Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within HIF-1-alpha transcription factor network 13.0 1006.0 76.0 -0.312 0.015 1000.0 -1000.0 -0.072 -1000.0 Glypican 2 network 13.0 54.0 4.0 -0.103 -0.006 1000.0 -1000.0 -0.007 -1000.0 Signaling events mediated by the Hedgehog family 12.0 666.0 52.0 -0.126 0.104 1000.0 -1000.0 -0.016 -1000.0 Ephrin A reverse signaling 10.0 75.0 7.0 -0.11 -0.0 1000.0 -1000.0 -0.015 -1000.0 FOXA2 and FOXA3 transcription factor networks 10.0 462.0 46.0 -0.375 0.011 1000.0 -1000.0 -0.055 -1000.0 Wnt signaling 10.0 71.0 7.0 -0.112 -0.024 1000.0 -1000.0 -0.014 -1000.0 S1P4 pathway 9.0 231.0 25.0 -0.192 0.015 1000.0 -1000.0 -0.016 -1000.0 Noncanonical Wnt signaling pathway 8.0 228.0 26.0 -0.112 0.009 1000.0 -1000.0 -0.027 -1000.0 Glypican 1 network 8.0 385.0 48.0 -0.181 0.014 1000.0 -1000.0 -0.019 -1000.0 S1P5 pathway 8.0 141.0 17.0 -0.192 0.068 1000.0 -1000.0 -0.016 -1000.0 Syndecan-1-mediated signaling events 7.0 261.0 34.0 -0.066 0.009 1000.0 -1000.0 -0.021 -1000.0 Thromboxane A2 receptor signaling 7.0 792.0 105.0 -0.125 0.036 1000.0 -1000.0 -0.035 -1000.0 Signaling events regulated by Ret tyrosine kinase 7.0 636.0 82.0 -0.111 0.009 1000.0 -1000.0 -0.051 -1000.0 Ephrin B reverse signaling 7.0 352.0 48.0 -0.09 0.05 1000.0 -1000.0 -0.027 -1000.0 FOXM1 transcription factor network 7.0 370.0 51.0 -0.198 0.019 1000.0 -1000.0 -0.134 -1000.0 IL12-mediated signaling events 6.0 525.0 87.0 -0.15 0.009 1000.0 -1000.0 -0.086 -1000.0 Osteopontin-mediated events 6.0 249.0 38.0 -0.071 0.009 1000.0 -1000.0 -0.047 -1000.0 BMP receptor signaling 6.0 542.0 81.0 -0.163 0.018 1000.0 -1000.0 -0.047 -1000.0 EPO signaling pathway 6.0 360.0 55.0 -0.057 0.009 1000.0 -1000.0 -0.041 -1000.0 Signaling mediated by p38-alpha and p38-beta 6.0 284.0 44.0 -0.132 0.009 1000.0 -1000.0 -0.019 -1000.0 TCR signaling in naïve CD8+ T cells 6.0 599.0 93.0 -0.094 0.013 1000.0 -1000.0 -0.043 -1000.0 EPHB forward signaling 6.0 561.0 85.0 -0.111 0.062 1000.0 -1000.0 -0.048 -1000.0 Nongenotropic Androgen signaling 6.0 335.0 52.0 -0.192 0.022 1000.0 -1000.0 -0.025 -1000.0 EGFR-dependent Endothelin signaling events 6.0 131.0 21.0 -0.076 0.013 1000.0 -1000.0 -0.028 -1000.0 Class IB PI3K non-lipid kinase events 6.0 18.0 3.0 -0.044 -1000.0 1000.0 -1000.0 -0.006 -1000.0 Ras signaling in the CD4+ TCR pathway 6.0 106.0 17.0 -0.08 0.017 1000.0 -1000.0 -0.02 -1000.0 Fc-epsilon receptor I signaling in mast cells 5.0 521.0 97.0 -0.102 0.024 1000.0 -1000.0 -0.046 -1000.0 S1P1 pathway 5.0 184.0 36.0 -0.193 0.011 1000.0 -1000.0 -0.031 -1000.0 Signaling mediated by p38-gamma and p38-delta 5.0 78.0 15.0 -0.072 0.011 1000.0 -1000.0 -0.013 -1000.0 LPA receptor mediated events 5.0 518.0 102.0 -0.137 0.014 1000.0 -1000.0 -0.043 -1000.0 IL6-mediated signaling events 5.0 384.0 75.0 -0.246 0.031 1000.0 -1000.0 -0.043 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 5.0 372.0 68.0 -0.141 0.041 1000.0 -1000.0 -0.082 -1000.0 BCR signaling pathway 5.0 523.0 