 44 4 37
AMP PEAK 30(12Q13.2) WILD-TYPE 316 15 56

Figure S46.  Get High-res Image Gene #30: 'amp_12q13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_13q34' versus 'AGE'

P value = 8.86e-07 (t-test), Q value = 0.00034

Table S47.  Gene #31: 'amp_13q34' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 31(13Q34) MUTATED 51 69.5 (7.6)
AMP PEAK 31(13Q34) WILD-TYPE 420 63.1 (11.5)

Figure S47.  Get High-res Image Gene #31: 'amp_13q34' versus Clinical Feature #2: 'AGE'

'amp_13q34' versus 'HISTOLOGICAL.TYPE'

P value = 3.55e-15 (Fisher's exact test), Q value = 1.6e-12

Table S48.  Gene #31: 'amp_13q34' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 31(13Q34) MUTATED 14 4 33
AMP PEAK 31(13Q34) WILD-TYPE 346 15 60

Figure S48.  Get High-res Image Gene #31: 'amp_13q34' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_14q24.3' versus 'Time to Death'

P value = 0.000418 (logrank test), Q value = 0.14

Table S49.  Gene #32: 'amp_14q24.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 32(14Q24.3) MUTATED 57 15 0.1 - 125.4 (18.2)
AMP PEAK 32(14Q24.3) WILD-TYPE 412 42 0.0 - 191.8 (21.4)

Figure S49.  Get High-res Image Gene #32: 'amp_14q24.3' versus Clinical Feature #1: 'Time to Death'

'amp_14q24.3' versus 'AGE'

P value = 0.000361 (t-test), Q value = 0.12

Table S50.  Gene #32: 'amp_14q24.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 32(14Q24.3) MUTATED 57 68.3 (9.4)
AMP PEAK 32(14Q24.3) WILD-TYPE 414 63.2 (11.4)

Figure S50.  Get High-res Image Gene #32: 'amp_14q24.3' versus Clinical Feature #2: 'AGE'

'amp_14q24.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.41e-12 (Fisher's exact test), Q value = 6.1e-10

Table S51.  Gene #32: 'amp_14q24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 32(14Q24.3) MUTATED 20 4 33
AMP PEAK 32(14Q24.3) WILD-TYPE 340 15 60

Figure S51.  Get High-res Image Gene #32: 'amp_14q24.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_16p11.2' versus 'AGE'

P value = 0.000287 (t-test), Q value = 0.099

Table S52.  Gene #33: 'amp_16p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 33(16P11.2) MUTATED 55 68.2 (8.9)
AMP PEAK 33(16P11.2) WILD-TYPE 416 63.2 (11.4)

Figure S52.  Get High-res Image Gene #33: 'amp_16p11.2' versus Clinical Feature #2: 'AGE'

'amp_16p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 3.46e-13 (Fisher's exact test), Q value = 1.5e-10

Table S53.  Gene #33: 'amp_16p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 33(16P11.2) MUTATED 19 2 34
AMP PEAK 33(16P11.2) WILD-TYPE 341 17 59

Figure S53.  Get High-res Image Gene #33: 'amp_16p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_17q11.2' versus 'AGE'

P value = 0.000546 (t-test), Q value = 0.18

Table S54.  Gene #34: 'amp_17q11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 34(17Q11.2) MUTATED 62 67.7 (8.9)
AMP PEAK 34(17Q11.2) WILD-TYPE 409 63.2 (11.5)

Figure S54.  Get High-res Image Gene #34: 'amp_17q11.2' versus Clinical Feature #2: 'AGE'

'amp_17q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 4.47e-21 (Fisher's exact test), Q value = 2.1e-18

Table S55.  Gene #34: 'amp_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 34(17Q11.2) MUTATED 15 6 41
AMP PEAK 34(17Q11.2) WILD-TYPE 345 13 52

Figure S55.  Get High-res Image Gene #34: 'amp_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_17q11.2' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.000564 (Fisher's exact test), Q value = 0.18

Table S56.  Gene #34: 'amp_17q11.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients R0 R1 R2 RX
ALL 325 24 16 27
AMP PEAK 34(17Q11.2) MUTATED 33 7 6 6
AMP PEAK 34(17Q11.2) WILD-TYPE 292 17 10 21

Figure S56.  Get High-res Image Gene #34: 'amp_17q11.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'amp_17q12' versus 'Time to Death'

P value = 0.000509 (logrank test), Q value = 0.17

Table S57.  Gene #35: 'amp_17q12' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 35(17Q12) MUTATED 61 14 0.1 - 97.4 (17.6)
AMP PEAK 35(17Q12) WILD-TYPE 408 43 0.0 - 191.8 (22.6)

Figure S57.  Get High-res Image Gene #35: 'amp_17q12' versus Clinical Feature #1: 'Time to Death'

'amp_17q12' versus 'AGE'

P value = 5.07e-05 (t-test), Q value = 0.018

Table S58.  Gene #35: 'amp_17q12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 35(17Q12) MUTATED 62 68.8 (9.6)
AMP PEAK 35(17Q12) WILD-TYPE 409 63.0 (11.3)

Figure S58.  Get High-res Image Gene #35: 'amp_17q12' versus Clinical Feature #2: 'AGE'

'amp_17q12' versus 'HISTOLOGICAL.TYPE'

P value = 1.01e-19 (Fisher's exact test), Q value = 4.6e-17

Table S59.  Gene #35: 'amp_17q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 35(17Q12) MUTATED 17 3 42
AMP PEAK 35(17Q12) WILD-TYPE 343 16 51

Figure S59.  Get High-res Image Gene #35: 'amp_17q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_17q25.1' versus 'AGE'

P value = 0.000108 (t-test), Q value = 0.038

Table S60.  Gene #36: 'amp_17q25.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 36(17Q25.1) MUTATED 87 67.6 (9.6)
AMP PEAK 36(17Q25.1) WILD-TYPE 384 62.9 (11.5)

Figure S60.  Get High-res Image Gene #36: 'amp_17q25.1' versus Clinical Feature #2: 'AGE'

'amp_17q25.1' versus 'HISTOLOGICAL.TYPE'

P value = 1.2e-17 (Fisher's exact test), Q value = 5.5e-15

Table S61.  Gene #36: 'amp_17q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 36(17Q25.1) MUTATED 33 9 45
AMP PEAK 36(17Q25.1) WILD-TYPE 327 10 48

Figure S61.  Get High-res Image Gene #36: 'amp_17q25.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_18p11.31' versus 'AGE'

P value = 0.000107 (t-test), Q value = 0.038

Table S62.  Gene #37: 'amp_18p11.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 37(18P11.31) MUTATED 79 67.7 (9.2)
AMP PEAK 37(18P11.31) WILD-TYPE 392 63.0 (11.5)

Figure S62.  Get High-res Image Gene #37: 'amp_18p11.31' versus Clinical Feature #2: 'AGE'

'amp_18p11.31' versus 'HISTOLOGICAL.TYPE'

