rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(1), ALPPL2(8), FPGS(14), SPR(1)	931966	25	23	7	2	0	9	3	13	0	0	0.0413	2.04e-13	1.26e-10
2	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), PRDX1(1), PRDX2(2), TPO(22)	1351480	26	25	7	2	3	0	21	0	2	0	0.0159	4.19e-09	1.29e-06
3	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), TPO(22)	1167797	23	22	4	2	2	0	21	0	0	0	0.0181	5.28e-08	1.08e-05
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CDKN2A(2), MDM2(2), TP53(18)	1136927	23	18	23	2	2	0	7	1	12	1	0.105	4.33e-07	6.66e-05
5	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), EPX(1), PRDX1(1), PRDX2(2), SHMT2(1), TPO(22)	1646854	28	27	9	3	4	0	22	0	2	0	0.0251	5.82e-07	7.17e-05
6	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(1), DAXX(4), PML(2), RARA(1), RB1(2), SIRT1(1), TNFRSF1A(1), TP53(18)	2581860	30	24	30	2	3	1	7	1	17	1	0.0464	8.93e-07	9.17e-05
7	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	NFKB1(1), TP53(18)	1406891	19	17	19	1	2	0	5	1	10	1	0.122	3.09e-06	0.000272
8	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(5), ATR(3), CHEK2(2), TP53(18)	2129466	28	24	28	4	3	0	6	3	15	1	0.479	4.06e-06	0.000308
9	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(5), MDM2(2), RB1(2), TIMP3(1), TP53(18)	2444225	29	23	29	3	2	0	6	1	19	1	0.214	4.50e-06	0.000308
10	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(5), GNB1(2), PRKACA(1), PRKAR1A(7)	931484	16	15	15	2	1	0	3	2	10	0	0.512	5.89e-05	0.00360
11	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(5), RB1(2), TP53(18)	2397901	25	22	25	6	2	0	5	1	16	1	0.785	6.44e-05	0.00360
12	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), IDI1(5), SQLE(2)	454373	8	8	5	0	0	1	7	0	0	0	0.120	0.000113	0.00580
13	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), MTHFR(1), SHMT2(1), TPO(22)	1601190	25	24	6	4	4	0	21	0	0	0	0.0698	0.000142	0.00675
14	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GNS(2), GUSB(1), HEXB(1), IDS(1), IDUA(15), LCT(1)	2024755	22	18	11	2	4	1	2	15	0	0	0.0605	0.000208	0.00917
15	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	AOC3(1), EPX(1), GOT1(1), GOT2(2), MAOA(3), PRDX1(1), PRDX2(2), TPO(22)	3081182	33	30	14	4	6	0	23	0	4	0	0.0222	0.000229	0.00942
16	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), IDI1(5), SQLE(2)	597161	8	8	5	0	0	1	7	0	0	0	0.123	0.000619	0.0238
17	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(4), CTNNB1(14), DLL1(1), DVL1(1), FZD1(6), NOTCH1(4), WNT1(2)	3041380	32	25	21	4	1	1	9	7	14	0	0.393	0.000700	0.0254
18	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(2), MDM2(2), PIK3CA(1), PIK3R1(1), POLR1A(1), POLR1C(2), RB1(2), TBX2(1), TP53(18)	2752754	30	24	30	5	3	0	10	2	14	1	0.272	0.00194	0.0664
19	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(2), BCAR1(1), CSK(1), CTNNA2(1), CTNNB1(14)	2729020	21	20	16	2	1	1	9	6	4	0	0.135	0.00308	0.0998
20	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(4), CD14(1), CTNNB1(14), DVL1(1), FZD1(6), GJA1(2), IRAK1(2), LBP(1), NFKB1(1), PIK3CA(1), PIK3R1(1), TLR4(3), WNT1(2)	4254910	39	29	28	4	0	1	14	11	13	0	0.174	0.00338	0.104
21	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(1), ATM(5), IGFBP3(1), MDM2(2), TP53(18)	2860933	27	20	27	9	3	0	6	2	15	1	0.887	0.00557	0.163
22	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(5), GNB1(2), PRKAA2(1), PRKACB(1), PRKAG2(3), PRKAR1A(7)	2150867	20	17	19	3	2	1	4	2	11	0	0.461	0.00690	0.191
23	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(5), CHEK2(2), MDM2(2), MRE11A(1), NFKB1(1), RAD50(3), RAD51(1), RBBP8(1), TP53(18), TP73(1)	4044941	35	25	35	5	3	0	10	3	18	1	0.341	0.00714	0.191
24	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	98644	2	2	2	0	1	0	0	0	1	0	0.514	0.0140	0.360
25	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), HSD17B1(5), HSD17B4(3), HSD17B7(2)	1109816	11	9	7	2	6	0	3	1	1	0	0.260	0.0182	0.449
26	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(1), BCL2L1(2), CASP8(1), FADD(2), GZMB(1), MAP3K1(2), MDM2(2), NFKB1(1), PARP1(3), TNFRSF1A(1), TP53(18)	5155929	34	25	34	4	6	1	11	1	14	1	0.0724	0.0204	0.483
27	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), CFTR(2), GNAS(5), PRKACB(1), PRKAR1A(7), SLC9A3R1(1)	1829960	17	14	16	3	1	0	3	2	11	0	0.584	0.0214	0.488
28	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), GZMB(1), HLA-A(4), ICAM1(1), ITGAL(1)	1205170	9	9	8	1	3	0	2	2	2	0	0.300	0.0253	0.543
29	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(5), GNB1(2), PRKACB(1), PRKAR1A(7)	1377337	16	14	15	3	1	0	3	2	10	0	0.663	0.0256	0.543
30	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(1), ATM(5), BCL2L1(2), TLN1(2), TP53(18)	3746024	28	22	28	6	4	0	6	1	16	1	0.610	0.0328	0.673
31	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2I(1), GTF2IRD1(1), STON1(1), TAF1(5), TAF1L(1), TAF4(1), TAF4B(1), TAF5(12), TAF7L(1), TBPL2(1)	4904385	25	21	14	1	2	0	8	13	2	0	0.0150	0.0356	0.690
32	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), HMGCR(1), IDI1(5), NQO2(1), SQLE(2)	1576060	11	10	8	1	0	1	8	0	2	0	0.212	0.0358	0.690
33	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(1), HMGCR(1), IDI1(5), NSDHL(1), SQLE(2)	1863747	11	11	8	1	0	1	8	1	1	0	0.236	0.0400	0.747
34	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), MAP2K3(2), NFATC1(1), PRKACB(1), PRKAR1A(7)	1676928	13	9	12	1	0	0	3	1	9	0	0.356	0.0576	1.000
35	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GNS(2), GUSB(1), HEXB(1), IDS(1), IDUA(15), LCT(1)	2901053	22	18	11	3	4	1	2	15	0	0	0.137	0.0634	1.000
36	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRB1(3)	332581	3	3	3	1	0	0	2	1	0	0	0.742	0.0649	1.000
37	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX5(3), CYP4F2(1), CYP4F3(1), EPX(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PRDX1(1), PRDX2(2), PTGDS(1), PTGS1(1), PTGS2(2), TPO(22)	3952812	44	35	25	9	5	1	29	3	6	0	0.121	0.0650	1.000
38	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1B(1), GLI2(2), GLI3(9), PRKACB(1), PRKAR1A(7), SHH(2), SMO(3), SUFU(1)	2273832	26	19	19	5	11	1	6	0	8	0	0.152	0.0780	1.000
39	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRB1(3), IL3(1)	411853	6	5	6	2	0	0	4	2	0	0	0.680	0.0876	1.000
40	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	GRM1(3), PLCB1(3), PPP1CA(2), PRKACB(1), PRKAR1A(7)	2210196	16	12	15	3	1	0	2	2	11	0	0.602	0.0890	1.000
41	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(1), HADHA(1), SDS(1)	672997	6	5	6	1	1	0	2	1	2	0	0.541	0.0954	1.000
42	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	GLUD1(1), PRODH(4)	817853	5	5	4	0	1	1	0	3	0	0	0.252	0.0975	1.000
43	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(5), FUCA2(1), HEXB(1), LCT(1), MANBA(2)	2330979	11	11	10	0	2	2	1	5	1	0	0.0616	0.109	1.000
44	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(1), GOT2(2), LDHA(3)	920795	7	7	7	2	3	0	2	1	1	0	0.652	0.110	1.000
45	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(2)	360688	3	3	3	0	2	0	1	0	0	0	0.399	0.115	1.000
46	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(3), IGF1R(1), RB1(2), TEP1(2), TERT(1), TNKS(1), TP53(18)	3828181	28	21	28	6	5	1	7	1	13	1	0.388	0.119	1.000
47	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS2(1), SUOX(2)	824400	6	5	6	1	0	0	3	0	2	1	0.783	0.126	1.000
48	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(1), GNAS(5), PLCE1(2), PRKACB(1), PRKAR1A(7), RAP2B(1)	2094377	17	13	16	3	1	0	4	2	10	0	0.566	0.130	1.000
49	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	PRKACB(1), PRKAR1A(7)	1765846	8	8	7	9	0	0	0	0	8	0	1.000	0.135	1.000
50	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), CREBBP(1), CTNNB1(14), DVL1(1), EP300(2), FZD1(6), HDAC1(1), LDB1(1), PITX2(3), TRRAP(1), WNT1(2)	4566579	36	27	26	5	3	0	12	7	14	0	0.341	0.136	1.000
51	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1)	975354	7	6	7	0	1	0	4	0	2	0	0.215	0.141	1.000
52	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(5), ATR(3), BRCA2(1), CHEK2(2), FANCF(1), MRE11A(1), RAD1(1), RAD17(1), RAD50(3), RAD51(1), RAD9A(1), TP53(18)	5960111	38	30	38	9	5	0	7	6	19	1	0.775	0.149	1.000
53	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(3), FUT6(2)	715421	5	5	5	1	2	0	2	1	0	0	0.442	0.155	1.000
54	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), DPYD(2), DPYS(2), PANK2(15), PPCS(1)	1908365	22	20	9	5	1	0	17	2	2	0	0.451	0.168	1.000
55	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(1), GOT1(1), GOT2(2)	1131322	6	6	6	1	3	0	1	2	0	0	0.436	0.168	1.000
56	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(1), HADHB(1), HSD17B4(3), MECR(1)	1183470	9	7	9	0	0	0	5	2	2	0	0.138	0.175	1.000
57	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(5), FUCA2(1), GALNS(1), GNS(2), GUSB(1), HEXB(1), IDS(1), IDUA(15), LCT(1), MAN2B1(1), MANBA(2)	4925288	32	23	20	4	5	4	2	20	1	0	0.0704	0.187	1.000
58	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(4), BMPR1A(2), BMPR2(1), CHRD(2), CTNNB1(14), DVL1(1), FZD1(6), GATA4(2), MEF2C(2), NKX2-5(1), NOG(1), RFC1(1), TGFBR2(2), TGFBR3(4), WNT1(2)	5054719	46	29	36	9	2	1	16	11	16	0	0.571	0.196	1.000
59	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(3)	835413	5	5	5	1	2	0	2	0	1	0	0.407	0.215	1.000
60	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	AOC3(1), EPX(1), ESCO2(1), GOT1(1), GOT2(2), MAOA(3), MIF(3), PNPLA3(2), TPO(22)	4689810	36	31	16	6	5	0	27	2	2	0	0.0794	0.229	1.000
61	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(5), FUCA2(1), HEXB(1), LCT(1), MAN2B1(1), MANBA(2)	2878376	12	11	11	1	2	3	1	5	1	0	0.179	0.234	1.000
62	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), GOT1(1), GOT2(2), HGD(1), MAOA(3), TH(3), TPO(22)	4419306	39	31	20	8	7	0	27	1	4	0	0.110	0.235	1.000
63	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(1), EP300(2), PRKACB(1), PRKAR1A(7), RARA(1)	2841876	12	11	11	4	0	0	2	0	10	0	0.954	0.258	1.000
64	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(2), CHIT1(3), CTBS(1), GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3), LHPP(2), MTMR1(1), MTMR2(1)	3988034	21	19	19	4	1	3	10	2	5	0	0.309	0.276	1.000
65	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), HLA-DRB1(3)	734916	5	4	5	2	0	0	3	2	0	0	0.778	0.287	1.000
66	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	BDKRB2(1), KNG1(1), NOS3(4)	1392698	6	6	6	1	2	1	2	1	0	0	0.356	0.297	1.000
67	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(1), SIRT1(1)	1646424	11	8	11	0	0	0	6	2	3	0	0.0870	0.303	1.000
68	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FSHR(1), GNAS(5), XPO1(1)	1325962	8	7	8	1	2	0	2	2	2	0	0.463	0.305	1.000
69	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	160064	1	1	1	0	0	0	1	0	0	0	0.783	0.342	1.000
70	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), GOT2(2)	642963	3	3	3	0	2	0	1	0	0	0	0.386	0.344	1.000
71	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), SDS(1)	1156648	6	5	6	1	1	0	2	1	2	0	0.567	0.349	1.000
72	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRB1(3), IL2(1)	550667	4	4	4	2	0	0	3	1	0	0	0.833	0.369	1.000
73	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), NFKB1(1), NOX1(1), XDH(3)	1402971	7	6	7	0	0	0	5	1	1	0	0.190	0.372	1.000
74	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), DPYD(2), DPYS(2), PANK2(15), PPCS(1), VNN1(1)	2385694	24	21	11	6	1	0	19	2	2	0	0.477	0.373	1.000
75	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	224397	1	1	1	0	0	0	1	0	0	0	0.772	0.379	1.000
76	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), RB1(2)	898917	3	3	3	1	0	0	1	0	2	0	0.824	0.386	1.000
77	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(1), B3GALT5(1), FUT3(3)	999590	5	5	5	0	2	0	2	1	0	0	0.210	0.389	1.000
78	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	231535	1	1	1	0	1	0	0	0	0	0	0.652	0.395	1.000
79	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3)	2357997	9	9	9	1	1	0	6	1	1	0	0.256	0.413	1.000
80	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(1)	682537	3	3	3	0	0	0	2	0	1	0	0.608	0.423	1.000
81	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD1(1), GLUD2(1)	617313	2	2	2	0	1	0	0	1	0	0	0.570	0.425	1.000
82	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(5), BMPR1B(1), CCND2(1), CEBPB(1), EGR1(2), FSHR(1), GJA4(1), MLH1(2), NCOR1(1), NR5A1(2), NRIP1(3), PGR(1), VDR(1)	4741926	22	16	22	3	2	2	8	1	9	0	0.296	0.430	1.000
83	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	FADS2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1)	1476693	8	7	8	0	1	0	3	1	3	0	0.169	0.431	1.000
84	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	204771	1	1	1	0	0	0	0	0	1	0	1.000	0.433	1.000
85	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(7), NDUFA12(1), NDUFB11(2)	581523	10	8	5	3	0	0	10	0	0	0	0.683	0.436	1.000
86	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	CMA1(1), CPA3(1), CTSA(2), ENPEP(3), LNPEP(1), MME(4), NLN(3)	2905448	15	13	15	3	1	2	9	1	1	1	0.325	0.440	1.000
87	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(1)	855203	5	4	5	0	1	1	2	1	0	0	0.278	0.444	1.000
88	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), DAXX(4)	1527421	5	5	5	1	0	1	0	0	4	0	0.715	0.456	1.000
89	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), EP300(2), EPO(1), LDHA(3), NOS3(4), P4HB(1)	2328228	12	11	12	2	1	1	5	3	2	0	0.365	0.462	1.000
90	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(3), HK3(3)	1448643	6	6	6	1	0	0	4	1	1	0	0.461	0.468	1.000
91	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(3), MAP2(2), PPP1CA(2), PRKACB(1)	2287748	8	8	8	1	0	0	3	1	4	0	0.649	0.469	1.000
92	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(2), EHHADH(1), HADHA(1), SDHB(1), SDS(1)	1070591	6	5	6	2	1	0	2	1	2	0	0.780	0.469	1.000
93	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(1), EGR3(1), MAP3K1(2), NFATC1(1), NFKB1(1), PLCG1(3), PPP3CB(1), PRKACB(1), PRKAR1A(7), VIP(1), VIPR2(1)	3827586	20	16	19	4	3	0	7	2	8	0	0.406	0.472	1.000
94	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ECHS1(2), HADHA(1)	747311	3	3	3	0	0	0	1	0	2	0	0.644	0.479	1.000
95	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(2), GPT(1), LDHA(3)	1258485	6	6	6	1	1	0	3	2	0	0	0.476	0.485	1.000
96	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(4), CREBBP(1), CTNNB1(14), DVL1(1), FZD1(6), HDAC1(1), WIF1(1), WNT1(2)	4178905	30	26	20	6	0	0	10	7	13	0	0.753	0.500	1.000
97	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(2), LEPR(2), PRKAA2(1), PRKAG2(3)	1965351	8	7	8	1	2	1	3	0	2	0	0.400	0.508	1.000
