rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(2), GHR(1), HRAS(3), IGF1R(1), PIK3CA(10), PIK3R1(1), SHC1(2), SOD2(1), SOD3(1)	5205667	23	22	23	3	7	4	5	5	2	0	0.0683	0.000174	0.107
2	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(10), PIK3R1(1), PLCB1(2), PLCG1(1), PRKCA(2), VAV1(3)	4997832	20	17	20	2	7	4	2	7	0	0	0.0607	0.00251	0.553
3	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), GHR(1), PDPK1(1), PIK3CA(10), PIK3R1(1), RELA(2), YWHAH(1)	5510447	17	16	17	2	3	6	3	5	0	0	0.0823	0.00269	0.553
4	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), GRB2(1), HRAS(3), IGF1R(1), IRS1(2), MAPK1(1), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), YWHAH(1)	7394322	25	22	25	4	9	5	5	5	1	0	0.0805	0.00836	1.000
5	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), GRB2(1), HRAS(3), KLK2(1), NTRK1(3), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), SHC1(2), SOS1(1)	6068612	26	21	26	4	10	7	3	5	1	0	0.0619	0.00881	1.000
6	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(1), CDKN1A(2), GRB2(1), HRAS(3), NTRK1(3), PIK3CA(10), SHC1(2), SOS1(1)	6320149	24	21	24	4	9	7	3	4	1	0	0.0507	0.0119	1.000
7	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), GRB2(1), HRAS(3), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(3), PIK3CA(10), PIK3R1(1), PLCG1(1), RPS6KA1(1), SHC1(2)	7409795	28	23	28	4	13	7	4	4	0	0	0.0234	0.0169	1.000
8	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), HRAS(3), PIK3CA(10), PIK3R1(1), RAC1(1), RAF1(1), RALBP1(1), RELA(2)	7441334	20	19	20	3	5	4	6	4	1	0	0.0910	0.0205	1.000
9	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(1), BCAR1(1), GRB2(1), MAPK1(1), PDPK1(1), PIK3CA(10), PIK3R1(1), PTK2(2), SHC1(2), SOS1(1)	7067443	21	18	21	3	8	6	2	4	1	0	0.0794	0.0407	1.000
10	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(2), CDKN1A(2), NEK1(2)	2705631	7	7	7	0	6	0	0	0	1	0	0.162	0.0479	1.000
11	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1)	6967054	15	15	15	2	3	4	0	5	3	0	0.168	0.0558	1.000
12	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1)	4001165	9	9	9	1	4	1	1	2	1	0	0.162	0.0608	1.000
13	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10RA(2), IL6(1), JAK1(3), STAT1(1), STAT3(5), TNF(1)	4756949	14	11	14	2	2	3	2	4	3	0	0.145	0.0775	1.000
14	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(2), GRB2(1), PRKCA(2), PTPRA(3)	3592415	9	8	9	1	5	2	0	2	0	0	0.147	0.0778	1.000
15	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1)	7388897	15	15	15	2	3	4	0	5	3	0	0.169	0.0790	1.000
16	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(2)	2076628	5	5	5	1	1	2	0	2	0	0	0.434	0.0809	1.000
17	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2A(1), ADORA3(1), P2RY1(1), P2RY6(1)	2328056	6	6	6	0	4	0	0	2	0	0	0.123	0.0851	1.000
18	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), EHHADH(2), HADHB(1)	3258971	7	7	7	0	1	1	1	3	1	0	0.164	0.0856	1.000
19	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), LEPR(1), PRKAA2(3), PRKAG1(2)	5634582	10	10	10	0	3	0	3	4	0	0	0.0574	0.0859	1.000
20	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(2), SP1(1), SP3(2)	2582385	8	7	8	2	1	2	1	1	2	1	0.462	0.0948	1.000
21	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(3)	1517642	4	4	3	0	2	0	0	2	0	0	0.303	0.108	1.000
22	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGDH(1), UGP2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1)	10605012	18	16	18	1	3	1	2	8	4	0	0.0618	0.108	1.000
23	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	GRB2(1), HRAS(3), KLK2(1), PIK3CA(10), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(2), SOS1(1)	7423408	21	19	21	4	9	3	4	4	1	0	0.182	0.110	1.000
24	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), SDHA(1), SDHC(1), UQCRC1(1)	2577129	5	5	5	0	0	1	1	1	2	0	0.244	0.115	1.000
25	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1)	4575404	9	9	9	1	4	1	1	2	1	0	0.152	0.131	1.000
26	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(1), LPO(1), MTHFR(2), SHMT1(1), SHMT2(1), TPO(1)	4541092	9	9	9	1	3	4	1	0	1	0	0.124	0.133	1.000
27	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IL12A(1)	1158749	3	3	3	1	1	0	0	1	1	0	0.685	0.136	1.000
28	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), GHR(1), IRS1(2), MAPK1(1), PDPK1(1), PIK3CA(10), PIK3R1(1), PRKCA(2)	10668129	24	21	24	3	5	4	2	10	3	0	0.0994	0.142	1.000
29	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(1), CDKN1A(2), CPB2(1), HIC1(3), MDM2(1), NQO1(1)	5367301	13	10	13	1	7	2	1	0	3	0	0.0719	0.143	1.000
30	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	282382	1	1	1	1	1	0	0	0	0	0	0.919	0.154	1.000
31	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	GRB2(1), HRAS(3), IGF1R(1), IRS1(2), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1)	9640973	22	19	22	4	8	3	5	5	1	0	0.150	0.157	1.000
32	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSB(1), ARSE(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), HSD17B3(1), STS(1), SULT1E1(2), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1)	10644504	18	16	18	1	5	3	1	4	5	0	0.0205	0.159	1.000
33	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(1), MEF2A(1), MEF2C(2), MEF2D(1), YWHAH(1)	3019972	9	8	9	2	5	1	1	2	0	0	0.329	0.160	1.000
34	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(4), CDKN2A(1), MDM2(1), PIK3CA(10), PIK3R1(1), POLR1B(1), POLR1C(1), RAC1(1), RB1(2)	7610078	22	16	22	3	4	2	5	6	4	1	0.135	0.163	1.000
35	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1), LARS(1), LARS2(2), PDHA2(2)	3897402	7	7	7	0	2	1	1	2	1	0	0.115	0.165	1.000
36	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	866929	2	2	2	0	0	0	0	0	2	0	0.475	0.183	1.000
37	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(1), CHSY1(1), DSE(1), UST(1), XYLT1(4), XYLT2(1)	5521977	13	13	13	1	7	1	0	3	2	0	0.0538	0.191	1.000
38	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(2), JUND(1)	1473756	3	3	3	1	1	0	1	1	0	0	0.640	0.191	1.000
39	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), PDGFRA(2), PIK3CA(10), PIK3R1(1), RAC1(1)	5210738	15	14	15	3	5	2	3	5	0	0	0.304	0.194	1.000
40	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1)	3623006	6	6	6	0	1	2	0	1	2	0	0.0843	0.197	1.000
41	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1)	3623006	6	6	6	0	1	2	0	1	2	0	0.0843	0.197	1.000
42	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS2(1), SULT1E1(2)	2370538	5	5	5	0	3	1	0	0	1	0	0.248	0.200	1.000
43	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO2(1), FH(1), IDH1(4)	3463235	6	6	4	0	3	0	1	2	0	0	0.147	0.200	1.000
44	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPARA(2), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1)	7912912	19	16	19	3	9	1	1	6	2	0	0.153	0.201	1.000
45	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	HRAS(3), MAPK1(1), PLCB1(2), PRKCA(2), RAF1(1), RELA(2), TNF(1)	6062873	12	11	12	1	6	2	3	1	0	0	0.0532	0.205	1.000
46	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	197830	1	1	1	0	0	0	0	0	1	0	0.607	0.206	1.000
47	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), PNMT(1), TPH1(1)	2382824	5	5	5	0	2	1	1	1	0	0	0.161	0.211	1.000
48	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(1), CDKN1A(2), HRAS(3), MAPK1(1), PIK3CA(10), PIK3R1(1), RAC1(1), RAF1(1), RB1(2), RELA(2), TFDP1(1)	7741810	25	22	25	5	8	4	8	4	0	1	0.125	0.225	1.000
49	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(2)	1889897	3	3	3	0	0	1	0	2	0	0	0.436	0.233	1.000
50	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), GRB2(1), HRAS(3), MAP2K4(1), MAP2K7(2), MAPK1(1), NFATC1(1), NFATC2(1), PAK2(1), PIK3CA(10), PIK3R1(1), PLA2G4A(2), PLCG1(1), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3)	16759350	39	34	39	6	15	4	5	14	1	0	0.0358	0.235	1.000
51	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(3), ITGAM(2), ITGB2(2), SELE(1)	4063705	8	7	8	1	4	1	1	2	0	0	0.169	0.236	1.000
52	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	GRB2(1), HRAS(3), IRS1(2), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1)	9923806	21	19	21	4	8	3	4	5	1	0	0.181	0.249	1.000
53	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), MARS2(1), MAT1A(1), PAPSS2(1), SEPHS1(1)	4834451	7	7	7	1	1	2	1	0	3	0	0.349	0.250	1.000
54	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	PLCB1(2), PRKCA(2), RELA(2)	3218922	6	6	6	0	2	2	1	1	0	0	0.108	0.251	1.000
55	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), HRAS(3), KLK2(1), MAPK1(1), RAF1(1)	3223084	7	7	7	2	4	0	2	0	1	0	0.541	0.254	1.000
56	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2)	824590	2	2	2	0	0	0	0	1	1	0	0.809	0.262	1.000
57	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(3), MMP14(1), MMP9(1)	2932749	5	5	5	0	2	0	2	1	0	0	0.196	0.264	1.000
58	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(2), DPYS(1), ENPP1(2), ENPP3(1), PANK1(2), PANK2(2), PANK3(1)	5450841	12	12	11	3	2	3	2	2	3	0	0.475	0.267	1.000
59	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	593383	1	1	1	0	0	1	0	0	0	0	0.718	0.269	1.000
60	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), HRAS(3), SHC1(2), SOS1(1)	3436806	7	7	7	2	5	1	1	0	0	0	0.450	0.272	1.000
61	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), XYLT1(4), XYLT2(1)	2601843	7	7	7	1	3	1	0	1	2	0	0.265	0.275	1.000
62	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), XYLT1(4), XYLT2(1)	2601843	7	7	7	1	3	1	0	1	2	0	0.265	0.275	1.000
63	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1)	3966667	6	6	6	1	1	0	1	3	1	0	0.484	0.278	1.000
64	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), ITPKB(2)	2378201	4	4	4	0	1	1	0	2	0	0	0.265	0.286	1.000
65	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(1), CDC25B(2), MYT1(1), YWHAH(1)	2923489	5	5	5	0	3	1	0	1	0	0	0.180	0.289	1.000
66	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), PAPSS2(1), SULT1A1(2), SULT1E1(2)	3603600	8	7	8	0	5	1	0	0	2	0	0.0493	0.290	1.000
67	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HADHB(1), HSD17B4(1), PPT2(1)	3304064	5	5	5	0	2	1	0	1	1	0	0.169	0.297	1.000
68	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(3), MAFF(1), MAPK1(1), PRKCA(2)	3479471	7	7	7	0	3	1	1	2	0	0	0.0838	0.305	1.000
69	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ7(1)	1569387	2	2	2	1	0	1	1	0	0	0	0.761	0.315	1.000
70	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRA(1), IL4(1)	1546474	2	2	2	0	2	0	0	0	0	0	0.487	0.319	1.000
71	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(1), B3GALT5(2), FUT1(1), FUT2(1), FUT3(1)	2809126	6	6	6	2	1	2	0	3	0	0	0.640	0.320	1.000
72	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), MUSK(2), PIK3CA(10), PIK3R1(1), PTK2(2), YWHAH(1)	6416599	17	14	17	3	5	6	2	4	0	0	0.117	0.321	1.000
73	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), GRB2(1), HRAS(3), MAPK1(1), MAPK8IP3(2), PAPPA(3), RAC1(1), RPS6KA1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3), VAV2(1), VAV3(1)	12515702	24	22	24	4	11	2	4	6	1	0	0.0776	0.347	1.000
74	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PRKCA(2)	1941501	4	4	4	0	1	1	0	1	1	0	0.297	0.350	1.000
75	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLD1(2), PPAP2A(1), PPAP2B(1)	9066246	18	15	18	2	6	1	0	6	5	0	0.109	0.350	1.000
76	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	HLA-DRA(1), IL4(1), IL6(1)	2077769	3	3	3	0	2	1	0	0	0	0	0.259	0.355	1.000
77	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ACAT1(1)	2108004	3	3	2	0	2	0	0	1	0	0	0.362	0.355	1.000
78	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12A(1), IL16(2), IL4(1), IL6(1), IL9(1), TNF(1)	3862971	7	6	7	1	2	1	1	2	1	0	0.253	0.367	1.000
79	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACPT(1), ALPI(1), ALPP(1), ALPPL2(1), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2)	7051429	14	11	14	2	5	1	2	3	3	0	0.0798	0.369	1.000
80	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), AKT1(1), DAG1(1), DGKA(1), ETFA(1), ITGA9(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NR1I3(1), PDE3B(1), PIK3CA(10), PIK3R1(1), PSME1(1)	19043170	30	27	30	3	7	8	3	7	5	0	0.0169	0.372	1.000
81	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	RELA(2), TNFRSF13B(2), TRAF2(3), TRAF5(1)	5681674	8	7	8	1	2	2	1	2	1	0	0.206	0.372	1.000
82	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), ILVBL(2), LARS(1), LARS2(2), PDHA2(2), VARS(2), VARS2(2)	7269956	13	11	13	2	3	1	1	5	3	0	0.312	0.377	1.000
83	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(1), GRB2(1), HRAS(3), MAP2K4(1), PIK3CA(10), PIK3R1(1), RAF1(1), SOS1(1), STAT1(1), STAT5B(1)	10976025	22	20	22	4	6	5	5	6	0	0	0.126	0.382	1.000
84	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), PIK3CA(10), PIK3R1(1), RAC1(1), SYK(2), VAV1(3)	7247813	18	17	18	4	6	2	3	7	0	0	0.329	0.389	1.000
85	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(1)	923917	1	1	1	0	1	0	0	0	0	0	0.692	0.391	1.000
86	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), DNMT1(2), MTNR1A(1), MTNR1B(1), PTGIR(1), TBXA2R(2)	4400245	9	8	9	2	6	2	0	0	1	0	0.152	0.393	1.000
87	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(1), LPO(1), SHMT1(1), SHMT2(1), TPO(1)	4620099	7	7	7	1	2	3	1	0	1	0	0.241	0.398	1.000
88	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(1), AKT1(1), AKT2(1), BTK(1), CDKN2A(1), GRB2(1), GSK3A(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(1), PIK3CA(10), PPP1R13B(1), RPS6KA1(1), SHC1(2), SOS1(1), YWHAH(1), YWHAQ(1)	13791797	30	27	30	5	9	6	3	7	5	0	0.0687	0.402	1.000
89	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), CTH(1), MUT(1)	1915637	3	3	3	0	1	0	0	0	2	0	0.682	0.409	1.000
90	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), GNGT1(1), HTR2C(2), PLCB1(2), TUB(1)	2789375	7	6	7	2	3	1	1	2	0	0	0.488	0.411	1.000
91	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(2)	3102703	4	4	4	1	2	0	1	0	1	0	0.677	0.412	1.000
92	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(4), CREBBP(4), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(1), TGFBR1(2)	10014559	20	17	20	3	6	0	3	6	5	0	0.212	0.414	1.000
93	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), PDPK1(1), PIK3CA(10), PIK3R1(1), TSC2(2)	10488594	20	18	20	3	4	4	2	8	2	0	0.146	0.415	1.000
94	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CRK(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(1), RAF1(1), RELA(2)	10790164	29	23	29	5	10	4	6	8	1	0	0.0940	0.421	1.000
95	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFB7(1), NDUFV1(1)	2719329	4	4	4	1	1	0	3	0	0	0	0.532	0.422	1.000
96	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(2)	1267396	2	2	2	1	1	0	0	1	0	0	0.837	0.429	1.000
97	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH4(1), ADH6(1)	2189340	3	3	3	0	1	0	1	1	0	0	0.348	0.437	1.000
98	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(3), F2(1), GNA13(1), GNAI1(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(10), PIK3R1(1), PLCB1(2), PRKCA(2), ROCK1(5)	10085979	31	26	30	6	8	4	6	10	3	0	0.186	0.440	1.000
99	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(2), MARCKS(1), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), SP1(1), SP3(2), SYT1(1)	8174078	14	12	14	1	5	1	1	5	2	0	0.0775	0.446	1.000
100	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(1), CDC25B(2), SHH(2)	3376913	5	5	5	1	4	0	1	0	0	0	0.381	0.448	1.000
101	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(1)	9067469	17	16	16	3	4	1	4	6	2	0	0.187	0.451	1.000
102	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(2), HADH(1), HSD17B4(1), SIRT1(1), SIRT2(1)	4619080	7	7	7	2	1	3	0	2	1	0	0.529	0.452	1.000
103	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), GOT1(1), PAH(1)	3228664	4	4	4	0	2	0	0	1	1	0	0.298	0.455	1.000
104	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), PPARG(1), TNF(1)	2257008	3	3	3	1	1	0	1	0	1	0	0.668	0.461	1.000