P value = 8.84e-22 (Fisher's exact test), Q value = 4.2e-19

Table S63.  Gene #37: 'amp_18p11.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 37(18P11.31) MUTATED 25 5 49
AMP PEAK 37(18P11.31) WILD-TYPE 335 14 44

Figure S63.  Get High-res Image Gene #37: 'amp_18p11.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_18q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.31e-16 (Fisher's exact test), Q value = 5.9e-14

Table S64.  Gene #38: 'amp_18q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 38(18Q11.2) MUTATED 18 4 38
AMP PEAK 38(18Q11.2) WILD-TYPE 342 15 55

Figure S64.  Get High-res Image Gene #38: 'amp_18q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_19p13.2' versus 'AGE'

P value = 2.6e-11 (t-test), Q value = 1.1e-08

Table S65.  Gene #39: 'amp_19p13.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 39(19P13.2) MUTATED 77 70.7 (8.6)
AMP PEAK 39(19P13.2) WILD-TYPE 394 62.4 (11.3)

Figure S65.  Get High-res Image Gene #39: 'amp_19p13.2' versus Clinical Feature #2: 'AGE'

'amp_19p13.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.46e-20 (Fisher's exact test), Q value = 6.8e-18

Table S66.  Gene #39: 'amp_19p13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 39(19P13.2) MUTATED 24 8 45
AMP PEAK 39(19P13.2) WILD-TYPE 336 11 48

Figure S66.  Get High-res Image Gene #39: 'amp_19p13.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_19p13.11' versus 'AGE'

P value = 1.55e-10 (t-test), Q value = 6.5e-08

Table S67.  Gene #40: 'amp_19p13.11' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 40(19P13.11) MUTATED 80 70.5 (9.1)
AMP PEAK 40(19P13.11) WILD-TYPE 391 62.4 (11.2)

Figure S67.  Get High-res Image Gene #40: 'amp_19p13.11' versus Clinical Feature #2: 'AGE'

'amp_19p13.11' versus 'HISTOLOGICAL.TYPE'

P value = 6.02e-23 (Fisher's exact test), Q value = 2.8e-20

Table S68.  Gene #40: 'amp_19p13.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 40(19P13.11) MUTATED 24 7 49
AMP PEAK 40(19P13.11) WILD-TYPE 336 12 44

Figure S68.  Get High-res Image Gene #40: 'amp_19p13.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_19q12' versus 'AGE'

P value = 3.84e-09 (t-test), Q value = 1.6e-06

Table S69.  Gene #41: 'amp_19q12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 41(19Q12) MUTATED 96 69.1 (8.7)
AMP PEAK 41(19Q12) WILD-TYPE 375 62.4 (11.5)

Figure S69.  Get High-res Image Gene #41: 'amp_19q12' versus Clinical Feature #2: 'AGE'

'amp_19q12' versus 'HISTOLOGICAL.TYPE'

P value = 2.79e-38 (Fisher's exact test), Q value = 1.4e-35

Table S70.  Gene #41: 'amp_19q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 41(19Q12) MUTATED 22 10 64
AMP PEAK 41(19Q12) WILD-TYPE 338 9 29

Figure S70.  Get High-res Image Gene #41: 'amp_19q12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20p13' versus 'AGE'

P value = 1.67e-05 (t-test), Q value = 0.0062

Table S71.  Gene #42: 'amp_20p13' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 42(20P13) MUTATED 99 68.3 (11.3)
AMP PEAK 42(20P13) WILD-TYPE 372 62.6 (11.0)

Figure S71.  Get High-res Image Gene #42: 'amp_20p13' versus Clinical Feature #2: 'AGE'

'amp_20p13' versus 'HISTOLOGICAL.TYPE'

P value = 4.63e-13 (Fisher's exact test), Q value = 2e-10

Table S72.  Gene #42: 'amp_20p13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 42(20P13) MUTATED 47 5 47
AMP PEAK 42(20P13) WILD-TYPE 313 14 46

Figure S72.  Get High-res Image Gene #42: 'amp_20p13' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20q11.21' versus 'Time to Death'

P value = 0.000363 (logrank test), Q value = 0.12

Table S73.  Gene #43: 'amp_20q11.21' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 43(20Q11.21) MUTATED 120 24 0.0 - 149.5 (17.3)
AMP PEAK 43(20Q11.21) WILD-TYPE 349 33 0.1 - 191.8 (23.2)

Figure S73.  Get High-res Image Gene #43: 'amp_20q11.21' versus Clinical Feature #1: 'Time to Death'

'amp_20q11.21' versus 'AGE'

P value = 7.39e-08 (t-test), Q value = 2.9e-05

Table S74.  Gene #43: 'amp_20q11.21' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 43(20Q11.21) MUTATED 121 68.2 (9.8)
AMP PEAK 43(20Q11.21) WILD-TYPE 350 62.2 (11.3)

Figure S74.  Get High-res Image Gene #43: 'amp_20q11.21' versus Clinical Feature #2: 'AGE'

'amp_20q11.21' versus 'HISTOLOGICAL.TYPE'

P value = 5.78e-24 (Fisher's exact test), Q value = 2.8e-21

Table S75.  Gene #43: 'amp_20q11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 43(20Q11.21) MUTATED 51 6 64
AMP PEAK 43(20Q11.21) WILD-TYPE 309 13 29

Figure S75.  Get High-res Image Gene #43: 'amp_20q11.21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20q13.12' versus 'AGE'

P value = 2.24e-08 (t-test), Q value = 9e-06

Table S76.  Gene #44: 'amp_20q13.12' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 44(20Q13.12) MUTATED 126 68.4 (10.2)
AMP PEAK 44(20Q13.12) WILD-TYPE 345 62.1 (11.2)

Figure S76.  Get High-res Image Gene #44: 'amp_20q13.12' versus Clinical Feature #2: 'AGE'

'amp_20q13.12' versus 'HISTOLOGICAL.TYPE'

P value = 5.62e-23 (Fisher's exact test), Q value = 2.7e-20

Table S77.  Gene #44: 'amp_20q13.12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 44(20Q13.12) MUTATED 55 7 64
AMP PEAK 44(20Q13.12) WILD-TYPE 305 12 29

Figure S77.  Get High-res Image Gene #44: 'amp_20q13.12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_20q13.33' versus 'AGE'

P value = 1.11e-07 (t-test), Q value = 4.4e-05

Table S78.  Gene #45: 'amp_20q13.33' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
AMP PEAK 45(20Q13.33) MUTATED 122 68.3 (10.4)
AMP PEAK 45(20Q13.33) WILD-TYPE 349 62.2 (11.2)

Figure S78.  Get High-res Image Gene #45: 'amp_20q13.33' versus Clinical Feature #2: 'AGE'

'amp_20q13.33' versus 'HISTOLOGICAL.TYPE'

