Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q amp_1p34.2 68 (27%) 182 0.00022355 0.141 0.23309 1 0.1535 1 0.60941 1 0.903 1 0.50901 1 0.088947 1 0.72088 1 0.89017 1 0.72961 1 amp_1q21.3 123 (49%) 127 7.2097e-13 4.96e-10 0.031812 1 0.3678 1 0.48632 1 0.012857 1 0.05706 1 0.11062 1 0.15133 1 0.38106 1 0.14043 1 amp_1q23.3 129 (52%) 121 8.3928e-09 5.7e-06 0.015344 1 0.5175 1 0.45193 1 0.089821 1 0.48621 1 0.0015485 0.952 0.001087 0.674 0.027859 1 0.012547 1 amp_3p25.2 122 (49%) 128 2.1554e-11 1.48e-08 0.0025782 1 0.077215 1 0.025556 1 1.9751e-05 0.0127 2.7011e-05 0.0174 8.4e-05 0.0535 0.0016481 1 1.703e-05 0.011 0.00017858 0.113 amp_3q26.32 136 (54%) 114 3.6443e-05 0.0234 0.75378 1 0.38912 1 0.1622 1 0.52082 1 0.43392 1 0.38982 1 0.051007 1 0.29983 1 0.10624 1 amp_4p16.3 52 (21%) 198 0.20721 1 0.0067387 1 0.027455 1 0.0082722 1 0.0034907 1 0.0016605 1 0.015973 1 0.016912 1 0.0084706 1 0.00814 1 amp_4q13.3 45 (18%) 205 0.00039587 0.247 0.025408 1 0.49905 1 0.8061 1 0.36791 1 0.33869 1 0.37172 1 0.21874 1 0.16873 1 0.1183 1 amp_5p15.33 128 (51%) 122 1.3515e-08 9.14e-06 0.21477 1 0.024077 1 0.045225 1 0.34798 1 0.022785 1 0.0584 1 0.047185 1 0.30494 1 0.015689 1 amp_6p22.3 107 (43%) 143 1.2282e-13 8.46e-11 0.11586 1 0.29919 1 0.53628 1 1 1 0.83408 1 0.34973 1 0.078315 1 0.48115 1 0.60885 1 amp_6q21 23 (9%) 227 0.27243 1 0.53971 1 0.45149 1 0.1951 1 0.44116 1 0.20908 1 0.52897 1 0.60788 1 0.68711 1 0.72495 1 amp_7p21.1 130 (52%) 120 7.2001e-08 4.82e-05 0.066959 1 0.12828 1 0.7167 1 0.6868 1 0.42471 1 0.16439 1 0.13483 1 0.70091 1 0.69915 1 amp_7p11.2 127 (51%) 123 1.0354e-07 6.91e-05 0.054856 1 0.087183 1 0.94347 1 0.77034 1 0.7172 1 0.26972 1 0.51523 1 0.63938 1 0.70165 1 amp_8p11.23 77 (31%) 173 1.6711e-05 0.0108 0.19002 1 0.7113 1 0.8172 1 0.97012 1 0.96338 1 0.48736 1 0.60422 1 0.24857 1 0.36009 1 amp_8q22.3 160 (64%) 90 0.0019825 1 0.020022 1 0.024726 1 0.12754 1 0.48008 1 0.47062 1 0.056471 1 0.1971 1 0.0056247 1 0.064907 1 amp_9p24.1 49 (20%) 201 1.8455e-06 0.00121 0.42437 1 0.58141 1 0.49932 1 0.059382 1 0.0064144 1 0.88594 1 1 1 0.78145 1 0.33081 1 amp_10p14 112 (45%) 138 2.513e-16 1.73e-13 0.15854 1 0.33145 1 0.40648 1 0.84207 1 0.13633 1 0.33728 1 0.32423 1 0.37567 1 0.4671 1 amp_11q13.3 95 (38%) 155 2.3464e-08 1.58e-05 0.47324 1 0.23673 1 0.068456 1 0.17961 1 1 1 0.12508 1 0.17134 1 0.47935 1 0.84773 1 