Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.075 0.227 -9999.0 0.0 -0.555 13.0 13.0 IHH -0.028 0.134 -9999.0 0.0 -0.559 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.076 0.161 -9999.0 0.0 -0.334 20.0 20.0 LRPAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.076 0.16 0.332 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.094 0.16 -9999.0 0.0 -0.306 25.0 25.0 SMO -0.103 0.167 -9999.0 0.0 -0.321 27.0 27.0 AKT1 -0.049 0.103 -9999.0 0.0 -0.393 2.0 2.0 ARRB2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.008 0.084 -9999.0 0.0 -0.512 2.0 2.0 ADRBK1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.102 0.165 -9999.0 0.0 -0.317 27.0 27.0 STIL -0.089 0.156 -9999.0 0.0 -0.289 23.0 23.0 DHH N/PTCH2 -0.009 0.065 -9999.0 0.0 -0.365 2.0 2.0 DHH N/PTCH1 -0.04 0.138 -9999.0 0.0 -0.296 17.0 17.0 PIK3CA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.021 0.09 -9999.0 0.0 -0.512 2.0 2.0 PTHLH -0.126 0.347 -9999.0 0.0 -0.868 13.0 13.0 determination of left/right symmetry -0.102 0.165 -9999.0 0.0 -0.317 27.0 27.0 PIK3R1 -0.014 0.101 -9999.0 0.0 -0.512 3.0 3.0 skeletal system development -0.124 0.342 -9999.0 0.0 -0.856 13.0 13.0 IHH N/Hhip -0.083 0.173 0.146 1.0 -0.402 17.0 18.0 DHH N/Hhip -0.077 0.152 -9999.0 0.0 -0.382 15.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.102 0.165 -9999.0 0.0 -0.317 27.0 27.0 pancreas development -0.091 0.19 -9999.0 0.0 -0.511 13.0 13.0 HHAT -0.017 0.114 -9999.0 0.0 -0.512 4.0 4.0 PI3K -0.003 0.073 -9999.0 0.0 -0.365 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.127 -9999.0 0.0 -0.512 5.0 5.0 somite specification -0.102 0.165 -9999.0 0.0 -0.317 27.0 27.0 SHH Np/Cholesterol/PTCH1 -0.09 0.153 -9999.0 0.0 -0.268 31.0 31.0 SHH Np/Cholesterol/PTCH2 -0.058 0.139 -9999.0 0.0 -0.31 17.0 17.0 SHH Np/Cholesterol/Megalin -0.061 0.139 -9999.0 0.0 -0.315 17.0 17.0 SHH -0.081 0.177 -9999.0 0.0 -0.405 17.0 17.0 catabolic process -0.042 0.139 -9999.0 0.0 -0.321 15.0 15.0 SMO/Vitamin D3 -0.113 0.165 -9999.0 0.0 -0.325 19.0 19.0 SHH Np/Cholesterol/Hhip -0.105 0.192 -9999.0 0.0 -0.359 25.0 25.0 LRP2 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.107 0.164 -9999.0 0.0 -0.379 11.0 11.0 SHH Np/Cholesterol/BOC -0.065 0.144 -9999.0 0.0 -0.309 19.0 19.0 SHH Np/Cholesterol/CDO -0.069 0.148 -9999.0 0.0 -0.31 20.0 20.0 mesenchymal cell differentiation 0.104 0.19 0.357 25.0 -9999.0 0.0 25.0 mol:Vitamin D3 -0.088 0.155 -9999.0 0.0 -0.268 31.0 31.0 IHH N/PTCH2 -0.008 0.082 -9999.0 0.0 -0.332 4.0 4.0 CDON -0.016 0.102 -9999.0 0.0 -0.512 3.0 3.0 IHH N/PTCH1 -0.034 0.145 -9999.0 0.0 -0.324 15.0 15.0 Megalin/LRPAP1 0.009 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.006 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.063 0.138 -9999.0 0.0 -0.315 17.0 17.0 PTCH1 -0.042 0.14 -9999.0 0.0 -0.322 15.0 15.0 HHIP -0.091 0.191 -9999.0 0.0 -0.512 13.0 13.0