P value = 2.06e-18 (Fisher's exact test), Q value = 9.5e-16

Table S79.  Gene #45: 'amp_20q13.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 45(20Q13.33) MUTATED 57 6 59
AMP PEAK 45(20Q13.33) WILD-TYPE 303 13 34

Figure S79.  Get High-res Image Gene #45: 'amp_20q13.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_22q12.2' versus 'Time to Death'

P value = 0.000717 (logrank test), Q value = 0.23

Table S80.  Gene #46: 'amp_22q12.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
AMP PEAK 46(22Q12.2) MUTATED 52 14 0.1 - 191.8 (18.0)
AMP PEAK 46(22Q12.2) WILD-TYPE 417 43 0.0 - 185.8 (22.0)

Figure S80.  Get High-res Image Gene #46: 'amp_22q12.2' versus Clinical Feature #1: 'Time to Death'

'amp_22q12.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.09e-21 (Fisher's exact test), Q value = 9.8e-19

Table S81.  Gene #46: 'amp_22q12.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
AMP PEAK 46(22Q12.2) MUTATED 11 2 40
AMP PEAK 46(22Q12.2) WILD-TYPE 349 17 53

Figure S81.  Get High-res Image Gene #46: 'amp_22q12.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'amp_22q12.2' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.000661 (Fisher's exact test), Q value = 0.21

Table S82.  Gene #46: 'amp_22q12.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients R0 R1 R2 RX
ALL 325 24 16 27
AMP PEAK 46(22Q12.2) MUTATED 28 3 7 5
AMP PEAK 46(22Q12.2) WILD-TYPE 297 21 9 22

Figure S82.  Get High-res Image Gene #46: 'amp_22q12.2' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'del_1p36.11' versus 'AGE'

P value = 9.44e-06 (t-test), Q value = 0.0035

Table S83.  Gene #49: 'del_1p36.11' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 1(1P36.11) MUTATED 69 69.0 (9.8)
DEL PEAK 1(1P36.11) WILD-TYPE 402 62.9 (11.3)

Figure S83.  Get High-res Image Gene #49: 'del_1p36.11' versus Clinical Feature #2: 'AGE'

'del_1p36.11' versus 'HISTOLOGICAL.TYPE'

P value = 3.64e-16 (Fisher's exact test), Q value = 1.6e-13

Table S84.  Gene #49: 'del_1p36.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 1(1P36.11) MUTATED 24 4 41
DEL PEAK 1(1P36.11) WILD-TYPE 336 15 52

Figure S84.  Get High-res Image Gene #49: 'del_1p36.11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_2q22.1' versus 'Time to Death'

P value = 6.83e-10 (logrank test), Q value = 2.8e-07

Table S85.  Gene #51: 'del_2q22.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 3(2Q22.1) MUTATED 42 15 0.5 - 125.4 (10.5)
DEL PEAK 3(2Q22.1) WILD-TYPE 427 42 0.0 - 191.8 (23.3)

Figure S85.  Get High-res Image Gene #51: 'del_2q22.1' versus Clinical Feature #1: 'Time to Death'

'del_2q22.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.4e-08 (Fisher's exact test), Q value = 9.6e-06

Table S86.  Gene #51: 'del_2q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 3(2Q22.1) MUTATED 16 2 24
DEL PEAK 3(2Q22.1) WILD-TYPE 344 17 69

Figure S86.  Get High-res Image Gene #51: 'del_2q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_2q37.3' versus 'AGE'

P value = 0.000512 (t-test), Q value = 0.17

Table S87.  Gene #52: 'del_2q37.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 4(2Q37.3) MUTATED 46 68.3 (8.4)
DEL PEAK 4(2Q37.3) WILD-TYPE 425 63.3 (11.5)

Figure S87.  Get High-res Image Gene #52: 'del_2q37.3' versus Clinical Feature #2: 'AGE'

'del_2q37.3' versus 'HISTOLOGICAL.TYPE'

P value = 0.000772 (Fisher's exact test), Q value = 0.24

Table S88.  Gene #52: 'del_2q37.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 4(2Q37.3) MUTATED 25 2 19
DEL PEAK 4(2Q37.3) WILD-TYPE 335 17 74

Figure S88.  Get High-res Image Gene #52: 'del_2q37.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_3p14.2' versus 'AGE'

P value = 0.000135 (t-test), Q value = 0.048

Table S89.  Gene #53: 'del_3p14.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 5(3P14.2) MUTATED 66 67.8 (8.4)
DEL PEAK 5(3P14.2) WILD-TYPE 405 63.1 (11.6)

Figure S89.  Get High-res Image Gene #53: 'del_3p14.2' versus Clinical Feature #2: 'AGE'

'del_3p14.2' versus 'HISTOLOGICAL.TYPE'

P value = 1.22e-15 (Fisher's exact test), Q value = 5.4e-13

Table S90.  Gene #53: 'del_3p14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 5(3P14.2) MUTATED 22 6 38
DEL PEAK 5(3P14.2) WILD-TYPE 338 13 55

Figure S90.  Get High-res Image Gene #53: 'del_3p14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_3q13.31' versus 'HISTOLOGICAL.TYPE'

P value = 2.41e-06 (Fisher's exact test), Q value = 0.00092

Table S91.  Gene #54: 'del_3q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 6(3Q13.31) MUTATED 9 2 16
DEL PEAK 6(3Q13.31) WILD-TYPE 351 17 77

Figure S91.  Get High-res Image Gene #54: 'del_3q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4p16.3' versus 'AGE'

P value = 6.95e-05 (t-test), Q value = 0.025

Table S92.  Gene #55: 'del_4p16.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 7(4P16.3) MUTATED 75 68.0 (9.2)
DEL PEAK 7(4P16.3) WILD-TYPE 396 63.0 (11.5)

Figure S92.  Get High-res Image Gene #55: 'del_4p16.3' versus Clinical Feature #2: 'AGE'

'del_4p16.3' versus 'HISTOLOGICAL.TYPE'

P value = 5.77e-16 (Fisher's exact test), Q value = 2.6e-13

Table S93.  Gene #55: 'del_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 7(4P16.3) MUTATED 28 4 43
DEL PEAK 7(4P16.3) WILD-TYPE 332 15 50

Figure S93.  Get High-res Image Gene #55: 'del_4p16.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4p15.31' versus 'AGE'

P value = 4.23e-05 (t-test), Q value = 0.015

Table S94.  Gene #56: 'del_4p15.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 8(4P15.31) MUTATED 77 68.1 (9.5)
DEL PEAK 8(4P15.31) WILD-TYPE 394 62.9 (11.4)

Figure S94.  Get High-res Image Gene #56: 'del_4p15.31' versus Clinical Feature #2: 'AGE'

'del_4p15.31' versus 'HISTOLOGICAL.TYPE'

P value = 2.77e-15 (Fisher's exact test), Q value = 1.2e-12

Table S95.  Gene #56: 'del_4p15.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 8(4P15.31) MUTATED 30 4 43
DEL PEAK 8(4P15.31) WILD-TYPE 330 15 50

