E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.002 0.097 -9999.0 0.0 -0.34 16.0 16.0 KLHL20 0.009 0.083 0.203 3.0 -0.204 17.0 20.0 CYFIP2 0.012 0.077 -9999.0 0.0 -0.431 7.0 7.0 Rac1/GDP 0.02 0.09 0.262 7.0 -0.252 8.0 15.0 ENAH -0.002 0.099 -9999.0 0.0 -0.339 17.0 17.0 AP1M1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.015 0.043 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.021 0.044 -9999.0 0.0 -0.14 18.0 18.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.041 0.069 -9999.0 0.0 -0.257 10.0 10.0 RAPGEF1 0.01 0.097 0.296 2.0 -0.36 9.0 11.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.004 0.103 -9999.0 0.0 -0.341 18.0 18.0 CRK 0.003 0.091 -9999.0 0.0 -0.385 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.062 -9999.0 0.0 -0.294 7.0 7.0 alphaE/beta7 Integrin 0.028 0.045 -9999.0 0.0 -0.303 4.0 4.0 IQGAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.003 0.096 -9999.0 0.0 -0.394 9.0 9.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.045 0.025 0.193 1.0 -0.236 1.0 2.0 PI3K 0.003 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.024 0.067 -9999.0 0.0 -0.343 7.0 7.0 TIAM1 0.023 0.03 -9999.0 0.0 -0.431 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.045 0.052 -9999.0 0.0 -0.224 7.0 7.0 AKT1 0.003 0.039 0.138 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.011 0.077 -9999.0 0.0 -0.431 7.0 7.0 RhoA/GDP 0.02 0.088 0.266 6.0 -0.255 7.0 13.0 actin cytoskeleton organization 0.01 0.065 0.172 4.0 -0.15 17.0 21.0 CDC42/GDP 0.021 0.09 0.261 7.0 -0.253 8.0 15.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.048 -9999.0 0.0 -0.249 7.0 7.0 ITGB7 0.018 0.059 -9999.0 0.0 -0.431 4.0 4.0 RAC1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.056 -9999.0 0.0 -0.239 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.033 0.047 -9999.0 0.0 -0.222 7.0 7.0 mol:GDP 0.008 0.095 0.268 7.0 -0.288 8.0 15.0 CDC42/GTP/IQGAP1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.03 -9999.0 0.0 -0.431 1.0 1.0 p120 catenin/RhoA/GDP 0.024 0.088 0.273 5.0 -0.261 7.0 12.0 RAC1/GTP/IQGAP1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.056 0.165 9.0 -0.172 4.0 13.0 NME1 0.026 0.017 0.273 1.0 -9999.0 0.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.002 0.092 -9999.0 0.0 -0.391 10.0 10.0 regulation of cell-cell adhesion 0.007 0.036 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.004 0.036 0.093 1.0 -9999.0 0.0 1.0 Rap1/GTP 0.022 0.058 0.27 2.0 -9999.0 0.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.075 -9999.0 0.0 -0.266 10.0 10.0 CCND1 0.014 0.065 0.187 9.0 -0.195 5.0 14.0 VAV2 -0.026 0.192 -9999.0 0.0 -0.569 19.0 19.0 RAP1/GDP 0.025 0.074 0.279 3.0 -9999.0 0.0 3.0 adherens junction assembly 0.002 0.09 -9999.0 0.0 -0.379 10.0 10.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.035 0.069 -9999.0 0.0 -0.256 10.0 10.0 E-cadherin/beta catenin 0.001 0.058 -9999.0 0.0 -0.308 8.0 8.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.002 0.097 -9999.0 0.0 -0.385 11.0 11.0 PIK3CA 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.022 0.107 0.233 4.0 -0.32 18.0 22.0 E-cadherin/beta catenin/alpha catenin 0.037 0.055 -9999.0 0.0 -0.262 7.0 7.0 ITGAE 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.004 0.105 -9999.0 0.0 -0.353 17.0 17.0