Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.007 0.104 0.321 20.0 -0.209 6.0 26.0 KIRREL -0.012 0.13 -9999.0 0.0 -0.44 20.0 20.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.007 0.105 0.209 6.0 -0.321 20.0 26.0 PLCG1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.035 0.094 0.266 1.0 -0.237 20.0 21.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.004 0.07 -9999.0 0.0 -0.229 16.0 16.0 FYN -0.001 0.099 0.275 10.0 -0.229 21.0 31.0 mol:Ca2+ 0.033 0.088 0.257 1.0 -0.237 17.0 18.0 mol:DAG 0.034 0.089 0.261 1.0 -0.238 17.0 18.0 NPHS2 0.013 0.067 0.274 12.0 -9999.0 0.0 12.0 mol:IP3 0.034 0.089 0.261 1.0 -0.238 17.0 18.0 regulation of endocytosis 0.022 0.081 -9999.0 0.0 -0.214 20.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.023 0.088 0.248 1.0 -0.234 20.0 21.0 establishment of cell polarity 0.007 0.104 0.209 6.0 -0.321 20.0 26.0 Nephrin/NEPH1/podocin/NCK1-2 0.045 0.091 0.268 1.0 -0.218 19.0 20.0 Nephrin/NEPH1/beta Arrestin2 0.024 0.082 -9999.0 0.0 -0.217 20.0 20.0 NPHS1 0.007 0.054 0.282 6.0 -9999.0 0.0 6.0 Nephrin/NEPH1/podocin 0.022 0.089 -9999.0 0.0 -0.23 21.0 21.0 TJP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.035 0.09 0.266 1.0 -0.239 17.0 18.0 CD2AP 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.035 0.094 0.266 1.0 -0.237 20.0 21.0 GRB2 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.001 0.097 0.284 10.0 -0.215 20.0 30.0 cytoskeleton organization -0.009 0.08 0.196 4.0 -0.251 19.0 23.0 Nephrin/NEPH1 0.01 0.075 0.172 6.0 -0.22 20.0 26.0 Nephrin/NEPH1/ZO-1 0.021 0.09 0.201 3.0 -0.254 20.0 23.0