Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.015 0.14 0.421 80.0 -0.226 11.0 91.0 KIRREL -0.023 0.163 -9999.0 0.0 -0.58 80.0 80.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.015 0.14 0.227 11.0 -0.422 80.0 91.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.034 0.118 0.287 4.0 -0.326 77.0 81.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.008 0.088 0.238 1.0 -0.274 75.0 76.0 FYN 0.015 0.129 0.271 106.0 -0.312 76.0 182.0 mol:Ca2+ 0.032 0.113 0.281 3.0 -0.323 72.0 75.0 mol:DAG 0.033 0.114 0.286 3.0 -0.324 72.0 75.0 NPHS2 0.014 0.032 0.266 5.0 -9999.0 0.0 5.0 mol:IP3 0.033 0.114 0.286 3.0 -0.324 72.0 75.0 regulation of endocytosis 0.024 0.105 0.244 6.0 -0.295 76.0 82.0 Nephrin/NEPH1/podocin/Cholesterol 0.024 0.113 0.252 9.0 -0.323 77.0 86.0 establishment of cell polarity 0.015 0.14 0.226 11.0 -0.421 80.0 91.0 Nephrin/NEPH1/podocin/NCK1-2 0.044 0.114 0.3 2.0 -0.301 75.0 77.0 Nephrin/NEPH1/beta Arrestin2 0.027 0.108 0.253 6.0 -0.298 76.0 82.0 NPHS1 0.06 0.092 0.262 161.0 -9999.0 0.0 161.0 Nephrin/NEPH1/podocin 0.026 0.111 0.306 4.0 -0.313 76.0 80.0 TJP1 0.023 0.02 -9999.0 0.0 -0.576 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.034 0.115 0.291 3.0 -0.326 72.0 75.0 CD2AP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.032 0.116 0.297 5.0 -0.325 74.0 79.0 GRB2 0.023 0.01 0.26 1.0 -9999.0 0.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.013 0.134 0.281 101.0 -0.313 82.0 183.0 cytoskeleton organization 0.004 0.108 0.271 17.0 -0.324 72.0 89.0 Nephrin/NEPH1 0.017 0.104 0.19 7.0 -0.304 78.0 85.0 Nephrin/NEPH1/ZO-1 0.026 0.121 -9999.0 0.0 -0.35 78.0 78.0