105	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGAL(3), ITGAM(2), ITGB2(2), SELE(1), SELP(2)	6220463	10	9	10	2	5	1	2	2	0	0	0.227	0.463	1.000
106	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), DPEP1(2), PLA2G2A(1), PLA2G6(1), PTGS1(1), PTGS2(2)	5906728	8	8	8	0	2	2	0	4	0	0	0.0701	0.464	1.000
107	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(4), ESR1(1), MAPK1(1), PELP1(1)	5781106	11	10	11	2	6	0	1	2	2	0	0.268	0.475	1.000
108	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10A(1), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL8(1), RPS11(2), RPS9(1)	8924203	12	12	12	1	2	2	0	5	3	0	0.284	0.478	1.000
109	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	GRB2(1), HRAS(3), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5), STAT5B(1)	11677760	29	23	29	5	10	5	5	8	1	0	0.0888	0.494	1.000
110	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(2), CTH(1), GOT1(1), SULT4A1(1)	4897323	6	6	6	0	2	0	0	2	2	0	0.318	0.496	1.000
111	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(3), HEXB(1), HK2(1), HK3(2), PGM3(1)	6618411	8	8	8	1	4	0	0	2	2	0	0.322	0.499	1.000
112	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PGM1(1), PYGL(2), TREH(1)	5244556	7	7	7	1	3	2	1	1	0	0	0.211	0.501	1.000
113	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	CDC25A(1), CDC25B(2), MYT1(1), RB1(2), YWHAH(1)	4081412	7	7	7	2	3	1	1	1	0	1	0.519	0.501	1.000
114	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), IL4(1), IL6(1), IL7(1), IL9(1)	2377944	5	5	5	2	1	1	1	1	1	0	0.686	0.503	1.000
115	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO2(1), HAO1(2), MTHFD1(2), MTHFD1L(1)	4981067	6	6	6	0	1	2	1	2	0	0	0.129	0.503	1.000
116	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	CDC25A(1), CDC25B(2), CDKN1A(2), EP300(4), MDM2(1), MYT1(1), PRKDC(7), RPS6KA1(1), YWHAH(1), YWHAQ(1)	13557806	21	17	21	2	10	4	1	4	2	0	0.0442	0.504	1.000
117	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(1), GRB2(1), GSK3A(2), GSK3B(1), IL4R(2), IRS1(2), IRS2(1), JAK1(3), MAP4K1(1), MAPK1(1), PDK1(1), PIK3CA(10), PIK3R1(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), STAT6(2)	14363833	35	29	35	7	10	5	3	10	7	0	0.163	0.512	1.000
118	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(1), APC(2), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LEF1(1), PDPK1(1), PIK3CA(10), PIK3R1(1), RELA(2)	11406655	24	22	24	5	7	6	5	4	2	0	0.112	0.514	1.000
119	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1)	1185332	1	1	1	0	1	0	0	0	0	0	0.686	0.515	1.000
120	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	SP1(1), SP3(2)	2434734	3	3	3	1	0	1	0	1	1	0	0.740	0.516	1.000
121	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(1), KARS(1)	2700380	3	3	3	0	0	0	1	2	0	0	0.459	0.517	1.000
122	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(1), BCR(1), BTK(1), CD81(1), DAG1(1), GRB2(1), GSK3A(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(3), ITPR3(1), MAP4K1(1), MAPK1(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3CA(10), PIK3R1(1), PLCG2(1), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(3), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3)	28955902	50	44	50	6	17	6	7	13	7	0	0.00471	0.518	1.000
123	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), NRG2(1), NRG3(2), PRKCA(2)	3518220	6	5	6	1	2	1	0	1	2	0	0.469	0.524	1.000
124	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), RDH12(1)	3521278	7	5	7	0	3	0	1	2	1	0	0.101	0.525	1.000
125	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD8A(1), ITGAL(3), ITGB2(2), PTPRC(3)	4185544	9	8	9	3	3	1	1	3	1	0	0.444	0.532	1.000
126	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), CYR61(1), JUND(1), WDR1(1)	4209067	4	4	4	0	0	0	3	0	1	0	0.339	0.537	1.000
127	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), EHHADH(2)	3046292	3	3	3	0	0	1	0	2	0	0	0.447	0.537	1.000
128	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1)	3783439	6	6	6	2	1	1	1	1	2	0	0.541	0.537	1.000
129	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), ATG7(1), IFNA10(1), IFNA13(1), IFNA16(1), PIK3R4(1), PRKAA2(3), ULK3(1)	8259581	11	11	11	2	5	0	2	3	1	0	0.275	0.540	1.000
130	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(2), PC(1)	3614609	4	4	4	1	0	1	0	1	2	0	0.537	0.541	1.000
131	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO2(1), HAO1(2), MTHFD1(2), MTHFD1L(1)	5218175	6	6	6	0	1	2	1	2	0	0	0.128	0.552	1.000
132	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(1), SNCAIP(2)	2506017	3	3	3	1	1	0	0	2	0	0	0.734	0.562	1.000
133	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR171(1), GPR18(1), GPR68(1), GPR75(1)	3806376	5	5	5	0	2	1	0	2	0	0	0.160	0.563	1.000
134	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	NFS1(1), THTPA(2)	2499223	3	3	3	1	1	0	1	0	1	0	0.671	0.563	1.000
135	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(1)	4197075	11	11	11	4	6	2	0	1	2	0	0.582	0.565	1.000
136	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CDKN1A(2), CDKN2A(1), CFL1(1), MDM2(1)	2845102	5	4	5	1	2	0	0	0	3	0	0.661	0.569	1.000
137	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), NAT6(1)	6443010	8	8	8	0	2	0	0	2	4	0	0.134	0.573	1.000
138	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), KARS(1)	1830493	2	2	2	0	0	0	1	1	0	0	0.556	0.573	1.000
139	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	1231979	1	1	1	1	1	0	0	0	0	0	0.887	0.581	1.000
140	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYD(2), DPYS(1), ENPP1(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(2), PANK3(1)	6770091	14	14	13	4	2	3	2	3	4	0	0.583	0.583	1.000
141	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), GOT1(1)	2670986	3	3	3	0	1	0	0	1	1	0	0.580	0.589	1.000
142	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPT(1), ALPI(1), ALPP(1), ALPPL2(1), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP2F1(2), CYP3A7(1), PON1(1)	11458328	22	19	22	4	9	2	5	2	4	0	0.104	0.595	1.000
143	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGDH(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1)	6846087	7	7	7	1	2	0	1	2	2	0	0.448	0.596	1.000
144	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), LRP8(1), RELN(3), VLDLR(2)	5458873	8	8	8	2	2	1	2	2	1	0	0.481	0.596	1.000
145	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(1), AKT2(1), BPNT1(2), GRB2(1), MAPK1(1), PDK1(1), PIK3CA(10), RBL2(1), SHC1(2), SOS1(1)	7649406	21	19	21	5	8	4	3	5	1	0	0.275	0.597	1.000
146	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1)	1510568	1	1	1	0	0	0	0	0	1	0	1.000	0.597	1.000
147	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(1), H6PD(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(2), RBKS(2), TKT(1)	7993694	12	12	12	2	3	0	3	4	2	0	0.366	0.599	1.000
148	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), BTK(1), EEA1(2), GSK3A(2), GSK3B(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(1), PLCG1(1), PRKCZ(2), RAC1(1), VAV2(1)	9836530	16	16	16	3	3	3	2	6	2	0	0.196	0.599	1.000
149	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(2), EXTL1(2), EXTL3(2), GLCE(1), HS6ST1(1), NDST1(2), NDST2(2), NDST4(3)	8097450	16	14	16	3	3	4	4	5	0	0	0.151	0.599	1.000
150	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), AKT1(1), ASAH1(1), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(2), MAPK1(1), PDGFRA(2), PIK3CA(10), PIK3R1(1), PLCB1(2), PRKCA(2), PTK2(2), RAC1(1)	10700424	29	22	29	5	9	5	4	9	2	0	0.104	0.600	1.000
151	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY2(2), CSNK1E(1), PER1(1)	3337669	4	4	4	0	1	0	1	2	0	0	0.341	0.602	1.000
152	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1)	1024487	1	1	1	0	0	0	0	1	0	0	0.830	0.613	1.000
153	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	5848963	9	9	9	2	1	1	0	5	2	0	0.660	0.616	1.000
154	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	5848963	9	9	9	2	1	1	0	5	2	0	0.660	0.616	1.000
155	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	5848963	9	9	9	2	1	1	0	5	2	0	0.660	0.616	1.000
156	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(1)	1629376	2	2	2	0	1	1	0	0	0	0	0.392	0.622	1.000
157	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), CREM(1), FHL5(1), FSHR(1), GNAS(2)	3725944	6	5	6	2	1	0	2	3	0	0	0.782	0.624	1.000
158	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(3), STAT1(1)	3190719	4	3	4	1	0	1	0	2	1	0	0.703	0.633	1.000
159	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO2(1), FH(1), IDH1(4), IDH3A(1), PC(1), SDHA(1)	8010748	9	9	7	1	3	0	1	4	1	0	0.274	0.638	1.000
160	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	CRK(1), GRB2(1), HGF(2), HRAS(3), MAP4K1(1), MAPK1(1), MET(1), PIK3CA(10), PIK3R1(1), PTK2(2), PXN(1), RAF1(1), SOS1(1), STAT3(5)	16955484	31	27	31	5	10	6	6	8	1	0	0.0419	0.646	1.000
161	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	GRB2(1), HLA-DRA(1), ITK(1), PIK3CA(10), PIK3R1(1)	4980432	14	12	14	4	6	2	2	4	0	0	0.536	0.646	1.000
162	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), CES1(1), DDHD1(3), ESCO1(4), NAT6(1)	9864118	11	11	11	1	2	0	2	4	3	0	0.193	0.649	1.000
163	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), GRB2(1), HRAS(3), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3)	14888175	23	21	23	3	11	1	4	7	0	0	0.0456	0.650	1.000
164	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), PLA2G4A(2), PLCB1(2), PRKCA(2), PTGS1(1), PTK2(2), RAF1(1), SYK(2)	9511616	20	16	20	4	10	3	3	4	0	0	0.128	0.656	1.000
165	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), MAP2K4(1), MAP2K7(2), MAPK1(1), MAPK8IP3(2), MAPKAPK5(1), NFKBIL1(1), PIK3CA(10), PIK3R1(1), SYT1(1), TRAF2(3), TRAF5(1)	13241627	25	20	25	3	8	3	2	8	4	0	0.0746	0.658	1.000
166	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	HLA-DRA(1), ITGAL(3), ITGB2(2), PTPRC(3)	5913029	9	8	9	2	4	1	1	3	0	0	0.326	0.658	1.000
167	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(1), AKT2(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(1), PITX2(1), PLD1(2), VN1R1(2)	17571316	20	19	20	1	4	5	2	2	7	0	0.0158	0.664	1.000
168	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	GRB2(1), HRAS(3), IL3RA(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1)	6895099	10	10	10	3	5	2	3	0	0	0	0.405	0.665	1.000
169	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	CEBPB(1), EGR1(1), FSHR(1), GJA4(1), INHA(1), LHCGR(1), MLH1(1), NCOR1(6), NRIP1(1), PGR(1)	11081551	15	14	15	2	3	1	2	1	8	0	0.242	0.668	1.000
170	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	KERA(1)	1401885	1	1	1	1	0	0	0	1	0	0	0.950	0.675	1.000
171	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOC(1)	1524260	1	1	1	1	0	0	0	1	0	0	0.947	0.675	1.000
172	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(1), H6PD(2), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(2), RBKS(2), TKT(1)	9512270	13	13	13	2	3	0	3	4	3	0	0.305	0.675	1.000
173	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), EHHADH(2)	4752331	8	8	7	3	2	1	1	4	0	0	0.657	0.676	1.000
174	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2), ST6GALNAC2(1), ST8SIA1(1)	2204203	4	4	4	2	2	1	0	0	1	0	0.749	0.677	1.000
175	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(2), ERBB3(2), NRG1(2)	4009657	6	6	6	2	0	1	0	3	2	0	0.691	0.679	1.000
176	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1)	1314575	1	1	1	0	0	0	0	1	0	0	0.819	0.681	1.000
177	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), CYP1A2(1), CYP2C18(1), CYP2C8(3), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), RDH12(1)	9330268	14	11	14	2	4	0	2	6	2	0	0.227	0.682	1.000
178	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(2), ESCO1(4), NAT6(1)	10111081	11	11	11	0	2	1	0	4	4	0	0.0570	0.684	1.000
179	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(3), TYK2(1)	4093255	7	6	7	2	0	1	1	2	3	0	0.593	0.686	1.000
180	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(3), TYK2(1)	4093255	7	6	7	2	0	1	1	2	3	0	0.593	0.686	1.000
181	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(1), EGFR(2), IGF1R(1), POLR2A(2), PRKCA(2), RB1(2), TEP1(3), TNKS(4)	10694987	17	14	17	2	4	3	3	5	1	1	0.0723	0.687	1.000
182	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(2), PDHA2(2)	2741704	5	5	5	2	2	0	0	1	2	0	0.582	0.698	1.000
183	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	SQLE(1)	1652230	1	1	1	1	1	0	0	0	0	0	0.887	0.698	1.000
184	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCG2(1), BCHE(1), CES1(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1)	8875058	8	8	8	0	2	0	1	2	3	0	0.181	0.699	1.000
185	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA2(1), HEXB(1), LCT(3), MAN2C1(1), NEU1(1), NEU4(1)	6499946	10	8	10	2	4	1	1	1	3	0	0.384	0.701	1.000
186	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), IL6(1), LDLR(1)	2074659	3	3	3	2	1	1	0	1	0	0	0.847	0.705	1.000
187	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), DAXX(1), FAS(1), FASLG(1), MAPKAPK3(1), TNF(1)	4423048	6	6	6	2	1	1	1	1	2	0	0.778	0.707	1.000
188	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO2(1), FH(1), IDH1(4)	5174184	7	7	5	2	3	0	1	2	1	0	0.531	0.708	1.000
189	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), CES1(1)	2347608	2	2	2	0	0	0	0	2	0	0	0.668	0.717	1.000
190	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(1), RELA(2), RIPK1(1), TNFAIP3(1), TRAF1(1), TRAF2(3)	8769907	10	9	10	1	3	2	2	2	1	0	0.111	0.728	1.000
191	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), TPO(1)	3277279	3	3	3	1	1	2	0	0	0	0	0.546	0.732	1.000
192	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	RIPK1(1), TNF(1), TRAF2(3)	3289561	5	4	5	2	2	0	1	2	0	0	0.658	0.734	1.000
193	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	RELA(2), TNF(1)	3859707	3	3	3	0	1	1	1	0	0	0	0.307	0.735	1.000
194	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	1206001	1	1	1	1	0	1	0	0	0	0	0.891	0.737	1.000
195	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY2(2), CSNK1E(1), NPAS2(1), PER1(1), PER2(1), PER3(2)	6670747	8	7	8	1	1	1	1	4	1	0	0.322	0.737	1.000
196	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	CPOX(1), HMBS(1)	2940471	2	2	2	0	1	0	0	1	0	0	0.612	0.744	1.000
197	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(1), GRB2(1), HRAS(3), IRS1(2), MAPK1(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(1), SHC1(2), SOS1(1), STAT5B(1)	12905387	28	24	28	5	11	5	4	7	1	0	0.0995	0.744	1.000
198	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(1), MARS2(1), MAT1A(1)	6799277	10	10	10	3	2	2	2	0	4	0	0.493	0.745	1.000
199	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(1), AKT2(1), BCR(1), BTK(1), CDKN2A(1), ITPR1(2), ITPR2(3), ITPR3(1), PDK1(1), PIK3CA(10), PITX2(1), PLCG2(1), PPP1R13B(1), PTPRC(3), RPS6KA1(1), SAG(1), SYK(2), VAV1(3)	21327523	35	33	35	6	7	6	5	9	8	0	0.0714	0.749	1.000
200	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1)	3125531	6	6	5	3	2	0	1	3	0	0	0.801	0.750	1.000
201	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1)	3125531	6	6	5	3	2	0	1	3	0	0	0.801	0.750	1.000
202	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(2), TERF2IP(1)	3764020	7	7	7	3	1	1	1	1	3	0	0.903	0.751	1.000
203	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(1), SHMT2(1)	2159645	2	2	2	0	1	1	0	0	0	0	0.407	0.755	1.000
204	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), SYT1(1)	4527827	8	8	8	3	4	0	0	3	1	0	0.738	0.762	1.000
205	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(1)	1892334	1	1	1	0	0	0	0	0	1	0	0.836	0.763	1.000
206	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(1), GSK3B(1), IGF1R(1), PDPK1(1), PIK3CA(10), PIK3R1(1)	7363935	15	14	15	4	3	4	3	4	1	0	0.375	0.764	1.000
207	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1B(1), PLCB1(2)	4358593	4	4	4	1	1	1	1	0	1	0	0.451	0.764	1.000
208	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP54(1)	2933848	2	2	2	0	0	0	0	1	1	0	0.609	0.766	1.000