Figure S95.  Get High-res Image Gene #56: 'del_4p15.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4q22.1' versus 'AGE'

P value = 5.21e-06 (t-test), Q value = 0.002

Table S96.  Gene #57: 'del_4q22.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 9(4Q22.1) MUTATED 86 68.2 (9.2)
DEL PEAK 9(4Q22.1) WILD-TYPE 385 62.8 (11.5)

Figure S96.  Get High-res Image Gene #57: 'del_4q22.1' versus Clinical Feature #2: 'AGE'

'del_4q22.1' versus 'HISTOLOGICAL.TYPE'

P value = 4.46e-26 (Fisher's exact test), Q value = 2.1e-23

Table S97.  Gene #57: 'del_4q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 9(4Q22.1) MUTATED 26 5 55
DEL PEAK 9(4Q22.1) WILD-TYPE 334 14 38

Figure S97.  Get High-res Image Gene #57: 'del_4q22.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_4q34.3' versus 'AGE'

P value = 5.33e-06 (t-test), Q value = 0.002

Table S98.  Gene #58: 'del_4q34.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 10(4Q34.3) MUTATED 107 67.9 (10.1)
DEL PEAK 10(4Q34.3) WILD-TYPE 364 62.6 (11.3)

Figure S98.  Get High-res Image Gene #58: 'del_4q34.3' versus Clinical Feature #2: 'AGE'

'del_4q34.3' versus 'HISTOLOGICAL.TYPE'

P value = 2.67e-27 (Fisher's exact test), Q value = 1.3e-24

Table S99.  Gene #58: 'del_4q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 10(4Q34.3) MUTATED 38 7 62
DEL PEAK 10(4Q34.3) WILD-TYPE 322 12 31

Figure S99.  Get High-res Image Gene #58: 'del_4q34.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_5q11.2' versus 'AGE'

P value = 5.45e-05 (t-test), Q value = 0.02

Table S100.  Gene #59: 'del_5q11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 11(5Q11.2) MUTATED 92 67.8 (10.0)
DEL PEAK 11(5Q11.2) WILD-TYPE 379 62.8 (11.4)

Figure S100.  Get High-res Image Gene #59: 'del_5q11.2' versus Clinical Feature #2: 'AGE'

'del_5q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.26e-25 (Fisher's exact test), Q value = 2.5e-22

Table S101.  Gene #59: 'del_5q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 11(5Q11.2) MUTATED 32 3 57
DEL PEAK 11(5Q11.2) WILD-TYPE 328 16 36

Figure S101.  Get High-res Image Gene #59: 'del_5q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_6q26' versus 'HISTOLOGICAL.TYPE'

P value = 1.2e-10 (Fisher's exact test), Q value = 5.1e-08

Table S102.  Gene #60: 'del_6q26' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 12(6Q26) MUTATED 12 3 25
DEL PEAK 12(6Q26) WILD-TYPE 348 16 68

Figure S102.  Get High-res Image Gene #60: 'del_6q26' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7p22.3' versus 'Time to Death'

P value = 0.000142 (logrank test), Q value = 0.05

Table S103.  Gene #61: 'del_7p22.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 13(7P22.3) MUTATED 62 16 0.0 - 97.7 (19.7)
DEL PEAK 13(7P22.3) WILD-TYPE 407 41 0.1 - 191.8 (21.7)

Figure S103.  Get High-res Image Gene #61: 'del_7p22.3' versus Clinical Feature #1: 'Time to Death'

'del_7p22.3' versus 'AGE'

P value = 7.03e-05 (t-test), Q value = 0.025

Table S104.  Gene #61: 'del_7p22.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 13(7P22.3) MUTATED 62 68.9 (10.2)
DEL PEAK 13(7P22.3) WILD-TYPE 409 63.0 (11.2)

Figure S104.  Get High-res Image Gene #61: 'del_7p22.3' versus Clinical Feature #2: 'AGE'

'del_7p22.3' versus 'HISTOLOGICAL.TYPE'

P value = 5.11e-15 (Fisher's exact test), Q value = 2.2e-12

Table S105.  Gene #61: 'del_7p22.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 13(7P22.3) MUTATED 21 5 37
DEL PEAK 13(7P22.3) WILD-TYPE 339 14 56

Figure S105.  Get High-res Image Gene #61: 'del_7p22.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7q11.22' versus 'AGE'

P value = 2.81e-05 (t-test), Q value = 0.01

Table S106.  Gene #62: 'del_7q11.22' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 14(7Q11.22) MUTATED 37 71.1 (9.8)
DEL PEAK 14(7Q11.22) WILD-TYPE 434 63.2 (11.2)

Figure S106.  Get High-res Image Gene #62: 'del_7q11.22' versus Clinical Feature #2: 'AGE'

'del_7q11.22' versus 'HISTOLOGICAL.TYPE'

P value = 3.51e-08 (Fisher's exact test), Q value = 1.4e-05

Table S107.  Gene #62: 'del_7q11.22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 14(7Q11.22) MUTATED 13 2 22
DEL PEAK 14(7Q11.22) WILD-TYPE 347 17 71

Figure S107.  Get High-res Image Gene #62: 'del_7q11.22' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7q31.1' versus 'AGE'

P value = 7.81e-07 (t-test), Q value = 3e-04

Table S108.  Gene #63: 'del_7q31.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 15(7Q31.1) MUTATED 46 70.2 (7.9)
DEL PEAK 15(7Q31.1) WILD-TYPE 425 63.1 (11.4)

Figure S108.  Get High-res Image Gene #63: 'del_7q31.1' versus Clinical Feature #2: 'AGE'

'del_7q31.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.2e-18 (Fisher's exact test), Q value = 1.5e-15

Table S109.  Gene #63: 'del_7q31.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 15(7Q31.1) MUTATED 9 3 34
DEL PEAK 15(7Q31.1) WILD-TYPE 351 16 59

Figure S109.  Get High-res Image Gene #63: 'del_7q31.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_7q36.1' versus 'AGE'

P value = 1.37e-09 (t-test), Q value = 5.6e-07

Table S110.  Gene #64: 'del_7q36.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 16(7Q36.1) MUTATED 56 71.4 (8.5)
DEL PEAK 16(7Q36.1) WILD-TYPE 415 62.8 (11.2)

Figure S110.  Get High-res Image Gene #64: 'del_7q36.1' versus Clinical Feature #2: 'AGE'

'del_7q36.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.41e-21 (Fisher's exact test), Q value = 1.6e-18

Table S111.  Gene #64: 'del_7q36.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 16(7Q36.1) MUTATED 12 4 40
DEL PEAK 16(7Q36.1) WILD-TYPE 348 15 53

Figure S111.  Get High-res Image Gene #64: 'del_7q36.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_8p23.2' versus 'AGE'

