Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	80.0	4087.0	51.0	-0.792	0.015	1000.0	-1000.0	-0.138	-1000.0
Glypican 2 network	59.0	238.0	4.0	-0.125	-0.098	1000.0	-1000.0	-0.019	-1000.0
Aurora B signaling	56.0	3809.0	67.0	-0.498	0.015	1000.0	-1000.0	-0.055	-1000.0
Signaling events regulated by Ret tyrosine kinase	55.0	4513.0	82.0	-0.29	0.015	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	47.0	3216.0	68.0	-0.678	0.339	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by the Hedgehog family	44.0	2323.0	52.0	-0.186	0.185	1000.0	-1000.0	-0.034	-1000.0
IL4-mediated signaling events	39.0	3573.0	91.0	-0.805	0.55	1000.0	-1000.0	-0.107	-1000.0
Nongenotropic Androgen signaling	39.0	2055.0	52.0	-0.249	0.138	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	2976.0	78.0	-0.28	0.094	1000.0	-1000.0	-0.049	-1000.0
Reelin signaling pathway	37.0	2097.0	56.0	-0.22	0.038	1000.0	-1000.0	-0.065	-1000.0
Endothelins	36.0	3467.0	96.0	-0.326	0.065	1000.0	-1000.0	-0.059	-1000.0
IGF1 pathway	36.0	2104.0	57.0	-0.251	0.048	1000.0	-1000.0	-0.081	-1000.0
Signaling mediated by p38-alpha and p38-beta	35.0	1564.0	44.0	-0.226	0.015	1000.0	-1000.0	-0.052	-1000.0
TCGA08_p53	34.0	242.0	7.0	-0.162	0.076	1000.0	-1000.0	-0.021	-1000.0
TCGA08_retinoblastoma	34.0	273.0	8.0	-0.235	0.063	1000.0	-1000.0	-0.012	-1000.0
Ephrin A  reverse signaling	31.0	221.0	7.0	-0.084	-0.0	1000.0	-1000.0	-0.03	-1000.0
Thromboxane A2 receptor signaling	31.0	3270.0	105.0	-0.183	0.036	1000.0	-1000.0	-0.051	-1000.0
p75(NTR)-mediated signaling	31.0	3930.0	125.0	-0.165	0.044	1000.0	-1000.0	-0.077	-1000.0
Fc-epsilon receptor I signaling in mast cells	31.0	3018.0	97.0	-0.188	0.039	1000.0	-1000.0	-0.067	-1000.0
PLK1 signaling events	30.0	2608.0	85.0	-0.343	0.05	1000.0	-1000.0	-0.035	-1000.0
IL23-mediated signaling events	28.0	1709.0	60.0	-0.611	0.015	1000.0	-1000.0	-0.118	-1000.0
HIF-1-alpha transcription factor network	27.0	2069.0	76.0	-0.32	0.032	1000.0	-1000.0	-0.054	-1000.0
Plasma membrane estrogen receptor signaling	27.0	2369.0	86.0	-0.246	0.114	1000.0	-1000.0	-0.065	-1000.0
Calcium signaling in the CD4+ TCR pathway	26.0	815.0	31.0	-0.286	0.015	1000.0	-1000.0	-0.07	-1000.0
Glypican 1 network	25.0	1217.0	48.0	-0.256	0.034	1000.0	-1000.0	-0.037	-1000.0
PDGFR-alpha signaling pathway	25.0	1119.0	44.0	-0.336	0.032	1000.0	-1000.0	-0.056	-1000.0
Integrins in angiogenesis	25.0	2172.0	84.0	-0.261	0.029	1000.0	-1000.0	-0.08	-1000.0
Rapid glucocorticoid signaling	25.0	517.0	20.0	-0.221	0.034	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	25.0	429.0	17.0	-0.158	0.02	1000.0	-1000.0	-0.026	-1000.0
Syndecan-1-mediated signaling events	24.0	822.0	34.0	-0.269	0.015	1000.0	-1000.0	-0.044	-1000.0
BMP receptor signaling	24.0	1989.0	81.0	-0.312	0.049	1000.0	-1000.0	-0.074	-1000.0
amb2 Integrin signaling	24.0	2034.0	82.0	-0.337	0.015	1000.0	-1000.0	-0.066	-1000.0
Glucocorticoid receptor regulatory network	24.0	2815.0	114.0	-0.601	0.266	1000.0	-1000.0	-0.064	-1000.0
TCR signaling in naïve CD8+ T cells	23.0	2178.0	93.0	-0.129	0.067	1000.0	-1000.0	-0.064	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	23.0	2805.0	120.0	-0.333	0.19	1000.0	-1000.0	-0.064	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	22.0	1148.0	52.0	-0.307	0.029	1000.0	-1000.0	-0.043	-1000.0
LPA receptor mediated events	22.0	2332.0	102.0	-0.218	0.036	1000.0	-1000.0	-0.067	-1000.0
IL6-mediated signaling events	22.0	1666.0	75.0	-0.249	0.068	1000.0	-1000.0	-0.06	-1000.0
Visual signal transduction: Cones	21.0	828.0	38.0	-0.118	0.017	1000.0	-1000.0	-0.05	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	20.0	1124.0	54.0	-0.183	0.03	1000.0	-1000.0	-0.077	-1000.0
S1P5 pathway	20.0	353.0	17.0	-0.152	0.108	1000.0	-1000.0	-0.023	-1000.0
S1P1 pathway	20.0	745.0	36.0	-0.285	0.015	1000.0	-1000.0	-0.05	-1000.0
BCR signaling pathway	20.0	2002.0	99.0	-0.19	0.034	1000.0	-1000.0	-0.069	-1000.0
LPA4-mediated signaling events	18.0	223.0	12.0	-0.168	0.022	1000.0	-1000.0	-0.012	-1000.0