98	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), CASP8(1), DFFA(1), GZMB(1), SCAP(4), SREBF2(2)	2606053	10	9	10	1	3	0	1	0	6	0	0.457	0.509	1.000
99	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	527377	3	2	3	0	0	0	1	0	2	0	0.437	0.510	1.000
100	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(1), MTMR2(1)	879691	4	4	3	2	0	3	0	0	1	0	0.872	0.519	1.000
101	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	NDUFA1(1), SDHA(1), SDHB(1), SDHD(1)	892258	4	3	4	1	0	0	2	2	0	0	0.697	0.520	1.000
102	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2B5(1), PPP1CA(2)	1565927	6	5	6	0	0	0	1	1	4	0	0.621	0.546	1.000
103	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCND2(1), CDKN2A(2), RB1(2), RBL1(1), TFDP1(1)	2172211	7	7	7	1	3	0	1	0	3	0	0.377	0.551	1.000
104	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), PRKAR1A(7), ZAP70(1)	3217980	24	18	23	6	1	0	9	3	11	0	0.655	0.600	1.000
105	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), PRKAR1A(7), ZAP70(1)	3217980	24	18	23	6	1	0	9	3	11	0	0.655	0.600	1.000
106	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(1)	274454	1	1	1	1	0	0	1	0	0	0	0.947	0.605	1.000
107	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL2L1(2), BCL2L11(1), CES1(1)	1569828	5	5	5	1	2	0	0	0	3	0	0.567	0.610	1.000
108	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), BCL2L1(2), CSF2RB(1), IGF1R(1), IL3(1), PIK3CA(1), PIK3R1(1), PRKACB(1), PRKAR1A(7)	3020520	16	14	15	5	2	0	3	2	9	0	0.827	0.623	1.000
109	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), KARS(1)	633927	2	2	2	1	1	0	1	0	0	0	0.863	0.628	1.000
110	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(2), SCAP(4), SREBF2(2)	1748855	9	6	9	1	3	0	2	0	4	0	0.424	0.640	1.000
111	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD8A(1), IL3(1)	855564	3	3	3	0	0	1	2	0	0	0	0.400	0.642	1.000
112	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(1), DFFA(1), GZMB(1)	1469864	5	5	5	1	2	0	2	1	0	0	0.507	0.645	1.000
113	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(2), MMP9(1), RECK(1), TIMP3(1)	1061594	5	4	5	2	2	0	1	0	2	0	0.843	0.651	1.000
114	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR171(1), GPR34(1), GPR39(2), GPR68(1), GPR75(1)	1356933	7	6	7	2	1	0	5	1	0	0	0.511	0.653	1.000
115	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3)	1065202	3	3	3	0	0	0	1	2	0	0	0.475	0.663	1.000
116	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(1), GBGT1(2), HEXB(1), ST3GAL1(1)	1469519	7	6	7	1	2	0	3	1	1	0	0.397	0.673	1.000
117	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(2), GABRA2(2), GABRA6(2), GPX1(1)	897238	7	6	7	3	0	0	6	1	0	0	0.808	0.683	1.000
118	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), CASP8(1), FADD(2), TNFRSF1A(1)	1155569	5	5	5	2	1	1	1	0	2	0	0.876	0.685	1.000
119	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), SNCAIP(1)	864719	2	2	2	1	0	0	2	0	0	0	0.877	0.692	1.000
120	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	517587	1	1	1	1	0	0	0	0	1	0	1.000	0.693	1.000
121	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(1), LARS(1), LARS2(1), PDHB(1)	1362163	6	6	6	2	0	0	2	3	1	0	0.829	0.693	1.000
122	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	RB1(2), TFDP1(1)	1162888	3	3	3	1	1	0	0	0	2	0	0.693	0.701	1.000
123	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1)	431503	1	1	1	0	0	0	1	0	0	0	0.759	0.705	1.000
124	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	RB1(2), TFDP1(1)	1182150	3	3	3	1	1	0	0	0	2	0	0.685	0.708	1.000
125	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT5(2), ST3GAL1(1)	1072831	3	3	3	0	1	0	0	2	0	0	0.493	0.709	1.000
126	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5)	1885266	5	5	5	5	0	0	1	0	4	0	0.999	0.715	1.000
127	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(1)	447106	1	1	1	0	0	0	1	0	0	0	0.745	0.716	1.000
128	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	DFFA(1), GZMB(1), TOP2A(1)	1406398	3	3	3	1	2	0	1	0	0	0	0.782	0.718	1.000
129	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(1), CTH(1), GOT1(1), GOT2(2), LDHA(3), SDS(1)	1736578	9	9	9	3	4	0	2	2	1	0	0.663	0.719	1.000
130	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	308646	1	1	1	0	0	0	1	0	0	0	0.764	0.723	1.000
131	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1)	776498	2	2	2	0	1	0	0	1	0	0	0.564	0.729	1.000
132	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1)	532068	1	1	1	1	0	0	1	0	0	0	0.928	0.741	1.000
133	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSB(1), GOT1(1), GOT2(2)	1202692	5	5	5	2	2	0	1	1	1	0	0.816	0.747	1.000
134	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(3), CHST11(1), CHST13(3), PAPSS2(1), SUOX(2)	1252465	10	8	9	4	0	0	4	3	2	1	0.886	0.751	1.000
135	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPS(1), CHPT1(2), ENPP2(2), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PPAP2C(1)	3271826	14	10	14	1	2	0	8	2	2	0	0.102	0.755	1.000
136	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	G6PD(2), GPX1(1), GPX7(1), GSS(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), OPLAH(3)	3177850	15	12	14	3	4	1	4	1	5	0	0.480	0.764	1.000
137	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	GOT1(1), GOT2(2), GPT(1), GPT2(2), MDH2(1), PGK2(3), RPIA(1), TKTL2(3)	2792787	14	10	13	4	3	2	6	1	2	0	0.532	0.772	1.000
138	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(1), DBH(2), MAOA(3), SLC18A3(1), TH(3)	2021928	11	9	11	3	2	1	5	0	3	0	0.529	0.772	1.000
139	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	464414	1	1	1	0	0	0	0	1	0	0	0.737	0.776	1.000
140	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH6(1), ADH7(2)	764432	3	3	3	5	1	0	0	1	1	0	0.999	0.776	1.000
141	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1)	812156	2	2	2	0	0	0	2	0	0	0	0.558	0.778	1.000
142	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BCL2L1(2), CASP8(1), DFFA(1)	1851028	5	5	5	1	2	0	0	0	3	0	0.686	0.781	1.000
143	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	RB1(2), TFDP1(1)	1151532	3	3	3	2	1	0	0	0	2	0	0.889	0.783	1.000
144	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), HEXB(1), LCT(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1)	2246514	6	6	6	1	2	0	2	1	1	0	0.487	0.786	1.000
145	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), GBGT1(2), HEXB(1), ST3GAL1(1)	1389093	5	4	5	1	1	0	2	1	1	0	0.618	0.788	1.000
146	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGFR(3), TF(1)	1743223	6	6	6	2	2	0	2	2	0	0	0.701	0.794	1.000
147	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(1), FLAD1(1)	1348104	3	3	3	1	0	0	2	1	0	0	0.762	0.798	1.000
148	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(2), MAPK1(1), NGFR(2)	1162579	5	5	5	1	3	0	1	1	0	0	0.386	0.800	1.000
149	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDHPPT(1), KARS(1)	929388	2	2	2	1	1	0	1	0	0	0	0.858	0.801	1.000
150	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), SHMT2(1)	605876	2	2	2	0	1	0	1	0	0	0	0.481	0.808	1.000
151	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	PTGS1(1), PTGS2(2)	724526	3	3	3	2	1	0	1	0	1	0	0.935	0.812	1.000
152	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), NOS1(2), PPP3CB(1), PRKACB(1), PRKAR1A(7)	3603540	17	14	16	9	4	0	4	1	8	0	0.965	0.813	1.000
153	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	SHH(2), XPO1(1)	1188340	3	3	3	1	1	0	2	0	0	0	0.725	0.817	1.000
154	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1)	1339107	7	7	7	8	1	0	4	0	2	0	0.997	0.818	1.000
155	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1)	1339107	7	7	7	8	1	0	4	0	2	0	0.997	0.818	1.000
156	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ALDH6A1(1), BCAT1(2), BCAT2(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HMGCS2(1), HSD17B4(3), MCCC1(2), MUT(1), OXCT1(1), PCCA(1)	6003604	19	16	19	0	0	0	10	6	3	0	0.0118	0.825	1.000
157	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1), CES1(1)	818102	2	2	2	1	2	0	0	0	0	0	0.780	0.825	1.000
158	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), BECN1(1), GABARAPL1(1), IFNA8(1), PIK3C3(1), PRKAA2(1), ULK1(1), ULK2(1), ULK3(1)	2929510	9	8	9	1	0	0	4	1	4	0	0.527	0.831	1.000
159	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB6A(1)	592069	1	1	1	0	0	0	0	1	0	0	0.794	0.836	1.000
160	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1)	1844537	5	4	5	1	1	1	1	1	1	0	0.562	0.837	1.000
161	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP72(3)	1026952	3	3	3	0	1	0	2	0	0	0	0.464	0.838	1.000
162	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2)	497015	2	1	2	1	0	0	2	0	0	0	0.813	0.841	1.000
163	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(2), MAPK1(1)	1270667	3	3	3	1	1	0	1	1	0	0	0.686	0.842	1.000
164	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), FDXR(2)	2209846	7	7	7	2	1	0	4	2	0	0	0.603	0.852	1.000
165	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ECHS1(2), EHHADH(1), HADHA(1), SDS(1)	1683340	5	4	5	1	1	0	2	0	2	0	0.606	0.858	1.000
166	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(3), TUB(1)	977439	7	7	7	3	2	0	4	1	0	0	0.759	0.861	1.000
167	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(1), ABCB11(1), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1)	1999026	8	8	8	3	3	1	2	2	0	0	0.667	0.862	1.000
168	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), LDLR(1)	728369	2	2	2	3	0	0	1	0	1	0	0.994	0.866	1.000
169	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACSL1(3), ACSL3(2), EHHADH(1), HADHA(1)	2304694	7	6	7	2	1	1	3	0	2	0	0.686	0.867	1.000
170	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	FUT3(3), FUT4(1), FUT6(2), GCNT2(1)	2210009	7	7	7	2	3	0	2	2	0	0	0.575	0.868	1.000
171	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2)	1075001	2	2	2	1	0	0	1	1	0	0	0.863	0.871	1.000
172	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(1), UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	3687872	15	10	14	2	1	0	12	2	0	0	0.230	0.872	1.000
173	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT3(2), GALNT4(1), GALNT8(2), ST3GAL1(1)	2031805	7	5	7	1	0	0	2	2	3	0	0.593	0.874	1.000
174	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), FADD(2), MAP3K1(2), MAPK1(1), NFKB1(1), NSMAF(3), TNFRSF1A(1)	2807302	11	11	9	3	2	1	3	4	1	0	0.630	0.877	1.000
175	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), CASP8(1), GZMB(1)	1740691	3	3	3	1	1	0	0	0	2	0	0.822	0.881	1.000
176	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGP2(1)	691070	1	1	1	0	0	0	1	0	0	0	0.780	0.882	1.000
177	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1)	947361	7	4	7	3	2	1	4	0	0	0	0.681	0.882	1.000
178	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1)	947361	7	4	7	3	2	1	4	0	0	0	0.681	0.882	1.000
179	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11B2(1), CYP17A1(1), HSD11B1(1)	953722	3	3	3	3	0	0	2	0	1	0	0.980	0.886	1.000
180	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN2(3), CAPNS1(1), CXCR3(2), EGFR(3), MAPK1(1), MYLK(2), PRKACB(1), PRKAR1A(7), TLN1(2)	4634158	22	18	21	9	5	0	6	2	9	0	0.864	0.887	1.000
181	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	PFKL(2), PGAM1(1)	1273189	3	3	3	1	1	1	0	1	0	0	0.699	0.888	1.000
182	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCS2(1), OXCT1(1)	1024486	2	2	2	0	0	0	1	1	0	0	0.599	0.892	1.000
183	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(1), UGT1A3(1), UGT1A5(2), UGT2B15(2)	2374377	6	6	6	0	1	0	3	2	0	0	0.194	0.899	1.000
184	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), AFMID(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1)	1843868	8	6	8	2	1	0	5	2	0	0	0.568	0.900	1.000
185	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(3)	1150369	4	3	4	2	1	0	2	1	0	0	0.799	0.902	1.000
186	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	FADD(2), IRAK1(2), MAP3K1(2), NFKB1(1), TLR4(3), TNFRSF1A(1)	3412238	11	10	10	3	2	1	6	2	0	0	0.563	0.902	1.000
187	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	G6PD(2), GPX1(1), GSS(1), GSTA2(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1)	2587866	10	10	10	3	2	1	2	1	4	0	0.793	0.906	1.000
188	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), CSF1(1), EPO(1), IL2(1), IL3(1)	865568	5	4	5	3	0	1	3	0	1	0	0.882	0.907	1.000
189	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(1), PEMT(1), SLC18A3(1)	966460	4	2	4	2	0	1	2	1	0	0	0.845	0.908	1.000
190	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	GCNT2(1)	869905	1	1	1	1	1	0	0	0	0	0	0.940	0.909	1.000
191	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(1), ALPPL2(8), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC2(19), ERCC3(1), FPGS(14), MOV10L1(1), PTS(1), RAD54B(1), RUVBL2(1), SETX(2), SMARCA2(4), SMARCA5(1), SPR(1)	8667075	68	44	31	13	21	10	10	18	9	0	0.0730	0.911	1.000
192	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1)	2572821	6	6	6	0	1	0	4	0	1	0	0.201	0.913	1.000
193	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	THBS1(1)	980131	1	1	1	0	0	0	0	1	0	0	0.808	0.913	1.000
194	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(3), ERBB3(1)	1408354	4	4	4	2	2	0	2	0	0	0	0.837	0.915	1.000
195	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1)	1757779	7	6	7	2	1	0	4	2	0	0	0.639	0.916	1.000
196	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLDN5(3), CRY2(1), GFRA1(3), GSTP1(1), HSPA8(1), IDI1(5), KLF9(1), NCKAP1(1), NCOA4(2), PER1(1), UGP2(1), VAPA(1), ZFR(1)	5095657	23	18	20	4	3	2	12	5	1	0	0.229	0.919	1.000
197	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACP6(1), ACPP(1), FLAD1(1), LHPP(2), MTMR1(1), MTMR2(1)	2095640	8	8	7	3	0	3	2	2	1	0	0.774	0.921	1.000
198	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(2), BCHE(2), CES1(1), UGT1A3(1), UGT1A5(2)	3108801	9	8	9	0	2	0	5	2	0	0	0.0688	0.925	1.000
199	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), FH(1), MDH2(1), SDHB(1)	1227121	4	3	4	2	0	0	3	1	0	0	0.871	0.926	1.000
200	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSL(1), ADSS(1), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), PC(1)	3648758	13	11	12	3	3	2	4	2	2	0	0.461	0.932	1.000
201	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(6)	902045	7	6	5	6	1	0	3	2	1	0	0.984	0.934	1.000
202	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(1), CP(1), EPRS(4), GUSB(1), UGT1A3(1), UGT1A5(2), UGT2B15(2)	3727806	14	10	14	3	2	0	6	5	1	0	0.406	0.934	1.000
203	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1)	2334131	8	7	7	2	1	1	3	2	1	0	0.645	0.934	1.000
204	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), MTFMT(4), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1)	2649091	10	10	8	3	2	0	1	7	0	0	0.585	0.935	1.000
