Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.018 0.203 -9999.0 0.0 -0.545 27.0 27.0 IHH 0.05 0.117 0.297 24.0 -0.352 6.0 30.0 SHH Np/Cholesterol/GAS1 -0.11 0.147 -9999.0 0.0 -0.262 108.0 108.0 LRPAP1 0.026 0.018 0.29 1.0 -9999.0 0.0 1.0 dorsoventral neural tube patterning 0.109 0.146 0.261 108.0 -9999.0 0.0 108.0 SMO/beta Arrestin2 -0.031 0.16 -9999.0 0.0 -0.403 23.0 23.0 SMO -0.043 0.162 -9999.0 0.0 -0.359 38.0 38.0 AKT1 -0.014 0.127 -9999.0 0.0 -0.462 11.0 11.0 ARRB2 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.124 -9999.0 0.0 -0.431 19.0 19.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.041 0.16 -9999.0 0.0 -0.354 38.0 38.0 STIL -0.065 0.142 0.252 1.0 -0.242 70.0 71.0 DHH N/PTCH2 0.003 0.102 -9999.0 0.0 -0.309 23.0 23.0 DHH N/PTCH1 -0.0 0.123 -9999.0 0.0 -0.265 35.0 35.0 PIK3CA 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.001 0.096 -9999.0 0.0 -0.431 11.0 11.0 PTHLH -0.057 0.305 -9999.0 0.0 -0.846 28.0 28.0 determination of left/right symmetry -0.041 0.16 -9999.0 0.0 -0.354 38.0 38.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.056 0.301 -9999.0 0.0 -0.836 28.0 28.0 IHH N/Hhip -0.042 0.181 0.201 18.0 -0.345 58.0 76.0 DHH N/Hhip -0.059 0.16 0.199 1.0 -0.32 63.0 64.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.041 0.16 -9999.0 0.0 -0.354 38.0 38.0 pancreas development -0.086 0.192 0.272 1.0 -0.43 56.0 57.0 HHAT 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.052 0.171 0.273 1.0 -0.431 40.0 41.0 somite specification -0.041 0.16 -9999.0 0.0 -0.354 38.0 38.0 SHH Np/Cholesterol/PTCH1 -0.075 0.142 -9999.0 0.0 -0.248 79.0 79.0 SHH Np/Cholesterol/PTCH2 -0.079 0.133 -9999.0 0.0 -0.248 88.0 88.0 SHH Np/Cholesterol/Megalin -0.05 0.136 0.173 23.0 -0.23 80.0 103.0 SHH -0.106 0.147 -9999.0 0.0 -0.308 82.0 82.0 catabolic process 0.002 0.123 -9999.0 0.0 -0.303 29.0 29.0 SMO/Vitamin D3 -0.081 0.164 -9999.0 0.0 -0.371 34.0 34.0 SHH Np/Cholesterol/Hhip -0.126 0.154 -9999.0 0.0 -0.272 117.0 117.0 LRP2 0.071 0.101 0.274 47.0 -9999.0 0.0 47.0 receptor-mediated endocytosis -0.079 0.159 -9999.0 0.0 -0.378 30.0 30.0 SHH Np/Cholesterol/BOC -0.082 0.135 -9999.0 0.0 -0.252 88.0 88.0 SHH Np/Cholesterol/CDO -0.096 0.138 -9999.0 0.0 -0.251 101.0 101.0 mesenchymal cell differentiation 0.126 0.153 0.271 117.0 -9999.0 0.0 117.0 mol:Vitamin D3 -0.072 0.146 -9999.0 0.0 -0.248 79.0 79.0 IHH N/PTCH2 0.029 0.111 0.197 22.0 -0.322 16.0 38.0 CDON -0.027 0.145 -9999.0 0.0 -0.431 27.0 27.0 IHH N/PTCH1 0.02 0.138 -9999.0 0.0 -0.305 29.0 29.0 Megalin/LRPAP1 0.066 0.067 0.207 43.0 -9999.0 0.0 43.0 PTCH2 0.002 0.1 -9999.0 0.0 -0.431 12.0 12.0 SHH Np/Cholesterol -0.073 0.116 -9999.0 0.0 -0.233 82.0 82.0 PTCH1 0.002 0.123 -9999.0 0.0 -0.304 29.0 29.0 HHIP -0.086 0.192 0.273 1.0 -0.431 56.0 57.0