Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.061 0.24 -9999.0 0.0 -0.636 29.0 29.0 IHH -0.068 0.185 -9999.0 0.0 -0.488 37.0 37.0 SHH Np/Cholesterol/GAS1 -0.177 0.204 -9999.0 0.0 -0.355 127.0 127.0 LRPAP1 0.013 0.031 -9999.0 0.0 -0.473 1.0 1.0 dorsoventral neural tube patterning 0.176 0.202 0.353 127.0 -9999.0 0.0 127.0 SMO/beta Arrestin2 -0.051 0.169 -9999.0 0.0 -0.464 24.0 24.0 SMO -0.062 0.177 -9999.0 0.0 -0.495 24.0 24.0 AKT1 -0.005 0.082 -9999.0 0.0 -0.297 2.0 2.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.037 0.167 -9999.0 0.0 -0.577 21.0 21.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.061 0.175 -9999.0 0.0 -0.487 24.0 24.0 STIL -0.157 0.211 -9999.0 0.0 -0.446 59.0 59.0 DHH N/PTCH2 -0.023 0.131 -9999.0 0.0 -0.417 24.0 24.0 DHH N/PTCH1 -0.039 0.153 -9999.0 0.0 -0.41 22.0 22.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.014 0.123 -9999.0 0.0 -0.577 11.0 11.0 PTHLH -0.112 0.365 -9999.0 0.0 -1.038 29.0 29.0 determination of left/right symmetry -0.061 0.175 -9999.0 0.0 -0.487 24.0 24.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.11 0.359 -9999.0 0.0 -1.02 29.0 29.0 IHH N/Hhip -0.146 0.233 -9999.0 0.0 -0.434 88.0 88.0 DHH N/Hhip -0.111 0.207 -9999.0 0.0 -0.429 70.0 70.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.061 0.175 -9999.0 0.0 -0.487 24.0 24.0 pancreas development -0.138 0.256 -9999.0 0.0 -0.573 62.0 62.0 HHAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.122 0.249 -9999.0 0.0 -0.575 56.0 56.0 somite specification -0.061 0.175 -9999.0 0.0 -0.487 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.126 0.191 -9999.0 0.0 -0.438 39.0 39.0 SHH Np/Cholesterol/PTCH2 -0.117 0.179 -9999.0 0.0 -0.331 96.0 96.0 SHH Np/Cholesterol/Megalin -0.153 0.198 -9999.0 0.0 -0.346 114.0 114.0 SHH -0.139 0.21 -9999.0 0.0 -0.416 88.0 88.0 catabolic process -0.035 0.154 -9999.0 0.0 -0.368 33.0 33.0 SMO/Vitamin D3 -0.12 0.203 -9999.0 0.0 -0.444 42.0 42.0 SHH Np/Cholesterol/Hhip -0.186 0.218 -9999.0 0.0 -0.378 125.0 125.0 LRP2 -0.084 0.194 -9999.0 0.0 -0.473 48.0 48.0 receptor-mediated endocytosis -0.155 0.204 -9999.0 0.0 -0.438 61.0 61.0 SHH Np/Cholesterol/BOC -0.128 0.191 -9999.0 0.0 -0.346 99.0 99.0 SHH Np/Cholesterol/CDO -0.147 0.188 -9999.0 0.0 -0.336 114.0 114.0 mesenchymal cell differentiation 0.185 0.217 0.375 125.0 -9999.0 0.0 125.0 mol:Vitamin D3 -0.125 0.193 -9999.0 0.0 -0.439 39.0 39.0 IHH N/PTCH2 -0.052 0.147 -9999.0 0.0 -0.324 50.0 50.0 CDON -0.069 0.206 -9999.0 0.0 -0.577 34.0 34.0 IHH N/PTCH1 -0.035 0.155 -9999.0 0.0 -0.372 33.0 33.0 Megalin/LRPAP1 -0.05 0.14 -9999.0 0.0 -0.328 49.0 49.0 PTCH2 -0.017 0.134 -9999.0 0.0 -0.577 13.0 13.0 SHH Np/Cholesterol -0.115 0.157 -9999.0 0.0 -0.323 88.0 88.0 PTCH1 -0.035 0.154 -9999.0 0.0 -0.369 33.0 33.0 HHIP -0.139 0.256 -9999.0 0.0 -0.574 62.0 62.0