Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.055 0.194 -9999.0 0.0 -0.6 45.0 45.0 IHH -0.133 0.188 -9999.0 0.0 -0.345 205.0 205.0 SHH Np/Cholesterol/GAS1 -0.144 0.124 -9999.0 0.0 -0.231 327.0 327.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.143 0.124 0.23 327.0 -9999.0 0.0 327.0 SMO/beta Arrestin2 -0.044 0.153 -9999.0 0.0 -0.428 21.0 21.0 SMO -0.052 0.16 -9999.0 0.0 -0.368 45.0 45.0 AKT1 -0.013 0.091 -9999.0 0.0 -0.479 4.0 4.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.015 0.102 -9999.0 0.0 -0.417 31.0 31.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.051 0.158 -9999.0 0.0 -0.364 45.0 45.0 STIL -0.047 0.11 -9999.0 0.0 -0.32 33.0 33.0 DHH N/PTCH2 -0.023 0.106 -9999.0 0.0 -0.302 62.0 62.0 DHH N/PTCH1 -0.062 0.135 -9999.0 0.0 -0.361 42.0 42.0 PIK3CA 0.01 0.019 -9999.0 0.0 -0.417 1.0 1.0 DHH -0.023 0.114 -9999.0 0.0 -0.417 40.0 40.0 PTHLH -0.069 0.216 -9999.0 0.0 -0.603 46.0 46.0 determination of left/right symmetry -0.051 0.158 -9999.0 0.0 -0.364 45.0 45.0 PIK3R1 0.007 0.038 -9999.0 0.0 -0.417 4.0 4.0 skeletal system development -0.068 0.214 -9999.0 0.0 -0.598 46.0 46.0 IHH N/Hhip -0.042 0.141 -9999.0 0.0 -0.257 141.0 141.0 DHH N/Hhip -0.024 0.095 -9999.0 0.0 -0.242 78.0 78.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.051 0.158 -9999.0 0.0 -0.364 45.0 45.0 pancreas development -0.013 0.08 -9999.0 0.0 -0.286 40.0 40.0 HHAT 0.008 0.033 -9999.0 0.0 -0.417 3.0 3.0 PI3K 0.013 0.03 -9999.0 0.0 -0.286 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.26 0.206 -9999.0 0.0 -0.417 325.0 325.0 somite specification -0.051 0.158 -9999.0 0.0 -0.364 45.0 45.0 SHH Np/Cholesterol/PTCH1 -0.043 0.113 -9999.0 0.0 -0.342 26.0 26.0 SHH Np/Cholesterol/PTCH2 -0.011 0.071 -9999.0 0.0 -0.234 29.0 29.0 SHH Np/Cholesterol/Megalin -0.052 0.084 -9999.0 0.0 -0.261 28.0 28.0 SHH -0.009 0.067 -9999.0 0.0 -0.184 64.0 64.0 catabolic process -0.057 0.135 -9999.0 0.0 -0.335 46.0 46.0 SMO/Vitamin D3 -0.037 0.14 -9999.0 0.0 -0.37 28.0 28.0 SHH Np/Cholesterol/Hhip -0.012 0.064 -9999.0 0.0 -0.236 13.0 13.0 LRP2 -0.094 0.136 -9999.0 0.0 -0.272 189.0 189.0 receptor-mediated endocytosis -0.063 0.13 -9999.0 0.0 -0.376 26.0 26.0 SHH Np/Cholesterol/BOC -0.014 0.074 -9999.0 0.0 -0.23 34.0 34.0 SHH Np/Cholesterol/CDO -0.038 0.101 -9999.0 0.0 -0.233 90.0 90.0 mesenchymal cell differentiation 0.012 0.063 0.234 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.031 0.123 -9999.0 0.0 -0.344 26.0 26.0 IHH N/PTCH2 -0.036 0.149 -9999.0 0.0 -0.278 126.0 126.0 CDON -0.062 0.16 -9999.0 0.0 -0.417 87.0 87.0 IHH N/PTCH1 -0.023 0.158 -9999.0 0.0 -0.338 46.0 46.0 Megalin/LRPAP1 -0.055 0.091 -9999.0 0.0 -0.175 189.0 189.0 PTCH2 -0.011 0.094 -9999.0 0.0 -0.417 26.0 26.0 SHH Np/Cholesterol -0.007 0.049 -9999.0 0.0 -0.134 64.0 64.0 PTCH1 -0.057 0.135 -9999.0 0.0 -0.336 46.0 46.0 HHIP -0.013 0.081 -9999.0 0.0 -0.287 40.0 40.0