205	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(1), JAK2(2)	1115155	3	2	3	2	0	0	1	2	0	0	0.921	0.935	1.000
206	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CDKN2A(2)	1232801	2	2	2	1	0	0	1	0	1	0	0.922	0.936	1.000
207	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1), TANK(1)	3164258	7	7	7	1	1	0	5	0	1	0	0.389	0.937	1.000
208	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), GNAS(5), GNB1(2), NFATC1(1), PLCG1(3), PPP3CB(1), PRKACB(1), PRKAR1A(7)	4837580	21	17	20	6	3	0	6	2	10	0	0.728	0.938	1.000
209	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(5), NRG2(2), NRG3(2)	1241813	9	6	8	4	2	0	5	2	0	0	0.794	0.938	1.000
210	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(1), PIK3R1(1), PLCB1(3), PLCG1(3), VAV1(3)	1784197	11	9	11	4	5	0	3	2	1	0	0.756	0.939	1.000
211	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ALDH6A1(1), BCAT1(2), ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), SDS(1)	4973049	14	13	14	2	1	0	5	5	3	0	0.283	0.940	1.000
212	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB1(2), PSMB3(1), PSMB5(1), PSMC2(2), PSMD6(1)	2199119	7	4	7	1	1	0	3	2	1	0	0.510	0.941	1.000
213	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	LRP8(1), RELN(7)	1915796	8	7	8	3	0	0	5	3	0	0	0.755	0.942	1.000
214	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC2(1)	1134013	1	1	1	3	0	0	0	0	1	0	1.000	0.943	1.000
215	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(4), FARS2(1), GARS(36), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(1), WARS2(1)	4350637	49	41	16	10	3	1	37	6	2	0	0.217	0.947	1.000
216	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1)	1736445	5	4	5	5	1	0	1	1	2	0	0.995	0.948	1.000
217	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), LCMT1(1), PCYT1B(1), WBSCR22(1)	1947781	5	5	5	2	0	1	3	1	0	0	0.723	0.949	1.000
218	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), GATA1(1)	1138108	3	3	3	2	1	0	1	1	0	0	0.899	0.951	1.000
219	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	GAB1(1), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAPK7(2), MYEF2(1), NR2C2(1), PAPPA(6), TP53(18)	6938411	35	23	34	9	5	2	14	2	11	1	0.559	0.951	1.000
220	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(2), MEF2C(2)	1182409	4	3	4	2	1	0	1	1	1	0	0.885	0.952	1.000
221	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(1), CPS1(3), EPRS(4), GLUD1(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), GSS(1), NADSYN1(2), QARS(1)	4592245	21	14	21	4	2	3	7	4	5	0	0.361	0.952	1.000
222	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT2(1)	802826	1	1	1	0	1	0	0	0	0	0	0.673	0.955	1.000
223	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR2(1), NFKB1(1), TNFRSF11A(1), TNFSF11(1)	1522686	5	5	5	2	1	0	4	0	0	0	0.757	0.956	1.000
224	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1)	2079943	5	5	5	2	1	0	3	1	0	0	0.741	0.957	1.000
225	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1)	2079943	5	5	5	2	1	0	3	1	0	0	0.741	0.957	1.000
226	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1)	2079943	5	5	5	2	1	0	3	1	0	0	0.741	0.957	1.000
227	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IL2(1), TGFBR2(2), TGFBR3(4), TOB2(1)	1478829	9	7	9	6	1	0	5	1	2	0	0.975	0.957	1.000
228	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	IL3(1), ITGAX(1), TLR2(2), TLR4(3), TLR7(1), TLR9(2)	2556677	10	8	10	3	0	0	8	1	1	0	0.590	0.960	1.000
229	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(2), ACACB(4), ACSS2(1), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1)	5424937	17	13	17	3	2	0	10	2	3	0	0.347	0.960	1.000
230	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB1(2), PSMB3(1), PSMB5(1), PSMB9(1)	1212754	5	2	5	1	1	0	4	0	0	0	0.577	0.961	1.000
231	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAPK1(1), NFKB1(1), PLCB1(3)	2123469	5	4	5	1	1	0	2	2	0	0	0.511	0.961	1.000
232	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	APC(4), CTNNB1(14), DACT1(3), DKK1(1), DKK2(1), DVL1(1), LRP1(7), NKD1(1), NKD2(1), PIN1(1), PTPRA(1), WIF1(1)	5701448	36	26	31	8	6	1	12	11	6	0	0.410	0.965	1.000
233	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AOC3(1), CHDH(6), CHKB(1), CTH(1), DAO(2), GARS(36), GCAT(2), MAOA(3), PEMT(1), PIPOX(1), SARDH(1), SDS(1), SHMT2(1)	6061825	59	48	20	14	6	1	38	10	4	0	0.185	0.965	1.000
234	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(4), LAT(1), PIK3CA(1), PIK3R1(1), PTPN6(1), SYK(1), VAV1(3)	2620308	13	10	12	5	3	0	2	3	5	0	0.895	0.969	1.000
235	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5B(1), GPRC5D(1), GRM1(3), GRM3(4), GRM4(1), GRM5(1), GRM8(4)	2875920	19	8	19	4	1	1	12	3	2	0	0.226	0.970	1.000
236	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	WDR1(2)	1518981	2	2	2	2	0	0	0	1	1	0	0.981	0.971	1.000
237	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(3), GLUD1(1), GOT1(1)	1070012	5	4	5	3	1	0	2	1	1	0	0.916	0.973	1.000
238	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKACB(1)	1385435	4	3	4	2	0	0	2	0	2	0	0.930	0.973	1.000
239	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2B(2), POLR2H(1), POLRMT(5)	1869478	8	8	5	3	1	4	2	0	1	0	0.766	0.973	1.000
240	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), TUBA8(2)	1557481	4	4	4	2	2	0	1	1	0	0	0.753	0.974	1.000
241	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1456665	7	6	7	3	0	1	2	2	2	0	0.846	0.974	1.000
242	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1456665	7	6	7	3	0	1	2	2	2	0	0.846	0.974	1.000
243	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	CHST1(1), ST3GAL1(1)	1682908	2	2	2	1	0	0	0	2	0	0	0.901	0.976	1.000
244	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(3), MAPK1(1), TYK2(2)	1678718	9	6	9	3	1	0	2	4	2	0	0.746	0.977	1.000
245	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1), TYK2(2)	1499568	4	4	4	2	1	0	1	0	2	0	0.848	0.978	1.000
246	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(1), CD8A(1), ICAM1(1), ITGAL(1)	1463437	4	4	4	2	1	1	2	0	0	0	0.782	0.978	1.000
247	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY2(1), PER1(1)	1194940	2	2	2	0	1	0	1	0	0	0	0.563	0.978	1.000
248	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(1), IRAK1(2), MAP2K3(2), MAP3K1(2), NFKB1(1), PPARA(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2)	5078289	18	15	17	4	1	1	9	5	2	0	0.485	0.978	1.000
249	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(3), HK3(3)	1662155	6	6	6	3	0	0	4	1	1	0	0.852	0.980	1.000
250	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS1(1)	1346924	1	1	1	2	0	0	0	0	1	0	0.974	0.980	1.000
251	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C6(1), C7(1), C9(3)	1748277	5	5	5	3	0	0	3	1	1	0	0.900	0.980	1.000
252	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), JAK1(1)	1674301	2	2	2	1	1	0	1	0	0	0	0.781	0.980	1.000
253	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(1), JAK2(2), PTPRU(1)	1575942	4	3	4	2	0	0	2	2	0	0	0.861	0.981	1.000
254	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1)	3437826	9	5	9	2	0	1	4	1	3	0	0.559	0.981	1.000
255	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	KHK(2), LCT(1), PYGL(1)	1911050	4	4	4	2	2	0	1	1	0	0	0.825	0.981	1.000
256	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK4(1), CAMKK2(1)	1658695	2	2	2	1	0	0	2	0	0	0	0.854	0.981	1.000
257	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(4)	1364446	5	5	4	3	1	1	2	0	1	0	0.900	0.982	1.000
258	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(2), ITGAL(1), SELE(1)	1705338	5	5	5	3	2	0	1	1	0	1	0.886	0.983	1.000
259	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC3(1), CES1(1), DDHD1(3), ESCO2(1), PNPLA3(2)	3434037	8	7	7	2	4	0	1	3	0	0	0.492	0.985	1.000
260	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC3F(1)	995826	1	1	1	0	0	0	1	0	0	0	0.764	0.985	1.000
261	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS3(1), PON1(1)	1238775	2	2	2	5	0	0	0	1	1	0	1.000	0.986	1.000
262	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), CR2(2), HLA-DRB1(3), ICAM1(1), ITGAL(1)	2098930	8	8	8	5	2	0	3	1	2	0	0.940	0.986	1.000
263	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(1), EP300(2), ESR1(1), MAPK1(1), PELP1(1)	2080413	6	6	6	3	0	0	2	2	2	0	0.943	0.987	1.000
264	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSD(2), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SPTLC1(1), SPTLC2(1)	3355778	10	9	10	3	1	0	8	0	1	0	0.537	0.989	1.000
265	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), HLA-DRB1(3), LCK(1), ZAP70(1)	1263516	6	6	6	3	0	0	4	1	1	0	0.832	0.989	1.000
266	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4R(1), JAK1(1), JAK3(3), STAT6(1)	2055244	6	5	6	2	1	1	2	2	0	0	0.704	0.989	1.000
267	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), CASP8(1), DFFA(1), GZMB(1), LMNB1(1), LMNB2(2)	2667353	7	6	7	3	4	0	0	0	3	0	0.853	0.990	1.000
268	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC2(1), PDGFRA(1), PIK3CA(1), PIK3R1(1)	1851687	4	4	4	7	0	0	1	2	1	0	1.000	0.991	1.000
269	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), IL3(1), JAK2(2), PTPN6(1), STAT5B(1)	2458981	6	4	6	2	0	0	2	2	2	0	0.797	0.992	1.000
270	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH6(1), ADH7(2)	1841760	3	3	3	6	1	0	0	1	1	0	1.000	0.992	1.000
271	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPRU(1)	2145152	8	7	8	3	1	0	4	3	0	0	0.731	0.992	1.000
272	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(1), TYK2(2)	1737988	4	3	4	2	0	0	2	0	2	0	0.861	0.992	1.000
273	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(2), SELE(1), SELP(2)	2263611	9	7	9	4	2	0	4	2	0	1	0.816	0.992	1.000
274	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	BST1(2), NADSYN1(2), NMNAT3(1), NNT(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1)	2958603	11	9	10	5	1	2	5	0	3	0	0.851	0.993	1.000
275	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F5(2), PROC(1), PROS1(1), TFPI(1)	2278315	5	5	5	2	1	0	2	2	0	0	0.736	0.993	1.000
276	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), PLCG1(3)	1870779	4	4	4	4	2	0	1	0	1	0	0.970	0.993	1.000
277	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ELOVL5(2), FADS2(1), FASN(3), HADHA(1)	2137694	7	6	7	5	0	0	2	3	2	0	0.992	0.994	1.000
278	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2)	2700718	10	9	10	4	1	0	4	3	2	0	0.817	0.994	1.000
279	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP8(1), DAXX(4), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), PTPN13(2), RB1(2), RIPK2(1), SPTAN1(3)	5902753	24	16	24	5	7	2	4	2	9	0	0.440	0.994	1.000
280	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(1), GRIN1(1), JAK2(2), NFKB1(1)	1840161	5	3	5	2	0	0	3	2	0	0	0.808	0.995	1.000
281	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY2(1), NR1D1(1), PER1(1), PER3(3)	2376080	6	4	6	2	1	0	3	0	2	0	0.751	0.996	1.000
282	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	GOT1(1), GOT2(2), GPT(1), GPT2(2), MDH2(1), ME2(1), RPIA(1)	2503494	9	8	9	4	2	1	4	0	2	0	0.813	0.996	1.000
283	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CXCR3(2), JAK2(2), TYK2(2)	2091937	7	3	7	5	1	0	1	3	2	0	0.968	0.996	1.000
284	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), HLA-DRB1(3), IL2(1), IL3(1)	1890439	6	6	6	9	0	0	4	1	1	0	1.000	0.996	1.000
285	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2), TFDP1(1)	2788890	7	7	7	3	1	0	2	2	2	0	0.807	0.997	1.000
286	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(1), MAPK1(1)	1595340	3	3	3	2	0	0	1	2	0	0	0.930	0.997	1.000
287	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR2(2), STX18(1), STX19(1), STX7(1), TSNARE1(2), VAMP1(1), VTI1B(1)	2363181	9	9	9	4	1	0	2	4	2	0	0.858	0.997	1.000
288	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA3(1), CPS1(3), CTH(1), GLUD1(1)	2606239	6	4	6	5	1	0	2	1	2	0	0.982	0.997	1.000
289	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(1), ICAM1(1), ITGAL(1)	1546364	3	3	3	2	1	0	2	0	0	0	0.865	0.997	1.000
290	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(1), ITGAM(2), SELE(1)	1506647	5	5	5	3	1	0	2	2	0	0	0.892	0.997	1.000
291	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC2(1), NCKAP1(1), NTRK1(1), WASF2(1)	2112710	4	4	4	4	0	0	2	1	1	0	0.987	0.997	1.000
292	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMB1(2), PSMB3(1), PSMB5(1), RPN2(2), UBE3A(1)	1818124	7	2	7	2	2	0	5	0	0	0	0.638	0.997	1.000
293	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CTLA4(2), HLA-DRB1(3), IL2(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1), PTPN11(1)	1753946	12	12	12	5	0	0	6	5	1	0	0.865	0.998	1.000
294	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(1), C2(1), C6(1), C7(1), C9(3)	2460506	7	7	7	4	1	0	3	2	1	0	0.876	0.998	1.000
295	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	CSF1(1), FCGR3A(3), IL6R(1), TNFRSF1A(1)	1935144	6	5	6	5	0	0	5	0	1	0	0.977	0.998	1.000
296	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	JAK1(1), JAK2(2), JAK3(3), STAT5B(1), TYK2(2)	2617327	9	7	9	4	1	0	2	3	3	0	0.878	0.998	1.000
297	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATP6V0C(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1)	2467374	7	7	7	3	2	0	2	3	0	0	0.746	0.998	1.000
298	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP8(1), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1)	5509460	19	15	19	5	7	1	4	0	7	0	0.559	0.998	1.000
299	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	BPNT1(3), MAPK1(1), PIK3CA(1)	2777816	5	4	5	4	0	0	1	2	1	1	0.992	0.998	1.000
300	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(2), ACACB(4), FASN(3), OLAH(1)	2284676	10	8	10	5	1	0	5	3	1	0	0.916	0.999	1.000
301	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	CAMK4(1), CREBBP(1), GATA4(2), LIF(1), MAPK1(1), MEF2C(2), MYH2(2), NFATC1(1), NKX2-5(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), PRKACB(1), PRKAR1A(7)	6933003	23	14	22	7	0	1	9	5	8	0	0.786	0.999	1.000
302	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA3(1), CPS1(3), CTH(1), GLUD1(1), GLUD2(1)	2910686	7	5	7	6	2	0	2	1	2	0	0.987	0.999	1.000
303	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX5(3), PTGDS(1), PTGS1(1), PTGS2(2)	2198503	8	8	8	5	1	1	3	2	1	0	0.955	0.999	1.000
304	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	NADSYN1(2), NNT(1), NT5E(1), NT5M(1)	2010070	5	4	5	5	1	2	1	0	1	0	0.988	0.999	1.000
305	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), F2RL1(1), MAPK1(1), MAPK7(2), MYEF2(1), PLD2(1), TEC(1), VAV1(3)	3843763	11	9	10	3	2	0	6	1	2	0	0.550	0.999	1.000
