Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.054 0.299 -9999.0 0.0 -0.818 124.0 124.0 IHH -0.014 0.082 -9999.0 0.0 -0.455 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.03 0.115 -9999.0 0.0 -0.501 57.0 57.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.114 0.498 57.0 -9999.0 0.0 57.0 SMO/beta Arrestin2 -0.076 0.233 -9999.0 0.0 -0.848 78.0 78.0 SMO -0.037 0.265 -9999.0 0.0 -0.908 78.0 78.0 AKT1 0.008 0.113 -9999.0 0.0 -0.328 77.0 77.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.06 0.212 -9999.0 0.0 -0.803 78.0 78.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.035 0.258 -9999.0 0.0 -0.882 78.0 78.0 STIL -0.04 0.212 -9999.0 0.0 -0.71 80.0 80.0 DHH N/PTCH2 -0.066 0.198 -9999.0 0.0 -0.644 105.0 105.0 DHH N/PTCH1 -0.09 0.245 -9999.0 0.0 -0.782 101.0 101.0 PIK3CA -0.0 0.009 -9999.0 0.0 -0.289 1.0 1.0 DHH -0.023 0.133 -9999.0 0.0 -0.803 29.0 29.0 PTHLH -0.082 0.381 -9999.0 0.0 -1.066 124.0 124.0 determination of left/right symmetry -0.035 0.258 -9999.0 0.0 -0.882 78.0 78.0 PIK3R1 -0.008 0.079 -9999.0 0.0 -0.803 10.0 10.0 skeletal system development -0.079 0.372 -9999.0 0.0 -1.043 124.0 124.0 IHH N/Hhip -0.014 0.046 -9999.0 0.0 -0.663 1.0 1.0 DHH N/Hhip -0.02 0.106 -9999.0 0.0 -0.625 30.0 30.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.035 0.258 -9999.0 0.0 -0.882 78.0 78.0 pancreas development -0.004 0.038 -9999.0 0.0 -0.336 11.0 11.0 HHAT -0.001 0.025 -9999.0 0.0 -0.803 1.0 1.0 PI3K -0.006 0.06 -9999.0 0.0 -0.614 10.0 10.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.043 0.182 -9999.0 0.0 -0.803 56.0 56.0 somite specification -0.035 0.258 -9999.0 0.0 -0.882 78.0 78.0 SHH Np/Cholesterol/PTCH1 -0.072 0.207 -9999.0 0.0 -0.764 77.0 77.0 SHH Np/Cholesterol/PTCH2 -0.042 0.136 -9999.0 0.0 -0.498 83.0 83.0 SHH Np/Cholesterol/Megalin -0.136 0.218 -9999.0 0.0 -0.498 272.0 272.0 SHH 0.01 0.036 -9999.0 0.0 -0.623 1.0 1.0 catabolic process -0.048 0.26 -9999.0 0.0 -0.861 86.0 86.0 SMO/Vitamin D3 -0.075 0.226 -9999.0 0.0 -0.824 78.0 78.0 SHH Np/Cholesterol/Hhip -0.005 0.034 -9999.0 0.0 -0.5 2.0 2.0 LRP2 -0.217 0.352 -9999.0 0.0 -0.803 271.0 271.0 receptor-mediated endocytosis -0.15 0.254 -9999.0 0.0 -0.829 94.0 94.0 SHH Np/Cholesterol/BOC -0.041 0.133 -9999.0 0.0 -0.5 79.0 79.0 SHH Np/Cholesterol/CDO -0.01 0.06 -9999.0 0.0 -0.493 14.0 14.0 mesenchymal cell differentiation 0.005 0.034 0.496 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.031 0.223 -9999.0 0.0 -0.768 77.0 77.0 IHH N/PTCH2 -0.065 0.186 -9999.0 0.0 -0.668 86.0 86.0 CDON -0.01 0.089 -9999.0 0.0 -0.803 13.0 13.0 IHH N/PTCH1 -0.046 0.263 -9999.0 0.0 -0.868 86.0 86.0 Megalin/LRPAP1 -0.165 0.269 -9999.0 0.0 -0.614 271.0 271.0 PTCH2 -0.064 0.217 -9999.0 0.0 -0.803 82.0 82.0 SHH Np/Cholesterol -0.004 0.026 -9999.0 0.0 -0.505 1.0 1.0 PTCH1 -0.048 0.261 -9999.0 0.0 -0.866 86.0 86.0 HHIP -0.004 0.038 -9999.0 0.0 -0.336 11.0 11.0