99.0 -0.103 0.01 1000.0 -1000.0 -0.046 -1000.0 IGF1 pathway 5.0 318.0 57.0 -0.061 0.019 1000.0 -1000.0 -0.046 -1000.0 IL23-mediated signaling events 5.0 304.0 60.0 -0.154 0.014 1000.0 -1000.0 -0.115 -1000.0 Plasma membrane estrogen receptor signaling 5.0 438.0 86.0 -0.213 0.067 1000.0 -1000.0 -0.046 -1000.0 S1P3 pathway 5.0 236.0 42.0 -0.192 0.016 1000.0 -1000.0 -0.028 -1000.0 Aurora B signaling 5.0 397.0 67.0 -0.114 0.009 1000.0 -1000.0 -0.03 -1000.0 ErbB2/ErbB3 signaling events 4.0 270.0 65.0 -0.066 0.02 1000.0 -1000.0 -0.031 -1000.0 Coregulation of Androgen receptor activity 4.0 309.0 76.0 -0.151 0.034 1000.0 -1000.0 -0.021 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 4.0 148.0 34.0 -0.039 0.009 1000.0 -1000.0 -0.018 -1000.0 p75(NTR)-mediated signaling 4.0 560.0 125.0 -0.169 0.027 1000.0 -1000.0 -0.047 -1000.0 PDGFR-alpha signaling pathway 4.0 210.0 44.0 -0.068 0.015 1000.0 -1000.0 -0.037 -1000.0 amb2 Integrin signaling 4.0 377.0 82.0 -0.077 0.012 1000.0 -1000.0 -0.039 -1000.0 Reelin signaling pathway 4.0 263.0 56.0 -0.076 0.02 1000.0 -1000.0 -0.03 -1000.0 Endothelins 4.0 428.0 96.0 -0.204 0.016 1000.0 -1000.0 -0.051 -1000.0 Integrins in angiogenesis 4.0 378.0 84.0 -0.117 0.013 1000.0 -1000.0 -0.042 -1000.0 Syndecan-4-mediated signaling events 4.0 272.0 67.0 -0.103 0.012 1000.0 -1000.0 -0.033 -1000.0 Angiopoietin receptor Tie2-mediated signaling 4.0 379.0 88.0 -0.186 0.012 1000.0 -1000.0 -0.067 -1000.0 Caspase cascade in apoptosis 3.0 233.0 74.0 -0.031 0.026 1000.0 -1000.0 -0.02 -1000.0 JNK signaling in the CD4+ TCR pathway 3.0 51.0 17.0 -0.039 0.014 1000.0 -1000.0 -0.016 -1000.0 Syndecan-2-mediated signaling events 3.0 223.0 69.0 -0.04 0.011 1000.0 -1000.0 -0.015 -1000.0 Arf6 signaling events 3.0 218.0 62.0 -0.098 0.021 1000.0 -1000.0 -0.022 -1000.0 Hedgehog signaling events mediated by Gli proteins 3.0 209.0 65.0 -0.193 0.051 1000.0 -1000.0 -0.044 -1000.0 Aurora C signaling 3.0 23.0 7.0 -0.065 0.0 1000.0 -1000.0 -0.014 -1000.0 IL4-mediated signaling events 3.0 335.0 91.0 -0.305 0.124 1000.0 -1000.0 -0.128 -1000.0 Nectin adhesion pathway 3.0 192.0 63.0 -0.047 0.014 1000.0 -1000.0 -0.045 -1000.0 Glucocorticoid receptor regulatory network 3.0 350.0 114.0 -0.15 0.035 1000.0 -1000.0 -0.043 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 3.0 147.0 37.0 -0.077 0.017 1000.0 -1000.0 -0.022 -1000.0 HIF-2-alpha transcription factor network 3.0 132.0 43.0 -0.067 0.018 1000.0 -1000.0 -0.052 -1000.0 Retinoic acid receptors-mediated signaling 3.0 174.0 58.0 -0.043 0.018 1000.0 -1000.0 -0.033 -1000.0 Syndecan-3-mediated signaling events 3.0 128.0 35.0 -0.125 0.027 1000.0 -1000.0 -0.018 -1000.0 IL2 signaling events mediated by STAT5 3.0 72.0 22.0 -0.077 0.009 1000.0 -1000.0 -0.026 -1000.0 TCGA08_retinoblastoma 3.0 30.0 8.0 -0.016 0.007 1000.0 -1000.0 -0.008 -1000.0 Visual signal transduction: Rods 3.0 194.0 52.0 -0.075 0.009 1000.0 -1000.0 -0.036 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 3.0 281.0 78.0 -0.062 0.021 1000.0 -1000.0 -0.045 -1000.0 ErbB4 signaling events 2.0 205.0 69.0 -0.131 0.028 1000.0 -1000.0 -0.041 -1000.0 Sphingosine 1-phosphate (S1P) pathway 2.0 82.0 28.0 -0.192 0.023 1000.0 -1000.0 -0.016 -1000.0 Visual signal transduction: Cones 2.0 94.0 38.0 -0.058 0.012 1000.0 -1000.0 -0.019 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 2.0 139.0 54.0 -0.076 0.017 1000.0 -1000.0 -0.043 -1000.0 a4b1 and a4b7 Integrin signaling 2.0 10.0 5.0 -0.012 0.002 1000.0 -1000.0 -0.006 -1000.0 Cellular roles of Anthrax toxin 2.0 80.0 39.0 -0.05 0.01 1000.0 -1000.0 -0.014 -1000.0 Signaling events mediated by PTP1B 2.0 220.0 76.0 -0.143 0.014 1000.0 -1000.0 -0.044 -1000.0 PLK1 signaling events 2.0 228.0 85.0 -0.054 0.014 1000.0 -1000.0 -0.03 -1000.0 TRAIL signaling pathway 2.0 136.0 48.0 -0.05 0.017 1000.0 -1000.0 -0.033 -1000.0 IL1-mediated signaling events 2.0 164.0 62.0 -0.075 0.039 1000.0 -1000.0 -0.037 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 2.0 138.0 52.0 -0.07 0.031 1000.0 -1000.0 -0.026 -1000.0 TCGA08_p53 2.0 20.0 7.0 -0.013 0.012 1000.0 -1000.0 -0.004 -1000.0 IL2 signaling events mediated by PI3K 2.0 135.0 58.0 -0.085 0.013 1000.0 -1000.0 -0.052 -1000.0 Canonical Wnt signaling pathway 2.0 108.0 51.0 -0.08 0.038 1000.0 -1000.0 -0.032 -1000.0 Calcium signaling in the CD4+ TCR pathway 2.0 64.0 31.0 -0.053 0.009 1000.0 -1000.0 -0.036 -1000.0 TCGA08_rtk_signaling 2.0 52.0 26.0 -0.046 0.026 1000.0 -1000.0 -0.012 -1000.0 Insulin Pathway 2.0 150.0 74.0 -0.186 0.024 1000.0 -1000.0 -0.044 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 2.0 323.0 120.0 -0.117 0.101 1000.0 -1000.0 -0.039 -1000.0 Regulation of Androgen receptor activity 2.0 151.0 70.0 -0.141 0.019 1000.0 -1000.0 -0.034 -1000.0 LPA4-mediated signaling events 1.0 21.0 12.0 -0.021 0.012 1000.0 -1000.0 -0.011 -1000.0 Regulation of nuclear SMAD2/3 signaling 1.0 155.0 136.0 -0.095 0.094 1000.0 -1000.0 -0.035 -1000.0 BARD1 signaling events 1.0 102.0 57.0 -0.019 0.025 1000.0 -1000.0 -0.029 -1000.0 Circadian rhythm pathway 1.0 38.0 22.0 -0.037 0.012 1000.0 -1000.0 -0.032 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 1.0 142.0 85.0 -0.027 0.015 1000.0 -1000.0 -0.042 -1000.0 Presenilin action in Notch and Wnt signaling 1.0 111.0 61.0 -0.08 0.028 1000.0 -1000.0 -0.037 -1000.0 Aurora A signaling 1.0 88.0 60.0 -0.084 0.03 1000.0 -1000.0 -0.011 -1000.0 mTOR signaling pathway 1.0 65.0 53.0 -0.017 0.014 1000.0 -1000.0 -0.032 -1000.0 IFN-gamma pathway 1.0 69.0 68.0 -0.054 0.038 1000.0 -1000.0 -0.054 -1000.0 Ceramide signaling pathway 1.0 116.0 76.0 -0.076 0.03 1000.0 -1000.0 -0.02 -1000.0 Signaling events mediated by HDAC Class III 1.0 76.0 40.0 -0.12 0.02 1000.0 -1000.0 -0.01 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 100.0 83.0 -0.079 0.034 1000.0 -1000.0 -0.034 -1000.0 FAS signaling pathway (CD95) 1.0 88.0 47.0 -0.058 0.013 1000.0 -1000.0 -0.021 -1000.0 Paxillin-dependent events mediated by a4b1 1.0 68.0 36.0 -0.077 0.021 1000.0 -1000.0 -0.037 -1000.0 Atypical NF-kappaB pathway 1.0 41.0 31.0 -0.014 0.019 1000.0 -1000.0 -0.013 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 1.0 45.0 45.0 -0.021 0.039 1000.0 -1000.0 -0.047 -1000.0 Regulation of p38-alpha and p38-beta 1.0 66.0 54.0 -0.059 0.023 1000.0 -1000.0 -0.036 -1000.0 Effects of Botulinum toxin 1.0 30.0 26.0 -0.063 0.016 1000.0 -1000.0 -0.027 -1000.0 IL27-mediated signaling events 1.0 68.0 51.0 -0.101 0.018 1000.0 -1000.0 -0.047 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 1.0 104.0 74.0 -0.076 0.036 1000.0 -1000.0 -0.046 -1000.0 E-cadherin signaling in the nascent adherens junction 1.0 83.0 76.0 -0.039 0.027 1000.0 -1000.0 -0.045 -1000.0 Class I PI3K signaling events 1.0 88.0 73.0 -0.059 0.02 1000.0 -1000.0 -0.029 -1000.0 Regulation of Telomerase 1.0 180.0 102.0 -0.17 0.026 1000.0 -1000.0 -0.074 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 1.0 40.0 33.0 -0.069 0.027 1000.0 -1000.0 -0.023 -1000.0 PDGFR-beta signaling pathway 1.0 110.0 97.0 -0.111 0.036 1000.0 -1000.0 -0.044 -1000.0 E-cadherin signaling in keratinocytes 1.0 52.0 43.0 -0.016 0.023 1000.0 -1000.0 -0.026 -1000.0 p38 MAPK signaling pathway 1.0 51.0 44.0 -0.054 0.017 1000.0 -1000.0 -0.04 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 4.0 23.0 -0.004 0.03 1000.0 -1000.0 -0.019 -1000.0 Canonical NF-kappaB pathway 0.0 15.0 39.0 -0.045 0.032 1000.0 -1000.0 -0.038 -1000.0 Signaling events mediated by HDAC Class II 0.0 22.0 75.0 -0.034 0.023 1000.0 -1000.0 -0.022 -1000.0 PLK2 and PLK4 events 0.0 2.0 3.0 0.002 0.01 1000.0 -1000.0 -0.009 -1000.0 Arf6 downstream pathway 0.0 7.0 43.0 -0.019 0.019 1000.0 -1000.0 -0.02 -1000.0 Insulin-mediated glucose transport 0.0 29.0 32.0 -0.035 0.023 1000.0 -1000.0 -0.029 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 34.0 68.0 -0.022 0.029 1000.0 -1000.0 -0.023 -1000.0 ceramide signaling pathway 0.0 24.0 49.0 -0.006 0.03 1000.0 -1000.0 -0.021 -1000.0 Signaling events mediated by HDAC Class I 0.0 15.0 104.0 -0.034 0.033 1000.0 -1000.0 -0.025 -1000.0 FoxO family signaling 0.0 57.0 64.0 -0.058 0.054 1000.0 -1000.0 -0.043 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 109.0 125.0 -0.05 0.04 1000.0 -1000.0 -0.049 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 0.0 27.0 -0.0 0.023 1000.0 -1000.0 -0.028 -1000.0 Arf6 trafficking events 0.0 28.0 71.0 -0.042 0.028 1000.0 -1000.0 -0.038 -1000.0 VEGFR1 specific signals 0.0 45.0 56.0 -0.017 0.034 1000.0 -1000.0 -0.028 -1000.0 Rapid glucocorticoid signaling 0.0 18.0 20.0 -0.023 0.013 1000.0 -1000.0 -0.01 -1000.0 Signaling events mediated by PRL 0.0 23.0 34.0 -0.02 0.013 1000.0 -1000.0 -0.018 -1000.0 E-cadherin signaling events 0.0 0.0 5.0 -0.004 0.021 1000.0 -1000.0 -0.006 -1000.0 Arf1 pathway 0.0 9.0 54.0 -0.019 0.017 1000.0 -1000.0 -0.013 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 0.0 0.027 1000.0 -1000.0 -0.01 -1000.0 Total 422 25436 7203 -11.8307746932 -996.950843525 131000 -131000 -4.42143123948 -131000