209	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(2), CPOX(1), EPRS(2), HMBS(1), HMOX2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1)	10684208	14	14	14	3	6	0	1	5	2	0	0.411	0.766	1.000
210	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACSL1(1), EHHADH(2), SLC25A20(1)	6565568	6	6	5	0	2	1	0	2	1	0	0.206	0.767	1.000
211	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11B2(1), HSD11B1(1)	2694122	2	2	2	0	0	0	0	0	2	0	0.447	0.767	1.000
212	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), AOX1(1), BCAT1(1), BCKDHA(1), EHHADH(2), HADHB(1), IVD(1), MUT(1)	14032119	22	20	20	4	7	2	3	7	3	0	0.145	0.770	1.000
213	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR1(2), NOS3(1)	3898716	5	4	5	1	2	0	0	2	1	0	0.631	0.773	1.000
214	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCS2(1)	2799481	2	2	2	0	1	0	0	1	0	0	0.572	0.780	1.000
215	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), HEXB(1), LCT(3)	5622498	7	6	7	1	3	1	0	2	1	0	0.325	0.784	1.000
216	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	THBS1(2)	2882717	2	2	2	0	1	0	1	0	0	0	0.466	0.785	1.000
217	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), IL12A(1), IL12RB2(1), IL4(1), IL4R(2)	4936971	6	5	6	2	2	0	0	1	3	0	0.657	0.788	1.000
218	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(1), CD38(1), ENPP1(2), ENPP3(1), NADSYN1(1), NNMT(1), NNT(2), NT5M(1)	5677473	10	10	10	4	3	2	1	1	3	0	0.561	0.794	1.000
219	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), RB1(2), TFDP1(1)	3324868	4	4	4	2	0	1	2	0	0	1	0.697	0.795	1.000
220	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	RELA(2)	3504581	2	2	2	0	0	1	1	0	0	0	0.440	0.796	1.000
221	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(1), CCNE2(1), CDKN2A(1)	3380597	3	3	3	1	0	1	0	1	1	0	0.670	0.798	1.000
222	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BIK(1), BIRC2(1), DFFA(1)	5304455	4	4	4	0	0	2	0	1	1	0	0.352	0.804	1.000
223	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1(2), MST1R(2), TNF(1)	2563789	5	4	5	2	3	1	0	0	1	0	0.707	0.808	1.000
224	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(1), AKT2(1), ANKRD6(1), APC(2), AXIN2(2), DACT1(3), DKK2(2), GSK3A(2), GSK3B(1), LRP1(3), NKD2(1), PTPRA(3), WIF1(2)	15185362	24	19	24	4	7	5	2	6	4	0	0.0794	0.812	1.000
225	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), FH(1), SDHA(1)	3659568	3	3	3	0	0	0	1	2	0	0	0.496	0.812	1.000
226	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB11A(1)	1651568	1	1	1	2	0	0	0	0	1	0	0.980	0.816	1.000
227	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGAL(3), ITGB2(2), SELE(1)	4714039	6	5	6	2	3	0	1	2	0	0	0.568	0.817	1.000
228	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1)	2172276	1	1	1	0	0	0	0	0	1	0	1.000	0.824	1.000
229	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	RELA(2), TNFSF11(1)	4333042	3	3	3	0	0	1	1	1	0	0	0.370	0.825	1.000
230	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(3), PLA2G2A(1), PTPRU(2), STAT1(1)	4471790	7	6	7	2	1	1	0	4	1	0	0.666	0.827	1.000
231	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR3(1), RAC1(1)	3154834	2	2	2	0	0	0	1	1	0	0	0.560	0.827	1.000
232	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGTR1(2), CMA1(1), COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1)	9784459	9	8	9	1	3	2	1	2	1	0	0.171	0.831	1.000
233	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	HLA-DRA(1), PTPRC(3), ZAP70(2)	3519574	6	6	6	3	3	1	1	1	0	0	0.684	0.831	1.000
234	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD8A(1), IL6(1)	2410205	2	2	2	3	0	1	0	0	1	0	0.942	0.834	1.000
235	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(2), DFFA(1), LMNA(2), PRF1(1)	7546343	9	9	9	2	3	2	0	2	2	0	0.490	0.834	1.000
236	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	JAK1(3), STAT1(1), TYK2(1)	4231346	5	4	5	2	0	1	0	2	2	0	0.781	0.834	1.000
237	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), MAPK1(1), STAT3(5), TYK2(1)	4613926	10	9	10	5	1	2	1	3	3	0	0.840	0.837	1.000
238	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	GRB2(1), HRAS(3), MAP2K4(1), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(1), RELA(2), SHC1(2), SOS1(1), SYT1(1), VAV1(3), ZAP70(2)	18632708	36	29	36	7	14	4	7	11	0	0	0.0704	0.844	1.000
239	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(2), GRIN1(1), RELA(2), SOD2(1)	4963536	8	6	8	2	4	1	1	0	2	0	0.553	0.844	1.000
240	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(1), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(1), MEF2A(1), MEF2C(2), MEF2D(1), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3R1(1), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1)	13622972	29	22	29	5	10	4	5	9	1	0	0.0688	0.845	1.000
241	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1B(1), ADH4(1), ADH6(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), NAT6(1)	9727352	11	9	11	0	3	0	1	3	4	0	0.0484	0.846	1.000
242	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15(1), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP4F2(1), DHRS4(1), GPX4(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PTGS1(1), PTGS2(2)	15236263	18	18	18	2	5	2	2	6	3	0	0.0811	0.849	1.000
243	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	GPX4(1), GSTA2(1), GSTM2(1), GSTM5(2), GSTO2(1), IDH1(4)	7063798	10	10	8	3	5	0	1	4	0	0	0.554	0.851	1.000
244	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	DIAPH1(1), GSN(1), HRAS(3), MAPK1(1), MYLK(3), PFN1(1), PIK3CA(10), PIK3R1(1), PTK2(2), PXN(1), RAF1(1), ROCK1(5), SHC1(2), TLN1(2)	14557694	34	29	33	8	12	3	7	8	4	0	0.246	0.852	1.000
245	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), FPR1(1), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), NCF1(1), NCF2(2), NFATC1(1), NFATC2(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(2), SYT1(1)	14907179	24	19	24	4	8	2	5	8	1	0	0.111	0.853	1.000
246	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(1), PRKCA(2)	2613530	3	3	3	1	2	0	0	1	0	0	0.710	0.854	1.000
247	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(1), FUT3(1)	1983972	3	3	3	2	0	2	0	1	0	0	0.818	0.855	1.000
248	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(1), GCNT2(1), ST8SIA1(1)	2398187	4	4	4	4	0	2	1	0	1	0	0.952	0.857	1.000
249	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(1), CCR4(1), CCR7(1), IL12A(1), IL12RB2(1), IL4(1), IL4R(2), TGFB1(1), TGFB2(1)	7774061	10	9	10	2	2	0	1	4	3	0	0.384	0.858	1.000
250	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(1), APAF1(1), PRKCA(2), PTK2(2), PXN(1), STAT1(1), TLN1(2)	7951287	10	8	10	0	3	3	0	3	1	0	0.0334	0.860	1.000
251	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	BCAR1(1), CTNNA2(4), PTK2(2), PXN(1)	6890159	8	7	8	0	4	1	0	2	1	0	0.0875	0.862	1.000
252	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD2(4)	2255572	4	4	4	4	1	1	0	1	1	0	0.938	0.866	1.000
253	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), DUSP1(1), EP300(4), MAP3K7(2), RELA(2), TGFBR1(2), TNF(1)	11605899	16	14	16	3	7	1	3	3	2	0	0.238	0.867	1.000
254	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CSF1R(2), EGFR(2), GRB2(1), MET(1), PDGFRA(2), PRKCA(2), SH3GLB2(1)	7574940	11	10	11	3	5	0	3	3	0	0	0.359	0.868	1.000
255	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPNS1(1), EP300(4), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(2), SYT1(1)	9521115	14	11	14	2	6	0	2	6	0	0	0.146	0.870	1.000
256	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSE(2), CYP11B1(1), CYP11B2(1), CYP19A1(2), HSD11B1(1), HSD17B3(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1), STS(1), SULT1E1(2), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1)	19565924	34	29	34	6	7	4	4	10	9	0	0.0951	0.870	1.000
257	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), GRB2(1), HRAS(3), IL6(1), IL6ST(2), JAK1(3), RAF1(1), SHC1(2), SOS1(1), STAT3(5)	9307424	20	19	20	6	5	4	3	3	5	0	0.523	0.871	1.000
258	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGFR(2), TF(1)	4997080	5	5	5	2	1	1	0	3	0	0	0.792	0.875	1.000
259	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), FH(1), IDH3A(1), PC(1), PDHA2(2), PDHX(1), PDK1(1), PDK4(1), PDP2(1), SDHA(1), SDHC(1)	11034239	12	12	12	2	1	3	1	4	3	0	0.221	0.876	1.000
260	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(1), BCR(1), BTK(1), DAG1(1), EPHB2(3), GRB2(1), ITPKB(2), MAPK1(1), NFKBIL1(1), PIK3CA(10), PIK3R1(1), PLCG2(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3)	20647755	35	32	35	7	13	5	5	8	4	0	0.106	0.879	1.000
261	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRA(1), IL12A(1), IL4(1), IL6(1), IL7(1), TGFB1(1), TGFB2(1), TNF(1)	5197202	8	7	8	3	3	1	1	2	1	0	0.578	0.882	1.000
262	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(1), GABRA5(1)	3070122	2	2	2	0	1	0	0	0	1	0	0.424	0.883	1.000
263	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGTR1(2), ATF2(1), EGFR(2), GRB2(1), HRAS(3), MAP2K4(1), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), PRKCA(2), PTK2(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1)	13042766	25	21	25	5	13	2	4	6	0	0	0.105	0.883	1.000
264	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(1), FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(1)	3955683	8	8	8	4	4	2	0	0	2	0	0.779	0.884	1.000
265	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(1), RELA(2), TNFAIP3(1)	7081521	5	5	5	0	1	2	1	0	1	0	0.137	0.885	1.000
266	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12A(1), IL12RB2(1), STAT4(3), TYK2(1)	5727151	6	6	6	3	0	0	1	1	4	0	0.820	0.885	1.000
267	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), EPHB2(3), F2(1), MAPK1(1), PLD1(2), PTK2(2), RAF1(1), RASAL1(2), VAV1(3)	10734193	16	14	16	3	8	1	1	4	2	0	0.250	0.886	1.000
268	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGDIB(1), CASP1(2), PRF1(1)	5021610	5	5	5	2	2	1	0	1	1	0	0.748	0.888	1.000
269	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), AGTR1(2), CMA1(1), ENPEP(1), MAS1(1), MME(2), THOP1(1)	8260739	10	8	10	2	4	1	1	4	0	0	0.358	0.889	1.000
270	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(3), ITGB2(2), PTPRC(3)	4389218	8	7	8	3	3	1	1	3	0	0	0.538	0.890	1.000
271	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS1(1), GSK3B(1)	3623559	2	2	2	1	0	0	0	1	1	0	0.826	0.890	1.000
272	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(4), CDKN1A(2), MDM2(1), RAD51(1), RELA(2)	8873589	10	6	10	0	3	1	2	1	3	0	0.0900	0.893	1.000
273	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA4(1), ANXA6(1), HPGD(1), HSD11B1(1), PLA2G4A(2), PTGIR(1), PTGS1(1), PTGS2(2), SCGB1A1(1)	8056814	12	12	12	4	2	3	1	4	2	0	0.550	0.897	1.000
274	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(2), PLCB1(2), PPP1CA(1), PPP3CA(1), PRKAR1A(1), PRKAR1B(1)	6260391	9	9	8	3	1	2	0	4	2	0	0.533	0.897	1.000
275	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(4), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), EHHADH(2), MUT(1)	12907888	16	14	15	3	4	1	3	7	1	0	0.238	0.898	1.000
276	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), PDE6B(1), PDE6C(1), SLC6A13(2), TF(1)	14001885	16	14	16	3	5	3	1	3	4	0	0.260	0.898	1.000
277	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	BCAR1(1), BCR(1), CAPNS1(1), GRB2(1), HRAS(3), MAPK1(1), PTK2(2), PXN(1), RAF1(1), ROCK1(5), SHC1(2), SOS1(1), TLN1(2)	18449494	22	20	21	3	8	2	5	4	3	0	0.0740	0.901	1.000
278	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	GPX4(1), GSTA2(1), GSTM2(1), GSTM5(2), GSTO2(1), IDH1(4), OPLAH(1)	8634646	11	11	9	3	5	0	1	4	1	0	0.463	0.902	1.000
279	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP3(1), ARFGEF2(1), COPA(1), GBF1(1), GPLD1(1), KDELR3(1)	6324602	6	6	6	2	2	2	0	1	1	0	0.540	0.902	1.000
280	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), TGFB1(1), TGFB2(1), TNF(1), TNFSF8(1)	5178989	6	5	6	2	2	0	2	2	0	0	0.595	0.902	1.000
281	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	2443656	1	1	1	1	0	0	0	1	0	0	0.957	0.902	1.000
282	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B3(1), HSD17B4(1)	3149127	3	3	3	2	1	0	1	0	1	0	0.804	0.903	1.000
283	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAPK1(1), PIK3CA(10), PIK3R1(1), RB1(2), RELA(2), SP1(1)	7582276	18	17	18	5	4	5	4	4	0	1	0.389	0.903	1.000
284	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	DFFA(1), TOP2A(2), TOP2B(2)	3538601	5	5	5	3	1	1	0	1	2	0	0.964	0.904	1.000
285	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), DAXX(1), DFFA(1), FAF1(2), LMNA(2), MAP2K4(1), MAP3K7(2), PAK2(1), PRKDC(7), PTPN13(1), RB1(2), RIPK2(2)	15924881	23	19	23	4	8	3	4	4	3	1	0.124	0.905	1.000
286	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	HMBS(1)	3034259	1	1	1	1	1	0	0	0	0	0	0.914	0.905	1.000
287	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA3(1), GABRA5(1), UBQLN1(1)	4663580	3	3	3	0	1	1	0	0	1	0	0.293	0.905	1.000
288	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGFR(2), GRB2(1), HRAS(3), JAK1(3), MAP2K4(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5)	14577459	34	27	34	8	10	5	5	12	2	0	0.215	0.911	1.000
289	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(2), PFKL(1)	3642995	3	3	3	2	1	0	0	0	2	0	0.872	0.914	1.000
290	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(1), ALPPL2(1), DHFR(1)	2584097	4	4	4	3	2	1	0	0	1	0	0.874	0.917	1.000
291	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(1), CDKN1A(2), MDM2(1), RB1(2)	4302296	6	4	6	2	2	1	1	0	1	1	0.607	0.917	1.000
292	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	RB1(2), TFDP1(1)	3179371	3	3	3	2	0	0	2	0	0	1	0.825	0.919	1.000
293	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1B(1), ADH4(1), ADH6(1), AKR1C4(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP2F1(2), CYP2S1(1), CYP3A43(1), CYP3A7(1), EPHX1(2), GSTA2(1), GSTM2(1), GSTM5(2), GSTO2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1)	22355242	43	35	43	8	10	3	8	15	7	0	0.106	0.920	1.000
294	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), HEXB(1), LCT(3), SPAM1(2)	8002072	9	8	9	2	4	1	0	3	1	0	0.476	0.920	1.000
295	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	RB1(2), TFDP1(1)	3212297	3	3	3	2	0	0	2	0	0	1	0.810	0.921	1.000
296	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH12(1)	1878306	1	1	1	0	1	0	0	0	0	0	0.673	0.923	1.000
297	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	GRB2(1), HRAS(3), JAK1(3), MAP2K4(1), PDGFRA(2), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5)	13577958	34	26	34	8	12	5	5	10	2	0	0.181	0.925	1.000
298	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), GRB2(1), HRAS(3), MAP2K4(1), MAPK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1)	11113431	16	14	16	4	9	1	3	2	1	0	0.328	0.926	1.000
299	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(2), GOT1(1), PAH(1), YARS2(1)	3385332	5	4	5	2	3	0	0	1	1	0	0.644	0.926	1.000
300	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(1), CD38(1), ENPP1(2), ENPP3(1), NADK(2), NADSYN1(1), NNMT(1), NNT(2), NT5C1B(1), NT5C2(2), NT5M(1), NUDT12(1)	8406672	16	14	16	5	6	3	1	2	4	0	0.422	0.929	1.000
301	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(2), SNAP25(2), VAMP1(1), VAMP5(1), VAMP7(1), VTI1A(1)	6549278	9	8	9	2	4	0	1	2	2	0	0.470	0.929	1.000
302	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), ASAH1(1), CERK(1), CREB3(1), DAG1(1), EPHB2(3), ITPKB(2), MAP2K4(1), MAP2K7(2), MAPK1(1), MAPK8IP3(2)	11203433	17	15	17	4	7	2	0	3	5	0	0.434	0.930	1.000
303	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C6(2), C9(1)	4885869	4	4	4	2	1	1	0	0	2	0	0.674	0.930	1.000
304	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), IL4(1), MAP3K5(1), RELA(2), TRAF2(3)	7567245	8	7	8	2	3	1	1	3	0	0	0.550	0.931	1.000
305	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(1), AKT2(1), BRD4(2), CAP1(1), CDKN2A(1), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(1), IRS4(3), MAPK1(1), PDK1(1), PIK3CA(10), PIK3R1(1), PTPN1(1), RAF1(1), RPS6KA1(1), SHC1(2), SORBS1(2), SOS1(1), YWHAH(1), YWHAQ(1)	23023644	39	33	39	7	10	7	4	10	8	0	0.0868	0.931	1.000
