E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.094 -9999.0 0.0 -0.278 58.0 58.0 KLHL20 -0.011 0.061 -9999.0 0.0 -0.203 30.0 30.0 CYFIP2 0.021 0.022 -9999.0 0.0 -0.318 2.0 2.0 Rac1/GDP -0.007 0.069 0.267 1.0 -0.249 10.0 11.0 ENAH -0.024 0.096 -9999.0 0.0 -0.281 59.0 59.0 AP1M1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.024 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.021 0.036 -9999.0 0.0 -0.138 33.0 33.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.029 0.229 2.0 -0.175 2.0 4.0 RAPGEF1 -0.02 0.079 0.219 1.0 -0.26 39.0 40.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.103 -9999.0 0.0 -0.285 63.0 63.0 CRK -0.014 0.083 -9999.0 0.0 -0.274 41.0 41.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.027 0.226 1.0 -0.269 2.0 3.0 alphaE/beta7 Integrin 0.031 0.014 0.235 1.0 -9999.0 0.0 1.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.018 0.09 -9999.0 0.0 -0.28 51.0 51.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.017 -9999.0 0.0 -0.125 2.0 2.0 MLLT4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.035 0.035 -9999.0 0.0 -0.169 13.0 13.0 PI3K -0.028 0.021 -9999.0 0.0 -0.157 2.0 2.0 ARF6 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.027 0.235 1.0 -0.312 2.0 3.0 TIAM1 0.013 0.056 -9999.0 0.0 -0.318 14.0 14.0 E-cadherin(dimer)/Ca2+ 0.046 0.025 0.214 1.0 -0.164 2.0 3.0 AKT1 -0.017 0.023 0.143 1.0 -9999.0 0.0 1.0 PIK3R1 0.019 0.031 -9999.0 0.0 -0.318 4.0 4.0 CDH1 0.019 0.026 0.323 1.0 -0.318 2.0 3.0 RhoA/GDP -0.008 0.068 -9999.0 0.0 -0.244 8.0 8.0 actin cytoskeleton organization -0.007 0.047 0.179 1.0 -0.149 30.0 31.0 CDC42/GDP -0.006 0.069 0.267 1.0 -0.248 10.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.01 0.02 -9999.0 0.0 -0.271 2.0 2.0 ITGB7 0.023 0.014 0.323 1.0 -9999.0 0.0 1.0 RAC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.027 0.229 1.0 -0.175 2.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.02 0.2 1.0 -0.159 2.0 3.0 mol:GDP -0.02 0.074 0.276 1.0 -0.276 12.0 13.0 CDC42/GTP/IQGAP1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.016 -9999.0 0.0 -0.318 1.0 1.0 p120 catenin/RhoA/GDP 0.0 0.071 -9999.0 0.0 -0.255 6.0 6.0 RAC1/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.001 0.034 0.134 3.0 -9999.0 0.0 3.0 NME1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.016 0.088 -9999.0 0.0 -0.279 49.0 49.0 regulation of cell-cell adhesion -0.023 0.018 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.009 0.025 -9999.0 0.0 -0.086 6.0 6.0 Rap1/GTP -0.019 0.038 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.034 0.228 2.0 -0.238 2.0 4.0 CCND1 -0.001 0.04 0.153 3.0 -0.137 1.0 4.0 VAV2 -0.036 0.168 -9999.0 0.0 -0.573 35.0 35.0 RAP1/GDP 0.01 0.058 -9999.0 0.0 -0.264 3.0 3.0 adherens junction assembly -0.016 0.086 -9999.0 0.0 -0.271 49.0 49.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.029 0.211 2.0 -0.232 2.0 4.0 E-cadherin/beta catenin 0.007 0.02 0.147 1.0 -0.277 2.0 3.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.095 -9999.0 0.0 -0.281 58.0 58.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.318 1.0 1.0 Rac1/GTP -0.022 0.088 -9999.0 0.0 -0.312 32.0 32.0 E-cadherin/beta catenin/alpha catenin 0.039 0.024 0.226 1.0 -0.19 2.0 3.0 ITGAE 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.015 0.105 -9999.0 0.0 -0.29 63.0 63.0