JNK signaling in the CD4+ TCR pathway	18.0	306.0	17.0	-0.158	0.017	1000.0	-1000.0	-0.024	-1000.0
S1P3 pathway	18.0	778.0	42.0	-0.151	0.03	1000.0	-1000.0	-0.025	-1000.0
S1P4 pathway	18.0	462.0	25.0	-0.152	0.029	1000.0	-1000.0	-0.042	-1000.0
Coregulation of Androgen receptor activity	17.0	1332.0	76.0	-0.245	0.031	1000.0	-1000.0	-0.038	-1000.0
IL12-mediated signaling events	17.0	1555.0	87.0	-0.411	0.029	1000.0	-1000.0	-0.098	-1000.0
Aurora A signaling	17.0	1022.0	60.0	-0.344	0.022	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	17.0	119.0	7.0	-0.202	0.0	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	17.0	51.0	3.0	-0.027	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Arf6 signaling events	15.0	975.0	62.0	-0.251	0.028	1000.0	-1000.0	-0.054	-1000.0
FAS signaling pathway (CD95)	15.0	723.0	47.0	-0.568	0.019	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	15.0	1326.0	88.0	-0.249	0.054	1000.0	-1000.0	-0.092	-1000.0
Osteopontin-mediated events	14.0	547.0	38.0	-0.183	0.015	1000.0	-1000.0	-0.086	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	13.0	448.0	34.0	-0.043	0.015	1000.0	-1000.0	-0.049	-1000.0
Syndecan-2-mediated signaling events	13.0	939.0	69.0	-0.086	0.036	1000.0	-1000.0	-0.037	-1000.0
Presenilin action in Notch and Wnt signaling	13.0	841.0	61.0	-0.169	0.041	1000.0	-1000.0	-0.058	-1000.0
Canonical Wnt signaling pathway	13.0	677.0	51.0	-0.169	0.081	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	13.0	97.0	7.0	-0.055	0.015	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Rods	13.0	683.0	52.0	-0.198	0.015	1000.0	-1000.0	-0.073	-1000.0
Sphingosine 1-phosphate (S1P) pathway	12.0	339.0	28.0	-0.152	0.029	1000.0	-1000.0	-0.024	-1000.0
Syndecan-4-mediated signaling events	12.0	845.0	67.0	-0.181	0.022	1000.0	-1000.0	-0.077	-1000.0
ErbB2/ErbB3 signaling events	11.0	727.0	65.0	-0.247	0.025	1000.0	-1000.0	-0.06	-1000.0
Effects of Botulinum toxin	11.0	292.0	26.0	-0.075	0.015	1000.0	-1000.0	-0.056	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	11.0	375.0	33.0	-0.278	0.043	1000.0	-1000.0	-0.042	-1000.0
Noncanonical Wnt signaling pathway	10.0	281.0	26.0	-0.091	0.015	1000.0	-1000.0	-0.047	-1000.0
Regulation of Androgen receptor activity	10.0	736.0	70.0	-0.25	0.03	1000.0	-1000.0	-0.055	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	9.0	835.0	85.0	-0.216	0.022	1000.0	-1000.0	-0.059	-1000.0
IL2 signaling events mediated by STAT5	9.0	204.0	22.0	-0.123	0.064	1000.0	-1000.0	-0.022	-1000.0
EGFR-dependent Endothelin signaling events	9.0	198.0	21.0	-0.06	0.022	1000.0	-1000.0	-0.053	-1000.0
Caspase cascade in apoptosis	8.0	650.0	74.0	-0.041	0.044	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	8.0	563.0	69.0	-0.247	0.036	1000.0	-1000.0	-0.077	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	581.0	65.0	-0.152	0.063	1000.0	-1000.0	-0.046	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	396.0	46.0	-0.197	0.106	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	8.0	546.0	63.0	-0.043	0.03	1000.0	-1000.0	-0.057	-1000.0
IL27-mediated signaling events	8.0	444.0	51.0	-0.25	0.02	1000.0	-1000.0	-0.071	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1022.0	136.0	-0.185	0.066	1000.0	-1000.0	-0.056	-1000.0
IL1-mediated signaling events	7.0	478.0	62.0	-0.1	0.072	1000.0	-1000.0	-0.087	-1000.0
IL2 signaling events mediated by PI3K	7.0	411.0	58.0	-0.182	0.052	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	7.0	518.0	74.0	-0.258	0.04	1000.0	-1000.0	-0.072	-1000.0
Cellular roles of Anthrax toxin	6.0	268.0	39.0	-0.096	0.018	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	6.0	531.0	76.0	-0.123	0.037	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by HDAC Class III	6.0	250.0	40.0	-0.222	0.025	1000.0	-1000.0	-0.038	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	523.0	83.0	-0.269	0.04	1000.0	-1000.0	-0.065	-1000.0
Syndecan-3-mediated signaling events	6.0	242.0	35.0	-0.131	0.044	1000.0	-1000.0	-0.043	-1000.0