306	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), CES1(1)	4218322	2	2	2	0	0	1	0	1	0	0	0.565	0.931	1.000
307	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), GSK3B(1), PPP1CA(1)	4483911	7	7	7	3	1	0	2	2	2	0	0.686	0.932	1.000
308	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL6(1), IL9(1), TGFB1(1), TGFB2(1)	3237606	5	5	5	4	0	1	2	1	1	0	0.938	0.932	1.000
309	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(2), B4GALT2(1), ST3GAL1(2)	3087543	5	4	5	2	5	0	0	0	0	0	0.747	0.934	1.000
310	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), ATP7B(1), NDUFA10(2), NDUFB7(1), NDUFV1(1), SDHA(1), SHMT1(1), UQCRC1(1)	14881166	17	16	17	3	2	2	3	8	2	0	0.310	0.935	1.000
311	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), JAK1(3), STAT1(1), STAT3(5), STAT5B(1), TYK2(1)	7214167	13	11	13	5	0	3	2	4	4	0	0.675	0.936	1.000
312	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(3), L1CAM(3), SELP(2)	6136060	9	8	9	3	4	0	2	1	2	0	0.569	0.939	1.000
313	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	YWHAH(1)	3461682	1	1	1	1	0	1	0	0	0	0	0.954	0.943	1.000
314	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(3), LIMK1(1), MAPK1(1), PLCB1(2), PRKCA(2), PTK2(2), RAF1(1)	9771787	17	12	17	3	6	2	2	6	1	0	0.282	0.943	1.000
315	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT3(1), B3GNT4(2), B4GALT1(2), B4GALT2(1), FUT1(1), FUT2(1), FUT3(1), GCNT2(1), ST8SIA1(1)	6331490	11	10	11	4	3	3	1	2	1	1	0.611	0.944	1.000
316	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CRY2(2), EIF4G2(1), HERPUD1(1), HSPA8(2), NCOA4(2), NR1D2(1), PER1(1), PER2(1), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(1), ZFR(1)	14266932	19	15	19	4	3	1	3	8	4	0	0.404	0.945	1.000
317	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(4), PPARG(1)	7201458	9	9	9	3	4	0	2	2	1	0	0.588	0.946	1.000
318	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA2(1), HEXB(1), LCT(3), MAN2B2(1), MAN2C1(1), NEU1(1), NEU4(1)	8006100	11	8	11	3	5	1	1	1	3	0	0.473	0.947	1.000
319	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(3), PTPRU(2), STAT1(1), TYK2(1)	4892224	7	6	7	3	1	1	0	3	2	0	0.781	0.947	1.000
320	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSE(2), ASAH1(1), GAL3ST1(1), LCT(3), NEU1(1), NEU4(1), PPAP2A(1), PPAP2B(1)	9469308	12	10	12	2	4	2	2	3	1	0	0.205	0.947	1.000
321	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(1), GOT1(1), ME1(2), ME3(1), PGK2(1), TKT(1)	7883067	7	7	7	2	0	1	1	4	1	0	0.526	0.948	1.000
322	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), DFFA(1), GZMA(1), PRF1(1)	4144084	7	7	7	4	3	1	0	1	2	0	0.881	0.950	1.000
323	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(3), GNA13(1), GNB1(1), GNGT1(1), MYLK(3), PLCB1(2), PRKCA(2), ROCK1(5)	8044060	18	16	17	5	4	2	4	6	2	0	0.492	0.955	1.000
324	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA2(1), PSMD1(1), PSMD2(1), PSMD6(1)	6234289	4	4	4	0	1	0	0	3	0	0	0.421	0.959	1.000
325	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA2(1)	3405192	1	1	1	0	0	0	0	1	0	0	0.825	0.959	1.000
326	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	PLCG1(1), PRKCA(2), SYT1(1)	5370437	4	4	4	1	3	0	0	1	0	0	0.534	0.959	1.000
327	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), GNAS(2), GRB2(1), HRAS(3), MAPK1(1), PIK3CA(10), PIK3R1(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(1)	11386378	32	27	32	9	10	5	4	13	0	0	0.404	0.960	1.000
328	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	CASP1(2), RERE(2), WWP1(2)	9363347	6	6	6	1	2	1	0	2	1	0	0.416	0.960	1.000
329	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX15(1), CYP4F2(1), EPX(1), LPO(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PTGS1(1), PTGS2(2), TPO(1)	10933042	12	12	12	3	3	4	0	5	0	0	0.352	0.961	1.000
330	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC2(1), ANAPC5(3), CDC23(1), CUL2(2), CUL3(3), FBXW11(1), FZR1(2), TCEB2(1), UBA1(1), VHL(1), WWP1(2)	15619271	19	18	19	4	1	2	7	7	2	0	0.251	0.961	1.000
331	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(1), C3(1), C6(2), C9(1), MASP1(2), MASP2(1)	8307730	8	8	8	3	2	1	1	2	2	0	0.548	0.961	1.000
332	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	RB1(2), RELA(2), TNF(1)	6801936	5	5	5	2	1	1	2	0	0	1	0.600	0.962	1.000
333	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(4), EP300(4), RELA(2), RIPK1(1), TNF(1)	8754647	12	12	12	4	5	1	3	2	1	0	0.524	0.962	1.000
334	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IRAK1(1), MAP3K7(2), RELA(2), RIPK1(1), TNF(1), TNFAIP3(1)	9505535	8	8	8	2	3	1	2	0	2	0	0.408	0.964	1.000
335	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), DAXX(1), HRAS(3), PML(3), RB1(2), SIRT1(1), SP100(2), TNF(1)	7112684	17	15	17	5	7	2	5	1	1	1	0.321	0.964	1.000
336	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(1), IL12A(1), IL12RB2(1), STAT4(3), TYK2(1)	7267183	7	7	7	4	0	1	1	1	4	0	0.843	0.965	1.000
337	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ME1(2), ME3(1), PC(1), PDHA2(2)	14430396	17	17	16	4	4	1	2	8	2	0	0.321	0.966	1.000
338	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), EPRS(2), GARS(1), IARS(1), KARS(1), LARS(1), LARS2(2), MARS2(1), QARS(1), SARS(1), TARS(1), WARS(1)	12453700	15	13	15	4	4	2	2	4	3	0	0.546	0.966	1.000
339	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKAG1(2)	3934067	3	3	3	2	0	0	2	1	0	0	0.861	0.967	1.000
340	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(1), MARS2(1), MAT1A(1)	8115169	10	10	10	4	2	2	2	0	4	0	0.640	0.969	1.000
341	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), AKT1(1), IGF1R(1), IL3RA(1), PIK3CA(10), PIK3R1(1), PRKAR1A(1), PRKAR1B(1), YWHAH(1)	8575880	18	16	18	6	3	4	4	7	0	0	0.558	0.970	1.000
342	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2)	5278515	3	3	3	1	2	0	0	1	0	0	0.768	0.970	1.000
343	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	EPN1(1), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(3), SYNJ2(2), SYT1(1)	8515519	11	11	11	4	1	0	1	7	2	0	0.796	0.971	1.000
344	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(1), GOT1(1), ME1(2), ME3(1), TKT(1)	7054776	6	6	6	2	0	1	0	4	1	0	0.613	0.971	1.000
345	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(1), ESCO1(4), GOT1(1), HPD(1), LPO(1), NAT6(1), TPO(1)	13315435	14	14	14	4	3	2	1	4	4	0	0.598	0.972	1.000
346	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ACOX3(1), ACSL1(1), ACSL6(2), ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1), CPT1C(3), EHHADH(2), HADH(1), HADHB(1), HSD17B4(1)	19102058	25	20	24	4	7	3	5	5	5	0	0.0642	0.972	1.000
347	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(1), IL4(1), IL4R(2), IRS1(2), JAK1(3), SHC1(2), STAT6(2)	5786694	14	12	14	5	5	2	0	4	3	0	0.639	0.972	1.000
348	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ACADS(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), EHHADH(2), GAD2(4), PDHA2(2)	10076472	18	18	16	6	7	2	1	6	2	0	0.430	0.973	1.000
349	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), ITGAL(3), ITGB2(2), PRF1(1)	3418047	7	6	7	4	3	0	0	3	1	0	0.813	0.973	1.000
350	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A3(1), ALDH3A1(1), CYP7A1(1), HADHB(1), RDH12(1), SOAT2(1)	12386404	14	13	14	3	3	1	4	4	2	0	0.305	0.974	1.000
351	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(1), ALDH3A1(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(2), ESCO1(4), NAT6(1)	12045738	12	12	12	3	2	1	1	4	4	0	0.488	0.975	1.000
352	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(4), CCNA1(1), CDC25A(1), CDKN1A(2), CDKN2A(1), DHFR(1), GSK3B(1), RB1(2), TFDP1(1), TGFB1(1), TGFB2(1)	8892019	16	12	16	6	4	1	4	1	5	1	0.693	0.975	1.000
353	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(2), CREBBP(4), FZD1(2), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(1), WIF1(2)	10881221	16	14	16	4	6	0	3	2	5	0	0.432	0.976	1.000
354	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), MAP2K4(1), MAP3K7(2), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TRAF2(3)	10670052	12	11	12	3	3	0	1	4	4	0	0.524	0.976	1.000
355	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(1)	3279597	1	1	1	1	0	0	0	0	1	0	1.000	0.977	1.000
356	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), TPO(1)	3775285	3	3	3	2	1	2	0	0	0	0	0.738	0.978	1.000
357	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CD97(1), ELTD1(1), EMR2(4), GLP2R(1), GPR64(1), LPHN1(1), LPHN2(3), LPHN3(6), SCTR(1), VIPR1(1)	10451171	22	20	21	7	7	2	2	7	4	0	0.417	0.979	1.000
358	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), AKT2(1), ASAH1(1), DAG1(1), DRD2(1), EGFR(2), EPHB2(3), GRB2(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(1), MAPK1(1), PIK3CB(1), PITX2(1), PLCB1(2), PLCB4(3), RAF1(1), SHC1(2), SOS1(1), STAT3(5), TERF2IP(1)	22280952	38	35	38	9	10	11	3	7	7	0	0.153	0.979	1.000
359	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(1), C3(1), C6(2), C8B(1), C9(1), MASP1(2)	8101778	8	8	8	3	3	1	1	1	2	0	0.510	0.979	1.000
360	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CBS(1), CTH(1), MARS2(1), MAT1A(1), METTL6(1), PAPSS2(1), PRMT3(1), PRMT5(2), PRMT8(1), SEPHS1(1), SEPHS2(3)	9741956	15	15	15	5	2	2	3	3	5	0	0.629	0.980	1.000
361	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(2), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(3), IGF1R(1), KLK2(1), MAPK1(1), PDGFRA(2), RAF1(1), RPS6KA1(1), RPS6KA5(3), SHC1(2), SOS1(1), STAT3(5)	12900634	28	26	28	8	9	3	4	10	2	0	0.382	0.980	1.000
362	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(1), ENO1(2), GCK(3), GOT1(1), HK2(1), HK3(2), PC(1), PDHA2(2), PDHX(1), PFKL(1), PFKM(1), PFKP(1), PGK2(1)	16592326	18	18	18	4	6	1	2	5	4	0	0.237	0.981	1.000
363	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(1), DHRS7(1), DHRSX(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1)	5872205	8	8	8	4	1	0	1	3	3	0	0.849	0.981	1.000
364	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), EP300(4), NOS3(1), VHL(1)	6639819	9	7	9	3	5	0	1	2	1	0	0.643	0.981	1.000
365	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(1), DFFA(1), LMNA(2), RELA(2), RIPK1(1), TNFRSF10A(1), TNFRSF10B(1), TNFSF12(1), TRAF2(3)	13072445	14	13	14	3	2	3	2	5	2	0	0.345	0.982	1.000
366	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), EGFR(2), HRAS(3), PLCG1(1), PRKCA(2), RELA(2)	8013649	11	10	11	4	4	1	2	4	0	0	0.534	0.982	1.000
367	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1)	5489751	5	5	5	4	0	0	1	2	2	0	0.965	0.983	1.000
368	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(2), ETV3(3), HDAC5(2), HRAS(3), NCOR2(2), RBL2(1)	10212538	13	12	13	4	4	0	4	1	4	0	0.515	0.983	1.000
369	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(1), APC(2), ASAH1(1), DAG1(1), EGFR(2), GNAI1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(1), MAPK1(1), PHKA2(1), PIK3CA(10), PIK3R1(1), PITX2(1), RAF1(1)	20259342	32	29	32	8	8	6	4	9	5	0	0.360	0.983	1.000
370	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA2(1), RPN1(1)	5024844	2	2	2	0	1	0	0	1	0	0	0.585	0.983	1.000
371	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1)	9738935	6	5	6	1	2	2	0	1	1	0	0.388	0.983	1.000
372	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1)	5858943	6	6	6	3	1	1	1	1	2	0	0.722	0.984	1.000
373	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(3), PIAS3(1), PTPRU(2), STAT3(5)	5983665	12	10	12	5	1	3	2	4	2	0	0.731	0.984	1.000
374	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(2), NCOR2(2), THRA(2)	6783177	6	6	6	2	3	0	0	2	1	0	0.576	0.984	1.000
375	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(2), FASN(1)	6267309	7	7	7	3	1	0	1	5	0	0	0.823	0.984	1.000
376	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(4), CTTN(1), KRT18(1), PRKCA(2), ROCK1(5), TUBA1A(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), YWHAQ(1)	19775678	34	26	33	6	7	3	3	11	10	0	0.206	0.985	1.000
377	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(4), CTTN(1), KRT18(1), PRKCA(2), ROCK1(5), TUBA1A(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), YWHAQ(1)	19775678	34	26	33	6	7	3	3	11	10	0	0.206	0.985	1.000
378	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1B(1), POLR1C(1), POLR2A(2), POLR3A(2), POLR3B(1)	9136704	7	7	7	2	2	2	0	2	1	0	0.635	0.985	1.000
379	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1)	5173978	5	5	5	3	1	0	2	2	0	0	0.851	0.985	1.000
380	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CYB5R1(1), GFPT2(2), GNPNAT1(1), HEXB(1), HK2(1), HK3(2), NAGK(1), PGM3(1)	11204002	10	10	10	3	3	0	0	4	3	0	0.694	0.986	1.000
381	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS2(3), ENPP7(1), GAL3ST1(1), LCT(3), NEU1(1), NEU4(1), PPAP2A(1), PPAP2B(1), SGMS1(1), SMPD3(1), SMPD4(1), SPHK2(1)	14011927	21	14	21	4	9	3	4	3	2	0	0.104	0.987	1.000
382	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(2), HEXB(1), LCT(3), SLC33A1(1), ST3GAL1(2), ST8SIA1(1)	6418517	10	8	10	5	5	1	0	2	2	0	0.809	0.988	1.000
383	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(1), GRB2(1), IARS(1), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(3), PIK3CA(10), PPP1R13B(1), SHC1(2), SOS1(1), STAT6(2), TYK2(1)	14435626	30	25	30	9	9	5	4	7	5	0	0.404	0.988	1.000
384	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(1), C3(1), C6(2), C9(1)	6818260	5	5	5	3	1	1	1	0	2	0	0.731	0.988	1.000
385	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2A1(1), CASP1(2), DAXX(1), DFFA(1), FAS(1), FASLG(1), MCL1(1), NTRK1(3), PTPN13(1), RIPK1(1), TNF(1), TRAF1(1), TRAF2(3)	17036748	19	16	19	4	6	6	2	4	1	0	0.143	0.989	1.000
386	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(1), LIMK1(1), MYLK(3), NCF2(2), PDGFRA(2), PIK3CA(10), PIK3R1(1), PLD1(2), RAC1(1), RALBP1(1), TRIO(4), VAV1(3)	13623845	31	27	31	9	10	2	5	10	4	0	0.393	0.989	1.000
387	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), NFATC1(1), NFATC2(1), PRKAR1A(1), PRKAR1B(1)	4773615	5	5	5	3	1	0	1	3	0	0	0.863	0.991	1.000
388	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(1), GNAS(2), GNB1(1), GNGT1(1), NOS3(1), NPPA(1), PIK3CA(10), PIK3R1(1), RELA(2), SYT1(1)	7024067	21	19	21	7	4	5	3	8	1	0	0.670	0.991	1.000
389	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), MTA1(1)	4304419	3	3	3	3	1	1	0	0	1	0	0.848	0.991	1.000
390	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), PPP1CA(1), PRKAG1(2)	7060256	8	8	8	5	0	0	1	5	2	0	0.935	0.991	1.000
391	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP2K4(1), MAPK1(1), NSMAF(1), RAF1(1), RELA(2), RIPK1(1), TRAF2(3)	8030823	10	9	10	4	2	2	3	3	0	0	0.648	0.991	1.000
392	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), CHAT(2), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), ESCO1(4), ETNK1(1), GNPAT(1), GPAM(2), NAT6(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLD1(2), PPAP2A(1), PPAP2B(1)	25636154	36	30	36	6	8	2	3	10	13	0	0.0906	0.991	1.000
393	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), FDXR(1), SHMT1(1)	6228507	10	10	10	4	2	1	0	5	2	0	0.870	0.992	1.000
394	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(1), F2(1), FGA(3), PLAT(2), PLAU(2), PLG(1), SERPINB2(1)	5213171	12	11	12	8	5	0	2	4	1	0	0.962	0.992	1.000
395	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), ALDOC(1), ENO1(2), GCK(3), HK2(1), HK3(2), PDHA2(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1)	19062981	26	24	25	6	9	0	4	9	4	0	0.218	0.993	1.000
396	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), ALDOC(1), ENO1(2), GCK(3), HK2(1), HK3(2), PDHA2(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1)	19062981	26	24	25	6	9	0	4	9	4	0	0.218	0.993	1.000
397	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	DHFR(1), POLD1(1), POLG(1)	4928437	3	3	3	5	1	1	0	0	1	0	0.994	0.993	1.000
