E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.115 -9999.0 0.0 -0.408 47.0 47.0 KLHL20 0.015 0.066 0.23 11.0 -0.218 17.0 28.0 CYFIP2 0.028 0.049 0.26 25.0 -0.576 3.0 28.0 Rac1/GDP -0.0 0.087 0.261 8.0 -0.309 21.0 29.0 ENAH -0.017 0.107 -9999.0 0.0 -0.403 44.0 44.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.05 -9999.0 0.0 -0.251 20.0 20.0 ABI1/Sra1/Nap1 -0.013 0.033 -9999.0 0.0 -0.148 20.0 20.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.07 -9999.0 0.0 -0.338 23.0 23.0 RAPGEF1 -0.019 0.109 0.258 2.0 -0.385 38.0 40.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.126 -9999.0 0.0 -0.414 56.0 56.0 CRK -0.017 0.105 -9999.0 0.0 -0.397 45.0 45.0 E-cadherin/gamma catenin/alpha catenin 0.031 0.064 -9999.0 0.0 -0.368 21.0 21.0 alphaE/beta7 Integrin 0.036 0.035 -9999.0 0.0 -0.427 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.028 -9999.0 0.0 -0.336 3.0 3.0 DLG1 -0.025 0.121 -9999.0 0.0 -0.408 53.0 53.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.032 -9999.0 0.0 -0.188 20.0 20.0 MLLT4 0.021 0.034 0.26 1.0 -0.576 3.0 4.0 ARF6/GTP/NME1/Tiam1 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.004 0.047 -9999.0 0.0 -0.242 20.0 20.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.019 0.07 -9999.0 0.0 -0.342 32.0 32.0 TIAM1 0.025 0.015 0.26 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.04 0.059 -9999.0 0.0 -0.319 21.0 21.0 AKT1 -0.007 0.036 -9999.0 0.0 -0.212 1.0 1.0 PIK3R1 0.018 0.056 -9999.0 0.0 -0.576 9.0 9.0 CDH1 0.009 0.085 -9999.0 0.0 -0.576 21.0 21.0 RhoA/GDP -0.0 0.087 0.259 8.0 -0.312 20.0 28.0 actin cytoskeleton organization 0.014 0.054 0.187 20.0 -0.163 13.0 33.0 CDC42/GDP 0.0 0.086 0.259 8.0 -0.307 22.0 30.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.046 -9999.0 0.0 -0.236 33.0 33.0 ITGB7 0.029 0.046 0.26 27.0 -0.576 2.0 29.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.043 0.063 -9999.0 0.0 -0.338 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.029 0.055 -9999.0 0.0 -0.316 21.0 21.0 mol:GDP -0.014 0.093 0.267 8.0 -0.355 22.0 30.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.089 0.264 5.0 -0.319 20.0 25.0 RAC1/GTP/IQGAP1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.049 0.178 42.0 -0.24 4.0 46.0 NME1 0.026 0.03 0.26 15.0 -9999.0 0.0 15.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.119 -9999.0 0.0 -0.415 49.0 49.0 regulation of cell-cell adhesion 0.003 0.042 -9999.0 0.0 -0.221 20.0 20.0 WASF2 0.007 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.012 0.06 0.239 2.0 -0.279 20.0 22.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.07 -9999.0 0.0 -0.322 23.0 23.0 CCND1 0.014 0.056 0.196 39.0 -0.303 4.0 43.0 VAV2 -0.02 0.151 -9999.0 0.0 -0.537 41.0 41.0 RAP1/GDP 0.006 0.072 0.264 3.0 -0.286 20.0 23.0 adherens junction assembly -0.022 0.116 -9999.0 0.0 -0.402 49.0 49.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.066 -9999.0 0.0 -0.311 23.0 23.0 E-cadherin/beta catenin -0.001 0.064 -9999.0 0.0 -0.346 32.0 32.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.12 -9999.0 0.0 -0.405 54.0 54.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.006 0.091 0.26 30.0 -0.339 25.0 55.0 E-cadherin/beta catenin/alpha catenin 0.032 0.064 -9999.0 0.0 -0.368 21.0 21.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.129 -9999.0 0.0 -0.423 56.0 56.0