Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	71.0	3629.0	51.0	0.024	0.441	1000.0	-1000.0	-0.015	-1000.0
Glypican 2 network	57.0	228.0	4.0	0.04	0.098	1000.0	-1000.0	0.014	-1000.0
Aurora B signaling	52.0	3530.0	67.0	-0.265	0.27	1000.0	-1000.0	-0.033	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	48.0	3290.0	68.0	-0.609	0.319	1000.0	-1000.0	-0.041	-1000.0
IGF1 pathway	47.0	2718.0	57.0	-0.175	0.057	1000.0	-1000.0	-0.019	-1000.0
Signaling mediated by p38-alpha and p38-beta	45.0	1986.0	44.0	-0.2	0.026	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by the Hedgehog family	43.0	2262.0	52.0	-0.126	0.126	1000.0	-1000.0	-0.012	-1000.0
Endothelins	43.0	4191.0	96.0	-0.373	0.139	1000.0	-1000.0	-0.027	-1000.0
Signaling events regulated by Ret tyrosine kinase	42.0	3492.0	82.0	-0.199	0.03	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	40.0	2114.0	52.0	-0.251	0.145	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	39.0	3069.0	78.0	-0.296	0.104	1000.0	-1000.0	-0.03	-1000.0
Reelin signaling pathway	37.0	2099.0	56.0	-0.119	0.07	1000.0	-1000.0	-0.016	-1000.0
IL4-mediated signaling events	35.0	3262.0	91.0	-0.708	0.487	1000.0	-1000.0	-0.069	-1000.0
TCGA08_retinoblastoma	35.0	282.0	8.0	-0.043	0.133	1000.0	-1000.0	-0.005	-1000.0
p75(NTR)-mediated signaling	34.0	4256.0	125.0	-0.108	0.086	1000.0	-1000.0	-0.045	-1000.0
IL23-mediated signaling events	34.0	2073.0	60.0	-0.413	0.056	1000.0	-1000.0	-0.035	-1000.0
Thromboxane A2 receptor signaling	32.0	3420.0	105.0	-0.201	0.047	1000.0	-1000.0	-0.032	-1000.0
Ephrin A  reverse signaling	31.0	219.0	7.0	-0.057	0.012	1000.0	-1000.0	-0.003	-1000.0
Aurora C signaling	29.0	209.0	7.0	0.0	0.128	1000.0	-1000.0	-0.011	-1000.0
Fc-epsilon receptor I signaling in mast cells	28.0	2763.0	97.0	-0.125	0.029	1000.0	-1000.0	-0.046	-1000.0
PLK1 signaling events	28.0	2391.0	85.0	-0.047	0.203	1000.0	-1000.0	-0.03	-1000.0
TCR signaling in naïve CD8+ T cells	28.0	2673.0	93.0	-0.101	0.055	1000.0	-1000.0	-0.033	-1000.0
Plasma membrane estrogen receptor signaling	27.0	2393.0	86.0	-0.252	0.14	1000.0	-1000.0	-0.036	-1000.0
Ras signaling in the CD4+ TCR pathway	27.0	459.0	17.0	-0.119	0.029	1000.0	-1000.0	-0.015	-1000.0
Integrins in angiogenesis	26.0	2186.0	84.0	-0.212	0.127	1000.0	-1000.0	-0.026	-1000.0
LPA receptor mediated events	26.0	2701.0	102.0	-0.206	0.086	1000.0	-1000.0	-0.059	-1000.0
BMP receptor signaling	24.0	1983.0	81.0	-0.225	0.076	1000.0	-1000.0	-0.02	-1000.0
amb2 Integrin signaling	24.0	2030.0	82.0	-0.278	0.086	1000.0	-1000.0	-0.018	-1000.0
TCGA08_p53	24.0	173.0	7.0	-0.018	0.026	1000.0	-1000.0	-0.009	-1000.0
S1P4 pathway	24.0	602.0	25.0	-0.102	0.045	1000.0	-1000.0	-0.012	-1000.0
PDGFR-alpha signaling pathway	23.0	1046.0	44.0	-0.285	0.037	1000.0	-1000.0	-0.028	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	23.0	2867.0	120.0	-0.216	0.168	1000.0	-1000.0	-0.031	-1000.0
JNK signaling in the CD4+ TCR pathway	22.0	378.0	17.0	-0.185	0.028	1000.0	-1000.0	-0.018	-1000.0