398	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR3(1), NTRK1(3), RAC1(1), WASF2(1)	5936062	6	6	6	3	0	3	1	2	0	0	0.749	0.993	1.000
399	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(1), FUCA2(1), GALNS(2), HEXB(1), LCT(3), MAN2B2(1), MAN2C1(1), NEU1(1), NEU4(1), SPAM1(2)	13524408	16	12	16	4	8	1	1	3	3	0	0.386	0.993	1.000
400	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(1), DBH(3), FAH(1), GOT1(1), HGD(1), HPD(1), PNMT(1), TPO(1)	12366043	17	17	17	5	4	2	3	4	4	0	0.437	0.993	1.000
401	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX3(1), ELOVL6(1), FASN(1), SCD(1)	5673059	6	6	6	3	0	0	2	2	2	0	0.890	0.993	1.000
402	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(4), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(2), CDC25A(1), CDC25B(2), CDC6(1), CDC7(1), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(1), E2F3(1), EP300(4), ESPL1(1), GSK3B(1), HDAC5(2), HDAC6(3), HDAC8(2), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MPEG1(5), PRKDC(7), PTPRA(3), RB1(2), SMAD4(4), TFDP1(1), TGFB1(1)	40064724	71	53	71	11	19	9	8	23	11	1	0.00779	0.993	1.000
403	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCC3(2)	5571866	6	6	6	4	2	1	1	1	1	0	0.909	0.994	1.000
404	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F3(1), F5(3), F7(2), FGA(3), PROS1(2)	6375613	13	13	13	5	6	2	2	3	0	0	0.541	0.994	1.000
405	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADH4(1), ADH6(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKQ(1), DGKZ(1), GK(1), LCT(3), LIPG(3), PNLIP(1), PPAP2A(1), PPAP2B(1)	18874271	32	25	31	7	10	3	4	9	6	0	0.141	0.994	1.000
406	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCND3(1), CDC25A(1), CDKN1A(2), CDKN2A(1), RB1(2), TFDP1(1)	6143903	9	7	9	5	3	1	2	1	1	1	0.771	0.994	1.000
407	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS2(1), SCAP(1), SREBF2(1)	4717051	4	4	4	4	1	0	0	2	1	0	0.984	0.995	1.000
408	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF2(1)	7189238	6	6	6	3	0	2	0	3	1	0	0.845	0.996	1.000
409	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRB(1), COX15(1), CP(2), CPOX(1), EPRS(2), HMBS(1), HMOX2(1), MMAB(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1)	16429831	26	22	26	6	8	1	2	10	5	0	0.365	0.996	1.000
410	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(2), DBH(3), GAD2(4), PAH(1), PNMT(1), TPH1(1)	5661082	13	13	13	6	5	2	1	3	2	0	0.650	0.996	1.000
411	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), POLR2A(2), PRKAR1A(1), PRKAR1B(1)	5037547	5	4	5	3	3	0	0	2	0	0	0.832	0.996	1.000
412	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(2), GLI2(3), GLI3(1), GSK3B(1), PRKAR1A(1), PRKAR1B(1), SHH(2), SUFU(1)	6528670	14	12	14	6	3	1	1	6	3	0	0.759	0.996	1.000
413	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), PIAS3(1), PTPRU(2)	5385242	6	5	6	4	1	1	1	2	1	0	0.927	0.996	1.000
414	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1RAP(2), IL6(1), IRAK1(1), IRAK2(2), MAP3K7(2), RELA(2), TGFB1(1), TGFB2(1), TNF(1)	11577058	13	12	13	4	6	2	2	1	2	0	0.422	0.996	1.000
415	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B2(1), EIF2B3(1), FLT1(2), FLT4(2), HRAS(3), KDR(3), NOS3(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(1), SHC1(2), VHL(1)	13283287	35	26	35	9	17	4	3	6	5	0	0.260	0.996	1.000
416	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(1), GOT1(1), HPD(1), LPO(1), TPO(1)	8569332	9	9	9	4	2	2	1	3	1	0	0.798	0.996	1.000
417	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(1), BTK(1), FCER1A(1), GAB2(5), GRB2(1), HRAS(3), IL4(1), INPP5D(2), MAP2K4(1), MAP2K7(2), MAPK1(1), PDK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCG1(1), PLCG2(1), PRKCA(2), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SYK(2), TNF(1), VAV1(3), VAV2(1), VAV3(1)	28229584	60	51	60	13	22	7	8	19	4	0	0.0593	0.996	1.000
418	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	BRCA2(5), FANCA(2), FANCG(1), HUS1(1), RAD17(1), RAD51(1)	14390483	11	11	11	3	0	0	1	5	5	0	0.862	0.997	1.000
419	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACOX3(1), ACSL1(1), ACSL6(2), AQP7(1), CPT1C(3), CYP7A1(1), EHHADH(2), FABP2(1), FABP4(1), GK(1), HMGCS2(1), ME1(2), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(1), PPARG(1), RXRB(2), RXRG(1), SCD(1), SLC27A1(1), SLC27A4(1), SLC27A6(1), SORBS1(2), UBC(1)	25555322	37	29	37	7	13	6	5	5	8	0	0.0569	0.997	1.000
420	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP6(1), ARHGEF1(3), ARHGEF11(2), ARHGEF5(2), CFL1(1), DIAPH1(1), GSN(1), LIMK1(1), MYLK(3), PFN1(1), ROCK1(5), TLN1(2)	17621517	24	22	23	6	3	2	4	6	9	0	0.545	0.997	1.000
421	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	GRB2(1), HRAS(3), PLCG1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1)	8353782	10	10	10	4	6	2	2	0	0	0	0.609	0.997	1.000
422	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), SYT1(1)	10021124	20	19	20	8	6	3	0	9	2	0	0.670	0.997	1.000
423	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(2), B4GALT2(1), GAA(1), GALK1(1), GALK2(1), GANAB(1), GCK(3), HK2(1), HK3(2), LCT(3), MGAM(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1)	12759908	22	19	22	6	11	1	2	5	3	0	0.285	0.997	1.000
424	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	IRAK1(1), MAP2K4(1), MAP3K7(2), PPARA(2), RELA(2), TLR10(1), TLR7(1), TLR9(1)	14207939	11	8	11	2	7	1	1	1	1	0	0.223	0.997	1.000
425	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), DFFA(1), LMNA(2), MADD(2), MAP2K4(1), MAP3K7(2), PAK2(1), PRKDC(7), RB1(2), RIPK1(1), TNF(1), TRAF2(3)	15134869	24	21	24	6	9	3	2	6	3	1	0.299	0.998	1.000
426	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT3(2), GALNT8(1), ST3GAL1(2), WBSCR17(1)	5617542	8	8	8	4	5	1	0	2	0	0	0.774	0.998	1.000
427	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	APC(2), ATF2(1), BMP5(2), BMP7(3), BMPR2(1), CHRD(1), FZD1(2), GSK3B(1), MAP3K7(2), MEF2C(2), NPPA(1), RFC1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1)	13618821	24	18	24	7	7	3	6	4	4	0	0.340	0.998	1.000
428	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), EBP(1), GGCX(1), NQO1(1), SQLE(1), TM7SF2(1)	7532144	8	8	8	5	4	1	1	0	2	0	0.886	0.998	1.000
429	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(2), B4GALT2(1), GAA(1), GALK1(1), GALK2(1), GANC(2), GCK(3), HK2(1), HK3(2), LCT(3), MGAM(2), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH12(1), UGP2(1)	15157079	26	22	26	7	12	1	2	7	4	0	0.233	0.998	1.000
430	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C6(2), IL6(1), ITGAL(3), ITGB2(2), SELP(2), SELPLG(1), TNF(1), VCAM1(1)	9649091	14	12	14	5	6	3	1	3	1	0	0.396	0.998	1.000
431	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3)	9302115	8	7	8	3	2	1	2	1	2	0	0.714	0.998	1.000
432	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(4), IL7(1), IL7R(1), JAK1(3), PIK3CA(10), PIK3R1(1), STAT5B(1)	10914795	25	21	25	9	7	4	3	9	2	0	0.703	0.998	1.000
433	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(1), APC(2), ASAH1(1), CAV3(1), DAG1(1), EPHB2(3), GNAI1(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(1), MAPK1(1), PITX2(1), RAC1(1), RYR1(8)	17943249	29	26	29	9	14	2	2	4	7	0	0.459	0.999	1.000
434	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(1), GPRC5B(1), GRM1(2), GRM3(1), GRM4(1), GRM5(3), GRM7(1), GRM8(1)	8177456	11	11	10	5	5	1	1	2	2	0	0.589	0.999	1.000
435	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(2), FZD1(2), GSK3B(1), NOTCH1(2)	7862196	7	7	7	4	2	1	2	0	2	0	0.753	0.999	1.000
436	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP5A1(2), ATP6V0A2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), CYC1(1), NDUFA10(2), NDUFB10(2), NDUFB7(1), NDUFS3(1), NDUFV1(1), SDHA(1), SDHC(1), UQCRC1(1)	21823261	27	24	27	6	3	4	4	11	5	0	0.330	0.999	1.000
437	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA1(1), CA14(1), CA2(1), CA3(1), CA6(1), CA8(2), CA9(1), CTH(1), HAL(1)	7397661	11	10	11	7	3	3	0	4	1	0	0.928	0.999	1.000
438	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CALML6(1), CAMK2A(1), CAMK2D(1), CLCA1(1), CLCA2(1), CNGA3(1), CNGA4(3), GNAL(1), PDE1C(1), PRKACA(1), PRKG1(1), PRKX(2)	11906939	16	16	16	8	3	3	2	4	4	0	0.748	0.999	1.000
439	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), AMY2B(2), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(2), GCK(3), HK2(1), HK3(2), MGAM(2), PGM1(1), PGM3(1), PYGL(2), SI(1), UGDH(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1)	22219893	31	29	31	8	8	4	5	6	8	0	0.293	0.999	1.000
440	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT1(2), B4GALT2(1), MAN1A1(2), MGAT5(1), RPN1(1), ST6GAL1(1)	7808124	8	7	8	3	5	1	0	2	0	0	0.668	0.999	1.000
441	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADSB(2), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), EHHADH(2), GAD2(4)	11338215	20	18	19	7	5	4	3	6	2	0	0.452	0.999	1.000
442	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR3(1), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RELA(2), SYT1(1)	10921944	11	10	11	4	2	1	2	5	1	0	0.644	0.999	1.000
443	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), CACNA1A(8), GNA13(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GNAZ(1), GRIA1(4), GRIA2(2), GRIA3(1), GRID2(5), GRM1(2), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), HRAS(3), IGF1R(1), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NOS1(2), NOS3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCB1(2), PLCB4(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(1), RAF1(1), RYR1(8)	42526490	83	67	82	16	37	7	7	18	14	0	0.0111	0.999	1.000
444	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	CAPNS1(1), PTK2(2), PXN(1), RAC1(1), TLN1(2)	11165871	7	7	7	2	2	1	1	2	1	0	0.514	0.999	1.000
445	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ACADS(2), ACAT1(1), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), DDHD1(3), EHHADH(2), GAD2(4), HADH(1), HMGCS2(1), HSD17B4(1), ILVBL(2), PDHA2(2), RDH12(1)	15852924	24	22	23	7	8	3	3	6	4	0	0.315	0.999	1.000
446	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(2), ACAA2(1), ACADS(2), ACAT1(1), ALDH1A3(1), ALDH3A1(1), AOX1(1), BCAT1(1), BCKDHA(1), EHHADH(2), HADH(1), HADHB(1), HMGCS2(1), HSD17B4(1), IVD(1), MUT(1)	16771232	19	19	18	5	6	3	2	5	3	0	0.346	0.999	1.000
447	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), AGXT(1), CAD(1), GAD2(4), GOT1(1), PC(1)	10177769	9	9	9	5	2	1	0	3	3	0	0.898	0.999	1.000
448	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), AKT2(1), CDKN2A(1), CREB3(1), EBP(1), ERBB4(1), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(1), IRS4(3), MET(1), PAK2(1), PDK1(1), PIK3CA(10), PPP1R13B(1), PTK2(2), PTPN1(1), RPS6KA1(1), SHC1(2), SOS1(1), TSC2(2), YWHAH(1), YWHAQ(1)	29783400	41	33	41	9	9	8	3	10	11	0	0.180	0.999	1.000
449	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), RDH12(1), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1), TARS2(1)	16693664	21	19	21	6	8	2	0	5	6	0	0.638	0.999	1.000
450	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH4(1), ADH6(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), AKR1A1(1), ALDH1A3(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), GK(1), GPAM(2), LCT(3), LIPG(3), PNLIP(1), PPAP2A(1), PPAP2B(1)	22958195	36	28	36	9	9	3	4	10	10	0	0.277	1.000	1.000
451	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA1(1), CA14(1), CA2(1), CA3(1), CA6(1), CA8(2), CA9(1), CTH(1), HAL(1)	8271239	11	10	11	7	3	3	0	4	1	0	0.925	1.000	1.000
452	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(2), CREBBP(4), EP300(4), FZD1(2), GSK3B(1), LEF1(1), PITX2(1), TRRAP(1)	12349762	16	15	16	6	7	1	2	3	3	0	0.579	1.000	1.000
453	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(1), GCK(3), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKM(1), PFKP(1), PMM1(1)	9356293	12	12	12	5	4	0	1	5	2	0	0.651	1.000	1.000
454	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(4), EP300(4), ERCC3(1), ESR1(1), GRIP1(3), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(2), NRIP1(1), PELP1(1), POLR2A(2)	17999601	26	19	26	7	11	3	2	5	5	0	0.234	1.000	1.000
455	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), PLCG1(1), PLCG2(1), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1)	16409564	21	19	21	7	7	2	1	5	6	0	0.723	1.000	1.000
456	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(1), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(2), EHMT2(1), PLOD1(1), PLOD3(1), SHMT1(1), SHMT2(1)	14480081	20	18	19	6	5	3	3	7	2	0	0.411	1.000	1.000
457	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), CHRM4(1), DRD2(1), DRD3(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2)	10050851	26	24	26	10	11	4	1	7	3	0	0.389	1.000	1.000
458	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ACY3(1), AGXT(1), CAD(1), DARS2(1), GAD2(4), GOT1(1), NARS2(1), PC(1), PDHA2(2)	14780591	14	14	14	6	5	1	0	3	5	0	0.762	1.000	1.000
459	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	IL12A(1), IL4(1), TLR7(1), TLR9(1)	7248393	4	4	4	3	3	0	0	0	1	0	0.822	1.000	1.000
460	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BIRC2(1), CASP1(2), DFFA(1), FAS(1), FASLG(1), IRF2(1), IRF3(2), IRF4(2), IRF6(1), MAP2K4(1), MDM2(1), PRF1(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF21(1), TRAF1(1), TRAF2(3)	22199872	26	22	26	6	4	3	2	8	9	0	0.436	1.000	1.000
461	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CAP1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), MYT1(1), PRKAR1A(1), PRKAR1B(1), RPS6KA1(1)	8042509	15	15	15	7	3	1	2	8	1	0	0.895	1.000	1.000
462	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(4), DUSP1(1), EHHADH(2), EP300(4), HSD17B4(1), MAPK1(1), ME1(2), NCOR1(6), NCOR2(2), NR2F1(1), NRIP1(1), PIK3CA(10), PIK3R1(1), PPARA(2), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PTGS2(2), RB1(2), RELA(2), SP1(1), STAT5B(1), TNF(1)	24730142	51	38	51	12	15	9	6	11	9	1	0.0940	1.000	1.000
463	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO2(1), FH(1), IDH1(4), IDH3A(1), PC(1), PCK2(2), SDHA(1), SDHC(1)	11616527	13	12	11	5	4	0	2	4	3	0	0.703	1.000	1.000
464	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(4), PRKAR1A(1), PRKAR1B(1)	8075753	10	9	10	7	4	0	1	4	1	0	0.946	1.000	1.000
465	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG12(1), ALG14(2), B4GALT1(2), B4GALT2(1), GANAB(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT5(1), MGAT5B(2), RPN1(1), ST6GAL1(1)	16537132	16	13	16	4	7	1	1	2	5	0	0.513	1.000	1.000
466	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(2), B3GALNT1(1), B3GALT2(1), B3GALT5(2), B3GNT3(1), B3GNT4(2), B4GALNT1(2), B4GALT1(2), B4GALT2(1), B4GALT6(1), FUT1(1), FUT2(1), FUT3(1), GCNT2(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3), ST3GAL1(2), ST8SIA1(1)	18985241	29	25	29	9	12	3	3	6	4	1	0.482	1.000	1.000
467	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), ITPKB(2), OCRL(1), PIK3C2A(1), PIK3C2B(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PLCB1(2), PLCB4(3), PLCG1(1), PLCG2(1)	17481385	28	22	28	8	9	9	5	5	0	0	0.244	1.000	1.000
468	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), ESR1(1), NR1D2(1), NR1I2(2), NR1I3(1), NR2E1(1), NR2F1(1), NR2F2(1), NR5A2(1), PGR(1), PPARA(2), PPARD(1), PPARG(1), RARB(2), ROR1(1), RXRB(2), RXRG(1), THRA(2)	16414238	23	19	23	6	13	2	3	2	3	0	0.232	1.000	1.000
469	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(1), DBH(3), ESCO1(4), FAH(1), GOT1(1), HGD(1), HPD(1), METTL6(1), NAT6(1), PNMT(1), PRMT3(1), PRMT5(2), PRMT8(1), TPO(1)	23179177	27	24	27	9	5	2	4	7	9	0	0.592	1.000	1.000
470	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(1), CAMK4(2), CD69(1), CDKN1A(2), CEBPB(1), CNR1(2), CREBBP(4), EGR3(1), EP300(4), FCER1A(1), GSK3A(2), GSK3B(1), HRAS(3), IL4(1), IL6(1), ITK(1), KPNA5(2), MAP2K7(2), MEF2A(1), MEF2D(1), NFATC1(1), NFATC2(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(2), SP1(1), SP3(2), TGFB1(1), TNF(1), TRAF2(3), TRPV6(1), VAV1(3), VAV2(1), VAV3(1), XPO5(1)	35614327	58	46	58	11	21	6	6	18	7	0	0.0260	1.000	1.000