306	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(2), C1GALT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), OGT(1), ST3GAL1(1), ST6GALNAC1(1)	4477793	20	14	17	6	3	1	5	4	7	0	0.797	0.999	1.000
307	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CDH1(1), CREBBP(1), EP300(2), SKIL(1), TGFBR2(2)	3526782	11	10	11	6	0	0	6	2	3	0	0.983	0.999	1.000
308	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(3), MAP3K1(2), NCOR2(4), RARA(1), THRA(1)	2418457	11	9	11	5	3	0	4	3	1	0	0.873	0.999	1.000
309	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTR(1)	2438047	5	5	5	7	1	1	0	2	1	0	0.999	0.999	1.000
310	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	ITPR1(2), ITPR2(4), ITPR3(5), TF(1)	5039658	12	10	12	3	2	0	5	5	0	0	0.483	0.999	1.000
311	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(4), PIK3CA(1), PIK3R1(1)	2550593	15	13	15	5	2	1	7	3	2	0	0.768	0.999	1.000
312	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(1), EP300(2), FADD(2), NFKB1(1), TNFRSF1A(1)	3108196	7	7	7	3	1	1	4	0	1	0	0.859	0.999	1.000
313	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(2), ETV5(2), IL18R1(2), JAK2(2), TYK2(2)	2600572	11	7	11	7	2	0	3	4	2	0	0.966	0.999	1.000
314	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(1), C2(1), C6(1), C7(1), C8B(1), C9(3)	2909219	8	8	8	4	2	0	3	2	1	0	0.813	0.999	1.000
315	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PCK1(1), SDHA(1), SDHB(1)	2856740	10	6	10	4	0	1	7	2	0	0	0.756	0.999	1.000
316	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), ESCO2(1), PNPLA3(2)	2213810	4	3	4	3	0	0	1	2	1	0	0.959	0.999	1.000
317	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH5A1(1), CAD(1), CPS1(3), EARS2(2), EPRS(4), GLUD1(1), GLUD2(1), GMPS(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), GSS(1), NADSYN1(2), QARS(1)	5469017	24	15	24	5	4	3	7	5	5	0	0.351	0.999	1.000
318	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), JAK2(2), PLCG1(3), PTPN6(1), STAT5B(1)	3024792	8	6	8	4	2	0	2	2	2	0	0.892	0.999	1.000
319	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS3(1), LCMT1(1), WBSCR22(1)	2071361	3	3	3	5	0	1	1	0	1	0	0.995	0.999	1.000
320	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR3(1), CCR4(1), CXCR3(2), CXCR4(1), IL18R1(2), IL2(1), IL4R(1)	2800581	9	9	9	9	2	1	3	2	1	0	0.996	0.999	1.000
321	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(1), C2(1), C6(1), C7(1), C9(3)	3004149	7	7	7	5	1	0	3	2	1	0	0.929	1.000	1.000
322	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CTH(1), LCMT1(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1), WBSCR22(1)	3469989	7	6	7	7	1	1	2	1	2	0	0.995	1.000	1.000
323	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2)	3526621	8	6	8	3	0	0	3	2	3	0	0.835	1.000	1.000
324	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACSS2(1), FH(1), MDH2(1)	1829450	4	2	4	2	0	0	4	0	0	0	0.854	1.000	1.000
325	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1)	3213977	6	5	6	2	1	0	4	0	1	0	0.775	1.000	1.000
326	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), P4HB(1), SLC23A2(1), SLC2A3(1)	3590123	12	11	12	7	2	1	5	1	3	0	0.892	1.000	1.000
327	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), EPN1(1), PICALM(1), PPP3CB(1), SYNJ1(1)	3143364	6	6	6	3	0	0	6	0	0	0	0.844	1.000	1.000
328	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), NDST2(1), NDST4(2)	2898605	13	8	13	8	1	0	6	4	2	0	0.960	1.000	1.000
329	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(1), EP300(2), NCOA1(2), NCOA2(1)	2512629	6	6	6	3	0	0	4	1	1	0	0.933	1.000	1.000
330	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(1)	2009600	1	1	1	1	0	0	1	0	0	0	0.949	1.000	1.000
331	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPN11(1), SRF(1)	3326361	10	8	10	4	2	0	3	4	1	0	0.827	1.000	1.000
332	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPN2(3), CAPNS1(1), EP300(2), HDAC1(1), HDAC2(1), NFATC1(1), PPP3CB(1)	3333216	11	10	11	6	1	0	7	1	2	0	0.911	1.000	1.000
333	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2L1(2), CASP8(1), DAXX(4), DFFA(1), FADD(2), NFKB1(1), NGFR(2), NTRK1(1), PTPN13(2), TNFRSF1A(1)	6064508	18	14	18	9	5	2	3	2	6	0	0.951	1.000	1.000
334	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IL2(1), MAP3K1(2), NFKB1(1), TNFSF9(2)	2736643	6	5	6	3	2	0	4	0	0	0	0.868	1.000	1.000
335	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(1), LARS(1), LARS2(1), PDHB(1), VARS(8), VARS2(1)	2555249	16	14	11	6	1	0	10	3	2	0	0.816	1.000	1.000
336	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACP6(1), ACPP(1), ALPI(1), ALPP(1), ALPPL2(8), DHRS3(1), PON1(1)	2522636	15	13	9	8	0	9	3	2	1	0	0.886	1.000	1.000
337	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C6(1), C7(1), ICAM1(1), ITGA4(2), ITGAL(1), SELP(2)	3419466	8	7	8	5	2	0	5	0	0	1	0.913	1.000	1.000
338	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CALCRL(1), CD97(1), ELTD1(2), EMR1(1), EMR2(4), GIPR(1), GLP1R(1), GPR64(1), LPHN1(3), LPHN2(1), LPHN3(3), VIPR1(1), VIPR2(1)	3879806	24	17	23	9	3	1	13	5	2	0	0.689	1.000	1.000
339	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), APOE(9), HMGCR(1), LDLR(1), LRP1(7), SCARB1(3)	3781411	22	16	14	6	6	0	5	10	1	0	0.482	1.000	1.000
340	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ALDH5A1(1), ECHS1(2), EHHADH(1), HADHA(1), OXCT1(1), PDHB(1), SDHB(1), SDS(1)	3555205	10	7	10	5	1	0	4	3	2	0	0.907	1.000	1.000
341	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	GMPPB(1), HK2(3), HK3(3), KHK(2)	3372319	9	9	9	4	2	0	5	1	1	0	0.728	1.000	1.000
342	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	AOC3(1), MAOA(3)	3408979	4	3	4	4	1	0	1	0	2	0	0.986	1.000	1.000
343	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(4), EGFR(3), ETS2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PRKCG(1), PRKCH(1), PRKCQ(2), TNFRSF1A(1)	6585044	19	17	19	7	3	1	6	3	6	0	0.812	1.000	1.000
344	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(2), JAK2(2), MAP3K1(2), PIK3CA(1), PIK3R1(1), STAT5B(1)	3803845	9	7	9	6	1	0	3	3	2	0	0.985	1.000	1.000
345	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SDS(1)	3975922	10	8	10	6	3	0	4	0	3	0	0.921	1.000	1.000
346	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), CDIPT(1), CHAT(1), CHKB(1), CHPT1(2), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), ESCO2(1), GNPAT(1), GPAM(3), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PNPLA3(2), PPAP2C(1)	9300413	35	20	33	8	5	1	15	9	5	0	0.309	1.000	1.000
347	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AOC3(1), ATP6V0C(1), CHDH(6), CHKB(1), CTH(1), DAO(2), GARS(36), GCAT(2), MAOA(3), PEMT(1), PLCG1(3), SARDH(1), SHMT2(1)	5946437	61	48	22	16	7	1	39	10	4	0	0.263	1.000	1.000
348	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	BDKRB2(1), FLT4(6), KDR(1), NOS3(4), PDE2A(1), PDE3A(2), PDE3B(1), PRKACB(1), PRKAR1A(7), PRKG2(2), RYR2(12)	5856860	38	23	37	11	8	4	10	6	10	0	0.522	1.000	1.000
349	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	GNB1(2), MAPK1(1), PLA2G4A(3), PLCB1(3), PTGS1(1), SYK(1)	3340399	11	8	11	6	1	0	6	3	1	0	0.939	1.000	1.000
350	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	CYP2C9(1), DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2)	4221008	9	6	9	4	0	0	4	2	3	0	0.876	1.000	1.000
351	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(1), EP300(2), JAK1(1), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5B(1)	3859213	11	10	11	5	1	0	5	2	3	0	0.907	1.000	1.000
352	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	IL2(1), JAK1(1), JAK3(3), LCK(1), STAT5B(1), SYK(1)	3289015	8	7	8	4	1	0	4	1	2	0	0.883	1.000	1.000
353	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAS(5), GNB1(2), MAPK1(1), NOX1(1), PIK3C2G(1), PLCB1(3)	3541354	15	13	15	7	2	0	6	5	2	0	0.917	1.000	1.000
354	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT2(1), B3GALT4(1), B3GALT5(1), FUT3(3), FUT4(1), FUT6(2), GBGT1(2), GCNT2(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1)	6846359	23	13	23	5	5	0	9	5	4	0	0.378	1.000	1.000
355	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	BCL2L1(2), H2AFX(1), NFKB1(1), PIK3CA(1), PIK3R1(1)	2725551	6	5	6	3	1	0	3	1	1	0	0.895	1.000	1.000
356	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(5), ATR(3), CASP8(1), CCNB3(2), CCND2(1), CDKN2A(2), CHEK2(2), DDB2(1), GADD45G(2), GTSE1(1), IGFBP3(1), MDM2(2), PMAIP1(1), RRM2(1), SERPINE1(1), SESN1(1), THBS1(1), TP53(18), TP53I3(1), TP73(1), TSC2(1)	9112483	50	32	50	11	6	0	14	6	23	1	0.496	1.000	1.000
357	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT5(2), MGAT3(1), RPN2(2)	2794751	6	4	6	3	2	0	2	2	0	0	0.874	1.000	1.000
358	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(2), ACTN2(2), CAPNS1(1), SPTAN1(3), TLN1(2)	4026477	10	8	10	4	4	1	4	0	1	0	0.652	1.000	1.000
359	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDHPPT(1), ATP6V0C(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(2), HADHA(1), PLOD3(2), SDS(1), SHMT2(1)	5069325	18	11	18	7	3	2	8	1	4	0	0.772	1.000	1.000
360	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F5(2), F8(2), F9(1), LPA(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1), VWF(6)	4810164	16	12	16	8	2	1	6	4	3	0	0.896	1.000	1.000
361	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ARRB2(1), CALML3(1), CALML6(1), GNAL(2), PDE1C(1), PRKACA(1), PRKACB(1), PRKG2(2)	4285561	10	9	10	7	2	0	3	3	2	0	0.985	1.000	1.000
362	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACSL1(3), ACSL3(2), ADH6(1), ADH7(2), CPT1C(1), CYP4A22(4), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(3)	6751402	22	16	22	8	3	2	8	4	5	0	0.771	1.000	1.000
363	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(2), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1), SDS(1)	4517530	13	11	13	5	3	0	7	1	2	0	0.789	1.000	1.000
364	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	JAK2(2), MPL(1), PIK3CA(1), PIK3R1(1), PLCG1(3), STAT5B(1)	4100194	9	7	9	6	2	0	2	3	2	0	0.985	1.000	1.000
365	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(1), BCL2L1(2), BCL2L11(1), BIRC5(1), CASP8(1), DFFA(1), FADD(2), GZMB(1), HELLS(1), IRF2(3), IRF3(1), IRF4(1), IRF5(1), IRF6(1), MAP3K1(2), MDM2(2), NFKB1(1), NFKBIE(2), PLEKHG5(1), TNFRSF1A(1), TNFRSF21(1), TP53(18), TP73(1)	8026023	47	30	47	12	9	1	15	3	18	1	0.443	1.000	1.000
366	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(1), DUSP1(1), EP300(2), MAP2K3(2), MAPK11(1), NFKB1(1), TGFBR2(2), TLR2(2)	4095385	12	8	12	6	0	0	7	3	2	0	0.956	1.000	1.000
367	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4)	4520468	13	10	13	5	1	0	8	2	2	0	0.730	1.000	1.000
368	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2L1(2), CBL(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN6(1), STAT5B(1), SYK(1)	4999893	13	11	13	8	2	1	4	3	3	0	0.975	1.000	1.000
369	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	CMA1(1), COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4)	3550610	10	9	10	6	2	1	5	1	1	0	0.890	1.000	1.000
370	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), MAP3K1(2), NFATC1(1), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3)	5234076	12	7	12	4	5	0	5	0	2	0	0.640	1.000	1.000
371	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4), MAPK1(1), MAPK8IP3(2)	3966704	7	4	7	5	0	0	4	2	1	0	0.971	1.000	1.000
372	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4G1(1), EIF4G3(1), MAPK1(1), MKNK1(1), PABPC1(5), PIK3CA(1), PIK3R1(1)	3826540	11	11	9	6	1	0	4	5	1	0	0.945	1.000	1.000
373	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), CASP8(1), DFFA(1), FADD(2), NFKB1(1), SPTAN1(3), TNFRSF10A(1)	4658136	10	8	10	8	4	1	3	0	2	0	0.983	1.000	1.000
374	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	BTK(1), EEA1(2), PFKL(2), PLCG1(3), VAV2(1)	3332566	9	8	9	5	3	0	3	2	1	0	0.877	1.000	1.000
375	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4G1(1), EIF4G3(1), MKNK1(1), PIK3CA(1), PIK3R1(1), TSC2(1)	3813275	6	6	6	6	1	0	2	2	1	0	0.995	1.000	1.000
376	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(1), ADSL(1), ADSS(1), ADSSL1(3), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT(1), GPT2(2), PC(1), PDHB(1)	5283699	18	15	17	6	5	2	6	3	2	0	0.669	1.000	1.000
377	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLK(1), POLM(1), POLQ(1), REV3L(1), RFC5(1)	5699953	13	9	12	4	1	1	6	3	2	0	0.778	1.000	1.000
378	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), ESCO2(1), GOT1(1), GOT2(2), HGD(1), LCMT1(1), MAOA(3), MIF(3), PNPLA3(2), TH(3), TPO(22), TYRP1(1), WBSCR22(1)	8201965	48	35	28	13	7	1	32	4	4	0	0.347	1.000	1.000
379	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	IARS(1), IL13RA1(1), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(1), SERPINA4(1), SOS2(1), STAT6(1), TYK2(2)	5108518	16	10	16	8	1	1	4	7	3	0	0.928	1.000	1.000
380	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), CDT1(1), DIAPH2(2), MCM3(1), NACA(4), POLA2(1), POLD1(2), POLD2(1), POLE(3), RFC1(1), RFC5(1), RPA2(1), RPA4(1), UBB(1)	6914128	21	14	20	6	3	1	7	7	3	0	0.680	1.000	1.000
381	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), MAN2A1(2), MGAT3(1), RPN2(2)	5937431	13	11	13	6	2	0	6	2	3	0	0.844	1.000	1.000
382	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC2(1), GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4), PFKL(2), UGP2(1)	5366229	17	11	17	7	2	0	9	4	2	0	0.780	1.000	1.000
383	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AFMID(1), AOC3(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), KMO(1), LCMT1(1), LNX1(2), MAOA(3), OGDHL(1), TDO2(1), WARS2(1), WBSCR22(1)	8371686	21	14	21	6	2	1	11	3	4	0	0.563	1.000	1.000
384	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ALDH5A1(1), DDHD1(3), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), OXCT1(1), PDHB(1)	5682444	16	11	15	6	2	0	8	4	2	0	0.777	1.000	1.000
385	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(2), ACACB(4), ACSS2(1), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1)	6409806	17	13	17	9	3	1	8	3	2	0	0.943	1.000	1.000
386	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(4), AR(2), BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PHKA2(2), PIK3CA(1), PIK3R1(1), PITX2(3), PTX3(1)	7502620	30	20	30	9	5	0	13	10	2	0	0.581	1.000	1.000
387	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(2), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1)	5063227	12	11	12	9	3	1	5	2	1	0	0.984	1.000	1.000
388	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(2), MAP3K1(2), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PLA2G4A(3), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3)	5895332	20	11	20	6	5	0	9	3	3	0	0.661	1.000	1.000