Glypican 1 network	22.0	1067.0	48.0	-0.181	0.049	1000.0	-1000.0	-0.016	-1000.0
Calcium signaling in the CD4+ TCR pathway	22.0	710.0	31.0	-0.159	0.025	1000.0	-1000.0	-0.018	-1000.0
Syndecan-1-mediated signaling events	21.0	731.0	34.0	-0.069	0.164	1000.0	-1000.0	-0.016	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1140.0	52.0	-0.219	0.037	1000.0	-1000.0	-0.029	-1000.0
S1P1 pathway	21.0	786.0	36.0	-0.279	0.025	1000.0	-1000.0	-0.025	-1000.0
IL6-mediated signaling events	21.0	1624.0	75.0	-0.188	0.055	1000.0	-1000.0	-0.046	-1000.0
LPA4-mediated signaling events	20.0	241.0	12.0	-0.122	0.006	1000.0	-1000.0	-0.016	-1000.0
Glucocorticoid receptor regulatory network	20.0	2313.0	114.0	-0.496	0.097	1000.0	-1000.0	-0.043	-1000.0
Rapid glucocorticoid signaling	20.0	419.0	20.0	-0.14	0.065	1000.0	-1000.0	-0.002	-1000.0
Osteopontin-mediated events	19.0	725.0	38.0	-0.113	0.13	1000.0	-1000.0	-0.024	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	19.0	1036.0	54.0	-0.119	0.07	1000.0	-1000.0	-0.019	-1000.0
S1P5 pathway	19.0	330.0	17.0	-0.102	0.073	1000.0	-1000.0	-0.004	-1000.0
S1P3 pathway	19.0	835.0	42.0	-0.102	0.037	1000.0	-1000.0	-0.017	-1000.0
IL12-mediated signaling events	18.0	1608.0	87.0	-0.386	0.061	1000.0	-1000.0	-0.048	-1000.0
Visual signal transduction: Cones	18.0	688.0	38.0	-0.073	0.086	1000.0	-1000.0	-0.005	-1000.0
BCR signaling pathway	18.0	1877.0	99.0	-0.103	0.033	1000.0	-1000.0	-0.047	-1000.0
Coregulation of Androgen receptor activity	17.0	1321.0	76.0	-0.186	0.133	1000.0	-1000.0	-0.014	-1000.0
HIF-1-alpha transcription factor network	16.0	1280.0	76.0	-0.112	0.139	1000.0	-1000.0	-0.015	-1000.0
FAS signaling pathway (CD95)	16.0	780.0	47.0	-0.53	0.042	1000.0	-1000.0	-0.025	-1000.0
ErbB2/ErbB3 signaling events	15.0	1001.0	65.0	-0.174	0.037	1000.0	-1000.0	-0.051	-1000.0
Aurora A signaling	15.0	930.0	60.0	-0.202	0.205	1000.0	-1000.0	-0.007	-1000.0
Wnt signaling	15.0	111.0	7.0	-0.008	0.03	1000.0	-1000.0	-0.002	-1000.0
Angiopoietin receptor Tie2-mediated signaling	15.0	1333.0	88.0	-0.166	0.057	1000.0	-1000.0	-0.052	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	481.0	34.0	-0.012	0.045	1000.0	-1000.0	-0.024	-1000.0
Noncanonical Wnt signaling pathway	14.0	389.0	26.0	-0.061	0.03	1000.0	-1000.0	-0.022	-1000.0
Syndecan-2-mediated signaling events	14.0	1015.0	69.0	-0.039	0.067	1000.0	-1000.0	-0.021	-1000.0
Arf6 signaling events	14.0	926.0	62.0	-0.168	0.058	1000.0	-1000.0	-0.034	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1210.0	85.0	-0.215	0.036	1000.0	-1000.0	-0.035	-1000.0
Class IB PI3K non-lipid kinase events	14.0	42.0	3.0	-0.002	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Presenilin action in Notch and Wnt signaling	13.0	806.0	61.0	-0.113	0.129	1000.0	-1000.0	-0.022	-1000.0
Effects of Botulinum toxin	12.0	319.0	26.0	-0.009	0.066	1000.0	-1000.0	-0.0	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	12.0	894.0	74.0	-0.169	0.063	1000.0	-1000.0	-0.043	-1000.0
