Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.058 -9999.0 0.0 -0.328 33.0 33.0 epithelial cell differentiation -0.014 0.078 -9999.0 0.0 -0.451 32.0 32.0 CYFIP2 -0.01 0.067 -9999.0 0.0 -0.358 30.0 30.0 ENAH 0.056 0.063 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.294 0.386 -9999.0 0.0 -0.797 383.0 383.0 EPHA2 -0.005 0.061 -9999.0 0.0 -0.803 6.0 6.0 MYO6 -0.014 0.075 -9999.0 0.0 -0.427 33.0 33.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.039 -9999.0 0.0 -0.53 4.0 4.0 AQP5 -0.239 0.296 -9999.0 0.0 -0.595 412.0 412.0 CTNND1 -0.0 0.009 -9999.0 0.0 -0.289 1.0 1.0 mol:PI-4-5-P2 -0.013 0.073 -9999.0 0.0 -0.42 32.0 32.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.119 -9999.0 0.0 -0.43 86.0 86.0 EGF -0.156 0.317 -9999.0 0.0 -0.798 202.0 202.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.039 0.142 -9999.0 0.0 -0.575 56.0 56.0 cortical microtubule organization -0.014 0.078 -9999.0 0.0 -0.451 32.0 32.0 GO:0000145 0.024 0.076 -9999.0 0.0 -0.401 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.079 -9999.0 0.0 -0.456 32.0 32.0 MLLT4 -0.005 0.062 -9999.0 0.0 -0.73 7.0 7.0 ARF6/GDP -0.013 0.066 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.037 -9999.0 0.0 -0.481 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.035 0.08 -9999.0 0.0 -0.392 32.0 32.0 PVRL2 -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.074 -9999.0 0.0 -0.427 32.0 32.0 ARF6/GTP -0.003 0.034 -9999.0 0.0 -0.442 6.0 6.0 CDH1 -0.025 0.139 -9999.0 0.0 -0.803 32.0 32.0 EGFR/EGFR/EGF/EGF -0.244 0.262 -9999.0 0.0 -0.474 533.0 533.0 RhoA/GDP -0.013 0.073 -9999.0 0.0 -0.422 32.0 32.0 actin cytoskeleton organization 0.031 0.079 -9999.0 0.0 -0.402 33.0 33.0 IGF-1R heterotetramer -0.021 0.119 -9999.0 0.0 -0.802 22.0 22.0 GIT1 -0.001 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.021 0.12 -9999.0 0.0 -0.803 22.0 22.0 IGF1 -0.179 0.334 -9999.0 0.0 -0.803 231.0 231.0 DIAPH1 -0.002 0.045 -9999.0 0.0 -0.699 4.0 4.0 Wnt receptor signaling pathway 0.014 0.078 0.451 32.0 -9999.0 0.0 32.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.066 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.031 0.08 -9999.0 0.0 -0.412 33.0 33.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.028 0.087 -9999.0 0.0 -0.403 40.0 40.0 Ephrin A1/EPHA2 -0.015 0.077 -9999.0 0.0 -0.408 38.0 38.0 SEC6/SEC8 -0.014 0.072 -9999.0 0.0 -0.763 1.0 1.0 MGAT3 -0.037 0.122 -9999.0 0.0 -0.438 86.0 86.0 HGF/MET -0.109 0.207 -9999.0 0.0 -0.462 244.0 244.0 HGF -0.053 0.199 -9999.0 0.0 -0.803 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.058 -9999.0 0.0 -0.331 33.0 33.0 actin cable formation 0.07 0.061 -9999.0 0.0 -0.327 1.0 1.0 KIAA1543 0.03 0.089 -9999.0 0.0 -0.437 33.0 33.0 KIFC3 -0.014 0.076 -9999.0 0.0 -0.428 34.0 34.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.075 -9999.0 0.0 -0.427 33.0 33.0 NCK1/GIT1 -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.014 0.078 -9999.0 0.0 -0.451 32.0 32.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.074 -9999.0 0.0 -0.427 32.0 32.0 PIP5K1C -0.013 0.074 -9999.0 0.0 -0.427 32.0 32.0 LIMA1 -0.001 0.025 -9999.0 0.0 -0.803 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.046 0.086 -9999.0 0.0 -0.644 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.115 0.2 -9999.0 0.0 -0.442 267.0 267.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.048 -9999.0 0.0 -0.614 6.0 6.0 MET -0.134 0.299 -9999.0 0.0 -0.803 172.0 172.0 PLEKHA7 -0.014 0.081 -9999.0 0.0 -0.455 32.0 32.0 mol:GTP -0.003 0.037 -9999.0 0.0 -0.477 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.013 0.068 -9999.0 0.0 -0.717 1.0 1.0 cortical actin cytoskeleton stabilization -0.01 0.058 -9999.0 0.0 -0.328 33.0 33.0 regulation of cell-cell adhesion 0.031 0.079 -9999.0 0.0 -0.402 33.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.058 -9999.0 0.0 -0.331 33.0 33.0