amp_11q22.2 46 (18%) 204 0.0092372 1 0.60596 1 0.64119 1 0.27579 1 0.094571 1 0.074823 1 0.065733 1 0.0075478 1 0.063079 1 0.16731 1 amp_12p13.32 87 (35%) 163 2.8321e-06 0.00185 0.12653 1 0.76147 1 0.7235 1 0.7478 1 0.74156 1 0.96701 1 0.001192 0.737 0.88836 1 0.34355 1 amp_12q15 75 (30%) 175 0.00087483 0.544 0.20701 1 0.049693 1 0.027031 1 0.10821 1 0.10586 1 0.10841 1 0.011122 1 0.08347 1 0.0035399 1 amp_13q22.1 77 (31%) 173 0.051932 1 0.55976 1 0.96205 1 0.87083 1 0.88069 1 0.69381 1 0.31877 1 0.66485 1 0.71291 1 0.45094 1 amp_14q11.2 60 (24%) 190 0.00021455 0.135 0.15779 1 0.52425 1 0.22277 1 0.10368 1 0.01069 1 0.30687 1 0.42373 1 0.65591 1 0.3825 1 amp_16p13.13 56 (22%) 194 0.0065113 1 0.58802 1 0.46229 1 0.8273 1 0.21834 1 0.77988 1 0.78962 1 0.83935 1 0.66838 1 0.44375 1 amp_16q22.1 74 (30%) 176 1.4327e-05 0.00928 0.55123 1 0.069992 1 0.47045 1 0.078013 1 0.040152 1 0.6091 1 0.080978 1 0.26479 1 0.65039 1 amp_17q11.2 111 (44%) 139 8.516e-07 0.000562 2.4468e-05 0.0158 0.033754 1 0.075348 1 0.00032782 0.206 0.0016186 0.991 0.020654 1 0.16089 1 0.00088632 0.55 0.0015994 0.98 amp_17q12 103 (41%) 147 0.00021382 0.135 0.0061363 1 0.076537 1 0.01662 1 0.016097 1 0.10195 1 0.0016212 0.991 0.019002 1 0.0015728 0.966 0.0020046 1 amp_19q12 104 (42%) 146 5.9326e-07 0.000393 0.049162 1 0.7214 1 0.80466 1 0.35791 1 0.20847 1 0.28585 1 0.070459 1 0.57798 1 0.20812 1 amp_19q13.43 97 (39%) 153 6.3671e-06 0.00415 0.012803 1 0.18508 1 0.33725 1 0.56674 1 0.9457 1 0.63682 1 0.035911 1 0.30115 1 0.022254 1 amp_20q11.21 163 (65%) 87 6.9066e-07 0.000457 0.076779 1 0.68802 1 0.068908 1 1 1 0.30254 1 0.1272 1 0.072513 1 0.1211 1 0.48836 1 amp_22q11.23 52 (21%) 198 1.287e-06 0.000846 0.0067387 1 0.56791 1 0.5608 1 0.10147 1 0.12718 1 0.11118 1 0.65473 1 0.50302 1 0.28142 1 del_1p36.11 49 (20%) 201 0.63837 1 0.27793 1 0.33517 1 0.027003 1 0.052558 1 0.17159 1 0.87748 1 0.38515 1 0.64257 1 0.74037 1 del_1p21.3 42 (17%) 208 0.023981 1 0.076445 1 0.34465 1 0.93705 1 0.44094 1 0.016494 1 0.30608 1 0.21679 1 0.7636 1 0.45816 1 del_1q32.1 45 (18%) 205 0.22637 1 0.67224 1 0.42609 1 0.61448 1 0.50935 1 0.013367 1 0.19524 1 0.32713 1 0.15351 1 0.31128 1 del_2q22.1 78 (31%) 172 0.00014388 0.0914 0.087139 1 0.2489 1 0.52859 1 0.25213 1 0.065978 1 0.23064 1 0.68014 1 0.054981 1 0.28281 1 del_2q37.1 126 (50%) 124 2.8135e-08 1.89e-05 0.0012456 0.769 0.56517 