Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.023 0.014 -9999.0 0.0 -0.197 2.0 2.0 epithelial cell differentiation -0.001 0.013 -9999.0 0.0 -0.189 2.0 2.0 CYFIP2 0.008 0.033 -9999.0 0.0 -0.417 3.0 3.0 ENAH 0.046 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.001 0.068 -9999.0 0.0 -0.406 14.0 14.0 EPHA2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.028 0.014 -9999.0 0.0 -0.175 2.0 2.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.02 0.019 -9999.0 0.0 -0.233 3.0 3.0 AQP5 0.036 0.042 -9999.0 0.0 -0.384 3.0 3.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.027 0.014 -9999.0 0.0 -0.173 2.0 2.0 regulation of calcium-dependent cell-cell adhesion 0.022 0.039 -9999.0 0.0 -0.196 15.0 15.0 EGF -0.002 0.058 -9999.0 0.0 -0.287 20.0 20.0 NCKAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.004 0.046 -9999.0 0.0 -0.452 5.0 5.0 cortical microtubule organization -0.001 0.013 -9999.0 0.0 -0.189 2.0 2.0 GO:0000145 0.026 0.013 -9999.0 0.0 -0.165 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.024 0.015 -9999.0 0.0 -0.19 2.0 2.0 MLLT4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.017 -9999.0 0.0 -0.203 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.028 0.014 -9999.0 0.0 -0.175 2.0 2.0 ARF6/GTP 0.029 0.016 -9999.0 0.0 -0.183 2.0 2.0 CDH1 0.008 0.029 -9999.0 0.0 -0.368 3.0 3.0 EGFR/EGFR/EGF/EGF -0.009 0.038 -9999.0 0.0 -0.23 7.0 7.0 RhoA/GDP -0.001 0.012 -9999.0 0.0 -0.174 2.0 2.0 actin cytoskeleton organization 0.031 0.014 -9999.0 0.0 -0.169 2.0 2.0 IGF-1R heterotetramer -0.006 0.083 -9999.0 0.0 -0.416 20.0 20.0 GIT1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.006 0.083 -9999.0 0.0 -0.417 20.0 20.0 IGF1 -0.074 0.17 -9999.0 0.0 -0.417 102.0 102.0 DIAPH1 -0.003 0.04 -9999.0 0.0 -0.528 3.0 3.0 Wnt receptor signaling pathway 0.001 0.013 0.189 2.0 -9999.0 0.0 2.0 RHOA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.032 0.014 -9999.0 0.0 -0.172 2.0 2.0 EFNA1 0.01 0.018 -9999.0 0.0 -0.272 2.0 2.0 LPP 0.032 0.013 -9999.0 0.0 -0.162 2.0 2.0 Ephrin A1/EPHA2 -0.001 0.012 -9999.0 0.0 -0.164 2.0 2.0 SEC6/SEC8 -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.022 0.039 -9999.0 0.0 -0.198 15.0 15.0 HGF/MET -0.034 0.073 -9999.0 0.0 -0.176 97.0 97.0 HGF -0.069 0.167 -9999.0 0.0 -0.417 96.0 96.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.023 0.014 -9999.0 0.0 -0.198 2.0 2.0 actin cable formation 0.059 0.017 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.031 0.026 -9999.0 0.0 -0.355 2.0 2.0 KIFC3 0.028 0.014 -9999.0 0.0 -0.175 2.0 2.0 NCK1 0.009 0.027 -9999.0 0.0 -0.417 2.0 2.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.028 0.014 -9999.0 0.0 -0.175 2.0 2.0 NCK1/GIT1 0.015 0.019 -9999.0 0.0 -0.286 2.0 2.0 mol:GDP -0.001 0.013 -9999.0 0.0 -0.189 2.0 2.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.028 0.014 -9999.0 0.0 -0.175 2.0 2.0 PIP5K1C 0.028 0.014 -9999.0 0.0 -0.175 2.0 2.0 LIMA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.043 0.028 -9999.0 0.0 -0.366 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.041 0.082 -9999.0 0.0 -0.187 112.0 112.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.005 0.045 -9999.0 0.0 -0.344 8.0 8.0 PLEKHA7 0.027 0.017 -9999.0 0.0 -0.176 3.0 3.0 mol:GTP 0.025 0.017 -9999.0 0.0 -0.202 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.045 0.012 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.023 0.014 -9999.0 0.0 -0.197 2.0 2.0 regulation of cell-cell adhesion 0.031 0.014 -9999.0 0.0 -0.169 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.023 0.014 -9999.0 0.0 -0.198 2.0 2.0