P value = 0.000167 (t-test), Q value = 0.058

Table S112.  Gene #65: 'del_8p23.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 17(8P23.2) MUTATED 96 67.2 (9.4)
DEL PEAK 17(8P23.2) WILD-TYPE 375 62.9 (11.6)

Figure S112.  Get High-res Image Gene #65: 'del_8p23.2' versus Clinical Feature #2: 'AGE'

'del_8p23.2' versus 'HISTOLOGICAL.TYPE'

P value = 4.8e-31 (Fisher's exact test), Q value = 2.3e-28

Table S113.  Gene #65: 'del_8p23.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 17(8P23.2) MUTATED 30 4 63
DEL PEAK 17(8P23.2) WILD-TYPE 330 15 30

Figure S113.  Get High-res Image Gene #65: 'del_8p23.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_8p21.2' versus 'AGE'

P value = 6.56e-06 (t-test), Q value = 0.0024

Table S114.  Gene #66: 'del_8p21.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 18(8P21.2) MUTATED 94 68.0 (9.2)
DEL PEAK 18(8P21.2) WILD-TYPE 377 62.8 (11.5)

Figure S114.  Get High-res Image Gene #66: 'del_8p21.2' versus Clinical Feature #2: 'AGE'

'del_8p21.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.41e-39 (Fisher's exact test), Q value = 2.6e-36

Table S115.  Gene #66: 'del_8p21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 18(8P21.2) MUTATED 22 5 67
DEL PEAK 18(8P21.2) WILD-TYPE 338 14 26

Figure S115.  Get High-res Image Gene #66: 'del_8p21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_9p23' versus 'HISTOLOGICAL.TYPE'

P value = 2.23e-12 (Fisher's exact test), Q value = 9.6e-10

Table S116.  Gene #67: 'del_9p23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 19(9P23) MUTATED 23 3 35
DEL PEAK 19(9P23) WILD-TYPE 337 16 58

Figure S116.  Get High-res Image Gene #67: 'del_9p23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_9q21.2' versus 'Time to Death'

P value = 0.000125 (logrank test), Q value = 0.044

Table S117.  Gene #68: 'del_9q21.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 20(9Q21.2) MUTATED 106 23 0.1 - 125.4 (17.2)
DEL PEAK 20(9Q21.2) WILD-TYPE 363 34 0.0 - 191.8 (23.3)

Figure S117.  Get High-res Image Gene #68: 'del_9q21.2' versus Clinical Feature #1: 'Time to Death'

'del_9q21.2' versus 'AGE'

P value = 7.01e-11 (t-test), Q value = 3e-08

Table S118.  Gene #68: 'del_9q21.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 20(9Q21.2) MUTATED 107 69.4 (9.1)
DEL PEAK 20(9Q21.2) WILD-TYPE 364 62.1 (11.3)

Figure S118.  Get High-res Image Gene #68: 'del_9q21.2' versus Clinical Feature #2: 'AGE'

'del_9q21.2' versus 'HISTOLOGICAL.TYPE'

P value = 7.76e-21 (Fisher's exact test), Q value = 3.6e-18

Table S119.  Gene #68: 'del_9q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 20(9Q21.2) MUTATED 43 9 55
DEL PEAK 20(9Q21.2) WILD-TYPE 317 10 38

Figure S119.  Get High-res Image Gene #68: 'del_9q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_9q34.2' versus 'AGE'

P value = 1.37e-09 (t-test), Q value = 5.6e-07

Table S120.  Gene #69: 'del_9q34.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 21(9Q34.2) MUTATED 109 68.8 (8.7)
DEL PEAK 21(9Q34.2) WILD-TYPE 362 62.3 (11.5)

Figure S120.  Get High-res Image Gene #69: 'del_9q34.2' versus Clinical Feature #2: 'AGE'

'del_9q34.2' versus 'HISTOLOGICAL.TYPE'

P value = 4.24e-19 (Fisher's exact test), Q value = 2e-16

Table S121.  Gene #69: 'del_9q34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 21(9Q34.2) MUTATED 46 9 54
DEL PEAK 21(9Q34.2) WILD-TYPE 314 10 39

Figure S121.  Get High-res Image Gene #69: 'del_9q34.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_10q23.31' versus 'HISTOLOGICAL.TYPE'

P value = 6.21e-09 (Fisher's exact test), Q value = 2.5e-06

Table S122.  Gene #70: 'del_10q23.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 22(10Q23.31) MUTATED 28 4 31
DEL PEAK 22(10Q23.31) WILD-TYPE 332 15 62

Figure S122.  Get High-res Image Gene #70: 'del_10q23.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_11p15.5' versus 'AGE'

P value = 1.59e-06 (t-test), Q value = 0.00061

Table S123.  Gene #71: 'del_11p15.5' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 23(11P15.5) MUTATED 84 68.6 (9.2)
DEL PEAK 23(11P15.5) WILD-TYPE 387 62.8 (11.4)

Figure S123.  Get High-res Image Gene #71: 'del_11p15.5' versus Clinical Feature #2: 'AGE'

'del_11p15.5' versus 'HISTOLOGICAL.TYPE'

P value = 1.36e-18 (Fisher's exact test), Q value = 6.3e-16

Table S124.  Gene #71: 'del_11p15.5' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 23(11P15.5) MUTATED 31 5 48
DEL PEAK 23(11P15.5) WILD-TYPE 329 14 45

Figure S124.  Get High-res Image Gene #71: 'del_11p15.5' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_11q14.1' versus 'AGE'

P value = 4.63e-05 (t-test), Q value = 0.017

Table S125.  Gene #72: 'del_11q14.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 24(11Q14.1) MUTATED 57 68.8 (9.1)
DEL PEAK 24(11Q14.1) WILD-TYPE 414 63.1 (11.4)

Figure S125.  Get High-res Image Gene #72: 'del_11q14.1' versus Clinical Feature #2: 'AGE'

'del_11q14.1' versus 'HISTOLOGICAL.TYPE'

P value = 2.88e-15 (Fisher's exact test), Q value = 1.3e-12

Table S126.  Gene #72: 'del_11q14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 24(11Q14.1) MUTATED 17 6 34
DEL PEAK 24(11Q14.1) WILD-TYPE 343 13 59

Figure S126.  Get High-res Image Gene #72: 'del_11q14.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_11q25' versus 'Time to Death'

P value = 0.000655 (logrank test), Q value = 0.21

Table S127.  Gene #73: 'del_11q25' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 25(11Q25) MUTATED 78 16 0.1 - 97.1 (16.2)
DEL PEAK 25(11Q25) WILD-TYPE 391 41 0.0 - 191.8 (23.3)

Figure S127.  Get High-res Image Gene #73: 'del_11q25' versus Clinical Feature #1: 'Time to Death'

'del_11q25' versus 'AGE'

P value = 0.000548 (t-test), Q value = 0.18

Table S128.  Gene #73: 'del_11q25' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 25(11Q25) MUTATED 79 67.6 (10.3)
DEL PEAK 25(11Q25) WILD-TYPE 392 63.0 (11.3)