389	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN2(2), BCAR1(1), BCR(2), CAPNS1(1), CSK(1), MAPK1(1), ROCK1(2), TLN1(2), ZYX(1)	6609163	15	12	15	7	3	1	8	1	2	0	0.830	1.000	1.000
390	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), BLVRA(1), CP(1), EARS2(2), EPRS(4), GUSB(1), MMAB(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	5740798	25	15	24	7	4	0	14	6	1	0	0.518	1.000	1.000
391	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	MAP3K1(2), MYLK(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), TRIO(1), VAV1(3)	4827775	11	9	11	9	4	0	4	2	1	0	0.993	1.000	1.000
392	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTG1(2), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), CTNNB1(14), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), TUBB2B(1), WAS(1), YWHAQ(1)	7139015	34	27	29	10	4	4	13	7	6	0	0.652	1.000	1.000
393	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTG1(2), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), CTNNB1(14), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), TUBB2B(1), WAS(1), YWHAQ(1)	7139015	34	27	29	10	4	4	13	7	6	0	0.652	1.000	1.000
394	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC10(1), CDC16(2), CDC20(1), CDC27(1), CUL3(1), FZR1(2), ITCH(1), WWP1(1), WWP2(1)	5590738	11	9	11	6	1	0	3	6	1	0	0.949	1.000	1.000
395	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2(2), EIF2AK1(1), EIF2AK3(1), EIF2B5(1), EIF4G1(1), EIF4G3(1), PABPC1(5), PABPC3(3), PAIP1(1)	6129439	16	12	14	7	1	0	7	6	2	0	0.884	1.000	1.000
396	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	GSN(1), MAPK1(1), MYLK(2), PIK3CA(1), PIK3R1(1), ROCK1(2), TLN1(2)	5177005	10	9	10	7	1	0	6	2	1	0	0.974	1.000	1.000
397	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), LAT(1), LCK(1), MAP3K1(2), NFATC1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PPP3CB(1), PTPN7(1), VAV1(3), ZAP70(1)	6601248	18	11	18	6	5	0	9	1	3	0	0.687	1.000	1.000
398	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(1), CARS2(1), EARS2(2), EPRS(4), FARS2(1), FARSB(1), GARS(36), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), MTFMT(4), QARS(1), RARS2(2), VARS(8), VARS2(1), WARS2(1)	7433563	69	52	29	18	6	1	46	12	4	0	0.394	1.000	1.000
399	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ITGA9(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PDE3A(2), PDE3B(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), SGCB(1), VASP(1)	6858282	21	15	21	7	2	0	11	7	1	0	0.656	1.000	1.000
400	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), F5(2), F8(2), F9(1), PROC(1), PROS1(1), SERPING1(1)	6224911	17	14	17	9	2	1	8	5	1	0	0.912	1.000	1.000
401	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(2), GAB1(1), HGF(1), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN11(1)	6270544	8	7	8	9	0	1	3	3	1	0	0.999	1.000	1.000
402	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(4), CCND2(1), CTNNB1(14), DVL1(1), DVL2(1), FZD1(6), FZD5(1), FZD7(1), FZD8(2), LDLR(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	8048515	47	31	37	14	5	1	15	10	15	1	0.828	1.000	1.000
403	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(1), DUSP1(1), EHHADH(1), EP300(2), HSD17B4(3), MAPK1(1), NCOA1(2), NCOR1(1), NCOR2(4), NR2F1(3), NRIP1(3), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACB(1), PRKAR1A(7), PTGS2(2), RB1(2), STAT5B(1)	8708257	38	27	37	12	3	1	12	9	13	0	0.805	1.000	1.000
404	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	CD14(1), CD19(2), CD1A(1), CD1C(2), CD1E(1), CD3D(1), CD8A(1), CD9(1), CR1(1), CR2(2), CSF1(1), CSF1R(1), CSF2RA(1), CSF3R(1), EPO(1), FLT3(1), GP9(2), HLA-DRB1(3), IL3(1), IL4R(1), IL6R(1), IL9R(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGAM(2), MME(4), TPO(22)	11457645	65	37	45	21	5	4	44	5	6	1	0.655	1.000	1.000
405	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(2), ADRA2A(2), ADRA2B(1), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CALCR(1), CALCRL(1), CHRM5(1), CYSLTR2(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GABBR1(2), GABRA1(2), GABRA2(2), GABRA6(2), GABRB1(1), GABRB2(1), GABRB3(2), GABRD(1), GABRE(1), GABRG1(1), GABRG2(3), GABRG3(1), GABRR2(1), GALR3(1), GH2(1), GIPR(1), GLP1R(1), GLRA1(3), GLRB(1), GPR156(1), GPR50(4), GPR83(1), GRIA2(3), GRID1(1), GRID2(1), GRIK1(3), GRIK2(2), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRIN3A(4), GRIN3B(7), GRM1(3), GRM3(4), GRM4(1), GRM5(1), GRM6(1), GRM8(4), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2), KISS1R(3), LEPR(2), MC1R(1), MC3R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(2), NPBWR2(1), NPFFR2(1), NPY1R(1), OPRD1(26), OPRL1(1), P2RX5(1), P2RY14(1), P2RY2(2), P2RY4(1), PARD3(1), PPYR1(3), PRLHR(2), PRSS1(1), PRSS3(1), PTGER4(1), PTGIR(1), RXFP1(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TAAR5(4), TACR3(1), TBXA2R(1), THRA(1), TRPV1(1), UTS2R(4), VIPR1(1), VIPR2(1)	30725925	192	67	157	116	28	9	106	37	12	0	1.000	1.000	1.000
406	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(2), ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), BRAF(1), CAPN2(3), CCND2(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), CTNNB1(14), DOCK1(2), EGFR(3), FARP2(1), FLNA(3), FLNB(1), FLNC(1), FN1(1), HGF(1), IGF1R(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), KDR(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(3), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), MAPK1(1), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PARVG(1), PDGFD(1), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), PRKCG(1), RAPGEF1(1), RELN(7), ROCK1(2), SHC2(2), SHC3(1), SOS2(1), THBS1(1), THBS2(2), THBS4(2), TLN1(2), TLN2(6), TNC(3), TNN(4), TNR(5), TNXB(3), VASP(1), VAV1(3), VAV2(1), VAV3(3), VEGFB(1), VTN(1), VWF(6), ZYX(1)	52339355	200	65	195	77	39	11	83	36	30	1	0.943	1.000	1.000
407	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(1), ARRB1(1), ARRB2(1), ATF4(1), BDNF(1), BRAF(1), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(3), CACNA2D1(2), CACNA2D4(4), CACNB3(1), CACNB4(1), CACNG3(1), CACNG6(1), CACNG7(1), CD14(1), DAXX(4), DUSP1(1), DUSP6(1), DUSP7(3), ECSIT(1), EGFR(3), ELK4(1), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(2), FGF5(1), FGFR2(2), FGFR4(1), FLNA(3), FLNB(1), FLNC(1), GADD45G(2), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MAPK8IP3(2), MEF2C(2), MKNK1(1), NF1(9), NFKB1(1), NFKB2(1), NR4A1(1), NRAS(1), NTF3(1), NTRK1(1), NTRK2(1), PDGFRA(1), PDGFRB(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PPP3CB(1), PPP5C(1), PRKACA(1), PRKACB(1), PRKCG(1), PTPN7(1), RAPGEF2(2), RASGRF1(2), RASGRF2(1), RASGRP1(2), RPS6KA1(1), RPS6KA4(2), RPS6KA6(1), SOS2(1), SRF(1), STK4(1), TAOK1(2), TAOK2(6), TAOK3(2), TGFBR2(2), TNFRSF1A(1), TP53(18)	41376394	184	64	175	96	32	10	73	26	42	1	1.000	1.000	1.000
408	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CADM3(2), CD276(1), CD8A(1), CD99(1), CDH1(1), CDH2(3), CDH3(1), CDH4(4), CDH5(2), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(1), CNTNAP2(1), CTLA4(2), ESAM(1), F11R(2), HLA-A(4), HLA-B(10), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), ICAM1(1), ITGA4(2), ITGA6(1), ITGA9(1), ITGAL(1), ITGAM(2), ITGB8(2), L1CAM(1), MADCAM1(5), MAG(1), NFASC(1), NLGN1(1), NLGN2(4), NRCAM(2), NRXN1(3), NRXN2(3), PTPRF(2), PVR(1), PVRL1(2), PVRL3(2), SDC1(1), SDC4(1), SELE(1), SELP(2), VCAN(4)	20667374	119	59	100	63	22	6	54	23	13	1	0.999	1.000	1.000
409	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTG1(2), COL11A1(1), COL17A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), DES(1), DSC2(3), DSC3(2), DSG1(3), DSG2(1), DSG3(2), DSG4(1), FN1(1), GJA1(2), GJA4(1), GJA8(1), GJB2(1), GJD3(1), GJD4(1), INA(1), ITGA6(1), ITGB4(1), KRT1(2), KRT12(2), KRT14(2), KRT17(1), KRT2(2), KRT20(1), KRT31(1), KRT32(3), KRT33A(1), KRT33B(3), KRT36(1), KRT39(2), KRT40(1), KRT6A(1), KRT71(1), KRT72(2), KRT73(1), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(1), KRT81(1), KRT83(2), KRT84(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(3), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), LMNB1(1), LMNB2(2), NES(1), RELN(7), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VIM(1), VTN(1), VWF(6)	35044362	161	57	158	77	44	9	70	21	17	0	0.994	1.000	1.000
410	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY1(1), ADCY2(3), ADCY4(1), ADCY7(1), ADCY8(3), ATP2A1(2), ATP2A2(2), ATP2A3(1), ATP2B3(4), AVPR1A(3), AVPR1B(1), BDKRB2(1), BST1(2), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(3), CALML3(1), CALML6(1), CAMK4(1), CHRM5(1), CYSLTR2(1), EDNRB(1), EGFR(3), ERBB3(1), ERBB4(5), GNAL(2), GNAS(5), GRIN1(1), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), NOS1(2), NOS3(4), P2RX5(1), PDE1A(2), PDE1C(1), PDGFRA(1), PDGFRB(1), PHKA2(2), PHKB(3), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A2(2), SLC8A3(1), SPHK1(2), SPHK2(2), TACR3(1), TBXA2R(1), TRPC1(1)	38934905	176	56	167	98	40	10	75	30	21	0	1.000	1.000	1.000
411	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(2), ACTN1(2), ACTN2(2), ACTN4(1), ASH1L(1), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CSDA(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), EPB41(1), EPB41L1(1), EPB41L3(1), EXOC3(1), F11R(2), INADL(1), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(2), MPDZ(4), MPP5(1), MYH11(2), MYH13(1), MYH14(3), MYH15(3), MYH2(2), MYH3(2), MYH4(3), MYH6(4), MYH7(1), MYH8(4), NRAS(1), PARD3(1), PPP2R1B(1), PPP2R3A(2), PPP2R3B(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), SPTAN1(3), SYMPK(2), TJAP1(1), TJP1(1), TJP2(1), TJP3(3), VAPA(1)	26957901	113	55	93	38	20	7	52	21	13	0	0.700	1.000	1.000
412	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1(1), ACVR1B(1), ACVR2B(1), AMH(1), AMHR2(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CCL11(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CNTFR(1), CSF1(1), CSF1R(1), CSF2RA(1), CSF2RB(1), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL14(1), CXCL3(1), CXCL9(2), CXCR3(2), CXCR4(1), EGFR(3), EPO(1), FLT3(1), FLT4(6), GDF5(1), GH2(1), HGF(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL17A(1), IL17RA(2), IL18R1(2), IL2(1), IL21R(2), IL23R(1), IL24(1), IL25(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), INHBA(2), INHBB(3), KDR(1), LEPR(2), LIF(1), MPL(1), NGFR(2), OSMR(4), PDGFRA(1), PDGFRB(1), TGFBR2(2), TNFRSF10A(1), TNFRSF11A(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF6B(1), TNFSF11(1), TNFSF9(2), TPO(22), VEGFB(1), XCL1(1)	24729043	119	52	99	44	24	5	62	14	14	0	0.744	1.000	1.000
413	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADRA2A(2), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CHRM5(1), CX3CR1(2), CXCR3(2), CXCR4(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GALR3(1), GPR173(2), GPR174(1), GPR3(1), GPR37(1), GPR4(3), GPR50(4), GPR6(1), GPR83(1), GPR85(1), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2), MC1R(1), MC3R(1), MTNR1A(2), MTNR1B(2), NPY1R(1), OPRD1(26), OPRL1(1), OR2H1(1), OR7A5(1), P2RY12(1), P2RY14(1), P2RY2(2), PPYR1(3), PTGER4(1), PTGIR(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), SUCNR1(1), TBXA2R(1)	16626464	108	51	79	71	17	3	64	19	5	0	1.000	1.000	1.000
414	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), FN1(1), FNDC1(4), GP6(2), GP9(2), HMMR(1), HSPG2(6), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(3), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), RELN(7), SDC1(1), SDC4(1), SV2C(1), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VTN(1), VWF(6)	31935819	126	50	124	47	26	8	56	23	12	1	0.798	1.000	1.000
415	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ARRB1(1), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP2A2(2), ATP2A3(1), ATP2B3(4), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1S(3), CACNB3(1), CAMK4(1), CHRM5(1), GJA1(2), GJA4(1), GJB2(1), GNB1(2), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(5), KCNB1(1), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A3(1), YWHAQ(1)	26882931	118	49	108	64	20	11	50	16	21	0	1.000	1.000	1.000
416	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ACTN1(2), ACTN2(2), ACTN4(1), APC(4), APC2(2), ARHGEF1(1), ARHGEF4(2), ARPC2(1), BCAR1(1), BDKRB2(1), BRAF(1), CD14(1), CHRM5(1), CSK(1), CYFIP1(1), CYFIP2(3), DIAPH2(2), DIAPH3(1), DOCK1(2), EGFR(3), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(2), FGF5(1), FGFR2(2), FGFR4(1), FN1(1), GIT1(1), GSN(1), IQGAP2(1), IQGAP3(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LIMK2(1), MAPK1(1), MYH14(3), MYLK(2), MYLK2(2), NCKAP1(1), NRAS(1), PAK3(3), PAK4(1), PAK7(2), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), ROCK1(2), SCIN(1), SLC9A1(1), SOS2(1), SSH1(1), TIAM1(4), TIAM2(3), VAV1(3), VAV2(1), VAV3(3), WAS(1), WASF2(1)	39316248	124	48	122	58	18	7	55	24	19	1	0.996	1.000	1.000
417	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(2), ABLIM2(1), ABLIM3(3), CXCR4(1), DCC(1), EFNA2(1), EPHA1(2), EPHA2(1), EPHA5(2), EPHA6(2), EPHA8(3), EPHB1(1), EPHB3(2), EPHB4(2), EPHB6(1), L1CAM(1), LIMK2(1), LRRC4C(3), MAPK1(1), NCK2(1), NFATC1(1), NRAS(1), NTN1(1), NTN4(2), NTNG1(2), PAK3(3), PAK4(1), PAK7(2), PLXNA1(3), PLXNA2(4), PLXNA3(3), PLXNB2(3), PLXNB3(7), PLXNC1(1), PPP3CB(1), RGS3(1), RHOD(2), RND1(1), ROBO1(3), ROBO2(4), ROBO3(1), ROCK1(2), SEMA3D(3), SEMA3E(1), SEMA3F(1), SEMA3G(2), SEMA4F(1), SEMA4G(1), SEMA5A(3), SEMA5B(17), SEMA6A(2), SEMA6B(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT2(6), UNC5A(2), UNC5B(1), UNC5C(3), UNC5D(2)	27803290	132	47	115	45	29	9	58	27	9	0	0.530	1.000	1.000
418	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	145	APC(4), APC2(2), CCND2(1), CHD8(1), CREBBP(1), CTBP2(4), CTNNB1(14), DAAM1(2), DAAM2(2), DKK1(1), DKK2(1), DVL1(1), DVL2(1), EP300(2), FZD1(6), FZD5(1), FZD7(1), FZD8(2), LRP6(1), NFATC1(1), NKD1(1), NKD2(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PPP3CB(1), PRICKLE2(1), PRKACA(1), PRKACB(1), PRKCG(1), ROCK1(2), TBL1X(3), TCF7L2(1), TP53(18), WIF1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	22427556	96	46	85	45	11	3	29	18	33	2	1.000	1.000	1.000