471	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGFR(2), GRB2(1), HRAS(3), MAPK1(1), PTPRB(1), RAF1(1), SHC1(2), SOS1(1), SPRY3(1)	9725760	13	13	13	5	6	1	2	3	1	0	0.687	1.000	1.000
472	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), CNDP1(2), HAL(1)	9500415	11	10	10	7	3	2	1	4	1	0	0.930	1.000	1.000
473	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CD8A(1), CD8B(1), HLA-DRA(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(1), KIR2DL1(1), KIR3DL1(2), NFYA(1), NFYC(2), PSME1(1), TAP1(1), TAP2(1)	18123186	21	18	21	6	3	7	5	4	2	0	0.228	1.000	1.000
474	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTG1(1), ACVR1B(1), CDH1(4), CREBBP(4), CSNK2A2(1), CTNNA2(4), CTNNA3(1), EGFR(2), EP300(4), ERBB2(1), IGF1R(1), IQGAP1(3), LEF1(1), LMO7(1), MAP3K7(2), MAPK1(1), MET(1), MLLT4(1), NLK(1), PTPN1(1), PTPRB(1), PTPRF(2), PVRL1(1), RAC1(1), RAC2(1), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(2), TGFBR1(2), TJP1(1), WASF2(1)	46092354	59	49	58	10	15	3	10	21	10	0	0.0328	1.000	1.000
475	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	GRB2(1), HRAS(3), JAK1(3), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2)	9095992	14	13	14	7	7	3	2	1	1	0	0.726	1.000	1.000
476	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(1), ACVR2A(1), ACVRL1(1), BMP5(2), BMP6(1), BMP7(3), BMP8B(1), BMPR2(1), CHRD(1), COMP(1), CREBBP(4), EP300(4), FST(1), GDF6(1), GDF7(1), INHBA(2), INHBC(1), INHBE(1), LTBP1(3), MAPK1(1), PITX2(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL2(1), ROCK1(5), RPS6KB2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SP1(1), TFDP1(1), TGFB1(1), TGFB2(1), TGFBR1(2), THBS1(2), THBS4(1), TNF(1), ZFYVE16(1), ZFYVE9(1)	38793123	65	54	64	14	18	8	13	20	6	0	0.0462	1.000	1.000
477	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB3(1), DUSP1(1), EEF2K(2), MAP2K4(1), MAP3K10(4), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPKAPK5(1)	13045956	15	11	15	9	7	2	1	2	3	0	0.932	1.000	1.000
478	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(1), ADCY9(2), ATP6V0A2(3), ATP6V1A(2), ATP6V1C2(3), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(1), PRKCA(2), SEC61A1(1), SEC61A2(1)	14393271	23	23	23	8	4	4	2	11	2	0	0.590	1.000	1.000
479	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(1), DUSP8(2), GCK(3), MAP2K4(1), MAP2K7(2), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAP3K9(1), PAPPA(3), SHC1(2)	19381873	27	20	27	9	11	3	2	3	8	0	0.536	1.000	1.000
480	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(1), ARHGEF11(2), GNA13(1), LPA(1), MAP2K4(1), MAP3K5(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(1), PLD1(2), PTK2(2), ROCK1(5), TBXA2R(2)	19140345	23	19	22	7	5	3	4	4	7	0	0.498	1.000	1.000
481	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BTK(1), CAD(1), DAXX(1), DEDD2(1), DFFA(1), EGFR(2), EPHB2(3), FAF1(2), MAP2K4(1), MAP2K7(2), MAP3K5(1), MAPK1(1), MAPK8IP3(2), MET(1), NFKBIL1(1), PFN1(1), PFN2(2), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TPX2(1), TRAF2(3)	28173141	37	28	36	9	11	2	5	10	9	0	0.337	1.000	1.000
482	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF2(1), EEF2K(2), EIF2AK3(4), EIF2B2(1), EIF2B3(1), EIF4A1(1), EIF4G1(1), EIF4G3(2), EIF5B(1)	17129103	16	15	16	8	3	1	3	4	5	0	0.872	1.000	1.000
483	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), INPP5B(1), IPMK(1), ITPK1(2), ITPKB(2), OCRL(1), PI4KA(2), PI4KB(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIP5K1C(2), PLCB1(2), PLCB4(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(1), PLCZ1(2), SYNJ1(3), SYNJ2(2)	28755086	46	39	46	11	11	11	8	15	1	0	0.102	1.000	1.000
484	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLD1(1), POLD3(1), POLE(2), POLG(1), POLL(1), POLM(1), POLQ(3), REV1(1), REV3L(1)	15784260	13	11	13	8	3	1	3	2	4	0	0.961	1.000	1.000
485	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), BCAR1(1), CAPN11(2), CAPN3(1), CAPNS1(1), CAV3(1), CRK(1), GIT2(1), GRB2(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAD(1), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), MYLK2(2), PAK2(1), PDPK1(1), PIK3R2(2), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(5), SHC1(2), SORBS1(2), SOS1(1), TLN1(2), TNS1(6), VAV2(1), VAV3(1)	52497819	74	56	73	13	21	10	5	31	7	0	0.0170	1.000	1.000
486	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(2), GALNT8(1), GALNTL5(3), OGT(1), ST3GAL1(2), WBSCR17(1)	12562043	14	12	14	5	6	2	1	4	1	0	0.623	1.000	1.000
487	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ALDH1A3(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), EHHADH(2), GAD2(4)	10547779	14	14	14	7	3	4	2	4	1	0	0.741	1.000	1.000
488	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOC(1), FUK(1), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKL(1), PFKM(1), PFKP(1), PGM2(1), PMM1(1), RDH12(1), TSTA3(2)	14565824	15	13	15	7	3	1	1	7	3	0	0.751	1.000	1.000
489	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	DAG1(1), EPHB2(3), GRB2(1), ITK(1), ITPKB(2), MAPK1(1), NFKBIL1(1), PAK2(1), PLCG1(1), PTPRC(3), RAF1(1), SOS1(1), VAV1(3), ZAP70(2)	21872986	22	21	22	6	10	3	2	5	2	0	0.379	1.000	1.000
490	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ADH1B(1), ADH4(1), ADH6(1), AKR1A1(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), ALDOC(1), ENO1(2), GCK(3), HK2(1), HK3(2), PDHA2(2), PFKL(1), PFKM(1), PFKP(1), PGK2(1), PGM1(1), PGM3(1)	22730375	24	23	24	8	7	0	5	7	5	0	0.488	1.000	1.000
491	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(3), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), RAF1(1), SYT1(1)	13612572	20	16	20	7	5	0	4	11	0	0	0.686	1.000	1.000
492	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(1), MCL1(1), MDM2(1), PARP1(1), PRF1(1), RELA(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(3)	14306727	17	14	17	6	3	4	2	5	3	0	0.620	1.000	1.000
493	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB3(1), EEF2K(2), GRB2(1), MAPK1(1), RPS6KA1(1), SHC1(2), SOS1(1)	10938948	9	9	9	5	5	3	0	0	1	0	0.765	1.000	1.000
494	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), NCOR2(2), POLR2A(2)	9772015	5	5	5	8	3	1	0	0	1	0	0.994	1.000	1.000
495	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(2), ACAT1(1), ACOT12(1), ALDH1A3(1), ALDH3A1(1), ME1(2), ME3(1), PC(1), PCK2(2), PDHA2(2)	18264861	18	18	18	6	4	1	3	8	2	0	0.532	1.000	1.000
496	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(1), BAI1(4), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), FAS(1), GTSE1(2), MDM2(1), MDM4(1), PPM1D(1), RCHY1(1), SERPINB5(2), SESN1(1), SESN2(2), SESN3(2), THBS1(2), TNFRSF10B(1), TSC2(2)	22513734	31	28	31	9	10	1	4	9	7	0	0.480	1.000	1.000
497	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), ARHGDIB(1), BIRC2(1), DAXX(1), DFFA(1), GSN(1), LMNA(2), MAP2K7(2), MAP3K5(1), MDM2(1), NUMA1(1), PAK2(1), PRKDC(7), PTK2(2), RB1(2), RELA(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(3)	27020326	34	25	34	7	11	8	4	6	4	1	0.106	1.000	1.000
498	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(2), ACSL1(1), ACSL6(2), ADIPOR1(1), ADIPOR2(1), AKT1(1), AKT2(1), CPT1C(3), IRS1(2), IRS2(1), IRS4(3), JAK1(3), LEPR(1), PCK2(2), POMC(1), PPARA(2), PPARGC1A(2), PRKAA2(3), PRKAG1(2), PRKAG3(1), PRKCQ(1), RELA(2), RXRB(2), RXRG(1), STAT3(5), TNF(1), TRAF2(3), TYK2(1)	32535120	51	39	51	12	15	8	6	12	10	0	0.0939	1.000	1.000
499	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), APOA4(1), CYP7A1(1), DGAT1(1), LDLR(1), LRP1(3), SCARB1(2)	10691879	10	10	10	6	5	2	1	1	1	0	0.814	1.000	1.000
500	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1), F10(1), F11(2), F12(1), F2(1), F5(3), FGA(3), KLKB1(1), PROS1(2)	17263038	20	19	20	8	8	4	1	5	2	0	0.616	1.000	1.000
501	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(1), ASAH1(1), CREB3(1), CREBBP(4), DAG1(1), EGR1(1), EGR3(1), FRS2(1), MAP1B(1), MAP2K4(1), MAP2K7(2), MAPK1(1), MAPK8IP3(2), NTRK1(3), PIK3CA(10), PIK3R1(1), SHC1(2), TERF2IP(1)	19541661	35	29	35	11	12	8	2	8	5	0	0.385	1.000	1.000
502	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AKT1(1), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(4), F2(1), GSK3B(1), HRAS(3), MAPK1(1), MEF2C(2), MYH2(1), NFATC1(1), NFATC2(1), NPPA(1), PIK3CA(10), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RAF1(1), SYT1(1)	19838436	39	32	39	13	14	4	6	12	3	0	0.475	1.000	1.000
503	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPNS1(1), EGFR(2), HRAS(3), MAPK1(1), MYLK(3), PRKAR1A(1), PRKAR1B(1), PTK2(2), PXN(1), TLN1(2)	12772709	17	16	17	9	6	1	2	7	1	0	0.849	1.000	1.000
504	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), DAXX(1), GRB2(1), HRAS(3), MAP2K4(1), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(2), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(3)	14279710	33	29	33	11	13	0	7	11	2	0	0.545	1.000	1.000
505	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), CHAT(2), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKQ(1), DGKZ(1), ETNK1(1), GNPAT(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCG1(1), PLCG2(1), PPAP2A(1), PPAP2B(1)	19567100	24	20	24	8	6	2	4	7	5	0	0.488	1.000	1.000
506	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	DMD(3), MYBPC1(1), MYBPC2(4), MYBPC3(2), MYH6(4), MYH7(4), MYH8(1), MYL1(1), MYOM1(2), NEB(5), TCAP(2), TPM1(1), TPM4(1), TTN(48)	52768572	79	61	79	15	26	9	12	20	11	1	0.0206	1.000	1.000
507	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOX1(1), ASMT(1), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP2F1(2), CYP3A7(1), EHHADH(2), KMO(1), KYNU(2), TDO2(1), TPH1(1), WARS(1)	21455288	36	30	35	10	9	3	7	10	7	0	0.387	1.000	1.000
508	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ATP6V0A2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(2), JAM2(1), MAP2K4(1), MET(1), NOD1(2), PLCG1(1), PLCG2(1), RAC1(1), RELA(2), TJP1(1)	27421272	26	23	26	8	3	4	5	12	2	0	0.531	1.000	1.000
509	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(1), ADCY8(4), ARAF(1), ATF4(1), CACNA1C(1), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CREBBP(4), EP300(4), GRIA1(4), GRIA2(2), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRM1(2), GRM5(3), HRAS(3), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), PLCB1(2), PLCB4(3), PPP1CA(1), PPP1R1A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RPS6KA1(1), RPS6KA6(1)	38295875	71	60	70	19	25	9	4	19	14	0	0.200	1.000	1.000
510	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(4), ACACB(2), ACAT1(1), ALDH1A3(1), ALDH3A1(1), EHHADH(2), MUT(1)	15482501	12	12	12	5	2	1	2	7	0	0	0.770	1.000	1.000
511	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CANT1(2), CTPS2(1), DHODH(1), DPYD(2), DPYS(1), NT5M(1), POLD1(1), POLE(2), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), TXNRD1(1), UCK2(1), UMPS(1), UPP1(2)	22426804	25	21	24	9	9	2	7	4	3	0	0.493	1.000	1.000
512	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E2(1), STON1(1), TAF1(1), TAF1L(3), TAF5(1), TAF7L(2)	14006924	9	8	9	8	3	2	1	2	1	0	0.988	1.000	1.000
513	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(4), CTBP2(1), DLL3(3), DLL4(1), DTX1(2), DTX2(1), DTX4(1), DVL2(2), EP300(4), JAG2(3), LFNG(1), MAML1(1), MAML2(1), MAML3(1), MFNG(1), NCOR2(2), NOTCH1(2), NOTCH2(4), NOTCH3(3), NOTCH4(2), NUMB(1), NUMBL(1), RBPJL(1), SNW1(2)	27410238	45	36	45	12	15	7	6	7	10	0	0.191	1.000	1.000
514	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(1), BTK(1), CARD11(1), CD81(1), GSK3B(1), HRAS(3), INPP5D(2), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), SYK(2), VAV1(3), VAV2(1), VAV3(1)	29137160	43	38	43	12	15	4	8	13	3	0	0.220	1.000	1.000
515	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(1), HRAS(3), KDR(3), MAPK1(1), MAPKAPK3(1), NFATC1(1), NFATC2(1), NOS3(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(2), PRKCG(1), PTGS2(2), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(1), SHC2(1), SPHK2(1), VEGFA(2)	28268470	55	40	55	14	18	8	9	13	7	0	0.128	1.000	1.000
516	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALML6(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), IMPA1(1), INPP5B(1), INPP5D(2), ITPK1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), OCRL(1), PI4KA(2), PI4KB(2), PIK3C2A(1), PIK3C2B(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PLCB1(2), PLCB4(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(1), PLCZ1(2), PRKCA(2), PRKCG(1), SYNJ1(3), SYNJ2(2)	48445546	73	54	73	16	20	16	9	18	10	0	0.0343	1.000	1.000
517	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(1), ACVR2A(1), BMP7(3), BMPR2(1), CCL17(1), CCL28(1), CCL7(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD27(1), CNTF(1), CSF1R(2), CSF2RA(2), CSF3R(1), CXCL16(1), CXCL9(1), CXCR6(1), EGFR(2), FAS(1), FASLG(1), FLT1(2), FLT3(1), FLT4(2), GH2(1), GHR(1), HGF(2), IFNA10(1), IFNA13(1), IFNA16(1), IFNW1(1), IL10RA(2), IL11RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(2), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL25(1), IL3RA(1), IL4(1), IL4R(2), IL6(1), IL6ST(2), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBC(1), INHBE(1), KDR(3), LEPR(1), LIFR(1), LTBR(2), MET(1), PDGFRA(2), PDGFRB(1), PF4(1), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(2), TNFRSF13B(2), TNFRSF18(1), TNFRSF21(1), TNFRSF4(1), TNFRSF6B(1), TNFSF11(1), TNFSF12(1), TNFSF14(1), TNFSF8(1), TPO(1), VEGFA(2), XCL1(1), XCR1(1)	69297217	107	72	107	24	26	14	17	30	20	0	0.0128	1.000	1.000
518	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(4), ACACB(2), AKT1(1), AKT2(1), ARAF(1), CALML6(1), CRK(1), FASN(1), GCK(3), GRB2(1), GSK3B(1), HRAS(3), INPP5D(2), IRS1(2), IRS2(1), IRS4(3), MAPK1(1), PCK2(2), PDE3B(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(1), PHKA1(1), PHKA2(1), PHKB(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(3), PPP1R3B(2), PRKAA2(3), PRKACA(1), PRKAG1(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(2), PYGL(2), RAF1(1), RAPGEF1(3), RPS6KB2(1), SHC1(2), SHC2(1), SORBS1(2), SOS1(1), TSC2(2)	62220205	97	75	96	23	31	15	12	27	12	0	0.0237	1.000	1.000
519	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR3(1), AKT1(1), AKT2(1), ARHGEF11(2), BTK(1), CFL1(1), ITPR1(2), ITPR2(3), ITPR3(1), LIMK1(1), MYLK(3), MYLK2(2), PAK2(1), PDK1(1), PIK3CA(10), PIK3CG(3), PIK3R1(1), PITX2(1), PPP1R13B(1), RACGAP1(1), ROCK1(5), SAG(1)	27050583	44	38	43	14	9	5	6	13	11	0	0.671	1.000	1.000
520	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(3), DOT1L(3), EED(1), EHMT2(1), EZH1(1), EZH2(1), JMJD4(1), KDM6A(6), MEN1(1), NSD1(1), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(1), PRDM9(2), PRMT1(1), PRMT5(2), PRMT8(1), RBBP5(2), SETD1A(2), SETD2(4), SETDB1(2), SETDB2(1), SUV420H2(1), WHSC1(1), WHSC1L1(3)	46385104	46	41	46	11	11	5	3	12	15	0	0.405	1.000	1.000
521	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), AMY2B(2), ASCC3(1), ATP13A2(1), DDX23(1), DDX47(3), DDX50(3), DDX56(1), ENPP1(2), ENPP3(1), ENTPD7(1), EP400(1), ERCC2(2), ERCC3(1), GAA(1), GANC(2), GBE1(2), GCK(3), HK2(1), HK3(2), MGAM(2), PGM1(1), PGM3(1), PYGL(2), RAD54L(1), RUVBL2(2), SETX(2), SI(1), SKIV2L2(3), SMARCA2(1), SMARCA5(3), TREH(1), UGDH(1), UGP2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1)	48260969	71	53	71	18	16	11	10	20	14	0	0.138	1.000	1.000
522	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(1), CADM3(2), CD226(1), CD276(1), CD8A(1), CD8B(1), CDH1(4), CDH2(2), CDH3(3), CDH4(4), CDH5(5), CLDN15(1), CLDN23(1), CLDN9(2), CNTN2(1), CNTNAP1(5), ESAM(1), GLG1(1), HLA-DRA(1), HLA-F(1), HLA-G(1), ICAM3(1), ITGA6(2), ITGA9(2), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB8(1), JAM2(1), L1CAM(3), MADCAM1(1), MAG(1), NCAM1(1), NCAM2(3), NEGR1(1), NEO1(1), NFASC(1), NLGN1(1), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(2), PDCD1(1), PTPRC(3), PTPRF(2), PVRL1(1), SDC3(1), SELE(1), SELP(2), SELPLG(1), SIGLEC1(5), VCAM1(1), VCAN(3)	57683605	99	71	96	28	36	14	10	22	17	0	0.101	1.000	1.000