Figure S128.  Get High-res Image Gene #73: 'del_11q25' versus Clinical Feature #2: 'AGE'

'del_11q25' versus 'HISTOLOGICAL.TYPE'

P value = 6.24e-17 (Fisher's exact test), Q value = 2.8e-14

Table S129.  Gene #73: 'del_11q25' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 25(11Q25) MUTATED 29 6 44
DEL PEAK 25(11Q25) WILD-TYPE 331 13 49

Figure S129.  Get High-res Image Gene #73: 'del_11q25' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_12q23.1' versus 'HISTOLOGICAL.TYPE'

P value = 4.5e-12 (Fisher's exact test), Q value = 1.9e-09

Table S130.  Gene #74: 'del_12q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 26(12Q23.1) MUTATED 11 2 27
DEL PEAK 26(12Q23.1) WILD-TYPE 349 17 66

Figure S130.  Get High-res Image Gene #74: 'del_12q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_12q24.33' versus 'AGE'

P value = 9.72e-05 (t-test), Q value = 0.035

Table S131.  Gene #75: 'del_12q24.33' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 27(12Q24.33) MUTATED 51 68.9 (9.2)
DEL PEAK 27(12Q24.33) WILD-TYPE 420 63.2 (11.4)

Figure S131.  Get High-res Image Gene #75: 'del_12q24.33' versus Clinical Feature #2: 'AGE'

'del_12q24.33' versus 'HISTOLOGICAL.TYPE'

P value = 1.49e-15 (Fisher's exact test), Q value = 6.6e-13

Table S132.  Gene #75: 'del_12q24.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 27(12Q24.33) MUTATED 15 1 35
DEL PEAK 27(12Q24.33) WILD-TYPE 345 18 58

Figure S132.  Get High-res Image Gene #75: 'del_12q24.33' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_13q11' versus 'HISTOLOGICAL.TYPE'

P value = 8.99e-13 (Fisher's exact test), Q value = 3.9e-10

Table S133.  Gene #76: 'del_13q11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 28(13Q11) MUTATED 34 4 41
DEL PEAK 28(13Q11) WILD-TYPE 326 15 52

Figure S133.  Get High-res Image Gene #76: 'del_13q11' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_13q14.2' versus 'AGE'

P value = 0.000363 (t-test), Q value = 0.12

Table S134.  Gene #77: 'del_13q14.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 29(13Q14.2) MUTATED 84 67.5 (9.9)
DEL PEAK 29(13Q14.2) WILD-TYPE 387 63.0 (11.4)

Figure S134.  Get High-res Image Gene #77: 'del_13q14.2' versus Clinical Feature #2: 'AGE'

'del_13q14.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.28e-07 (Fisher's exact test), Q value = 8.9e-05

Table S135.  Gene #77: 'del_13q14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 29(13Q14.2) MUTATED 44 5 35
DEL PEAK 29(13Q14.2) WILD-TYPE 316 14 58

Figure S135.  Get High-res Image Gene #77: 'del_13q14.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_14q13.1' versus 'HISTOLOGICAL.TYPE'

P value = 9.63e-11 (Fisher's exact test), Q value = 4.1e-08

Table S136.  Gene #78: 'del_14q13.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 30(14Q13.1) MUTATED 23 5 31
DEL PEAK 30(14Q13.1) WILD-TYPE 337 14 62

Figure S136.  Get High-res Image Gene #78: 'del_14q13.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_15q15.1' versus 'Time to Death'

P value = 0.00067 (logrank test), Q value = 0.21

Table S137.  Gene #79: 'del_15q15.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 31(15Q15.1) MUTATED 115 23 0.0 - 102.0 (17.9)
DEL PEAK 31(15Q15.1) WILD-TYPE 354 34 0.1 - 191.8 (23.3)

Figure S137.  Get High-res Image Gene #79: 'del_15q15.1' versus Clinical Feature #1: 'Time to Death'

'del_15q15.1' versus 'AGE'

P value = 5.52e-08 (t-test), Q value = 2.2e-05

Table S138.  Gene #79: 'del_15q15.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 31(15Q15.1) MUTATED 116 68.4 (9.9)
DEL PEAK 31(15Q15.1) WILD-TYPE 355 62.3 (11.3)

Figure S138.  Get High-res Image Gene #79: 'del_15q15.1' versus Clinical Feature #2: 'AGE'

'del_15q15.1' versus 'HISTOLOGICAL.TYPE'

P value = 1.92e-23 (Fisher's exact test), Q value = 9.2e-21

Table S139.  Gene #79: 'del_15q15.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 31(15Q15.1) MUTATED 47 8 61
DEL PEAK 31(15Q15.1) WILD-TYPE 313 11 32

Figure S139.  Get High-res Image Gene #79: 'del_15q15.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_15q23' versus 'AGE'

P value = 1.86e-05 (t-test), Q value = 0.0069

Table S140.  Gene #80: 'del_15q23' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 32(15Q23) MUTATED 97 67.8 (9.7)
DEL PEAK 32(15Q23) WILD-TYPE 374 62.7 (11.4)

Figure S140.  Get High-res Image Gene #80: 'del_15q23' versus Clinical Feature #2: 'AGE'

'del_15q23' versus 'HISTOLOGICAL.TYPE'

P value = 2.51e-23 (Fisher's exact test), Q value = 1.2e-20

Table S141.  Gene #80: 'del_15q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 32(15Q23) MUTATED 35 6 56
DEL PEAK 32(15Q23) WILD-TYPE 325 13 37

Figure S141.  Get High-res Image Gene #80: 'del_15q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_16p13.3' versus 'AGE'

P value = 6.91e-08 (t-test), Q value = 2.7e-05

Table S142.  Gene #81: 'del_16p13.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 33(16P13.3) MUTATED 75 69.4 (8.8)
DEL PEAK 33(16P13.3) WILD-TYPE 396 62.7 (11.4)

Figure S142.  Get High-res Image Gene #81: 'del_16p13.3' versus Clinical Feature #2: 'AGE'

'del_16p13.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.26e-21 (Fisher's exact test), Q value = 5.9e-19

Table S143.  Gene #81: 'del_16p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 33(16P13.3) MUTATED 23 4 48
DEL PEAK 33(16P13.3) WILD-TYPE 337 15 45

Figure S143.  Get High-res Image Gene #81: 'del_16p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_16q21' versus 'AGE'

P value = 1.79e-08 (t-test), Q value = 7.2e-06

Table S144.  Gene #82: 'del_16q21' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 34(16Q21) MUTATED 130 68.1 (9.4)
DEL PEAK 34(16Q21) WILD-TYPE 341 62.1 (11.5)

Figure S144.  Get High-res Image Gene #82: 'del_16q21' versus Clinical Feature #2: 'AGE'

'del_16q21' versus 'HISTOLOGICAL.TYPE'

