Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.046 -9999.0 0.0 -0.262 22.0 22.0 epithelial cell differentiation 0.035 0.057 -9999.0 0.0 -0.316 21.0 21.0 CYFIP2 0.028 0.049 0.26 25.0 -0.576 3.0 28.0 ENAH -0.004 0.06 0.294 10.0 -9999.0 0.0 10.0 EGFR -0.19 0.287 -9999.0 0.0 -0.576 363.0 363.0 EPHA2 0.02 0.042 -9999.0 0.0 -0.576 5.0 5.0 MYO6 -0.013 0.054 0.361 1.0 -0.306 22.0 23.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.035 -9999.0 0.0 -0.368 3.0 3.0 AQP5 -0.188 0.262 0.332 1.0 -0.502 404.0 405.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.052 0.358 1.0 -0.301 21.0 22.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.078 0.358 1.0 -0.305 62.0 63.0 EGF -0.083 0.23 0.26 2.0 -0.576 182.0 184.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.017 0.118 0.289 1.0 -0.463 52.0 53.0 cortical microtubule organization 0.035 0.057 -9999.0 0.0 -0.316 21.0 21.0 GO:0000145 -0.013 0.05 0.351 1.0 -0.288 21.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.059 -9999.0 0.0 -0.319 21.0 21.0 MLLT4 0.021 0.034 0.26 1.0 -0.576 3.0 4.0 ARF6/GDP -0.021 0.04 -9999.0 0.0 -0.279 20.0 20.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.039 -9999.0 0.0 -0.335 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.002 0.052 -9999.0 0.0 -0.287 21.0 21.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.052 0.361 1.0 -0.305 21.0 22.0 ARF6/GTP 0.049 0.041 -9999.0 0.0 -0.314 5.0 5.0 CDH1 0.009 0.085 -9999.0 0.0 -0.576 21.0 21.0 EGFR/EGFR/EGF/EGF -0.144 0.198 -9999.0 0.0 -0.335 491.0 491.0 RhoA/GDP 0.036 0.056 -9999.0 0.0 -0.303 21.0 21.0 actin cytoskeleton organization -0.014 0.051 0.343 1.0 -0.298 22.0 23.0 IGF-1R heterotetramer 0.012 0.082 0.259 2.0 -0.575 19.0 21.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.082 0.26 2.0 -0.576 19.0 21.0 IGF1 -0.104 0.246 -9999.0 0.0 -0.576 217.0 217.0 DIAPH1 0.026 0.102 -9999.0 0.0 -0.574 11.0 11.0 Wnt receptor signaling pathway -0.035 0.057 0.316 21.0 -9999.0 0.0 21.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.04 -9999.0 0.0 -0.28 20.0 20.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.052 0.346 1.0 -0.305 22.0 23.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.055 -9999.0 0.0 -0.296 28.0 28.0 Ephrin A1/EPHA2 0.024 0.055 -9999.0 0.0 -0.298 21.0 21.0 SEC6/SEC8 -0.022 0.045 -9999.0 0.0 -0.299 23.0 23.0 MGAT3 -0.025 0.079 0.361 1.0 -0.31 62.0 63.0 HGF/MET -0.04 0.155 -9999.0 0.0 -0.326 216.0 216.0 HGF -0.011 0.141 -9999.0 0.0 -0.576 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.046 -9999.0 0.0 -0.264 22.0 22.0 actin cable formation 0.04 0.095 0.317 31.0 -0.277 2.0 33.0 KIAA1543 -0.013 0.054 0.354 1.0 -0.318 21.0 22.0 KIFC3 -0.013 0.051 0.361 1.0 -0.306 21.0 22.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.052 -9999.0 0.0 -0.306 21.0 21.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.035 0.057 -9999.0 0.0 -0.316 21.0 21.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.05 0.361 1.0 -0.306 19.0 20.0 PIP5K1C -0.013 0.053 0.361 1.0 -0.306 21.0 22.0 LIMA1 0.024 0.019 -9999.0 0.0 -0.576 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.088 0.305 23.0 -9999.0 0.0 23.0 adherens junction assembly -0.023 0.104 0.298 3.0 -0.637 15.0 18.0 IGF-1R heterotetramer/IGF1 -0.044 0.151 -9999.0 0.0 -0.315 225.0 225.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.03 -9999.0 0.0 -0.303 6.0 6.0 MET -0.071 0.219 -9999.0 0.0 -0.576 162.0 162.0 PLEKHA7 -0.013 0.057 0.361 1.0 -0.333 21.0 22.0 mol:GTP 0.043 0.038 -9999.0 0.0 -0.333 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.009 0.068 0.373 6.0 -0.523 1.0 7.0 cortical actin cytoskeleton stabilization 0.011 0.046 -9999.0 0.0 -0.262 22.0 22.0 regulation of cell-cell adhesion -0.014 0.051 0.343 1.0 -0.298 22.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.046 -9999.0 0.0 -0.264 22.0 22.0