Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.042 -9999.0 0.0 -0.214 7.0 7.0 epithelial cell differentiation 0.04 0.05 -9999.0 0.0 -0.222 7.0 7.0 CYFIP2 0.012 0.077 -9999.0 0.0 -0.431 7.0 7.0 ENAH 0.012 0.088 0.284 13.0 -0.276 1.0 14.0 EGFR 0.022 0.078 0.29 6.0 -0.431 5.0 11.0 EPHA2 0.022 0.042 -9999.0 0.0 -0.431 2.0 2.0 MYO6 -0.003 0.065 0.351 1.0 -0.216 7.0 8.0 CTNNB1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.054 -9999.0 0.0 -0.259 7.0 7.0 AQP5 0.014 0.058 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.005 0.06 0.174 17.0 -0.213 7.0 24.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.076 0.336 2.0 -0.211 10.0 12.0 EGF 0.036 0.061 0.273 14.0 -9999.0 0.0 14.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.083 0.186 -9999.0 0.0 -0.453 41.0 41.0 cortical microtubule organization 0.04 0.05 -9999.0 0.0 -0.222 7.0 7.0 GO:0000145 -0.005 0.057 0.162 17.0 -0.203 7.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.052 -9999.0 0.0 -0.224 7.0 7.0 MLLT4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.022 0.036 -9999.0 0.0 -0.229 6.0 6.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.039 -9999.0 0.0 -0.239 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.005 0.055 0.187 11.0 -0.199 7.0 18.0 PVRL2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.004 0.067 0.186 18.0 -0.214 8.0 26.0 ARF6/GTP 0.063 0.04 -9999.0 0.0 -0.225 1.0 1.0 CDH1 0.011 0.077 -9999.0 0.0 -0.431 7.0 7.0 EGFR/EGFR/EGF/EGF 0.031 0.065 -9999.0 0.0 -0.226 11.0 11.0 RhoA/GDP 0.04 0.049 -9999.0 0.0 -0.214 7.0 7.0 actin cytoskeleton organization -0.005 0.061 0.174 17.0 -0.215 7.0 24.0 IGF-1R heterotetramer 0.023 0.03 -9999.0 0.0 -0.43 1.0 1.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.03 -9999.0 0.0 -0.431 1.0 1.0 IGF1 -0.169 0.225 -9999.0 0.0 -0.431 101.0 101.0 DIAPH1 -0.003 0.155 -9999.0 0.0 -0.536 16.0 16.0 Wnt receptor signaling pathway -0.04 0.05 0.222 7.0 -9999.0 0.0 7.0 RHOA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.036 -9999.0 0.0 -0.23 6.0 6.0 CTNNA1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.005 0.062 0.338 1.0 -0.219 7.0 8.0 EFNA1 0.03 0.038 0.286 5.0 -9999.0 0.0 5.0 LPP -0.008 0.058 0.181 13.0 -0.209 7.0 20.0 Ephrin A1/EPHA2 0.032 0.051 -9999.0 0.0 -0.243 6.0 6.0 SEC6/SEC8 -0.018 0.029 -9999.0 0.0 -0.202 5.0 5.0 MGAT3 0.001 0.077 0.339 2.0 -0.214 10.0 12.0 HGF/MET -0.015 0.109 -9999.0 0.0 -0.211 54.0 54.0 HGF -0.069 0.196 0.273 6.0 -0.431 52.0 58.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.042 -9999.0 0.0 -0.215 7.0 7.0 actin cable formation 0.034 0.095 0.279 18.0 -0.236 1.0 19.0 KIAA1543 -0.004 0.065 0.173 18.0 -0.233 7.0 25.0 KIFC3 -0.005 0.063 0.351 1.0 -0.216 7.0 8.0 NCK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.064 0.351 1.0 -0.216 7.0 8.0 NCK1/GIT1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.04 0.05 -9999.0 0.0 -0.222 7.0 7.0 EXOC4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.003 0.063 0.351 1.0 -0.216 6.0 7.0 PIP5K1C -0.005 0.061 0.176 17.0 -0.216 7.0 24.0 LIMA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.098 0.305 14.0 -0.319 1.0 15.0 adherens junction assembly -0.002 0.076 0.273 1.0 -0.297 4.0 5.0 IGF-1R heterotetramer/IGF1 -0.069 0.126 -9999.0 0.0 -0.214 100.0 100.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.004 0.069 0.186 18.0 -0.244 7.0 25.0 mol:GTP 0.056 0.038 -9999.0 0.0 -0.238 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.027 0.105 0.344 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.013 0.042 -9999.0 0.0 -0.214 7.0 7.0 regulation of cell-cell adhesion -0.005 0.061 0.174 17.0 -0.215 7.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.042 -9999.0 0.0 -0.215 7.0 7.0