Syndecan-4-mediated signaling events	12.0	836.0	67.0	-0.112	0.086	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	12.0	423.0	33.0	-0.195	0.132	1000.0	-1000.0	-0.015	-1000.0
Visual signal transduction: Rods	12.0	638.0	52.0	-0.073	0.131	1000.0	-1000.0	-0.02	-1000.0
Regulation of Androgen receptor activity	12.0	886.0	70.0	-0.202	0.031	1000.0	-1000.0	-0.032	-1000.0
FOXA2 and FOXA3 transcription factor networks	11.0	507.0	46.0	-0.15	0.229	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	11.0	581.0	51.0	-0.087	0.129	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	297.0	28.0	-0.102	0.056	1000.0	-1000.0	-0.008	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	659.0	65.0	-0.101	0.061	1000.0	-1000.0	-0.023	-1000.0
Ephrin B reverse signaling	10.0	481.0	48.0	-0.04	0.044	1000.0	-1000.0	-0.032	-1000.0
IL27-mediated signaling events	10.0	514.0	51.0	-0.169	0.071	1000.0	-1000.0	-0.035	-1000.0
Nectin adhesion pathway	9.0	602.0	63.0	-0.033	0.053	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	9.0	586.0	62.0	-0.008	0.062	1000.0	-1000.0	-0.023	-1000.0
ceramide signaling pathway	9.0	483.0	49.0	-0.0	0.049	1000.0	-1000.0	-0.025	-1000.0
IL2 signaling events mediated by PI3K	9.0	562.0	58.0	-0.058	0.123	1000.0	-1000.0	-0.028	-1000.0
IL2 signaling events mediated by STAT5	9.0	201.0	22.0	-0.038	0.095	1000.0	-1000.0	-0.015	-1000.0
Insulin Pathway	9.0	705.0	74.0	-0.175	0.063	1000.0	-1000.0	-0.027	-1000.0
ErbB4 signaling events	8.0	604.0	69.0	-0.174	0.044	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by PTP1B	8.0	636.0	76.0	-0.1	0.046	1000.0	-1000.0	-0.025	-1000.0
Ceramide signaling pathway	8.0	640.0	76.0	-0.169	0.069	1000.0	-1000.0	-0.019	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	678.0	83.0	-0.228	0.047	1000.0	-1000.0	-0.013	-1000.0
EPHB forward signaling	8.0	736.0	85.0	-0.027	0.068	1000.0	-1000.0	-0.043	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	996.0	136.0	-0.131	0.107	1000.0	-1000.0	-0.027	-1000.0
Cellular roles of Anthrax toxin	7.0	293.0	39.0	-0.065	0.037	1000.0	-1000.0	-0.017	-1000.0
Regulation of p38-alpha and p38-beta	7.0	393.0	54.0	-0.088	0.055	1000.0	-1000.0	-0.039	-1000.0
EGFR-dependent Endothelin signaling events	7.0	159.0	21.0	-0.023	0.072	1000.0	-1000.0	-0.027	-1000.0
PDGFR-beta signaling pathway	7.0	771.0	97.0	-0.074	0.057	1000.0	-1000.0	-0.036	-1000.0
Caspase cascade in apoptosis	6.0	506.0	74.0	-0.034	0.046	1000.0	-1000.0	-0.024	-1000.0
EPO signaling pathway	6.0	343.0	55.0	-0.015	0.068	1000.0	-1000.0	-0.01	-1000.0
IFN-gamma pathway	6.0	431.0	68.0	-0.12	0.079	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	283.0	45.0	-0.009	0.06	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	5.0	328.0	57.0	-0.045	0.107	1000.0	-1000.0	-0.039	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	29.0	5.0	0.015	0.028	1000.0	-1000.0	0.014	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	407.0	68.0	-0.134	0.058	1000.0	-1000.0	-0.019	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	206.0	37.0	-0.016	0.053	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class III	5.0	236.0	40.0	-0.152	0.047	1000.0	-1000.0	-0.034	-1000.0
