Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.092 0.22 -9999.0 0.0 -0.59 7.0 7.0 IHH -0.13 0.226 -9999.0 0.0 -0.497 15.0 15.0 SHH Np/Cholesterol/GAS1 -0.054 0.123 -9999.0 0.0 -0.257 15.0 15.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.054 0.122 0.256 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 -0.053 0.153 -9999.0 0.0 -0.468 3.0 3.0 SMO -0.062 0.16 -9999.0 0.0 -0.456 4.0 4.0 AKT1 -0.015 0.08 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.023 0.129 -9999.0 0.0 -0.489 4.0 4.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.061 0.158 -9999.0 0.0 -0.449 4.0 4.0 STIL -0.073 0.167 -9999.0 0.0 -0.376 9.0 9.0 DHH N/PTCH2 -0.015 0.103 -9999.0 0.0 -0.344 5.0 5.0 DHH N/PTCH1 -0.081 0.156 -9999.0 0.0 -0.428 5.0 5.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.025 0.129 -9999.0 0.0 -0.49 4.0 4.0 PTHLH -0.126 0.295 -9999.0 0.0 -0.799 7.0 7.0 determination of left/right symmetry -0.061 0.158 -9999.0 0.0 -0.449 4.0 4.0 PIK3R1 -0.006 0.093 -9999.0 0.0 -0.49 2.0 2.0 skeletal system development -0.124 0.292 -9999.0 0.0 -0.789 7.0 7.0 IHH N/Hhip -0.171 0.234 -9999.0 0.0 -0.421 24.0 24.0 DHH N/Hhip -0.111 0.183 -9999.0 0.0 -0.361 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.061 0.158 -9999.0 0.0 -0.449 4.0 4.0 pancreas development -0.131 0.226 -9999.0 0.0 -0.489 16.0 16.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.005 0.067 -9999.0 0.0 -0.345 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.05 0.166 -9999.0 0.0 -0.489 7.0 7.0 somite specification -0.061 0.158 -9999.0 0.0 -0.449 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.082 0.176 -9999.0 0.0 -0.39 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.024 0.102 -9999.0 0.0 -0.257 9.0 9.0 SHH Np/Cholesterol/Megalin -0.103 0.154 -9999.0 0.0 -0.28 23.0 23.0 SHH -0.034 0.127 -9999.0 0.0 -0.346 8.0 8.0 catabolic process -0.075 0.165 -9999.0 0.0 -0.487 4.0 4.0 SMO/Vitamin D3 -0.075 0.173 -9999.0 0.0 -0.494 3.0 3.0 SHH Np/Cholesterol/Hhip -0.097 0.176 -9999.0 0.0 -0.326 19.0 19.0 LRP2 -0.14 0.231 -9999.0 0.0 -0.49 17.0 17.0 receptor-mediated endocytosis -0.118 0.172 -9999.0 0.0 -0.442 6.0 6.0 SHH Np/Cholesterol/BOC -0.039 0.114 -9999.0 0.0 -0.258 12.0 12.0 SHH Np/Cholesterol/CDO -0.019 0.097 -9999.0 0.0 -0.257 8.0 8.0 mesenchymal cell differentiation 0.097 0.175 0.324 19.0 -9999.0 0.0 19.0 mol:Vitamin D3 -0.081 0.178 -9999.0 0.0 -0.392 10.0 10.0 IHH N/PTCH2 -0.071 0.151 -9999.0 0.0 -0.306 15.0 15.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.075 0.167 -9999.0 0.0 -0.491 4.0 4.0 Megalin/LRPAP1 -0.092 0.167 -9999.0 0.0 -0.345 17.0 17.0 PTCH2 0.003 0.067 -9999.0 0.0 -0.49 1.0 1.0 SHH Np/Cholesterol -0.027 0.097 -9999.0 0.0 -0.264 8.0 8.0 PTCH1 -0.076 0.165 -9999.0 0.0 -0.488 4.0 4.0 HHIP -0.131 0.227 -9999.0 0.0 -0.49 16.0 16.0