Regulation of p38-alpha and p38-beta	6.0	355.0	54.0	-0.147	0.039	1000.0	-1000.0	-0.041	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	450.0	74.0	-0.246	0.074	1000.0	-1000.0	-0.076	-1000.0
BARD1 signaling events	5.0	289.0	57.0	-0.147	0.045	1000.0	-1000.0	-0.054	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	29.0	5.0	-0.002	0.01	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	5.0	295.0	55.0	-0.042	0.051	1000.0	-1000.0	-0.07	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	390.0	68.0	-0.214	0.058	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	5.0	283.0	48.0	-0.042	0.016	1000.0	-1000.0	-0.06	-1000.0
Regulation of Telomerase	5.0	555.0	102.0	-0.169	0.036	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by PRL	5.0	185.0	34.0	-0.103	0.025	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling events	5.0	25.0	5.0	-0.013	0.015	1000.0	-1000.0	-0.035	-1000.0
IFN-gamma pathway	4.0	330.0	68.0	-0.176	0.055	1000.0	-1000.0	-0.071	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	181.0	37.0	-0.033	0.037	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	67.0	15.0	-0.0	0.032	1000.0	-1000.0	-0.019	-1000.0
EPHB forward signaling	4.0	363.0	85.0	-0.038	0.044	1000.0	-1000.0	-0.079	-1000.0
Arf6 trafficking events	4.0	287.0	71.0	-0.418	0.048	1000.0	-1000.0	-0.065	-1000.0
PDGFR-beta signaling pathway	4.0	390.0	97.0	-0.06	0.058	1000.0	-1000.0	-0.068	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	0.005	0.018	1000.0	-1000.0	-0.007	-1000.0
Ceramide signaling pathway	3.0	240.0	76.0	-0.246	0.043	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	3.0	186.0	48.0	-0.02	0.047	1000.0	-1000.0	-0.061	-1000.0
Retinoic acid receptors-mediated signaling	3.0	189.0	58.0	-0.081	0.034	1000.0	-1000.0	-0.065	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	157.0	45.0	-0.033	0.066	1000.0	-1000.0	-0.074	-1000.0
TCGA08_rtk_signaling	3.0	90.0	26.0	-0.074	0.045	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	232.0	76.0	-0.017	0.056	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by HDAC Class II	2.0	177.0	75.0	-0.081	0.037	1000.0	-1000.0	-0.046	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	84.0	36.0	-0.034	0.036	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events	2.0	172.0	73.0	-0.06	0.037	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in keratinocytes	2.0	97.0	43.0	-0.044	0.047	1000.0	-1000.0	-0.05	-1000.0
p38 MAPK signaling pathway	2.0	109.0	44.0	-0.04	0.044	1000.0	-1000.0	-0.054	-1000.0
Canonical NF-kappaB pathway	1.0	72.0	39.0	-0.03	0.088	1000.0	-1000.0	-0.072	-1000.0
Circadian rhythm pathway	1.0	22.0	22.0	-0.015	0.05	1000.0	-1000.0	-0.034	-1000.0
Insulin-mediated glucose transport	1.0	46.0	32.0	-0.143	0.039	1000.0	-1000.0	-0.052	-1000.0
ceramide signaling pathway	1.0	72.0	49.0	-0.024	0.049	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	1.0	58.0	43.0	-0.159	0.162	1000.0	-1000.0	-0.058	-1000.0
FoxO family signaling	1.0	105.0	64.0	-0.071	0.095	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	213.0	125.0	-0.039	0.096	1000.0	-1000.0	-0.076	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	0.0	0.052	1000.0	-1000.0	-0.044	-1000.0
Arf6 downstream pathway	0.0	6.0	43.0	-0.037	0.038	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	0.0	50.0	53.0	-0.006	0.04	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by HDAC Class I	0.0	65.0	104.0	-0.01	0.064	1000.0	-1000.0	-0.057	-1000.0
Atypical NF-kappaB pathway	0.0	22.0	31.0	-0.0	0.053	1000.0	-1000.0	-0.028	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	14.0	27.0	-0.0	0.037	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	0.0	50.0	56.0	-0.05	0.07	1000.0	-1000.0	-0.057	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.003	0.038	1000.0	-1000.0	-0.041	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.044	1000.0	-1000.0	-0.028	-1000.0
Total	1983	117228	7203	-23.8318100153	-993.366251732	131000	-131000	-6.89216679631	-131000