Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.024 -9999.0 0.0 -0.172 8.0 8.0 epithelial cell differentiation 0.041 0.023 0.197 1.0 -0.162 2.0 3.0 CYFIP2 0.021 0.022 -9999.0 0.0 -0.318 2.0 2.0 ENAH -0.014 0.055 0.258 9.0 -9999.0 0.0 9.0 EGFR 0.013 0.054 -9999.0 0.0 -0.318 13.0 13.0 EPHA2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.018 0.023 0.167 5.0 -0.16 2.0 7.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.016 -9999.0 0.0 -0.19 1.0 1.0 AQP5 0.097 0.091 0.256 8.0 -0.281 7.0 15.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.019 0.017 0.165 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.031 0.165 5.0 -0.29 1.0 6.0 EGF 0.032 0.058 0.323 18.0 -0.318 1.0 19.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.014 0.061 -9999.0 0.0 -0.299 18.0 18.0 cortical microtubule organization 0.041 0.023 0.197 1.0 -0.162 2.0 3.0 GO:0000145 -0.018 0.016 0.153 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.025 0.214 1.0 -0.164 2.0 3.0 MLLT4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.027 0.02 -9999.0 0.0 -0.158 4.0 4.0 ARF6 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.042 0.031 0.229 1.0 -0.175 2.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.018 0.023 0.167 5.0 -0.16 2.0 7.0 ARF6/GTP 0.046 0.033 0.217 1.0 -0.167 2.0 3.0 CDH1 0.019 0.026 0.323 1.0 -0.318 2.0 3.0 EGFR/EGFR/EGF/EGF 0.033 0.043 -9999.0 0.0 -0.172 11.0 11.0 RhoA/GDP 0.041 0.025 -9999.0 0.0 -0.158 2.0 2.0 actin cytoskeleton organization -0.02 0.02 0.153 4.0 -0.163 2.0 6.0 IGF-1R heterotetramer 0.01 0.063 -9999.0 0.0 -0.317 18.0 18.0 GIT1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.063 -9999.0 0.0 -0.318 18.0 18.0 IGF1 -0.045 0.136 -9999.0 0.0 -0.318 101.0 101.0 DIAPH1 0.027 0.1 -9999.0 0.0 -0.504 12.0 12.0 Wnt receptor signaling pathway -0.041 0.023 0.162 2.0 -0.197 1.0 3.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.026 0.02 -9999.0 0.0 -0.158 4.0 4.0 CTNNA1 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.02 0.154 4.0 -0.166 2.0 6.0 EFNA1 0.019 0.016 0.323 1.0 -9999.0 0.0 1.0 LPP -0.021 0.019 0.157 3.0 -9999.0 0.0 3.0 Ephrin A1/EPHA2 0.029 0.027 -9999.0 0.0 -0.159 2.0 2.0 SEC6/SEC8 -0.028 0.014 -9999.0 0.0 -0.159 1.0 1.0 MGAT3 -0.021 0.031 0.167 5.0 -0.294 1.0 6.0 HGF/MET 0.003 0.08 -9999.0 0.0 -0.163 85.0 85.0 HGF -0.037 0.129 -9999.0 0.0 -0.318 88.0 88.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.025 -9999.0 0.0 -0.173 8.0 8.0 actin cable formation 0.036 0.104 0.291 31.0 -0.252 2.0 33.0 KIAA1543 -0.018 0.022 0.155 5.0 -0.153 3.0 8.0 KIFC3 -0.018 0.022 0.167 5.0 -9999.0 0.0 5.0 NCK1 0.021 0.022 -9999.0 0.0 -0.318 2.0 2.0 EXOC3 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.021 0.167 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.03 0.019 -9999.0 0.0 -0.223 2.0 2.0 mol:GDP 0.041 0.023 0.197 1.0 -0.162 2.0 3.0 EXOC4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.018 0.024 0.167 6.0 -9999.0 0.0 6.0 PIP5K1C -0.019 0.017 0.167 2.0 -9999.0 0.0 2.0 LIMA1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.01 0.087 0.312 15.0 -9999.0 0.0 15.0 adherens junction assembly -0.051 0.138 -9999.0 0.0 -0.551 29.0 29.0 IGF-1R heterotetramer/IGF1 -0.007 0.088 -9999.0 0.0 -0.17 106.0 106.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.022 0.041 0.323 4.0 -0.318 4.0 8.0 PLEKHA7 -0.019 0.023 0.167 5.0 -9999.0 0.0 5.0 mol:GTP 0.041 0.03 0.223 1.0 -0.174 2.0 3.0 establishment of epithelial cell apical/basal polarity -0.011 0.07 0.346 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.011 0.024 -9999.0 0.0 -0.172 8.0 8.0 regulation of cell-cell adhesion -0.02 0.02 0.153 4.0 -0.163 2.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.025 -9999.0 0.0 -0.173 8.0 8.0