TCGA08_rtk_signaling	5.0	149.0	26.0	-0.043	0.053	1000.0	-1000.0	-0.009	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	446.0	76.0	-0.026	0.049	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	5.0	566.0	102.0	-0.109	0.129	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by PRL	5.0	175.0	34.0	-0.061	0.04	1000.0	-1000.0	-0.033	-1000.0
mTOR signaling pathway	4.0	257.0	53.0	-0.039	0.033	1000.0	-1000.0	-0.024	-1000.0
HIF-2-alpha transcription factor network	4.0	184.0	43.0	-0.107	0.111	1000.0	-1000.0	-0.034	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	72.0	15.0	-0.016	0.024	1000.0	-1000.0	-0.021	-1000.0
Syndecan-3-mediated signaling events	4.0	158.0	35.0	-0.061	0.059	1000.0	-1000.0	-0.015	-1000.0
Arf6 trafficking events	4.0	338.0	71.0	-0.267	0.047	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling in keratinocytes	4.0	197.0	43.0	-0.027	0.041	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling events	4.0	22.0	5.0	0.011	0.036	1000.0	-1000.0	0.013	-1000.0
Insulin-mediated glucose transport	3.0	113.0	32.0	-0.142	0.047	1000.0	-1000.0	-0.01	-1000.0
FoxO family signaling	3.0	203.0	64.0	-0.018	0.159	1000.0	-1000.0	-0.026	-1000.0
Retinoic acid receptors-mediated signaling	3.0	216.0	58.0	-0.057	0.057	1000.0	-1000.0	-0.026	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	117.0	36.0	-0.041	0.042	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events	3.0	280.0	73.0	-0.028	0.045	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	3.0	132.0	44.0	-0.003	0.062	1000.0	-1000.0	-0.013	-1000.0
Canonical NF-kappaB pathway	2.0	112.0	39.0	-0.0	0.062	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by HDAC Class II	2.0	179.0	75.0	-0.044	0.063	1000.0	-1000.0	-0.022	-1000.0
TRAIL signaling pathway	2.0	122.0	48.0	-0.019	0.054	1000.0	-1000.0	-0.02	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	61.0	27.0	-0.01	0.061	1000.0	-1000.0	-0.027	-1000.0
VEGFR1 specific signals	2.0	165.0	56.0	-0.06	0.065	1000.0	-1000.0	-0.029	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	0.003	0.046	1000.0	-1000.0	-0.008	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	0.013	0.031	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by HDAC Class I	1.0	134.0	104.0	-0.047	0.063	1000.0	-1000.0	-0.036	-1000.0
Atypical NF-kappaB pathway	1.0	38.0	31.0	0.0	0.034	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	202.0	125.0	-0.047	0.067	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	0.0	19.0	22.0	-0.008	0.055	1000.0	-1000.0	-0.031	-1000.0
Arf6 downstream pathway	0.0	37.0	43.0	-0.049	0.05	1000.0	-1000.0	-0.023	-1000.0
Arf1 pathway	0.0	33.0	54.0	-0.001	0.045	1000.0	-1000.0	-0.01	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.067	1000.0	-1000.0	-0.0	-1000.0
Total	2065	122333	7203	-15.8989327121	-989.586929088	131000	-131000	-3.04723907652	-131000