419	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	BCL2L1(2), CBL(1), CBLC(1), CCND2(1), CNTFR(1), CREBBP(1), CSF2RA(1), CSF2RB(1), CSF3R(1), EP300(2), EPO(1), GH2(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL2(1), IL21R(2), IL23R(1), IL24(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), LIF(1), MPL(1), OSMR(4), PIAS2(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PTPN11(1), PTPN6(1), SOCS5(1), SOCS7(1), SOS2(1), SPRED1(1), STAM(1), STAT5B(1), STAT6(1), TPO(22), TYK2(2)	20192727	86	46	67	23	6	4	47	12	17	0	0.484	1.000	1.000
420	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC2(19), ERCC3(1), G6PC2(1), GAA(1), GUSB(1), HK2(3), HK3(3), LYZL1(2), MGAM(4), MOV10L1(1), PYGL(1), RAD54B(1), RUVBL2(1), SETX(2), SI(5), SMARCA2(4), SMARCA5(1), UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	17163314	79	45	59	25	23	1	29	12	13	1	0.680	1.000	1.000
421	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), CD99(1), CDH5(2), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), CXCR4(1), ESAM(1), F11R(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(2), ITK(1), MAPK11(1), MMP9(1), NOX1(1), NOX3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), PTPN11(1), RAPGEF3(1), RASSF5(3), ROCK1(2), VASP(1), VAV1(3), VAV2(1), VAV3(3)	17495091	84	45	67	27	12	2	39	17	13	1	0.702	1.000	1.000
422	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), CALML3(1), CALML6(1), CREB3L1(1), CREB3L3(2), CREBBP(1), CTNNB1(14), DCT(1), DVL1(1), DVL2(1), EDNRB(1), EP300(2), FZD1(6), FZD5(1), FZD7(1), FZD8(2), GNAS(5), MAPK1(1), MC1R(1), NRAS(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), TCF7L2(1), TYRP1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	15262449	76	45	65	33	9	2	27	16	21	1	0.992	1.000	1.000
423	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), AKAP1(2), AKAP11(1), AKAP12(4), AKAP2(7), AKAP4(2), AKAP5(1), AKAP6(1), AKAP8(2), AKAP9(3), ARHGEF1(1), GNAL(2), GNB1(2), ITPR1(2), NRAS(1), PDE1A(2), PDE1C(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), SLC9A1(1)	16203839	71	44	63	31	15	1	26	12	17	0	0.978	1.000	1.000
424	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSL(1), ADSS(1), ADSSL1(3), AK5(2), ENTPD2(1), ENTPD4(3), ENTPD8(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), NUDT9(2), PAPSS2(1), PDE10A(1), PDE1A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PDE9A(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), PRPS1L1(1), RFC5(1), RRM2(1), XDH(3)	22918465	77	44	74	35	11	6	36	17	7	0	0.979	1.000	1.000
425	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADM(1), ARRB1(1), ARRB2(1), ATF4(1), ATP2A2(2), ATP2A3(1), CACNB3(1), CALCA(1), CNN1(1), CORIN(1), DGKZ(6), ETS2(1), GABPB2(1), GJA1(2), GNB1(2), GRK4(1), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP6(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK2(2), NFKB1(1), NOS1(2), NOS3(4), PDE4B(1), PDE4D(1), PLCB3(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCH(1), PRKCQ(2), PRKD1(1), RAMP3(2), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), TNXB(3), YWHAQ(1)	24652747	114	44	110	70	16	8	50	22	18	0	1.000	1.000	1.000
426	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(1), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CX3CR1(2), CXCR3(2), CXCR4(1), EDNRB(1), FPR1(2), FSHR(1), GALR3(1), MC1R(1), MC3R(1), NPY1R(1), OPRD1(26), OPRL1(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TACR3(1)	7075076	62	43	36	28	8	1	45	6	2	0	0.794	1.000	1.000
427	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(1), CAMK4(1), CEBPB(1), CREBBP(1), CTLA4(2), EGR2(1), EGR3(1), EP300(2), FCER1A(2), FCGR3A(3), GATA3(2), GATA4(2), IL2(1), IL3(1), ITK(1), KPNA5(2), NCK2(1), NFATC1(1), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(26), PIN1(1), PPP3CB(1), RPL13A(1), SLA(2), VAV1(3), VAV2(1), VAV3(3)	12703118	69	41	44	36	4	0	53	6	6	0	0.999	1.000	1.000
428	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), EGFR(3), GJA1(2), GNAS(5), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), MAPK7(2), NRAS(1), PDGFD(1), PDGFRA(1), PDGFRB(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), PRKG2(2), SOS2(1), TJP1(1), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), TUBB2B(1)	18527419	71	40	69	37	15	1	28	17	10	0	0.991	1.000	1.000
429	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSL(1), ADSS(1), AK5(2), ATP1B1(1), ATP5F1(1), ENTPD2(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NT5E(1), NT5M(1), NUDT2(1), PAPSS2(1), PDE1A(2), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE9A(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), PRPS1L1(1), RRM2(1)	17959345	59	39	54	30	10	9	23	12	5	0	0.989	1.000	1.000
430	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(1), APAF1(1), ATM(5), BCL2L1(2), CAPN2(3), CASP8(1), CSF2RB(1), DFFA(1), FADD(2), IL3(1), IRAK1(2), IRAK2(2), NFKB1(1), NFKB2(1), NTRK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKAR1A(7), TNFRSF10A(1), TNFRSF1A(1), TP53(18)	11703551	62	38	60	38	7	2	19	6	27	1	1.000	1.000	1.000
431	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(10), CACNA1B(6), GNAS(5), GNB1(2), GRM4(1), ITPR3(5), KCNB1(1), PDE1A(2), PRKACA(1), PRKACB(1), SCNN1A(2), SCNN1B(2), TAS1R2(1), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R42(1), TAS2R43(4), TAS2R46(1), TAS2R5(1), TAS2R50(1)	8148492	58	37	51	27	8	6	34	5	5	0	0.946	1.000	1.000
432	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC10(1), ATM(5), ATR(3), CCNB3(2), CCND2(1), CDC14A(1), CDC16(2), CDC20(1), CDC27(1), CDC7(1), CDKN2A(2), CHEK2(2), CREBBP(1), DBF4(3), E2F3(1), EP300(2), ESPL1(1), FZR1(2), GADD45G(2), HDAC1(1), HDAC2(1), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), PRKDC(3), RB1(2), RBL1(1), SMC1A(2), TFDP1(1), TP53(18), YWHAQ(1)	18825167	69	36	69	27	11	3	20	6	28	1	0.981	1.000	1.000
433	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTG1(2), ACTN1(2), ACTN2(2), ACTN4(1), ACVR1B(1), CDH1(1), CREBBP(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), EGFR(3), EP300(2), FARP2(1), IGF1R(1), INSR(1), MAPK1(1), PARD3(1), PTPN6(1), PTPRF(2), PTPRJ(3), PVRL1(2), PVRL3(2), PVRL4(1), SORBS1(1), TCF7L2(1), TGFBR2(2), TJP1(1), WAS(1), WASF2(1)	16698913	54	36	49	18	9	3	21	9	12	0	0.791	1.000	1.000
434	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(1), CACNA1A(10), GNAS(5), GRIA2(3), GRID2(1), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IGF1R(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NOS1(2), NOS3(4), NRAS(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PRKCG(1), PRKG2(2), RYR1(4)	15662151	70	36	67	47	10	1	32	18	9	0	1.000	1.000	1.000
435	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ATF4(1), CACNA1C(1), CACNA1D(3), CACNA1F(3), CACNA1S(3), CALML3(1), CALML6(1), EGFR(3), GNAS(5), ITPR1(2), ITPR2(4), ITPR3(5), MAP2K3(2), MAP3K1(2), MAP3K3(1), MAP3K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MMP14(2), NRAS(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PLD2(1), PRKACA(1), PRKACB(1), SOS2(1)	18256392	74	36	70	31	16	1	30	14	13	0	0.935	1.000	1.000
436	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(1), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(2), FBXO11(1), HCFC1(2), JMJD4(6), MEN1(8), MLL(5), MLL2(4), MLL3(7), MLL4(8), MLL5(1), NSD1(4), OGT(1), PPP1CA(2), PRDM6(2), PRDM9(5), SETD1A(1), SETD1B(2), SETD2(3), SETDB1(1), SETDB2(1), SETMAR(1), SUV420H1(1), WHSC1(1), WHSC1L1(1)	17576762	78	35	72	20	18	2	21	10	26	1	0.519	1.000	1.000
437	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CANX(1), CD8A(1), CIITA(2), CTSL1(1), HLA-A(4), HLA-B(10), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), HSPA5(1), IFNA8(1), KIR2DL1(1), KIR3DL2(1), NFYA(1), TAP1(1), TAP2(1)	6394736	42	35	39	22	2	4	15	13	8	0	0.997	1.000	1.000
438	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(1), ACVR1B(1), ACVRL1(1), AURKB(1), BMPR1A(2), BMPR2(1), CDIPT(1), CLK1(2), CLK2(1), COL4A3BP(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), INPP4A(2), NEK1(1), OCRL(1), PAK4(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RPS6KA1(1), RPS6KA4(2), STK11(2)	15979496	57	34	54	41	11	2	15	13	16	0	1.000	1.000	1.000
439	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(5), CCNB3(2), CCND2(1), CDC14A(1), CDC20(1), CDC7(1), CDH1(1), CDKN2A(2), CHEK2(2), DTX4(1), E2F3(1), EP300(2), ESPL1(1), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), MPL(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), TBC1D8(2), TFDP1(1), TP53(18)	15435044	60	33	60	28	9	2	19	4	25	1	0.995	1.000	1.000
440	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(1), CTBP2(4), DLL1(1), DLL3(1), DTX2(2), DTX4(1), DVL1(1), DVL2(1), EP300(2), HDAC1(1), HDAC2(1), JAG2(1), MAML1(1), MAML3(2), NCOR2(4), NOTCH1(4), NOTCH2(12), NOTCH3(3), NOTCH4(2), PTCRA(2), RBPJL(2), SNW1(2)	10049565	51	33	38	33	7	15	15	7	7	0	0.999	1.000	1.000
441	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(1), CD247(1), FCGR3A(3), GZMB(1), HLA-A(4), HLA-B(10), HLA-C(2), HLA-G(1), ICAM1(1), IFNA8(1), IFNAR2(1), ITGAL(1), KIR2DL1(1), KIR3DL2(1), LAT(1), LCK(1), MAPK1(1), MICA(2), MICB(1), NFATC1(1), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTPN11(1), PTPN6(1), SHC2(2), SHC3(1), SOS2(1), SYK(1), TNFRSF10A(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1)	15717954	65	33	62	23	11	4	22	12	16	0	0.871	1.000	1.000
442	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(2), BFAR(1), BTK(1), CAD(1), CASP8(1), DAXX(4), DFFA(1), EGFR(3), FADD(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PTPN13(2), ROCK1(2), TNFRSF6B(1), TP53(18)	10341157	48	33	48	36	8	2	16	5	16	1	1.000	1.000	1.000
443	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(5), CCND2(1), CDKN2A(2), CREB3L1(1), CREB3L3(2), E2F3(1), MCM3(1), MDM2(2), NACA(4), POLA2(1), POLE(3), RB1(2), RBL1(1), RPA2(1), TFDP1(1), TNXB(3), TP53(18)	10593271	49	32	48	22	8	2	13	5	20	1	0.980	1.000	1.000
444	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), EGFR(3), ERBB4(5), ETS2(1), FMN2(3), MAPK1(1), NOTCH1(4), NOTCH2(12), NOTCH3(3), NOTCH4(2), PIWIL1(1), PIWIL3(2), SOS2(1), SPIRE2(4)	7293778	43	30	30	18	7	13	10	7	6	0	0.907	1.000	1.000
445	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(3), ATF4(1), BRAF(1), CACNA1C(1), CALML3(1), CALML6(1), CAMK4(1), CREBBP(1), EP300(2), GRIA2(3), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NRAS(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP1CA(2), PPP1R12A(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RAPGEF3(1), RPS6KA1(1), RPS6KA6(1)	14248219	54	29	53	35	10	1	19	13	11	0	1.000	1.000	1.000
446	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), COX4I1(1), COX4I2(1), COX6B1(1), COX7A1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(1), NDUFB10(1), NDUFB11(2), NDUFB5(2), NDUFB7(1), NDUFB8(1), NDUFS2(1), PPA1(1), SDHA(1), SDHB(1), SDHD(1), TCIRG1(1), UQCRFS1(12)	7869869	45	28	33	17	4	2	15	18	6	0	0.898	1.000	1.000
447	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR1B(1), ACVR2B(1), ACVRL1(1), AMH(1), AMHR2(1), BMP6(1), BMP8A(3), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CHRD(2), CREBBP(1), DCN(2), EP300(2), GDF5(1), GDF6(1), ID1(1), INHBA(2), INHBB(3), LEFTY2(1), LTBP1(1), MAPK1(1), NOG(1), PITX2(3), PPP2R1B(1), RBL1(1), ROCK1(2), SMAD6(1), SMAD7(1), TFDP1(1), TGFBR2(2), THBS1(1), THBS2(2), THBS4(2), ZFYVE16(1), ZFYVE9(3)	13632184	55	28	53	30	15	2	23	13	2	0	0.992	1.000	1.000
448	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(1), CAPN2(3), CAPN6(4), CAPN9(1), CAPNS1(1), CSK(1), DOCK1(2), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), MAP2K3(2), MAPK7(2), MYLK2(2), PAK3(3), PAK4(1), PIK3R2(1), RAPGEF1(1), ROCK1(2), SHC3(1), SORBS1(1), TLN1(2), TNS1(3), VASP(1), VAV2(1), VAV3(3), ZYX(1)	19075816	60	28	59	22	9	0	34	10	6	1	0.750	1.000	1.000
449	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), B3GNT6(4), B4GALT5(2), B4GALT7(1), C1GALT1(1), CHPF(2), CHST1(1), CHST11(1), CHST13(3), CHST3(1), EXT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), MAN2A1(2), MGAT3(1), NDST2(1), NDST4(2), OGT(1), RPN2(2), ST3GAL1(1), ST6GALNAC1(1), XYLT1(1)	15375772	56	27	52	26	7	4	19	14	12	0	0.978	1.000	1.000
450	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML3(1), CALML6(1), CDIPT(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), INPP4A(2), INPP5B(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), OCRL(1), PI4KA(4), PIK3C2G(1), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PRKCG(1), SYNJ1(1)	17732023	57	27	55	36	10	1	22	18	6	0	1.000	1.000	1.000
451	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(2), ACACB(4), BRAF(1), CALML3(1), CALML6(1), CBL(1), CBLC(1), FASN(3), G6PC2(1), INPP5D(1), INSR(1), IRS4(1), LIPE(2), MAPK1(1), MKNK1(1), NRAS(1), PCK1(1), PDE3A(2), PDE3B(1), PFKL(2), PHKA2(2), PHKB(3), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPARGC1A(2), PPP1CA(2), PPP1R3A(1), PRKAA2(1), PRKACA(1), PRKACB(1), PRKAG2(3), PRKAG3(1), PRKAR1A(7), PRKCI(1), PTPRF(2), PYGL(1), RAPGEF1(1), SHC2(2), SHC3(1), SORBS1(1), SOS2(1), TSC2(1)	22668856	71	27	70	40	14	3	18	16	20	0	1.000	1.000	1.000
452	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA12(3), ABCA13(3), ABCA2(2), ABCA3(1), ABCA5(2), ABCA6(3), ABCA7(2), ABCB1(1), ABCB11(1), ABCB4(2), ABCB5(1), ABCC1(1), ABCC10(1), ABCC11(4), ABCC12(1), ABCC2(2), ABCC3(2), ABCC5(1), ABCC6(2), ABCC9(1), ABCD1(1), ABCD2(1), ABCD4(1), ABCG5(1), CFTR(2), TAP1(1), TAP2(1)	16652984	45	26	45	47	7	2	19	6	11	0	1.000	1.000	1.000
453	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(5), ATR(3), CDKN2A(2), HDAC1(1), RB1(2), TFDP1(1), TP53(18)	4108867	32	25	32	10	4	0	8	2	17	1	0.878	1.000	1.000
454	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(5), ATR(3), CHEK2(2), EP300(2), MDM2(2), PRKDC(3), RPS6KA1(1), TP53(18), YWHAQ(1)	5907518	37	25	37	17	3	1	10	3	19	1	0.994	1.000	1.000
455	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	BDKRB2(1), C1QC(1), C1S(1), C2(1), C3AR1(1), C6(1), C7(1), C8B(1), C9(3), CFB(1), CFD(1), CFH(2), CR1(1), CR2(2), F13A1(1), F5(2), F8(2), F9(1), KNG1(1), PLAT(1), PLG(1), PROC(1), PROS1(1), SERPINA1(1), SERPIND1(1), SERPINE1(1), SERPING1(1), TFPI(1), VWF(6)	12597142	40	25	40	17	9	2	13	10	6	0	0.861	1.000	1.000
456	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	CASP8(1), CD14(1), CXCL9(2), FADD(2), IFNA8(1), IFNAR2(1), IRAK1(2), IRF3(1), IRF5(1), LBP(1), MAP2K3(2), MAP3K8(1), MAPK1(1), MAPK11(1), NFKB1(1), NFKB2(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), TBK1(1), TICAM1(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2)	12413567	38	25	37	40	4	3	14	11	6	0	1.000	1.000	1.000
