Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q PIK3CA 26 (20%) 104 0.22013 1 0.79711 1 0.16666 1 0.78427 1 0.36284 1 0.26888 1 0.65596 1 0.053422 1 0.4557 1 0.54749 1 TP53 64 (49%) 66 0.071235 1 0.23291 1 0.040864 1 0.013021 1 0.10323 1 0.26055 1 0.41452 1 0.58909 1 0.23701 1 0.32529 1 CDKN1A 18 (14%) 112 0.24562 1 0.4987 1 0.86127 1 0.49099 1 0.92302 1 0.77525 1 0.86776 1 0.91105 1 0.53931 1 0.53799 1 RB1 17 (13%) 113 0.020941 1 0.33055 1 0.51813 1 0.11538 1 0.50082 1 0.62783 1 0.66064 1 1 1 0.20055 1 0.32948 1 ARID1A 32 (25%) 98 0.78964 1 0.75307 1 0.61382 1 0.20968 1 0.57544 1 0.50068 1 0.050555 1 0.14504 1 0.23486 1 0.18469 1 MLL2 36 (28%) 94 0.29318 1 0.65959 1 0.36876 1 0.20492 1 0.24489 1 0.62148 1 0.53798 1 0.81414 1 0.4732 1 0.64783 1 FBXW7 13 (10%) 117 0.90994 1 0.026491 1 0.38508 1 0.3489 1 0.089457 1 0.13867 1 0.21182 1 0.16731 1 0.014527 1 0.11997 1 KDM6A 31 (24%) 99 0.34454 1 0.94192 1 0.36216 1 0.19346 1 0.51381 1 0.88623 1 0.14168 1 0.19474 1 0.77947 1 0.20093 1 ELF3 11 (8%) 119 0.76123 1 0.023284 1 0.63112 1 0.58544 1 0.67403 1 0.15402 1 0.48182 1 0.6625 1 0.7802 1 0.42162 1 FGFR3 16 (12%) 114 0.54977 1 0.11921 1 0.06213 1 0.023781 1 0.080088 1 0.011359 1 0.28873 1 0.60892 1 0.011726 1 0.031815 1 FOXQ1 7 (5%) 123 0.48953 1 0.40996 1 0.48579 1 0.29488 1 0.72107 1 0.89083 1 0.25321 1 0.80511 1 0.4663 1 0.5683 1 STAG2 14 (11%) 116 0.38726 1 0.17349 1 0.23982 1 0.54709 1 0.37403 1 0.12743 1 0.27845 1 0.63557 1 0.12659 1 0.012336 1 NFE2L2 11 (8%) 119 0.23264 1 0.2116 1 0.48371 1 0.6717 1 0.082155 1 0.23238 1 0.85327 1 0.28771 1 1 1 0.6899 1 CDKN2A 7 (5%) 123 0.36974 1 0.5231 1 0.35585 1 0.11085 1 1 1 0.89083 1 0.41875 1 0.80511 1 0.4663 1 1 1 KLF5 10 (8%) 120 0.71099 1 0.76783 1 0.3773 1 0.31746 1 0.9157 1 0.12949 1 0.76539 1 0.86851 1 0.35219 1 0.024552 1 ASXL2 9 (7%) 121 0.32609 1 0.48997 1 0.42058 1 0.19352 1 0.6179 1 0.37436 1 0.75635 1 0.84477 1 0.14719 1 0.50583 1 TSC1 11 (8%) 119 0.51058 1 0.50962 1 0.34553 1 0.13938 1 0.34301 1 0.019765 1 0.52134 1 0.6625 1 0.66112 1 0.13502 1 ERCC2 16 (12%) 114 0.89687 1 0.60437 1 0.13864 1 0.044199 1 0.13427 1 0.21868 1 0.1759 1 0.39204 1 0.87149 1 1 1 TXNIP 9 (7%) 121 0.66014 1 0.90998 1 0.7956 1 0.43927 1 0.5617 1 0.49468 1 1 1 0.071266 1 0.48762 1 1 1 EP300 21 (16%) 109 0.59401 1 0.45457 1 0.45028 1 0.58718 1 0.52543 1 0.79654 1 0.30197 1 0.63045 1 0.33665 1 0.33719 1 RXRA 12 (9%) 118 0.83709 1 0.060992 1 0.18118 1 1 1 0.73965 1 0.14709 1 0.46672 1 0.20378 1 0.85593 1 0.45601 1 FOXA1 7 (5%) 123 0.40339 1 0.60786 1 0.66767 1 0.84966 1 0.36756 1 0.54325 1 0.69999 1 1 1 0.6874 1 0.6539 1 PHLDA3 4 (3%) 126 0.46681 1 0.52978 1 0.50764 1 0.51039 1 0.21862 1 0.35642 1 0.68316 1 1 1 0.83344 1 0.38556 1