1 0.28621 1 0.45905 1 0.079931 1 0.094249 1 0.11337 1 0.052709 1 0.051884 1 del_3p21.31 72 (29%) 178 1.277e-06 0.00084 0.26027 1 0.029599 1 0.031052 1 7.9822e-06 0.0052 0.010288 1 0.23573 1 0.14716 1 0.46343 1 0.15912 1 del_3p14.2 71 (28%) 179 2.1842e-08 1.47e-05 0.41777 1 0.041273 1 0.031973 1 8.0409e-05 0.0513 0.036998 1 0.64338 1 0.41128 1 0.34287 1 0.14439 1 del_3p13 66 (26%) 184 3.8089e-07 0.000253 0.39535 1 0.15576 1 0.0048923 1 4.2838e-05 0.0274 0.070559 1 0.84022 1 0.91202 1 0.45693 1 0.020834 1 del_4q22.1 105 (42%) 145 0.00020013 0.127 0.10911 1 0.51295 1 0.42078 1 0.032661 1 0.036728 1 0.43826 1 0.69428 1 0.048138 1 0.075028 1 del_4q34.2 113 (45%) 137 3.6363e-07 0.000242 0.59424 1 0.429 1 0.91052 1 0.70736 1 0.36338 1 0.074448 1 0.15363 1 0.19097 1 0.16603 1 del_5q11.2 128 (51%) 122 3.7091e-09 2.52e-06 0.13151 1 0.95382 1 0.30411 1 0.50764 1 0.30402 1 0.31608 1 0.64225 1 0.61737 1 0.30349 1 del_6p25.3 67 (27%) 183 7.0584e-05 0.0451 0.068058 1 0.80802 1 0.66231 1 0.64063 1 0.12221 1 0.5133 1 0.88182 1 0.83684 1 0.74842 1 del_6q21 111 (44%) 139 2.3204e-09 1.58e-06 0.015706 1 0.84261 1 0.62742 1 0.87121 1 0.071568 1 0.37414 1 0.56892 1 0.33699 1 0.42542 1 del_6q27 113 (45%) 137 3.5398e-10 2.42e-07 0.0025011 1 0.6573 1 0.62742 1 0.63385 1 0.036153 1 0.10586 1 0.13933 1 0.18226 1 0.32343 1 del_7q36.3 38 (15%) 212 0.14274 1 0.11697 1 0.28655 1 0.22189 1 0.15086 1 0.38932 1 0.58013 1 0.10964 1 0.84156 1 0.73955 1 del_8p23.3 143 (57%) 107 2.8921e-10 1.98e-07 0.0092341 1 0.5227 1 0.23106 1 0.077263 1 0.13294 1 0.0022777 1 0.07271 1 0.043117 1 0.0097598 1 del_8p12 123 (49%) 127 1.2154e-08 8.23e-06 0.075026 1 0.54829 1 0.50718 1 0.097979 1 0.37937 1 0.044612 1 0.031727 1 0.19161 1 0.034017 1 del_8p11.21 66 (26%) 184 1.0941e-05 0.0071 0.71656 1 0.21722 1 0.10784 1 0.21291 1 0.029347 1 0.14762 1 0.82723 1 0.14587 1 0.015411 1 del_9p23 112 (45%) 138 3.8064e-06 0.00249 0.53921 1 0.20426 1 0.13667 1 0.95699 1 0.11728 1 0.48477 1 0.37198 1 0.63987 1 0.78316 1 del_9p21.3 148 (59%) 102 1.1975e-06 0.000789 0.97036 1 0.41453 1 0.002493 1 0.70752 1 0.51746 1 0.76875 1 0.51356 1 0.57592 1 0.79122 1 del_9q33.2 99 (40%) 151 0.39832 1 0.0078217 1 0.073021 1 0.0025663 1 0.027675 1 9.4822e-05 0.0603 0.39111 1 0.32035 1 0.071356 1 0.24332 1 del_10p12.1 40 (16%) 210 0.00055327 0.345 0.061378 1 0.76929 1 0.64629 1 0.0093637 1 0.12723 1 0.28568 