457	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(2), ACTN4(1), DES(1), DMD(4), MYBPC1(1), MYBPC2(1), MYH3(2), MYH6(4), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(7), TNNT1(1), TNNT2(1), TPM2(2), TTN(28), VIM(1)	19293053	63	25	63	25	8	7	27	13	8	0	0.915	1.000	1.000
458	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), DHODH(3), DPYD(2), DPYS(2), ENTPD4(3), ENTPD8(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), RFC5(1), RRM2(1), TXNRD2(1), UCK2(1)	11408708	36	24	34	14	6	4	14	6	6	0	0.865	1.000	1.000
459	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	CARD11(3), CBL(1), CBLC(1), CD247(1), CD3D(1), CD8A(1), CTLA4(2), IL2(1), ITK(1), LAT(1), LCK(1), MAP3K8(1), NCK2(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), NRAS(1), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCQ(2), PTPN6(1), RASGRP1(2), SOS2(1), TEC(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1)	14113652	54	24	54	44	8	3	24	8	11	0	1.000	1.000	1.000
460	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ACTN1(2), BCAR1(1), BRAF(1), CDKN2A(2), DOCK1(2), ITGA10(2), ITGA2(1), ITGA3(2), ITGA4(2), ITGA6(1), ITGA9(1), MAPK1(1), MAPK8IP3(2), MYLK(2), MYLK2(2), P4HB(1), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PLCG1(3), ROCK1(2), SOS2(1), TLN1(2), TLN2(6), VASP(1), WAS(1), ZYX(1)	17141779	50	24	50	19	7	1	26	8	7	1	0.829	1.000	1.000
461	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), HSD17B1(5), HSD17B7(2), LCMT1(1), STS(2), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1), WBSCR22(1)	6891599	31	23	26	26	8	1	19	2	1	0	1.000	1.000	1.000
462	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	AMDHD1(18), AOC3(1), LCMT1(1), MAOA(3), UROC1(1), WBSCR22(1)	5576448	25	23	8	22	1	1	3	18	2	0	1.000	1.000	1.000
463	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(1), AREG(1), BRAF(1), CBL(1), CBLC(1), EGFR(3), ERBB3(1), ERBB4(5), GAB1(1), MAPK1(1), NCK2(1), NRAS(1), NRG2(2), NRG3(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), SHC2(2), SHC3(1), SOS2(1), STAT5B(1)	14418237	44	23	43	20	10	3	15	8	8	0	0.956	1.000	1.000
464	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(4), ACSL1(3), ACSL3(2), ADIPOR1(1), CAMKK2(1), CPT1C(1), G6PC2(1), IRS4(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), NFKB1(1), NFKB2(1), NFKBIE(2), PCK1(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG2(3), PRKAG3(1), PRKCQ(2), PTPN11(1), STK11(2), TNFRSF1A(1), TYK2(2)	11651382	43	23	43	44	5	3	18	8	9	0	1.000	1.000	1.000
465	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), ATP7B(3), COX4I1(1), COX6B1(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRFS1(12)	5287352	32	23	21	15	3	0	11	15	3	0	0.963	1.000	1.000
466	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ARHGAP4(1), ARHGEF11(2), BTK(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3R1(1), PITX2(3), ROCK1(2)	9764406	32	23	32	21	5	0	15	8	4	0	0.996	1.000	1.000
467	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), JAK2(2), NFKB1(1), RB1(2), TNFRSF1A(1), TP53(18), USH1C(2), WT1(2)	2542449	29	23	29	14	4	1	8	3	12	1	0.967	1.000	1.000
468	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(1), BAG4(1), CASP8(1), DAXX(4), DFFA(1), FADD(2), GSN(1), LMNB1(1), LMNB2(2), MAP3K1(2), MDM2(2), NFKB1(1), NUMA1(1), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1)	9734495	31	22	31	14	8	4	6	0	13	0	0.933	1.000	1.000
469	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP6(1), BMP8A(3), BMP8B(1), CSNK1G1(1), DHH(2), GLI2(2), GLI3(9), HHIP(2), LRP2(2), PRKACA(1), PRKACB(1), PTCH1(2), SHH(2), SMO(3), SUFU(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	8341391	42	22	34	16	14	3	11	6	7	1	0.791	1.000	1.000
470	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK2(1), COL2A1(1), CPSF1(2), CPSF3(1), CSTF2(1), DHX15(1), DHX38(1), DICER1(1), GIPC1(1), NCBP1(1), NXF1(1), PAPOLA(2), PRPF4B(1), PRPF8(2), PTBP2(1), RBM5(1), SF3B1(2), SNRPB2(1), SNRPE(1), SNRPN(1), SNURF(1), SRPK1(1), SRPK2(1), SRRM1(3), SUPT5H(1), U2AF1(1)	14722487	32	22	32	12	7	1	12	4	7	1	0.925	1.000	1.000
471	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	CKM(2), CKMT2(1), CPS1(3), DAO(2), EPRS(4), GLUD1(1), GLUD2(1), GOT1(1), GOT2(2), LAP3(1), NOS1(2), NOS3(4), PRODH(4), PYCRL(1), RARS2(2)	5034378	31	21	30	20	6	2	12	7	4	0	0.994	1.000	1.000
472	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(1), DAXX(4), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MEF2C(2), MKNK1(1), NFKB1(1), RPS6KA1(1), RPS6KA4(2)	13721453	27	21	26	25	6	1	9	7	4	0	1.000	1.000	1.000
473	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), DHODH(3), DPYD(2), DPYS(2), NT5E(1), NT5M(1), NUDT2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), RRM2(1), UCK2(1)	8059053	29	21	25	11	5	7	9	4	4	0	0.850	1.000	1.000
474	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(2), BTK(1), CD19(2), CDKN2A(2), DAPP1(1), GAB1(1), ITPR1(2), ITPR2(4), ITPR3(5), PIK3CA(1), PITX2(3), PREX1(4), RPS6KA1(1), SYK(1), TEC(1), VAV1(3)	7727437	34	21	34	21	6	2	16	6	4	0	0.997	1.000	1.000
475	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH6(1), ADH7(2), AGK(1), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), GK2(1), GPAM(3), LCT(1), PNLIP(3), PNLIPRP1(2), PNPLA3(2), PPAP2C(1)	8295723	30	20	28	13	5	0	12	8	5	0	0.891	1.000	1.000
476	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH6(1), ADH7(2), AKR1C3(1), AKR1C4(1), CYP2B6(3), CYP2C9(1), DHDH(1), EPHX1(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	7961062	31	20	30	17	5	0	15	5	6	0	0.986	1.000	1.000
477	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACSL1(3), ACSL3(2), ANGPTL4(1), AQP7(4), CPT1C(1), CYP4A22(4), EHHADH(1), FABP2(1), FADS2(1), GK2(1), HMGCS2(1), PCK1(1), PPARA(1), SLC27A1(3), SLC27A5(1), SORBS1(1)	9000793	27	20	25	11	5	3	10	6	3	0	0.822	1.000	1.000
478	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(2), ESR1(1), HNF4A(1), NR1D1(1), NR1H2(2), NR2C2(1), NR2F1(3), NR4A1(1), NR4A2(2), NR5A1(2), NR5A2(1), PGR(1), PPARA(1), RARA(1), ROR1(1), RORA(1), RORC(2), THRA(1), VDR(1)	5931895	28	20	28	19	3	3	8	6	7	1	0.999	1.000	1.000
479	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), AOC3(1), CKM(2), CKMT2(1), CPS1(3), DAO(2), GLUD1(1), GOT1(1), GOT2(2), MAOA(3), NOS1(2), NOS3(4), P4HB(1)	6175914	24	19	24	27	5	1	10	3	5	0	1.000	1.000	1.000
480	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ALG6(1), CCR3(1), CELSR1(3), CELSR2(1), CXCR3(2), EMR2(4), EMR3(1), FSHR(1), GPR133(1), GPR61(2), GPR84(2), GRM1(3), LGR6(2), LPHN2(1), LPHN3(3), SMO(3), SSTR2(1), TAAR5(4)	9265747	36	18	35	17	6	2	17	9	2	0	0.871	1.000	1.000
481	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(1), ALOX5(3), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP2U1(2), CYP4A22(4), CYP4F2(1), CYP4F3(1), GPX1(1), GPX7(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PTGDS(1), PTGS1(1), PTGS2(2)	5561261	32	18	32	11	3	3	14	5	7	0	0.739	1.000	1.000
482	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(2), BTK(1), CD19(2), CR2(2), CSK(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), SOS2(1), SYK(1), VAV1(3)	10205656	30	18	30	15	4	0	12	8	6	0	0.966	1.000	1.000
483	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), FLNA(3), FLNC(1), MYH2(2), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), ROCK1(2), VASP(1)	6673173	21	18	21	12	3	3	8	4	3	0	0.932	1.000	1.000
484	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), TP53(18), WT1(2)	978266	21	18	21	13	3	0	6	1	10	1	0.993	1.000	1.000
485	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(2), INPP5B(1), IPMK(1), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), SYNJ1(1)	10455225	25	17	25	27	6	1	10	6	2	0	1.000	1.000	1.000
486	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ARF3(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), GNAS(5), PDIA4(1), PLCG1(3)	5171329	22	17	22	10	4	3	8	3	4	0	0.883	1.000	1.000
487	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), CSK(1), CXCL1(1), EGFR(3), F11R(2), GIT1(1), MAPK11(1), NFKB1(1), NFKB2(1), NOD1(1), PLCG1(3), PTPN11(1), PTPRZ1(3), TCIRG1(1), TJP1(1)	9829690	30	17	30	29	5	0	13	4	8	0	1.000	1.000	1.000
488	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), POLR1A(1), POLR2B(2), POLR2H(1), TAF5(12)	4794079	17	17	6	12	0	0	3	12	2	0	0.998	1.000	1.000
489	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD3D(1), CSK(1), CTLA4(2), ITK(1), LAT(1), LCK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PAK3(3), PAK4(1), PAK7(2), PLCG1(3), RASGRP1(2), SOS2(1), VAV1(3), ZAP70(1)	7943137	29	17	29	33	5	1	13	3	7	0	1.000	1.000	1.000
490	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), GAA(1), GUSB(1), HK2(3), HK3(3), MGAM(4), PYGL(1), SI(5), UGT1A3(1), UGT1A5(2), UGT2B15(2)	7959088	25	17	25	12	2	0	13	6	4	0	0.933	1.000	1.000
491	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(1), EP300(2), ERCC3(1), ESR1(1), GRIP1(3), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MEF2C(2), NCOR2(4), NRIP1(3), PELP1(1)	6593744	23	16	23	23	0	0	12	6	5	0	1.000	1.000	1.000
492	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(1), ALPI(1), ALPP(1), ALPPL2(8), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), PON1(1)	4067840	20	16	14	10	1	9	8	2	0	0	0.880	1.000	1.000
493	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDIPT(1), CHAT(1), CHKB(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), GNPAT(1), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPAP2C(1)	7155619	29	16	27	11	5	1	13	6	4	0	0.782	1.000	1.000
494	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ENO2(1), ENO3(1), GOT1(1), GOT2(2), HK2(3), HK3(3), LDHA(3), MDH2(1), PC(1), PCK1(1), PDHB(1), PFKL(2), PGAM1(1), PGK2(3)	5825718	24	16	24	10	5	1	10	6	2	0	0.776	1.000	1.000
495	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	FUK(3), GMPPB(1), HK2(3), HK3(3), KHK(2), LHPP(2), MTMR1(1), MTMR2(1), PFKL(2)	5284899	18	16	17	12	5	3	6	2	2	0	0.965	1.000	1.000
496	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	KDR(1), MAPK1(1), MAPK11(1), NFATC1(1), NOS3(4), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTGS2(2), SH2D2A(1), SHC2(2), SPHK1(2), SPHK2(2)	10141267	37	16	37	13	7	2	14	8	6	0	0.784	1.000	1.000
497	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PIK3CB(1), PITX2(3), PLCB1(3), PLCB3(1), PLCB4(1), SOS2(1)	8109429	26	16	26	15	6	1	10	8	1	0	0.965	1.000	1.000
498	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ITPR1(2), ITPR2(4), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PITX2(3), PLD2(1)	6392959	22	16	22	30	3	1	13	5	0	0	1.000	1.000	1.000
499	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF1(1), EIF2B5(1), FLT4(6), KDR(1), NOS3(4), PIK3CA(1), PIK3R1(1), PLCG1(3)	4790033	18	16	18	7	6	3	5	4	0	0	0.691	1.000	1.000
500	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH6(1), ADH7(2), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), LCT(1), PNLIP(3), PNLIPRP1(2), PPAP2C(1)	6842404	22	15	20	10	3	0	9	7	3	0	0.925	1.000	1.000
501	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), G6PC2(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PFKL(2), PGAM1(1), PGK2(3)	8038336	24	15	24	15	4	1	8	8	3	0	0.987	1.000	1.000
502	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(2), HADH(1), HADHA(1), HSD17B4(3), NSD1(4), OGDHL(1), PIPOX(1), PLOD3(2), SETD1A(1), SETDB1(1), SHMT2(1)	8016166	28	15	28	11	4	2	13	3	6	0	0.803	1.000	1.000
503	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	BTK(1), FCER1A(2), IL3(1), INPP5D(1), LAT(1), MAP2K3(2), MAPK1(1), MAPK11(1), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), SOS2(1), SYK(1), VAV1(3), VAV2(1), VAV3(3)	9889341	37	15	37	15	5	1	13	9	9	0	0.929	1.000	1.000
504	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), GNAS(5), GNB1(2), MAPK1(1), PIN1(1), PRKACB(1), PRKAR1A(7), RPS6KA1(1)	2901366	19	15	18	11	2	0	4	3	10	0	0.998	1.000	1.000
505	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), B3GALT4(1), CDR1(1), DGKI(1), RPL12(1), RPL13A(1), RPL14(1), RPL22(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS6KA1(1), RPS6KA6(1), RPS9(1), SLC36A2(1), UBB(1)	7157472	24	15	24	30	3	0	14	4	3	0	1.000	1.000	1.000
506	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	BCL2L1(2), CDKN2A(2), ERBB4(5), GAB1(1), IGFBP1(1), IRS4(1), PAK3(3), PAK4(1), PAK7(2), PARD3(1), PIK3CA(1), PREX1(4), RPS6KA1(1), SOS2(1), TSC2(1), YWHAQ(1)	10609618	28	15	28	31	4	3	12	3	6	0	1.000	1.000	1.000
507	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(4), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PITX2(3), PTX3(1), RYR1(4)	6493567	24	15	24	14	4	0	11	7	2	0	0.965	1.000	1.000
508	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), GNAS(5), MAPK1(1), PIK3CA(1), PIK3R1(1), PRKACB(1), PRKAR1A(7), RPS6KA1(1)	4065742	18	14	17	13	1	0	3	4	10	0	1.000	1.000	1.000
509	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), CASP8(1), INSR(1), ITCH(1), MAGI1(2), MAGI2(4), RERE(2), WWP1(1), WWP2(1)	3267801	18	14	15	10	2	0	13	2	1	0	0.967	1.000	1.000
510	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(1), CREBBP(1), EGR1(2), EGR2(1), EGR3(1), EGR4(3), MAP1B(2), MAPK1(1), MAPK8IP3(2), NTRK1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PTPN11(1), TH(3)	7298494	22	14	22	11	5	0	9	6	2	0	0.920	1.000	1.000
511	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(5), GNB1(2), IGF1R(1), MAPK1(1), MKNK1(1), NGFR(2), PDGFRA(1), RPS6KA1(1)	4682544	17	13	17	14	7	0	5	3	2	0	0.998	1.000	1.000
512	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1)	6723625	17	13	17	12	3	1	6	5	2	0	0.986	1.000	1.000
513	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1)	6723625	17	13	17	12	3	1	6	5	2	0	0.986	1.000	1.000
514	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(2), DHCR7(1), FDFT1(1), HMGCR(1), HSD17B7(2), IDI1(5), NSDHL(1), SQLE(2)	2729005	15	13	12	21	1	1	10	1	2	0	1.000	1.000	1.000
515	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	BTK(1), CARD11(3), CD19(2), CR2(2), INPP5D(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), NRAS(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PTPN6(1), SYK(1), VAV1(3), VAV2(1), VAV3(3)	10381980	32	13	32	37	3	1	15	6	7	0	1.000	1.000	1.000
516	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), OCRL(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3)	6301369	14	13	14	19	3	1	5	5	0	0	1.000	1.000	1.000
517	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(3), ARPC2(1), GSN(1), MYLK(2), ROCK1(2), TLN1(2)	6482355	17	13	17	12	3	1	7	4	2	0	0.990	1.000	1.000
