Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.007 0.098 -9999.0 0.0 -0.304 5.0 5.0 epithelial cell differentiation 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.007 0.053 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.045 0.193 -9999.0 0.0 -0.584 6.0 6.0 EPHA2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.018 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.047 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.031 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.014 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.013 0.05 -9999.0 0.0 -0.303 1.0 1.0 EGF -0.136 0.268 -9999.0 0.0 -0.584 14.0 14.0 NCKAP1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.01 0.079 -9999.0 0.0 -0.365 2.0 2.0 cortical microtubule organization 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.003 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.051 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.001 0.038 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.039 0.061 -9999.0 0.0 -0.338 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.013 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.014 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.043 0.06 -9999.0 0.0 -0.316 1.0 1.0 CDH1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.08 0.19 -9999.0 0.0 -0.35 16.0 16.0 RhoA/GDP 0.047 0.02 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.008 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.205 0.295 -9999.0 0.0 -0.584 20.0 20.0 DIAPH1 0.037 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.001 0.038 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.008 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.007 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.032 0.024 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.011 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.013 0.051 -9999.0 0.0 -0.308 1.0 1.0 HGF/MET 0.043 0.019 -9999.0 0.0 -9999.0 0.0 0.0 HGF 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.007 0.099 -9999.0 0.0 -0.306 5.0 5.0 actin cable formation 0.08 0.107 0.339 3.0 -9999.0 0.0 3.0 KIAA1543 0.001 0.024 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.083 -9999.0 0.0 -0.584 1.0 1.0 EXOC3 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.014 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.025 0.064 -9999.0 0.0 -0.431 1.0 1.0 mol:GDP 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.017 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.033 0.178 -9999.0 0.0 -0.584 5.0 5.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.052 0.089 0.311 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.023 0.132 -9999.0 0.0 -0.527 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.087 0.165 -9999.0 0.0 -0.298 20.0 20.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.017 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.037 0.06 -9999.0 0.0 -0.336 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.035 0.065 0.326 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.007 0.098 -9999.0 0.0 -0.304 5.0 5.0 regulation of cell-cell adhesion 0.008 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.007 0.099 -9999.0 0.0 -0.306 5.0 5.0