Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.03 0.105 0.279 75.0 -9999.0 0.0 75.0 KIRREL -0.044 0.143 -9999.0 0.0 -0.42 65.0 65.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.03 0.105 -9999.0 0.0 -0.28 75.0 75.0 PLCG1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.009 0.077 -9999.0 0.0 -0.206 65.0 65.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.006 0.079 -9999.0 0.0 -0.212 65.0 65.0 FYN -0.014 0.073 -9999.0 0.0 -0.201 65.0 65.0 mol:Ca2+ -0.015 0.075 -9999.0 0.0 -0.205 65.0 65.0 mol:DAG -0.01 0.076 -9999.0 0.0 -0.205 65.0 65.0 NPHS2 -0.002 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.01 0.076 -9999.0 0.0 -0.205 65.0 65.0 regulation of endocytosis -0.003 0.07 -9999.0 0.0 -0.183 65.0 65.0 Nephrin/NEPH1/podocin/Cholesterol -0.018 0.076 -9999.0 0.0 -0.212 65.0 65.0 establishment of cell polarity -0.03 0.105 -9999.0 0.0 -0.279 75.0 75.0 Nephrin/NEPH1/podocin/NCK1-2 -0.0 0.073 -9999.0 0.0 -0.359 3.0 3.0 Nephrin/NEPH1/beta Arrestin2 -0.002 0.07 -9999.0 0.0 -0.185 65.0 65.0 NPHS1 -0.003 0.042 -9999.0 0.0 -0.27 11.0 11.0 Nephrin/NEPH1/podocin -0.01 0.074 -9999.0 0.0 -0.202 65.0 65.0 TJP1 0.01 0.019 -9999.0 0.0 -0.417 1.0 1.0 NCK1 0.009 0.027 -9999.0 0.0 -0.417 2.0 2.0 NCK2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.009 0.077 -9999.0 0.0 -0.206 65.0 65.0 CD2AP 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.009 0.077 -9999.0 0.0 -0.206 65.0 65.0 GRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.027 0.097 -9999.0 0.0 -0.221 92.0 92.0 cytoskeleton organization -0.003 0.083 -9999.0 0.0 -0.218 65.0 65.0 Nephrin/NEPH1 -0.018 0.072 -9999.0 0.0 -0.202 65.0 65.0 Nephrin/NEPH1/ZO-1 -0.015 0.084 -9999.0 0.0 -0.229 65.0 65.0