523	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), CANT1(2), CTPS2(1), DHODH(1), DPYD(2), DPYS(1), ENTPD6(2), NT5C1B(1), NT5C2(2), NT5M(1), POLA1(1), POLD1(1), POLD3(1), POLE(2), POLR1B(1), POLR1C(1), POLR2A(2), POLR3A(2), POLR3B(1), TXNRD1(1), UCK2(1), UMPS(1), UPP1(2)	31599877	31	27	30	10	11	4	7	4	5	0	0.386	1.000	1.000
524	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	BCAR1(1), CDH5(5), CLDN15(1), CLDN23(1), CLDN9(2), CTNNA2(4), CTNNA3(1), CYBB(1), ESAM(1), GNAI1(1), GNAI2(1), ITGAL(3), ITGAM(2), ITGB2(2), ITK(1), JAM2(1), MLLT4(1), MMP9(1), MSN(1), MYL5(1), NCF1(1), NCF2(2), NCF4(1), NOX3(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(2), PRKCG(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF4(1), RASSF5(1), ROCK1(5), SIPA1(1), VAV1(3), VAV2(1), VAV3(1), VCAM1(1)	47943902	79	59	78	21	27	8	9	24	11	0	0.210	1.000	1.000
525	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTR3(1), AKT1(1), AKT2(1), ARHGEF6(1), BCAR1(1), CDKN2A(1), CRK(1), CSE1L(1), EPHB2(3), GRB2(1), GRB7(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), MAP2K4(1), MAP2K7(2), MAP3K11(2), MAPK1(1), MAPK8IP3(2), MRAS(1), MYLK(3), MYLK2(2), PAK2(1), PIK3CA(10), PIK3CB(1), PLCG1(1), PLCG2(1), PTK2(2), RAF1(1), ROCK1(5), SHC1(2), SOS1(1), TERF2IP(1), TLN1(2), TLN2(2)	46953063	73	52	72	19	18	11	9	22	13	0	0.196	1.000	1.000
526	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(1), CARD11(1), CD8A(1), CD8B(1), GRB2(1), HRAS(3), IL4(1), ITK(1), NFATC1(1), NFATC2(1), PAK2(1), PDCD1(1), PDK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(1), PTPRC(3), SOS1(1), TNF(1), VAV1(3), VAV2(1), VAV3(1), ZAP70(2)	39667724	50	41	50	15	17	6	8	16	3	0	0.288	1.000	1.000
527	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AKT1(1), AKT2(1), APAF1(1), BIRC2(1), DFFA(1), FAS(1), FASLG(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(2), IRAK4(1), NTRK1(3), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(3)	29947312	49	39	49	17	11	10	7	16	5	0	0.504	1.000	1.000
528	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL2(3), CSNK2A2(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKQ(1), DGKZ(1), IMPA1(1), ITPKB(2), MAP3K10(4), NEK1(2), OCRL(1), PIK3C2A(1), PIK3C2B(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PLCB1(2), PLCB4(3), PLCG1(1), PLCG2(1), PLK3(3), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA4(2), TGFBR1(2)	44222274	73	50	73	19	19	14	14	18	8	0	0.107	1.000	1.000
529	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(4), AKT1(1), AKT2(1), ARAF(1), CAMK2A(1), CAMK2D(1), CDKN1A(2), CRK(1), EGFR(2), ERBB2(1), ERBB3(2), ERBB4(1), GRB2(1), GSK3B(1), HRAS(3), MAP2K4(1), MAP2K7(2), MAPK1(1), NRG1(2), NRG2(1), NRG3(2), PAK2(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(2), PRKCG(1), PTK2(2), RAF1(1), RPS6KB2(1), SHC1(2), SHC2(1), SOS1(1), STAT5B(1)	39497686	65	49	65	22	24	10	8	13	10	0	0.392	1.000	1.000
530	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(4), ANAPC1(1), ANAPC2(1), ANAPC5(3), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(2), CDC23(1), CDC25A(1), CDC25B(2), CDC6(1), CDC7(1), CDKN1A(2), CDKN2A(1), CREBBP(4), E2F3(1), EP300(4), ESPL1(1), FZR1(2), GSK3B(1), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), PRKDC(7), RB1(2), RBL2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMC1B(1), TFDP1(1), TGFB1(1), TGFB2(1), YWHAH(1), YWHAQ(1)	50060012	70	51	70	17	20	6	13	19	11	1	0.124	1.000	1.000
531	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(1), CCND3(1), CNTF(1), CREBBP(4), CSF2RA(2), CSF3R(1), EP300(4), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(1), IFNW1(1), IL10RA(2), IL11RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL3RA(1), IL4(1), IL4R(2), IL6(1), IL6ST(2), IL7(1), IL7R(1), IL9(1), JAK1(3), LEPR(1), LIFR(1), PIAS3(1), PIAS4(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), SOCS5(1), SOS1(1), SPRED2(1), SPRY3(1), STAT1(1), STAT3(5), STAT4(3), STAT5B(1), STAT6(2), TPO(1), TYK2(1)	56758984	85	62	85	25	18	13	15	23	16	0	0.239	1.000	1.000
532	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(1), IL12A(1), IL6(1), IRAK1(1), IRAK4(1), IRF3(2), MAP2K4(1), MAP2K7(2), MAP3K7(2), MAPK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), RAC1(1), RELA(2), RIPK1(1), STAT1(1), TLR7(1), TLR9(1), TNF(1)	35090378	44	35	44	15	12	7	9	10	6	0	0.416	1.000	1.000
533	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTG1(1), AKT1(1), AKT2(1), BCAR1(1), BIRC2(1), CAV3(1), CCND3(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(3), COL5A3(2), COL6A1(2), COL6A3(5), COL6A6(2), COMP(1), CRK(1), DIAPH1(1), EGFR(2), ERBB2(1), FLNC(1), FLT1(2), FN1(2), GRB2(1), GSK3B(1), HGF(2), HRAS(3), IGF1R(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), KDR(3), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(4), LAMB2(2), LAMB3(1), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(1), MAPK1(1), MET(1), MYL5(1), MYLK(3), MYLK2(2), PAK2(1), PARVB(1), PARVG(2), PDGFRA(2), PDGFRB(1), PDPK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PRKCA(2), PRKCG(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(3), ROCK1(5), SHC1(2), SHC2(1), SOS1(1), THBS1(2), THBS4(1), TLN1(2), TLN2(2), TNC(2), TNN(2), TNXB(7), VAV1(3), VAV2(1), VAV3(1), VEGFA(2), VWF(4)	143688844	204	123	203	66	73	28	18	58	27	0	0.136	1.000	1.000
534	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CHRM4(1), CNR1(2), CYSLTR2(1), DRD2(1), DRD3(1), F2(1), FPR1(1), FSHR(1), GABBR2(1), GABRA3(1), GABRA5(1), GABRB1(4), GABRB2(2), GABRD(1), GABRE(2), GABRG1(4), GABRP(1), GABRQ(1), GABRR1(1), GABRR2(2), GH2(1), GHR(1), GLP2R(1), GLRA1(2), GLRA2(2), GNRHR(3), GPR156(2), GPR35(1), GPR50(2), GPR83(1), GRIA1(4), GRIA2(2), GRIA3(1), GRIA4(2), GRID1(2), GRID2(5), GRIK1(2), GRIK2(1), GRIK3(1), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRIN3A(1), GRIN3B(1), GRM1(2), GRM3(1), GRM4(1), GRM5(3), GRM7(1), GRM8(1), GZMA(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LEPR(1), LHCGR(1), MAS1(1), MC3R(1), MCHR1(1), MCHR2(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NTSR1(1), P2RY1(1), P2RY10(1), P2RY14(1), P2RY4(2), P2RY6(1), P2RY8(1), PTGIR(1), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR5(1), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(1), TACR3(1), TBXA2R(2), THRA(2), TRHR(1), TSHR(1), VIPR1(1)	86712491	173	117	170	50	79	19	11	41	23	0	0.00595	1.000	1.000
535	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY3(1), ADCY4(2), ADCY8(4), ADCY9(2), ADORA2A(1), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2B1(1), ATP2B2(4), ATP2B3(2), ATP2B4(4), AVPR1B(1), BDKRB1(1), CACNA1A(8), CACNA1C(1), CACNA1D(2), CACNA1E(7), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(2), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CCKAR(2), CCKBR(1), CD38(1), CYSLTR2(1), EGFR(2), ERBB2(1), ERBB3(2), ERBB4(1), GNAL(1), GNAS(2), GRIN1(1), GRIN2A(6), GRIN2C(1), GRM1(2), GRM5(3), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), LHCGR(1), MYLK(3), MYLK2(2), NOS1(2), NOS3(1), NTSR1(1), PDE1B(1), PDE1C(1), PDGFRA(2), PDGFRB(1), PHKA1(1), PHKA2(1), PHKB(2), PLCB1(2), PLCB4(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(1), PLCZ1(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RYR1(8), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(1), TBXA2R(2), TRHR(1), VDAC1(1)	105372452	182	113	181	79	71	21	10	43	37	0	0.837	1.000	1.000
536	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	APC(2), ARAF(1), ARHGEF1(3), ARHGEF6(1), ARPC5(1), ARPC5L(1), BCAR1(1), BDKRB1(1), CFL1(1), CHRM4(1), CRK(1), CYFIP1(2), CYFIP2(4), DIAPH1(1), DIAPH3(2), EGFR(2), F2(1), FGD1(1), FGD3(1), FGF10(1), FGF16(1), FGF23(2), FGF5(2), FGF9(3), FGFR2(2), FGFR3(1), FN1(2), GNA13(1), GSN(1), HRAS(3), IQGAP1(3), IQGAP2(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAD(1), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), LIMK1(1), LIMK2(3), MAPK1(1), MRAS(1), MSN(1), MYH10(4), MYH9(1), MYL5(1), MYLK(3), MYLK2(2), NCKAP1L(2), PAK2(1), PDGFRA(2), PDGFRB(1), PFN1(1), PFN2(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(1), ROCK1(5), RRAS2(1), SLC9A1(1), SOS1(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(2), TIAM2(2), VAV1(3), VAV2(1), VAV3(1), WASF2(1)	107585393	161	112	160	34	49	15	17	60	20	0	0.00979	1.000	1.000
537	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), COL11A1(7), COL11A2(4), COL17A1(1), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(3), COL5A3(2), COL6A1(2), COL6A3(5), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(3), FN1(2), GJA1(1), GJA4(1), GJA5(2), GJA8(3), GJB4(1), GJB5(1), GJC2(1), ITGA6(2), ITGB4(2), KRT1(1), KRT14(1), KRT15(2), KRT16(1), KRT18(1), KRT23(2), KRT24(1), KRT25(4), KRT31(2), KRT33A(1), KRT38(2), KRT39(1), KRT4(1), KRT5(1), KRT6A(1), KRT6C(3), KRT7(1), KRT73(1), KRT75(1), KRT77(1), KRT78(3), KRT79(1), KRT83(1), KRT84(1), KRT85(1), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(4), LAMB2(2), LAMB3(1), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(1), LMNA(2), NES(2), RELN(3), THBS1(2), THBS4(1), TNC(2), TNN(2), TNXB(7), VWF(4)	97388752	148	95	148	45	67	21	7	34	19	0	0.0595	1.000	1.000
538	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(1), AKT1(1), AKT2(1), ATF2(1), ATF4(1), CACNA1A(8), CACNA1C(1), CACNA1D(2), CACNA1E(7), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(2), CACNA2D1(1), CACNA2D3(1), CACNA2D4(1), CACNB1(2), CACNB2(2), CACNB4(2), CACNG3(1), CACNG4(1), CACNG7(2), CACNG8(1), CDC25B(2), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP7(1), DUSP8(2), ECSIT(2), EGFR(2), FAS(1), FASLG(1), FGF10(1), FGF16(1), FGF23(2), FGF5(2), FGF9(3), FGFR2(2), FGFR3(1), FLNC(1), GRB2(1), HRAS(3), JUND(1), MAP2K4(1), MAP2K7(2), MAP3K10(4), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAP4K1(1), MAPK1(1), MAPK8IP3(2), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MRAS(1), NF1(1), NFATC2(1), NLK(1), NTRK1(3), PAK2(1), PDGFRA(2), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(1), RASGRF1(2), RASGRF2(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(1), SOS1(1), STK4(2), TAOK1(1), TAOK2(3), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TRAF2(3)	111111286	153	93	153	51	52	15	19	38	29	0	0.452	1.000	1.000
539	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(1), ATP2A2(1), ATP2B1(1), ATP2B2(4), ATP2B3(2), CACNA1A(8), CACNA1C(1), CACNA1D(2), CACNA1E(7), CACNA1S(2), CACNB1(2), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CHRM4(1), GJA1(1), GJA4(1), GJA5(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK6(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNB1(3), KCNJ5(1), MIB1(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS11(1), RGS16(2), RGS6(1), RGS9(2), RYR1(8), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(3), YWHAH(1), YWHAQ(1)	73428182	129	87	129	54	55	10	7	32	25	0	0.847	1.000	1.000
540	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(3), COL5A3(2), COL6A1(2), COL6A3(5), COL6A6(2), DAG1(1), FN1(2), FNDC1(3), FNDC3A(1), GP5(3), GP9(1), HSPG2(7), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(4), LAMB2(2), LAMB3(1), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(1), RELN(3), SDC3(1), SV2A(1), SV2B(1), THBS1(2), THBS4(1), TNC(2), TNN(2), TNXB(7), VWF(4)	87908901	128	84	128	41	51	17	5	35	20	0	0.177	1.000	1.000
541	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(2), CFL1(1), DCC(2), DPYSL2(1), DPYSL5(1), EFNA5(1), EFNB3(1), EPHA1(1), EPHA2(1), EPHA3(4), EPHA4(1), EPHA5(1), EPHA6(1), EPHA7(2), EPHB1(3), EPHB2(3), EPHB3(2), FES(2), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(3), L1CAM(3), LIMK1(1), LIMK2(3), LRRC4C(1), MAPK1(1), MET(1), NFATC1(1), NFATC2(1), NGEF(1), NRP1(1), NTN1(1), NTNG1(3), PAK2(1), PLXNA1(1), PLXNA2(1), PLXNB1(1), PLXNB2(1), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RHOD(1), ROBO1(5), ROBO2(3), ROBO3(1), ROCK1(5), SEMA3A(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4C(2), SEMA4F(1), SEMA5A(1), SEMA5B(1), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(1), SRGAP1(4), UNC5A(1), UNC5B(4), UNC5D(1)	77195808	117	80	116	31	42	11	16	35	13	0	0.0741	1.000	1.000
542	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(2), AXIN2(2), CACYBP(1), CAMK2A(1), CAMK2D(1), CCND3(1), CHD8(1), CREBBP(4), CSNK1A1L(1), CSNK1E(1), CSNK2A2(1), CTBP2(1), DAAM2(2), DKK2(2), DVL2(2), EP300(4), FBXW11(1), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(1), FZD6(1), FZD9(2), GSK3B(1), LEF1(1), LRP5(2), LRP6(1), MAP3K7(2), NFATC1(1), NFATC2(1), NKD2(1), NLK(1), PLCB1(2), PLCB4(3), PPARD(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), ROCK1(5), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(2), VANGL2(2), WIF1(2), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1)	62561298	103	73	101	36	31	15	15	25	17	0	0.453	1.000	1.000
543	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHRM4(1), CMKLR1(1), CNR1(2), DRD2(1), DRD3(1), FPR1(1), FSHR(1), GPR17(1), GPR174(1), GPR35(1), GPR37L1(2), GPR4(1), GPR50(2), GPR83(1), GPR87(2), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NTSR1(1), OR1Q1(1), OR7A5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY6(1), PTGIR(1), RGR(1), SSTR1(1), SSTR2(1), SSTR3(1), TBXA2R(2), TRHR(1)	47523331	88	69	88	33	35	12	5	26	10	0	0.286	1.000	1.000
544	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTG1(1), AKT1(1), AKT2(1), ASH1L(3), CGN(2), CLDN15(1), CLDN23(1), CLDN9(2), CSNK2A2(1), CTNNA2(4), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(1), GNAI1(1), GNAI2(1), HRAS(3), INADL(4), JAM2(1), LLGL2(1), MAGI3(1), MLLT4(1), MPDZ(2), MRAS(1), MYH1(2), MYH10(4), MYH13(5), MYH15(1), MYH2(1), MYH4(6), MYH6(4), MYH7(4), MYH7B(4), MYH8(1), MYH9(1), MYL5(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), RRAS2(1), TJAP1(1), TJP1(1), TJP2(3), TJP3(2), VAPA(1)	74033910	94	68	94	24	36	9	6	28	15	0	0.0813	1.000	1.000
545	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ATF2(1), ATF4(1), ATP2A2(1), CAMK2A(1), CAMK2D(1), CORIN(2), CREB3(1), DGKZ(1), GJA1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK6(1), GUCY1A3(1), IL6(1), ITPR1(2), ITPR2(3), ITPR3(1), MAFF(1), MIB1(1), MYLK2(2), NOS1(2), NOS3(1), PDE4D(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP2(1), RGS11(1), RGS16(2), RGS6(1), RGS9(2), RYR1(8), RYR2(10), RYR3(5), SLC8A1(1), SP1(1), TNXB(7), YWHAH(1), YWHAQ(1)	67860714	98	66	98	53	38	10	7	23	20	0	0.992	1.000	1.000
546	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ADRB1(1), DRD2(1), EGFR(2), GJA1(1), GNAI1(1), GNAI2(1), GNAS(2), GRB2(1), GRM1(2), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), HRAS(3), HTR2A(2), HTR2B(1), HTR2C(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), PDGFRA(2), PDGFRB(1), PLCB1(2), PLCB4(3), PRKACA(1), PRKCA(2), PRKCG(1), PRKG1(1), PRKX(2), RAF1(1), SOS1(1), TJP1(1), TUBA1A(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1)	51649626	79	61	78	26	29	10	5	21	14	0	0.361	1.000	1.000
547	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), AK5(1), AK7(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD6(2), FHIT(1), GART(1), GMPR(1), GMPR2(1), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), NT5C1B(1), NT5C2(2), NT5M(1), PAPSS2(1), PDE10A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE7A(1), PDE8A(2), PDE8B(1), POLA1(1), POLD1(1), POLD3(1), POLE(2), POLR1B(1), POLR1C(1), POLR2A(2), POLR3A(2), POLR3B(1), PRPS1L1(2)	63787391	72	59	71	31	24	12	10	15	11	0	0.764	1.000	1.000