518	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	BRD4(1), CBL(1), CDKN2A(2), IGFBP1(1), IRS4(1), LNPEP(1), MAPK1(1), PARD3(1), PIK3CA(1), PIK3R1(1), PPYR1(3), RPS6KA1(1), SORBS1(1), SOS2(1), YWHAQ(1)	8102309	18	13	18	25	3	2	8	2	3	0	1.000	1.000	1.000
519	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CXCR4(1), GNB1(2), MAPK1(1), NFKB1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PLCG1(3)	3930721	12	12	12	11	2	0	7	2	1	0	0.997	1.000	1.000
520	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	FPR1(2), GNB1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), NFATC1(1), NFKB1(1), PIK3C2G(1), PLCB1(3), PPP3CB(1)	5402763	16	12	16	7	2	0	11	3	0	0	0.824	1.000	1.000
521	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(2), DEGS2(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SGPP1(1), SMPD4(1), SPHK1(2), SPHK2(2), SPTLC1(1), SPTLC2(1)	4959348	17	12	17	10	3	0	11	1	2	0	0.944	1.000	1.000
522	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	ARHGEF11(2), LPA(1), MAP3K1(2), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PLD2(1), ROCK1(2), SERPINA4(1), SRF(1), TBXA2R(1)	6776364	18	12	18	32	4	1	11	2	0	0	1.000	1.000	1.000
523	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AOC3(1), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), ECHS1(2), EHHADH(1), HADHA(1), KMO(1), MAOA(3), SDS(1), TDO2(1), WARS2(1)	7589596	19	12	19	11	3	0	10	2	4	0	0.976	1.000	1.000
524	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), STS(2), UGT1A3(1), UGT1A5(2), UGT2B15(2)	3737212	14	11	14	21	2	0	9	2	1	0	1.000	1.000	1.000
525	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MAPK1(1), MAPK7(2), MEF2C(2), NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), RPS6KA1(1)	2746477	12	11	11	11	2	0	7	3	0	0	0.998	1.000	1.000
526	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(1), MAPK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PRKAA2(1), RPS6KA1(1), RPS6KA6(1), STK11(2), TSC2(1), ULK1(1), ULK2(1), ULK3(1), VEGFB(1)	7461347	19	11	19	16	0	2	7	5	5	0	1.000	1.000	1.000
527	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(4), MAP3K1(2), MEF2C(2), MKNK1(1), PLA2G4A(3)	5167366	12	11	12	11	2	1	4	2	3	0	0.999	1.000	1.000
528	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), PAPPA(6), RPS6KA1(1), SYK(1), VAV1(3), VAV2(1), VAV3(3)	4474000	22	11	22	13	3	1	12	2	4	0	0.987	1.000	1.000
529	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BCR(2), BTK(1), CD19(2), CSK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1), SERPINA4(1), SOS2(1), SYK(1), VAV1(3)	7364458	19	11	19	34	2	0	10	3	4	0	1.000	1.000	1.000
530	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), CASP8(1), FADD(2), MAP3K3(1), NFKB1(1), NFKB2(1), NFKBIE(2), NR2C2(1), TNFRSF1A(1)	3855721	11	11	11	28	2	1	6	0	2	0	1.000	1.000	1.000
531	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), GNB1(2), MAPK1(1), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCB1(3), SPHK1(2)	3738001	12	10	12	10	2	0	4	5	1	0	0.996	1.000	1.000
532	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGFR(3), JAK1(1), MAP3K1(2), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1)	5144481	12	10	12	7	6	0	5	1	0	0	0.916	1.000	1.000
533	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(1), IGF1R(1), INSR(1), MAPK7(2), MEF2C(2), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1)	4835171	11	10	10	7	2	0	6	3	0	0	0.934	1.000	1.000
534	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTAP(1), MTFMT(4), MTR(1), SRM(1)	2902790	11	10	9	16	2	1	1	6	1	0	1.000	1.000	1.000
535	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA2A(2), ADRA2C(4), CHRM5(1), DRD3(1), DRD5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(2)	3557253	16	10	15	10	4	2	5	3	2	0	0.916	1.000	1.000
536	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(1), ANXA5(1), EDNRB(1), HSD11B1(1), PLA2G4A(3), PTGDS(1), PTGER4(1), PTGIR(1), PTGS1(1), PTGS2(2)	2881890	13	10	13	29	2	0	6	3	2	0	1.000	1.000	1.000
537	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	GNB1(2), JAK2(2), MAPK1(1), MYLK(2), PLCG1(3)	5840599	10	9	10	8	2	0	5	3	0	0	0.985	1.000	1.000
538	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH18A1(2), AOC3(1), CPS1(3), MAOA(3), SAT1(2), SRM(1)	4123592	13	9	13	21	1	0	7	0	5	0	1.000	1.000	1.000
539	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1RN(2), IRAK1(2), IRAK2(2), MAP2K3(2), MAP3K1(2), NFKB1(1)	4092020	11	9	10	8	3	0	5	3	0	0	0.981	1.000	1.000
540	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(1), GNB1(2), MYLK(2), PLCB1(3), ROCK1(2)	2821921	10	9	10	5	1	0	8	1	0	0	0.882	1.000	1.000
541	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(1), GNB1(2), PIK3CA(1), PIK3R1(1), PLCB1(3), ROCK1(2)	3528287	11	9	11	8	1	0	7	3	0	0	0.981	1.000	1.000
542	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(1), ETS2(1), HDAC2(1), NCOR2(4), RBL1(1), SIN3B(2)	3753036	11	8	11	10	3	0	3	3	2	0	0.996	1.000	1.000
543	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	INSR(1), JAK2(2), MAPK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PTPN6(1), RPS6KA1(1), SRF(1), STAT5B(1)	4567681	13	8	13	15	4	0	3	4	2	0	1.000	1.000	1.000
544	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SLC27A5(1), SOAT2(1)	4425646	10	8	10	29	3	0	4	2	1	0	1.000	1.000	1.000
545	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SRM(1)	3700339	10	8	10	13	2	0	5	0	3	0	1.000	1.000	1.000
546	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(3), CYP2C9(1), CYP2J2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1)	3355977	12	8	12	10	1	1	6	2	2	0	0.993	1.000	1.000
547	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	JAK1(1), MAP3K1(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1)	4808114	10	8	10	8	4	0	4	2	0	0	0.979	1.000	1.000
548	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), MAP2K3(2), MAP3K1(2), MAPK1(1), PLCG1(3)	3956837	9	8	9	5	3	0	4	2	0	0	0.870	1.000	1.000
549	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IL4R(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), SOS2(1), STAT6(1)	5033104	10	8	10	12	1	1	3	4	1	0	1.000	1.000	1.000
550	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	DUSP1(1), MAP2K3(2), MAP3K4(1), MAPK1(1), MAPK11(1), MKNK1(1), MYEF2(1), NFKB1(1), NR2C2(1), SRF(1)	4725995	11	8	11	11	3	0	5	3	0	0	0.998	1.000	1.000
551	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), BTK(1), CDKN2A(2), DAPP1(1), IARS(1), IGFBP1(1), INPP5D(1), PIK3CA(1), RPS6KA1(1), SOS2(1), TEC(1), YWHAQ(1)	4913381	13	8	13	14	1	1	5	3	3	0	1.000	1.000	1.000
552	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGEF2(2), CLTB(3), COPA(1), GPLD1(1)	2237046	8	7	8	5	2	1	4	1	0	0	0.911	1.000	1.000
553	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	EGFR(3), MAP3K1(2), MAPK1(1), MEF2C(2)	4706781	8	7	8	7	3	0	3	2	0	0	0.971	1.000	1.000
554	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SOAT2(1)	3197010	9	7	9	24	3	0	3	2	1	0	1.000	1.000	1.000
555	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(2), GABRA2(2), GABRA6(2), UBQLN1(1)	1666679	7	7	7	5	0	0	6	1	0	0	0.955	1.000	1.000
556	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), OGDHL(1), PC(1), PCK1(1), SDHA(1), SDHB(1), SDHD(1)	4121947	12	7	12	8	1	1	7	3	0	0	0.954	1.000	1.000
557	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	G6PD(2), PFKL(2), PRPS1L1(1), RPIA(1), TKTL2(3)	3388656	9	7	8	22	3	2	2	2	0	0	1.000	1.000	1.000
558	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT2(1), B4GALT7(1), CHPF(2), CHST11(1), CHST13(3), CHST3(1), DSE(2), XYLT1(1)	1975850	12	7	11	7	1	3	4	4	0	0	0.907	1.000	1.000
559	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PDHB(1), PDK3(1), SDHA(1), SDHB(1), SDHD(1)	3941144	11	7	11	6	0	1	7	3	0	0	0.902	1.000	1.000
560	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	NGFR(2), PIK3CA(1), PIK3R1(1), PLCG1(3)	2622224	7	7	7	5	4	0	2	1	0	0	0.944	1.000	1.000
561	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), NCOA1(2), NCOA2(1), NCOR2(4), RARA(1)	3497593	9	7	9	19	0	0	4	3	2	0	1.000	1.000	1.000
562	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1A(2), PLCB1(3), TRH(1), VIP(1)	1529228	8	7	8	8	1	1	3	3	0	0	0.994	1.000	1.000
563	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(1), MAPK1(1), MAPK11(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1)	4905966	11	7	11	27	0	0	8	3	0	0	1.000	1.000	1.000
564	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(1), DUSP6(1), MAP3K8(1), MAPK1(1), MKNK1(1), NFKB1(1), RPS6KA1(1), SOS2(1)	4154375	8	7	8	13	2	0	2	3	1	0	1.000	1.000	1.000
565	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRB1(3), IL18R1(2), IL2(1), IL4R(1)	1757866	7	7	7	5	0	1	5	1	0	0	0.950	1.000	1.000
566	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(2), CKM(2), CKMT2(1), CPS1(3), GLUD1(1)	2478521	9	7	9	18	1	0	4	2	2	0	1.000	1.000	1.000
567	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(3), PIK3CA(1), PIK3R1(1), TERT(1)	2334257	6	6	6	5	1	1	2	2	0	0	0.972	1.000	1.000
568	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), EDNRB(1), EGFR(3), NFKB1(1), PLCG1(3)	2820401	10	6	10	5	5	1	4	0	0	0	0.786	1.000	1.000
569	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(1), EGFR(3), PDGFRA(1)	2688027	6	6	6	6	3	1	1	1	0	0	0.974	1.000	1.000
570	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL12(1), RPL13A(1), RPL14(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS9(1)	3005463	9	6	9	18	1	0	5	2	1	0	1.000	1.000	1.000
571	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2), JAK3(3), PTPRU(1)	1949573	7	6	7	4	1	0	3	3	0	0	0.895	1.000	1.000
572	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	MAP2K3(2), MAP3K1(2), NFKB1(1), TANK(1), TNFRSF1A(1)	3392925	7	6	7	5	1	0	5	1	0	0	0.957	1.000	1.000
573	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3)	2149728	6	6	6	5	2	0	3	1	0	0	0.973	1.000	1.000
574	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	NFATC1(1), PLCG1(3), PPP3CB(1)	2810464	5	5	5	3	2	0	3	0	0	0	0.850	1.000	1.000
575	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH6(1), ADH7(2), DHRS3(1), ESCO2(1), PNPLA3(2)	3373856	7	5	7	10	1	0	1	3	2	0	1.000	1.000	1.000
576	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	IGF1R(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1)	3393530	5	5	5	6	2	0	1	2	0	0	0.994	1.000	1.000
577	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	INSR(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1)	3500430	5	5	5	6	2	0	1	2	0	0	0.995	1.000	1.000
578	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), IMPDH1(1), OAZ1(1), POLD1(2), POLG(1), SRM(1)	1820802	8	5	8	10	1	0	6	0	1	0	1.000	1.000	1.000
579	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(2), MTNR1B(2), PTGER4(1), PTGIR(1), TBXA2R(1)	1592463	7	5	6	24	1	0	4	2	0	0	1.000	1.000	1.000
580	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGFR(3), MAPK1(1)	3440258	5	5	5	3	2	1	1	1	0	0	0.897	1.000	1.000
581	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(1), L1CAM(1), SELP(2)	2160102	4	4	4	3	0	0	3	1	0	0	0.950	1.000	1.000
582	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A6(1), XDH(3)	1104561	4	4	4	4	0	0	4	0	0	0	0.981	1.000	1.000
583	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(1), IGF1R(1), PIK3CA(1), PIK3R1(1)	2737483	4	4	4	3	1	0	2	1	0	0	0.941	1.000	1.000
584	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(1), MAPK1(1), PIK3CA(1), PIK3R1(1)	2578803	4	4	4	5	1	0	1	2	0	0	0.994	1.000	1.000
585	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(3)	932023	5	4	5	6	4	0	1	0	0	0	0.979	1.000	1.000
586	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	G6PD(2), PRPS1L1(1), RPIA(1)	2792592	4	4	4	21	1	1	1	1	0	0	1.000	1.000	1.000
587	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK4(1), MEF2C(2), PPARA(1), PPP3CB(1)	2947084	5	4	5	4	0	0	3	2	0	0	0.951	1.000	1.000
588	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), MAPK1(1), PIK3CA(1), PIK3R1(1)	2652790	4	4	4	4	0	0	2	2	0	0	0.984	1.000	1.000
589	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	NGFR(2), NTRK1(1), PIK3CA(1)	2310427	4	4	4	3	2	0	1	1	0	0	0.922	1.000	1.000
590	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	NFKB1(1), PIK3CA(1), PIK3R1(1)	1960870	3	3	3	3	0	0	2	1	0	0	0.974	1.000	1.000
591	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	EPO(1), FLT3(1), IL3(1)	1181788	3	3	3	3	0	1	2	0	0	0	0.971	1.000	1.000
592	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	IGF1R(1), PIK3CA(1), PIK3R1(1)	1819978	3	3	3	10	1	0	1	1	0	0	1.000	1.000	1.000
593	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL2(1), IL3(1)	1357080	2	2	2	3	0	0	2	0	0	0	0.986	1.000	1.000
594	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(1), FH(1), SDHA(1)	1302039	3	2	3	3	0	0	3	0	0	0	0.955	1.000	1.000
595	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	CS(1), PC(1)	1285111	2	2	2	2	0	0	1	1	0	0	0.946	1.000	1.000
596	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CSK(1), PTPRA(1)	1289703	2	2	2	2	0	0	2	0	0	0	0.942	1.000	1.000
597	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2S(1), UBE3A(1)	1438151	2	2	2	2	0	0	1	1	0	0	0.969	1.000	1.000
598	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1)	745186	1	1	1	3	0	0	1	0	0	0	0.995	1.000	1.000
599	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL2(1)	421269	1	1	1	3	0	0	1	0	0	0	0.998	1.000	1.000
600	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(2)	797566	2	1	2	3	2	0	0	0	0	0	0.951	1.000	1.000
601	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	TGM2(1)	705469	1	1	1	4	1	0	0	0	0	0	0.996	1.000	1.000
602	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	NEK1(1)	1044551	1	1	1	3	0	0	1	0	0	0	0.997	1.000	1.000
603	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1)	795888	1	1	1	2	0	0	1	0	0	0	0.985	1.000	1.000
604	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8		1102162	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8		1102162	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5		438328	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8		1200125	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9		1184524	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2		242694	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7		659724	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		68925	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		297389	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5		664942	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4		525727	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5		550206	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6		822643	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
