Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.036 0.082 -9999.0 0.0 -0.507 1.0 1.0 IHH -0.054 0.071 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.326 0.193 -9999.0 0.0 -0.417 43.0 43.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.324 0.192 0.414 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 0.044 0.056 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.038 0.059 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.037 0.059 -9999.0 0.0 -0.337 1.0 1.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.05 0.205 -9999.0 0.0 -0.69 5.0 5.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.038 0.058 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.006 0.093 -9999.0 0.0 -0.373 1.0 1.0 DHH N/PTCH2 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.034 0.043 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.002 0.095 -9999.0 0.0 -0.69 1.0 1.0 DHH 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.032 0.145 -9999.0 0.0 -1.005 1.0 1.0 determination of left/right symmetry 0.038 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.002 0.095 -9999.0 0.0 -0.69 1.0 1.0 skeletal system development 0.032 0.143 -9999.0 0.0 -0.99 1.0 1.0 IHH N/Hhip -0.048 0.07 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.01 0.049 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.038 0.058 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.036 0.076 -9999.0 0.0 -9999.0 0.0 0.0 HHAT -0.024 0.162 -9999.0 0.0 -0.69 3.0 3.0 PI3K 0.005 0.129 -9999.0 0.0 -0.936 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.533 0.293 -9999.0 0.0 -0.69 42.0 42.0 somite specification 0.038 0.058 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.017 0.098 -9999.0 0.0 -0.356 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.004 0.097 -9999.0 0.0 -0.398 3.0 3.0 SHH Np/Cholesterol/Megalin -0.083 0.187 -9999.0 0.0 -0.399 14.0 14.0 SHH -0.004 0.123 -9999.0 0.0 -0.513 3.0 3.0 catabolic process 0.028 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.035 0.104 -9999.0 0.0 -0.41 1.0 1.0 SHH Np/Cholesterol/Hhip -0.02 0.098 -9999.0 0.0 -0.398 3.0 3.0 LRP2 -0.128 0.284 -9999.0 0.0 -0.69 11.0 11.0 receptor-mediated endocytosis -0.028 0.154 -9999.0 0.0 -0.466 2.0 2.0 SHH Np/Cholesterol/BOC -0.035 0.151 -9999.0 0.0 -0.398 8.0 8.0 SHH Np/Cholesterol/CDO 0.004 0.097 -9999.0 0.0 -0.398 3.0 3.0 mesenchymal cell differentiation 0.02 0.097 0.395 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 0.03 0.101 -9999.0 0.0 -0.354 3.0 3.0 IHH N/PTCH2 -0.01 0.035 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.051 0.052 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.086 0.216 -9999.0 0.0 -0.513 11.0 11.0 PTCH2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.097 -9999.0 0.0 -0.407 3.0 3.0 PTCH1 0.028 0.049 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.036 0.076 -9999.0 0.0 -9999.0 0.0 0.0