1 0.064021 1 0.54435 1 0.46419 1 del_10q23.31 100 (40%) 150 4.9082e-07 0.000325 0.016541 1 0.60028 1 0.73488 1 0.26449 1 0.46808 1 0.65571 1 0.34314 1 0.74795 1 0.66368 1 del_10q26.13 102 (41%) 148 1.9025e-07 0.000127 0.02828 1 0.384 1 0.66231 1 0.46324 1 0.39269 1 0.41238 1 0.37138 1 0.36564 1 0.47572 1 del_11p15.5 123 (49%) 127 3.6991e-08 2.48e-05 0.00027552 0.173 0.34812 1 0.76744 1 0.073392 1 0.0017905 1 0.0049222 1 0.0052283 1 0.0037603 1 0.037166 1 del_11q25 91 (36%) 159 1.0321e-07 6.89e-05 0.0041216 1 0.8528 1 0.78537 1 0.12313 1 0.037081 1 0.69011 1 0.10406 1 0.26891 1 0.41141 1 del_13q14.2 100 (40%) 150 9.8532e-09 6.68e-06 0.63257 1 0.0084927 1 0.0034251 1 0.012963 1 0.13253 1 0.87996 1 0.21376 1 0.55122 1 0.73064 1 del_14q12 79 (32%) 171 1.8575e-08 1.25e-05 0.36622 1 0.14877 1 0.090614 1 0.16493 1 0.0018125 1 0.066279 1 0.24125 1 0.064451 1 0.24812 1 del_14q24.1 83 (33%) 167 3.2887e-09 2.24e-06 0.020186 1 0.43243 1 0.35455 1 0.014775 1 8.0068e-06 0.0052 0.049704 1 0.35511 1 0.055273 1 0.23385 1 del_15q13.1 103 (41%) 147 2.0069e-06 0.00131 0.01165 1 0.28639 1 0.45044 1 0.82585 1 0.1467 1 0.13382 1 0.17999 1 0.25135 1 0.32562 1 del_16p13.3 99 (40%) 151 7.1301e-10 4.87e-07 0.12868 1 0.19248 1 0.20368 1 0.72978 1 0.57173 1 0.92218 1 0.75136 1 0.58886 1 0.71834 1 del_16q23.1 69 (28%) 181 4.9111e-08 3.29e-05 0.011152 1 0.42666 1 0.10987 1 0.22468 1 0.52551 1 0.035372 1 0.39268 1 0.10397 1 0.12604 1 del_17p12 130 (52%) 120 2.8145e-05 0.0181 0.019149 1 0.20054 1 0.44808 1 0.34761 1 0.067999 1 0.61075 1 0.82859 1 0.73585 1 0.48592 1 del_18q21.2 110 (44%) 140 0.0013276 0.818 0.7019 1 0.86248 1 0.98246 1 0.82684 1 0.84754 1 0.0039298 1 0.0022262 1 0.023005 1 0.17232 1 del_18q23 104 (42%) 146 0.00081983 0.511 0.55137 1 0.59924 1 1 1 1 1 0.9397 1 0.00113 0.699 0.00033054 0.207 0.0052266 1 0.11059 1 del_19p13.3 93 (37%) 157 0.00029543 0.186 0.75716 1 0.86494 1 0.81296 1 0.088846 1 0.32075 1 0.49815 1 0.30509 1 0.26787 1 0.39146 1 del_22q13.31 114 (46%) 136 1.3345e-10 9.15e-08 0.0085948 1 0.42003 1 0.018063 1 0.011094 1 0.0063074 1 0.97103 1 0.53793 1 0.091172 1 0.19846 1 del_xp11.3 57 (23%) 193 0.0068415 1 0.36674 1 0.64437 1 0.71809 1 0.40794 1 0.96129 1 0.11009 1 0.44936 1 0.11803 1 0.53746 1 del_xq21.33 50 (20%) 200 0.010212 1 0.009568 1 0.98102 1 0.097354 1 0.017726 1 0.60852 1 0.030968 1 0.8337 1 0.056455 1 0.090345 1