Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.012 0.09 -9999.0 0.0 -0.219 9.0 9.0 epithelial cell differentiation -0.015 0.095 -9999.0 0.0 -0.233 9.0 9.0 CYFIP2 0.003 0.066 -9999.0 0.0 -0.489 1.0 1.0 ENAH 0.021 0.075 -9999.0 0.0 -0.282 1.0 1.0 EGFR -0.015 0.113 -9999.0 0.0 -0.49 3.0 3.0 EPHA2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.017 0.099 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.02 0.041 -9999.0 0.0 -0.283 1.0 1.0 AQP5 -0.096 0.175 -9999.0 0.0 -0.486 8.0 8.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.008 0.09 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.094 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.023 0.129 -9999.0 0.0 -0.49 4.0 4.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.042 0.102 -9999.0 0.0 -0.615 1.0 1.0 cortical microtubule organization -0.015 0.095 -9999.0 0.0 -0.233 9.0 9.0 GO:0000145 -0.008 0.086 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.013 0.097 -9999.0 0.0 -0.235 9.0 9.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.027 0.063 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.002 0.087 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.008 0.091 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.068 0.184 -9999.0 0.0 -0.489 9.0 9.0 EGFR/EGFR/EGF/EGF -0.06 0.111 -9999.0 0.0 -0.438 2.0 2.0 RhoA/GDP -0.039 0.094 -9999.0 0.0 -0.455 1.0 1.0 actin cytoskeleton organization -0.011 0.096 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.023 0.129 -9999.0 0.0 -0.488 4.0 4.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.023 0.129 -9999.0 0.0 -0.489 4.0 4.0 IGF1 -0.086 0.199 -9999.0 0.0 -0.49 11.0 11.0 DIAPH1 -0.01 0.084 -9999.0 0.0 -0.634 1.0 1.0 Wnt receptor signaling pathway 0.015 0.095 0.233 9.0 -9999.0 0.0 9.0 RHOA 0.003 0.066 -9999.0 0.0 -0.489 1.0 1.0 RhoA/GTP -0.032 0.077 -9999.0 0.0 -0.385 1.0 1.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.098 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.002 0.087 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.033 0.075 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.029 0.067 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.013 0.095 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.112 0.134 -9999.0 0.0 -0.439 4.0 4.0 HGF -0.149 0.235 -9999.0 0.0 -0.49 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.012 0.091 -9999.0 0.0 -0.22 9.0 9.0 actin cable formation 0.036 0.076 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.06 0.187 -9999.0 0.0 -0.458 9.0 9.0 KIFC3 -0.008 0.091 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.008 0.091 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.015 0.095 -9999.0 0.0 -0.233 9.0 9.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.008 0.091 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.008 0.091 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.085 -9999.0 0.0 -0.335 1.0 1.0 adherens junction assembly -0.052 0.197 -9999.0 0.0 -0.47 9.0 9.0 IGF-1R heterotetramer/IGF1 -0.091 0.146 -9999.0 0.0 -0.494 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.014 0.113 -9999.0 0.0 -0.489 3.0 3.0 PLEKHA7 -0.034 0.15 -9999.0 0.0 -0.457 5.0 5.0 mol:GTP 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.015 0.082 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.012 0.09 -9999.0 0.0 -0.219 9.0 9.0 regulation of cell-cell adhesion -0.011 0.096 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.012 0.091 -9999.0 0.0 -0.22 9.0 9.0