P value = 5.9e-24 (Fisher's exact test), Q value = 2.8e-21

Table S145.  Gene #82: 'del_16q21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 34(16Q21) MUTATED 57 7 66
DEL PEAK 34(16Q21) WILD-TYPE 303 12 27

Figure S145.  Get High-res Image Gene #82: 'del_16q21' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_16q23.1' versus 'AGE'

P value = 2.53e-07 (t-test), Q value = 9.8e-05

Table S146.  Gene #83: 'del_16q23.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 35(16Q23.1) MUTATED 139 67.6 (9.6)
DEL PEAK 35(16Q23.1) WILD-TYPE 332 62.2 (11.6)

Figure S146.  Get High-res Image Gene #83: 'del_16q23.1' versus Clinical Feature #2: 'AGE'

'del_16q23.1' versus 'HISTOLOGICAL.TYPE'

P value = 1.3e-26 (Fisher's exact test), Q value = 6.3e-24

Table S147.  Gene #83: 'del_16q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 35(16Q23.1) MUTATED 62 6 71
DEL PEAK 35(16Q23.1) WILD-TYPE 298 13 22

Figure S147.  Get High-res Image Gene #83: 'del_16q23.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17p13.3' versus 'Time to Death'

P value = 7e-04 (logrank test), Q value = 0.22

Table S148.  Gene #84: 'del_17p13.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 36(17P13.3) MUTATED 99 20 0.0 - 125.4 (17.6)
DEL PEAK 36(17P13.3) WILD-TYPE 370 37 0.1 - 191.8 (23.3)

Figure S148.  Get High-res Image Gene #84: 'del_17p13.3' versus Clinical Feature #1: 'Time to Death'

'del_17p13.3' versus 'AGE'

P value = 0.000207 (t-test), Q value = 0.072

Table S149.  Gene #84: 'del_17p13.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 36(17P13.3) MUTATED 100 67.1 (9.4)
DEL PEAK 36(17P13.3) WILD-TYPE 371 62.9 (11.6)

Figure S149.  Get High-res Image Gene #84: 'del_17p13.3' versus Clinical Feature #2: 'AGE'

'del_17p13.3' versus 'HISTOLOGICAL.TYPE'

P value = 3.33e-21 (Fisher's exact test), Q value = 1.6e-18

Table S150.  Gene #84: 'del_17p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 36(17P13.3) MUTATED 38 9 53
DEL PEAK 36(17P13.3) WILD-TYPE 322 10 40

Figure S150.  Get High-res Image Gene #84: 'del_17p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17p11.2' versus 'AGE'

P value = 1.14e-06 (t-test), Q value = 0.00044

Table S151.  Gene #85: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 37(17P11.2) MUTATED 107 68.1 (9.6)
DEL PEAK 37(17P11.2) WILD-TYPE 364 62.5 (11.4)

Figure S151.  Get High-res Image Gene #85: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

'del_17p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 7.52e-27 (Fisher's exact test), Q value = 3.6e-24

Table S152.  Gene #85: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 37(17P11.2) MUTATED 38 8 61
DEL PEAK 37(17P11.2) WILD-TYPE 322 11 32

Figure S152.  Get High-res Image Gene #85: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17p11.2' versus 'AGE'

P value = 3.16e-06 (t-test), Q value = 0.0012

Table S153.  Gene #86: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 38(17P11.2) MUTATED 101 68.0 (9.5)
DEL PEAK 38(17P11.2) WILD-TYPE 370 62.6 (11.5)

Figure S153.  Get High-res Image Gene #86: 'del_17p11.2' versus Clinical Feature #2: 'AGE'

'del_17p11.2' versus 'HISTOLOGICAL.TYPE'

P value = 2.66e-20 (Fisher's exact test), Q value = 1.2e-17

Table S154.  Gene #86: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 38(17P11.2) MUTATED 40 7 54
DEL PEAK 38(17P11.2) WILD-TYPE 320 12 39

Figure S154.  Get High-res Image Gene #86: 'del_17p11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17q11.2' versus 'AGE'

P value = 4.33e-06 (t-test), Q value = 0.0016

Table S155.  Gene #87: 'del_17q11.2' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 39(17Q11.2) MUTATED 87 68.4 (9.7)
DEL PEAK 39(17Q11.2) WILD-TYPE 384 62.7 (11.3)

Figure S155.  Get High-res Image Gene #87: 'del_17q11.2' versus Clinical Feature #2: 'AGE'

'del_17q11.2' versus 'HISTOLOGICAL.TYPE'

P value = 6.21e-12 (Fisher's exact test), Q value = 2.7e-09

Table S156.  Gene #87: 'del_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 39(17Q11.2) MUTATED 40 5 42
DEL PEAK 39(17Q11.2) WILD-TYPE 320 14 51

Figure S156.  Get High-res Image Gene #87: 'del_17q11.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_17q21.31' versus 'AGE'

P value = 1e-04 (t-test), Q value = 0.036

Table S157.  Gene #88: 'del_17q21.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 40(17Q21.31) MUTATED 86 67.8 (10.1)
DEL PEAK 40(17Q21.31) WILD-TYPE 385 62.9 (11.3)

Figure S157.  Get High-res Image Gene #88: 'del_17q21.31' versus Clinical Feature #2: 'AGE'

'del_17q21.31' versus 'HISTOLOGICAL.TYPE'

P value = 6.14e-13 (Fisher's exact test), Q value = 2.7e-10

Table S158.  Gene #88: 'del_17q21.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 40(17Q21.31) MUTATED 38 5 43
DEL PEAK 40(17Q21.31) WILD-TYPE 322 14 50

Figure S158.  Get High-res Image Gene #88: 'del_17q21.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_18q21.2' versus 'HISTOLOGICAL.TYPE'

P value = 5.91e-12 (Fisher's exact test), Q value = 2.5e-09

Table S159.  Gene #89: 'del_18q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 41(18Q21.2) MUTATED 32 5 38
DEL PEAK 41(18Q21.2) WILD-TYPE 328 14 55

Figure S159.  Get High-res Image Gene #89: 'del_18q21.2' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_18q23' versus 'HISTOLOGICAL.TYPE'

P value = 1.79e-16 (Fisher's exact test), Q value = 8e-14

Table S160.  Gene #90: 'del_18q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 42(18Q23) MUTATED 31 5 45
DEL PEAK 42(18Q23) WILD-TYPE 329 14 48

Figure S160.  Get High-res Image Gene #90: 'del_18q23' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_19p13.3' versus 'Time to Death'

P value = 3.63e-06 (logrank test), Q value = 0.0014

Table S161.  Gene #91: 'del_19p13.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 43(19P13.3) MUTATED 128 29 0.0 - 125.4 (18.2)
DEL PEAK 43(19P13.3) WILD-TYPE 341 28 0.1 - 191.8 (23.3)

Figure S161.  Get High-res Image Gene #91: 'del_19p13.3' versus Clinical Feature #1: 'Time to Death'

'del_19p13.3' versus 'AGE'