548	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), CALML6(1), CAMK2A(1), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(1), CREBBP(4), DVL2(2), EP300(4), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(1), FZD6(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GSK3B(1), HRAS(3), LEF1(1), MAPK1(1), PLCB1(2), PLCB4(3), POMC(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7L1(1), TCF7L2(2), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1)	42102211	74	55	74	38	25	15	8	15	11	0	0.873	1.000	1.000
549	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(1), CD48(2), FAS(1), FASLG(1), GRB2(1), HLA-G(1), HRAS(3), IFNA10(1), IFNA13(1), IFNA16(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(2), MAPK1(1), MICB(1), NCR2(1), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRF1(1), PRKCA(2), PRKCG(1), RAC1(1), RAC2(1), RAF1(1), SHC1(2), SHC2(1), SOS1(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), VAV1(3), VAV2(1), VAV3(1), ZAP70(2)	43730551	71	52	71	23	27	7	11	20	6	0	0.339	1.000	1.000
550	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), AKAP1(1), AKAP11(1), AKAP12(5), AKAP3(1), AKAP4(1), AKAP6(1), AKAP8(1), AKAP9(5), ARHGEF1(3), GNA13(1), GNAI2(1), GNAL(1), GNAO1(1), GNAZ(1), GNB1(1), GNB3(1), GNB5(1), GNGT1(1), HRAS(3), ITPR1(2), PDE1B(1), PDE1C(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE7A(1), PDE8A(2), PDE8B(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(1), SLC9A1(1)	45694199	71	50	71	28	23	7	7	22	12	0	0.711	1.000	1.000
551	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ATF4(1), CACNA1C(1), CACNA1D(2), CACNA1F(1), CACNA1S(2), CALML6(1), CAMK2A(1), CAMK2D(1), EGFR(2), GNAS(2), GNRHR(3), GRB2(1), HRAS(3), ITPR1(2), ITPR2(3), ITPR3(1), MAP2K4(1), MAP2K7(2), MAPK1(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCB1(2), PLCB4(3), PLD1(2), PRKACA(1), PRKCA(2), PRKX(2), RAF1(1), SOS1(1)	49650415	63	50	63	25	19	12	4	15	13	0	0.734	1.000	1.000
552	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), AK5(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), ATP5A1(2), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), NT5M(1), PAPSS2(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE6B(1), PDE6C(1), PDE8A(2), POLD1(1), POLE(2), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), PRPS1L1(2)	50126451	59	48	58	28	18	8	11	14	8	0	0.897	1.000	1.000
553	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA12(4), ABCA13(5), ABCA3(1), ABCA4(3), ABCA5(5), ABCA9(1), ABCB1(4), ABCB5(2), ABCB6(1), ABCB7(1), ABCC10(1), ABCC11(3), ABCC12(2), ABCC3(2), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(1), ABCG2(1), CFTR(1), TAP1(1), TAP2(1)	45999186	52	42	52	29	13	10	8	12	9	0	0.938	1.000	1.000
554	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(1), C1S(1), C3(1), C3AR1(1), C6(2), C8B(1), C9(1), CD46(2), CFB(2), CFH(6), CFI(1), CPB2(1), F10(1), F11(2), F12(1), F13A1(1), F13B(1), F2(1), F3(1), F5(3), F7(2), FGA(3), KLKB1(1), MASP1(2), MASP2(1), PLAT(2), PLAU(2), PLG(1), PROS1(2), SERPIND1(2), VWF(4)	35268195	55	42	55	22	17	5	6	18	9	0	0.765	1.000	1.000
555	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG12(1), ALG14(2), B3GNT7(1), B4GALT1(2), B4GALT2(1), CHPF(1), CHST11(1), CHST4(1), CHSY1(1), EXT1(1), EXT2(2), EXTL1(2), EXTL3(2), GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(2), GALNT8(1), GALNTL5(3), GANAB(1), HS6ST1(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT5(1), MGAT5B(2), NDST1(2), NDST2(2), NDST4(3), OGT(1), RPN1(1), ST3GAL1(2), ST6GAL1(1), UST(1), WBSCR17(1), XYLT1(4), XYLT2(1)	43048449	57	41	57	15	22	8	6	13	8	0	0.163	1.000	1.000
556	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(1), DAXX(1), GRB2(1), HRAS(3), MAP2K4(1), MAP2K7(2), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAP4K1(1), MAPK1(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KB2(1), SHC1(2), SP1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(3)	36767646	53	40	53	17	19	4	10	11	9	0	0.460	1.000	1.000
557	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), CCKBR(1), CCR2(1), CELSR1(2), CELSR2(4), CELSR3(2), EMR2(4), FSHR(1), GNRHR(3), GPR132(1), GPR133(2), GPR17(1), GPR18(1), GPR55(1), GRM1(2), LPHN2(3), LPHN3(6), NTSR1(1), OR2M4(1), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2)	26082924	43	37	41	19	16	4	5	13	5	0	0.606	1.000	1.000
558	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(8), GNAS(2), GNB1(1), GNB3(1), GRM4(1), ITPR3(1), KCNB1(3), PRKACA(1), PRKX(2), SCNN1B(3), SCNN1G(1), TAS1R2(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R46(1), TAS2R5(1), TRPM5(1)	22337556	41	34	41	19	17	3	3	11	7	0	0.844	1.000	1.000
559	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	CD1B(1), CD1C(1), CD1E(1), CD38(1), CD8A(1), CD8B(1), CSF1R(2), CSF2RA(2), CSF3R(1), FCGR1A(1), FLT3(1), GP5(3), GP9(1), HLA-DRA(1), IL11RA(1), IL3RA(1), IL4(1), IL4R(2), IL6(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGAM(2), MME(2), TNF(1), TPO(1)	31837614	40	33	40	17	9	6	3	14	8	0	0.728	1.000	1.000
560	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK3(2), CPSF2(1), CSTF2T(1), CSTF3(1), DHX15(1), DHX16(1), DHX38(1), DHX8(1), DHX9(1), DICER1(1), METTL3(2), NONO(1), PHF5A(1), POLR2A(2), PPM1G(2), PRPF3(2), PRPF4(1), PRPF4B(1), PRPF8(2), PTBP1(2), RBM17(1), RBM5(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(1), SF3B5(1), SNRPD2(1), SNRPD3(1), SNRPN(1), SUPT5H(1)	40940459	41	33	41	12	10	6	10	7	8	0	0.437	1.000	1.000
561	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP5(2), BMP6(1), BMP7(3), BMP8B(1), CSNK1A1L(1), CSNK1E(1), CSNK1G1(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(3), GLI3(1), GSK3B(1), HHIP(3), LRP2(2), PRKACA(1), PRKX(2), PTCH1(1), PTCH2(4), SHH(2), STK36(1), SUFU(1), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1)	23860463	42	31	42	19	17	7	5	9	4	0	0.631	1.000	1.000
562	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(2), CCND3(1), CSNK1E(1), DVL2(2), FZD1(2), FZD10(2), FZD2(4), FZD5(1), FZD6(1), FZD9(2), GSK3B(1), LDLR(1), PLAU(2), PPP2R5E(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), WNT2(1), WNT5A(1), WNT6(2)	22950506	37	29	37	15	13	3	6	9	6	0	0.629	1.000	1.000
563	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(1), AKT2(1), DDIT4(1), MAPK1(1), PDPK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PRKAA2(3), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), TSC2(2), ULK3(1), VEGFA(2)	20243988	34	28	34	12	11	7	4	8	4	0	0.533	1.000	1.000
564	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CDC25A(1), CDKN1A(2), CDKN2A(1), CREB3(1), CREB3L3(1), E2F3(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MYT1(1), NACA(1), POLE(2), RB1(2), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(7)	27259723	36	27	36	18	13	4	5	7	6	1	0.863	1.000	1.000
565	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(1), ALPPL2(1), ASCC3(1), ATP13A2(1), DDX23(1), DDX47(3), DDX50(3), DDX56(1), DHFR(1), ENTPD7(1), EP400(1), ERCC2(2), ERCC3(1), RAD54L(1), RUVBL2(2), SETX(2), SKIV2L2(3), SMARCA2(1), SMARCA5(3)	24540655	31	27	31	12	8	7	4	7	5	0	0.610	1.000	1.000
566	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CXCR6(1), FPR1(1), FSHR(1), GNRHR(3), LHCGR(1), MC3R(1), NPY1R(1), NPY2R(1), NTSR1(1), SSTR1(1), SSTR2(1), SSTR3(1), TACR1(1), TACR3(1), TRHR(1), TSHR(1)	20412369	31	27	31	13	10	2	2	12	5	0	0.687	1.000	1.000
567	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(4), CDR1(1), DGKI(2), IL6ST(2), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL5(1), RPL8(1), RPS11(2), RPS27A(2), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), RPS9(1), SLC36A2(1), UBB(1), UBC(1)	20483815	29	27	29	14	7	4	2	8	8	0	0.971	1.000	1.000
568	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ACAT1(1), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOX1(1), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(1), EHHADH(2), HADH(1), HSD17B4(1), KMO(1), KYNU(2), LNX1(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1), TDO2(1), TPH1(1), TPH2(1), WARS(1)	23617551	28	26	28	17	2	4	4	11	7	0	0.982	1.000	1.000
569	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(1), EGFR(2), ERBB2(1), ERBB4(1), FMN2(2), GRB2(1), MAPK1(1), NOTCH1(2), NOTCH2(4), NOTCH3(3), NOTCH4(2), PIWIL1(3), PIWIL2(1), PIWIL3(2), RAF1(1), SOS1(1)	19959520	28	26	28	12	9	5	3	5	6	0	0.750	1.000	1.000
570	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), GRB2(1), HRAS(3), IRS1(2), JAK1(3), MAPK1(1), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2)	14123518	29	26	29	11	11	6	4	6	2	0	0.569	1.000	1.000
571	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), FLT1(2), FLT4(2), KDR(3), NOS3(1), PDE2A(1), PDE3B(1), PRKAR1A(1), PRKAR1B(1), PRKG1(1), RYR2(10), SYT1(1)	15870708	25	24	25	14	11	3	0	6	5	0	0.912	1.000	1.000
572	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2A(1), CAMK2D(1), F2(1), GNAI1(1), GNB1(1), GNGT1(1), GRB2(1), HRAS(3), MAPK1(1), MYLK(3), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5), SYT1(1)	16253310	28	23	28	11	12	2	5	8	1	0	0.629	1.000	1.000
573	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTR3(1), AKT1(1), CFL1(1), FLNC(1), FSCN2(1), FSCN3(3), LIMK1(1), MYH2(1), MYLK(3), MYLK2(2), PAK2(1), PFN1(1), PFN2(2), ROCK1(5)	18680178	25	23	24	13	6	3	3	10	3	0	0.927	1.000	1.000
574	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(2), F12(1), F13B(1), F2(1), F5(3), F7(2), FGA(3), LPA(1), PLAT(2), PLAU(2), PLG(1), SERPINB2(1), VWF(4)	13735914	25	22	25	13	10	3	3	6	3	0	0.876	1.000	1.000
575	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH4A1(1), AOC2(1), ARG2(1), CKB(1), CKMT2(2), DAO(1), GOT1(1), NOS1(2), NOS3(1), P4HA1(3), P4HA2(1), P4HA3(1)	17301100	22	21	21	16	5	2	3	10	2	0	0.995	1.000	1.000
576	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(1), EGFR(2), HRAS(3), MAP2K4(1), MAP2K7(2), MAP3K5(1), MAPK1(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RELA(2), RIPK1(1), SP1(1), TNF(1), TRAF2(3)	19188879	25	21	25	12	8	3	5	7	2	0	0.822	1.000	1.000
577	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDT1(1), MCM10(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), NACA(1), POLD1(1), POLD3(1), POLE(2), RFC1(1), RFC3(1), RPA1(1), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1)	19728642	26	20	26	14	8	5	3	5	5	0	0.873	1.000	1.000
578	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), ACAT1(1), ALDH1A3(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(2), EHMT2(1), HADH(1), HSD17B4(1), NSD1(1), PLOD1(1), PLOD3(1), RDH12(1), SETD1A(2), SETDB1(2), SHMT1(1), SHMT2(1)	22695148	23	20	23	10	6	5	3	5	4	0	0.726	1.000	1.000
579	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), CARS(1), CARS2(2), DARS2(1), EPRS(2), FARSB(2), GARS(1), IARS(1), KARS(1), LARS(1), LARS2(2), MARS2(1), NARS2(1), PARS2(1), QARS(1), SARS(1), TARS(1), TARS2(1), VARS(2), VARS2(2), WARS(1), YARS2(1)	21149893	28	20	28	10	11	2	2	6	7	0	0.755	1.000	1.000
580	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), CKB(1), CKMT2(2), DAO(1), EPRS(2), GOT1(1), NOS1(2), NOS3(1), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(1)	14075517	18	18	18	14	5	2	2	7	2	0	0.993	1.000	1.000
581	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AMDHD1(1), AOC2(1), CNDP1(2), HAL(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1), UROC1(3)	15452102	17	17	17	11	4	2	3	5	3	0	0.962	1.000	1.000
582	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(4), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(2)	8978040	17	16	17	11	5	1	1	9	1	0	0.973	1.000	1.000
583	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(4), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(2)	8978040	17	16	17	11	5	1	1	9	1	0	0.973	1.000	1.000
584	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), ALDH5A1(1), CAD(1), EPRS(2), GAD2(4), GFPT2(2), GNPNAT1(1), GOT1(1), NADSYN1(1), NAGK(1), QARS(1)	15437491	16	15	16	13	6	1	1	4	4	0	0.993	1.000	1.000
585	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), ALDH5A1(1), CAD(1), EPRS(2), GAD2(4), GOT1(1), NADSYN1(1), QARS(1)	12963407	12	12	12	12	5	1	1	3	2	0	0.996	1.000	1.000
586	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAA2(3), PRKAG1(2), PRKAR1A(1), PRKAR1B(1)	5991763	12	11	12	6	2	0	1	9	0	0	0.927	1.000	1.000
587	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), GNAS(2), PLCE1(2), PRKAR1A(1), PRKAR1B(1), RAP2B(1)	5761782	8	8	8	7	1	0	0	7	0	0	0.994	1.000	1.000
588	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2)	3752928	8	7	8	5	1	0	0	7	0	0	0.963	1.000	1.000
589	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLE(2), POLG(1), POLL(1), POLQ(3)	6532244	8	7	8	5	3	1	2	2	0	0	0.880	1.000	1.000
590	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(1)	2574393	7	7	7	5	0	0	0	7	0	0	0.990	1.000	1.000
591	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2E2(1), POLR1B(1), POLR2A(2), POLR3B(1), TAF5(1)	13646924	7	7	7	11	2	1	0	3	1	0	1.000	1.000	1.000
592	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	MAP2K4(1), RELA(2), RIPK1(1), TNF(1), TRAF2(3)	9457968	8	7	8	5	2	1	2	3	0	0	0.858	1.000	1.000
593	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), CFTR(1), GNAS(2), PRKAR1A(1), PRKAR1B(1)	5107439	6	6	6	7	0	1	0	5	0	0	0.998	1.000	1.000
594	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IL4(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1)	4132422	6	6	6	4	1	1	2	2	0	0	0.880	1.000	1.000
595	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1A3(1), ALDH3A1(1), AOC2(1), ARG2(1)	11497653	5	5	5	9	1	0	1	3	0	0	1.000	1.000	1.000
596	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), B4GALT1(2), B4GALT2(1), CHST4(1), ST3GAL1(2)	4886960	7	5	7	4	6	1	0	0	0	0	0.823	1.000	1.000
597	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG2(1), CKB(1), CKMT2(2)	6862442	5	5	5	7	2	0	1	2	0	0	0.994	1.000	1.000
598	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC1(1), APOBEC3B(2)	2854084	4	4	4	3	2	1	0	1	0	0	0.916	1.000	1.000
599	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH3A1(1), UGDH(1)	3338245	3	3	3	4	0	0	2	1	0	0	0.983	1.000	1.000
600	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	NQO1(1), SQLE(1)	4329877	2	2	2	4	2	0	0	0	0	0	0.988	1.000	1.000
601	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGDH(1), UGP2(1)	1914236	2	2	2	2	0	0	1	1	0	0	0.938	1.000	1.000
602	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	NOTCH1(2)	3722814	2	2	2	3	0	1	1	0	0	0	0.941	1.000	1.000
603	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	SQLE(1)	5152381	1	1	1	5	1	0	0	0	0	0	0.999	1.000	1.000
604	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1)	2123138	1	1	1	3	1	0	0	0	0	0	0.993	1.000	1.000
605	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	717133	1	1	1	2	0	0	0	1	0	0	0.985	1.000	1.000
606	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1)	1829183	1	1	1	2	0	0	0	1	0	0	0.982	1.000	1.000
607	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1)	1505542	1	1	1	2	0	0	1	0	0	0	0.972	1.000	1.000
608	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2I(1)	4107065	1	1	1	2	0	1	0	0	0	0	0.980	1.000	1.000
609	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	GOT1(1)	3036045	1	1	1	4	0	0	0	1	0	0	0.999	1.000	1.000
610	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		642057	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		1775527	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2		785675	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		665789	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10		3490639	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
615	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		1248585	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		442966	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