P value = 1.49e-11 (t-test), Q value = 6.3e-09

Table S162.  Gene #91: 'del_19p13.3' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 43(19P13.3) MUTATED 129 68.9 (8.8)
DEL PEAK 43(19P13.3) WILD-TYPE 342 61.9 (11.5)

Figure S162.  Get High-res Image Gene #91: 'del_19p13.3' versus Clinical Feature #2: 'AGE'

'del_19p13.3' versus 'HISTOLOGICAL.TYPE'

P value = 1.19e-49 (Fisher's exact test), Q value = 5.8e-47

Table S163.  Gene #91: 'del_19p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 43(19P13.3) MUTATED 38 8 83
DEL PEAK 43(19P13.3) WILD-TYPE 322 11 10

Figure S163.  Get High-res Image Gene #91: 'del_19p13.3' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_19p12' versus 'HISTOLOGICAL.TYPE'

P value = 7.94e-09 (Fisher's exact test), Q value = 3.2e-06

Table S164.  Gene #92: 'del_19p12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 44(19P12) MUTATED 16 5 23
DEL PEAK 44(19P12) WILD-TYPE 344 14 70

Figure S164.  Get High-res Image Gene #92: 'del_19p12' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_19q13.43' versus 'HISTOLOGICAL.TYPE'

P value = 4.05e-17 (Fisher's exact test), Q value = 1.8e-14

Table S165.  Gene #93: 'del_19q13.43' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 45(19Q13.43) MUTATED 14 4 36
DEL PEAK 45(19Q13.43) WILD-TYPE 346 15 57

Figure S165.  Get High-res Image Gene #93: 'del_19q13.43' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_20p12.1' versus 'Time to Death'

P value = 0.000152 (logrank test), Q value = 0.053

Table S166.  Gene #94: 'del_20p12.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 46(20P12.1) MUTATED 30 11 0.1 - 149.5 (19.1)
DEL PEAK 46(20P12.1) WILD-TYPE 439 46 0.0 - 191.8 (21.7)

Figure S166.  Get High-res Image Gene #94: 'del_20p12.1' versus Clinical Feature #1: 'Time to Death'

'del_20p12.1' versus 'HISTOLOGICAL.TYPE'

P value = 0.000574 (Fisher's exact test), Q value = 0.19

Table S167.  Gene #94: 'del_20p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 46(20P12.1) MUTATED 14 2 14
DEL PEAK 46(20P12.1) WILD-TYPE 346 17 79

Figure S167.  Get High-res Image Gene #94: 'del_20p12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_22q12.1' versus 'AGE'

P value = 0.000589 (t-test), Q value = 0.19

Table S168.  Gene #95: 'del_22q12.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 47(22Q12.1) MUTATED 79 67.5 (9.9)
DEL PEAK 47(22Q12.1) WILD-TYPE 392 63.0 (11.4)

Figure S168.  Get High-res Image Gene #95: 'del_22q12.1' versus Clinical Feature #2: 'AGE'

'del_22q12.1' versus 'HISTOLOGICAL.TYPE'

P value = 1.76e-08 (Fisher's exact test), Q value = 7.1e-06

Table S169.  Gene #95: 'del_22q12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 47(22Q12.1) MUTATED 39 8 32
DEL PEAK 47(22Q12.1) WILD-TYPE 321 11 61

Figure S169.  Get High-res Image Gene #95: 'del_22q12.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_22q13.31' versus 'AGE'

P value = 3.83e-09 (t-test), Q value = 1.6e-06

Table S170.  Gene #96: 'del_22q13.31' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 48(22Q13.31) MUTATED 114 68.8 (9.4)
DEL PEAK 48(22Q13.31) WILD-TYPE 357 62.2 (11.4)

Figure S170.  Get High-res Image Gene #96: 'del_22q13.31' versus Clinical Feature #2: 'AGE'

'del_22q13.31' versus 'HISTOLOGICAL.TYPE'

P value = 4.25e-23 (Fisher's exact test), Q value = 2e-20

Table S171.  Gene #96: 'del_22q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 48(22Q13.31) MUTATED 46 8 60
DEL PEAK 48(22Q13.31) WILD-TYPE 314 11 33

Figure S171.  Get High-res Image Gene #96: 'del_22q13.31' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_22q13.32' versus 'AGE'

P value = 9.91e-08 (t-test), Q value = 3.9e-05

Table S172.  Gene #97: 'del_22q13.32' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 49(22Q13.32) MUTATED 118 68.3 (10.1)
DEL PEAK 49(22Q13.32) WILD-TYPE 353 62.3 (11.3)

Figure S172.  Get High-res Image Gene #97: 'del_22q13.32' versus Clinical Feature #2: 'AGE'

'del_22q13.32' versus 'HISTOLOGICAL.TYPE'

P value = 1.53e-22 (Fisher's exact test), Q value = 7.2e-20

Table S173.  Gene #97: 'del_22q13.32' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 49(22Q13.32) MUTATED 49 9 60
DEL PEAK 49(22Q13.32) WILD-TYPE 311 10 33

Figure S173.  Get High-res Image Gene #97: 'del_22q13.32' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'del_xp21.1' versus 'Time to Death'

P value = 0.000547 (logrank test), Q value = 0.18

Table S174.  Gene #98: 'del_xp21.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 469 57 0.0 - 191.8 (20.9)
DEL PEAK 50(XP21.1) MUTATED 72 17 0.0 - 113.3 (16.5)
DEL PEAK 50(XP21.1) WILD-TYPE 397 40 0.1 - 191.8 (22.8)

Figure S174.  Get High-res Image Gene #98: 'del_xp21.1' versus Clinical Feature #1: 'Time to Death'

'del_xp21.1' versus 'AGE'

P value = 0.000291 (t-test), Q value = 0.1

Table S175.  Gene #98: 'del_xp21.1' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 471 63.8 (11.3)
DEL PEAK 50(XP21.1) MUTATED 72 67.8 (9.6)
DEL PEAK 50(XP21.1) WILD-TYPE 399 63.1 (11.4)

Figure S175.  Get High-res Image Gene #98: 'del_xp21.1' versus Clinical Feature #2: 'AGE'

'del_xp21.1' versus 'HISTOLOGICAL.TYPE'

P value = 3.23e-16 (Fisher's exact test), Q value = 1.4e-13

Table S176.  Gene #98: 'del_xp21.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 360 19 93
DEL PEAK 50(XP21.1) MUTATED 27 2 43
DEL PEAK 50(XP21.1) WILD-TYPE 333 17 50

Figure S176.  Get High-res Image Gene #98: 'del_xp21.1' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data
Input

  • Copy number data file = transformed.cor.cli.txt

  • Clinical data file = UCEC-TP.merged_data.txt

  • Number of patients = 472

  • Number of significantly focal cnvs = 98

  • Number of selected clinical features = 5

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
Copyright © 2014 Broad Institute TCGA GDAC as part of the TCGA Research Network. All rights reserved.
Made with Nozzle